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Positive-strand RNA viruses

Section Editor: Alexander A Khromykh, University of Queensland, Australia
Deputy Section Editor: Michael Beard, University of Adelaide, Australia

The Positive-strand RNA viruses section of Virology Journal invites submissions of research articles and reviews covering all aspects of positive-strand RNA virus biology. Basic research topics of interest include all facets of the viral life cycle from viral attachment and entry, viral RNA replication and translation, viral gene expression/regulation, viral protein processing, viral particle assembly and secretion. We welcome studies that investigate interactions between the virus and host that impact viral replication and the cellular response to infection. Other topics include but are not limited to viral pathogenesis, epidemiology, and viral immunology. We also welcome basic and translational studies on the development of novel model systems, antiviral drugs and vaccines.

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  1. Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease, which mostly affects infants and children and leads to severe neurological diseases. Vaccination offers the best option for...

    Authors: Ting Yang, Hua Li, Lei Yue, Xia Song, Tianhong Xie, Shaohui Ma, Huaqing Meng, Ye Zhang, Xin He, Runxiang Long, Rong Yang, Fangyu Luo, Zhongping Xie and Qihan Li

    Citation: Virology Journal 2017 14:206

    Content type: Research

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  2. The need to investigate the contribution of non-polio enteroviruses to acute flaccid paralysis (AFP) cannot be over emphasized as we move towards a poliovirus free world. Hence, we aim to identify non-polio en...

    Authors: T. O. C. Faleye, M. O. Adewumi, M. O. Japhet, O. M. David, A. O. Oluyege, J. A. Adeniji and O. Famurewa

    Citation: Virology Journal 2017 14:175

    Content type: Research

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  3. Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principl...

    Authors: Yakov Vitrenko, Iryna Kostenko, Kateryna Kulebyakina and Khrystyna Sorochynska

    Citation: Virology Journal 2017 14:167

    Content type: Research

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  4. Echovirus 30 (E30) causes acute aseptic meningitis. Viral replication requires energy and macromolecular precursors derived from the metabolic network of the host cell. The effect of viral infection within a h...

    Authors: Sarika Tiwari and Tapan N. Dhole

    Citation: Virology Journal 2017 14:144

    Content type: Research

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    The Erratum to this article has been published in Virology Journal 2017 14:182

  5. Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeut...

    Authors: Chris M. Cirimotich, Eric M. Vela, Jennifer Garver, Roy E. Barnewall, Brian D. Miller, Gabriel T. Meister and James V. Rogers

    Citation: Virology Journal 2017 14:135

    Content type: Research

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  6. Bovine coronavirus (BCoV) belong to the genus Betacoronavirus of the family Coronaviridae. BCoV are widespread around the world and cause enteric or respiratory infections among cattle, leading to important econo...

    Authors: Matías Castells, Matías Victoria, Rodney Colina, Héctor Musto and Juan Cristina

    Citation: Virology Journal 2017 14:115

    Content type: Research

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  7. We previously reported the discovery of a novel, putative flavivirus designated T’Ho virus in Culex quinquefasciatus mosquitoes in the Yucatan Peninsula of Mexico. A 1358-nt region of the NS5 gene was amplified a...

    Authors: Thomas Briese, Maria A. Loroño-Pino, Julian E. Garcia-Rejon, Jose A. Farfan-Ale, Carlos Machain-Williams, Karin S. Dorman, W. Ian Lipkin and Bradley J. Blitvich

    Citation: Virology Journal 2017 14:110

    Content type: Research

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  8. Zika virus is an emerging pathogen of global importance. It has been responsible for recent outbreaks in the Americas and in the Pacific region. This study assessed five different mosquito species from the tem...

    Authors: Jean-Bernard Duchemin, Peter T. Mee, Stacey E. Lynch, Ravikiran Vedururu, Lee Trinidad and Prasad Paradkar

    Citation: Virology Journal 2017 14:108

    Content type: Research

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  9. Rodents represent the most diverse mammals on the planet and are important reservoirs of human pathogens. Coronaviruses infect various animals, but to date, relatively few coronaviruses have been identified in...

    Authors: Xing-Yi Ge, Wei-Hong Yang, Ji-Hua Zhou, Bei Li, Wei Zhang, Zheng-Li Shi and Yun-Zhi Zhang

    Citation: Virology Journal 2017 14:98

    Content type: Research

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  10. Flaviviruses are small viruses with single-stranded RNA, which include the yellow fever virus, dengue virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus; and are...

    Authors: Leidy L. García, Leonardo Padilla and Jhon C. Castaño

    Citation: Virology Journal 2017 14:95

    Content type: Review

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  11. Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemic of Zika virus (ZIKV). Here we report that immunocompetent guinea pigs are susceptible to infection by a ...

    Authors: Mukesh Kumar, Keeton K. Krause, Francine Azouz, Eileen Nakano and Vivek R. Nerurkar

    Citation: Virology Journal 2017 14:75

    Content type: Research

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  12. Zika virus is a mosquito-borne flavivirus that causes clinical symptoms similar to those observed in dengue and chikungunya virus infections. The Korea Centers for Disease Control and Prevention initiated labo...

    Authors: Young Eui Jeong, Go-Woon Cha, Jung Eun Cho, Eun Ju Lee, Youngmee Jee and Won-Ja Lee

    Citation: Virology Journal 2017 14:70

    Content type: Short report

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  13. The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) continues to pose one of the greatest threats to the swine industry. M protein is the most conserved and important structura...

    Authors: Qian Wang, Yanwei Li, Hong Dong, Li Wang, Jinmei Peng, Tongqing An, Xufu Yang, Zhijun Tian and Xuehui Cai

    Citation: Virology Journal 2017 14:39

    Content type: Research

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  14. The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular li...

    Authors: Natthida Tongluan, Suwipa Ramphan, Phitchayapak Wintachai, Janthima Jaresitthikunchai, Sarawut Khongwichit, Nitwara Wikan, Supoth Rajakam, Sutee Yoksan, Nuttaporn Wongsiriroj, Sittiruk Roytrakul and Duncan R. Smith

    Citation: Virology Journal 2017 14:28

    Content type: Research

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  15. Life-threatening infections with type B Coxsackieviruses (CV-B) are frequently encountered among newborns and are partly attributed to vertically-transmitted virus. Our current study investigates this alternat...

    Authors: Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Moncef Mokni and Mahjoub Aouni

    Citation: Virology Journal 2017 14:16

    Content type: Research

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  16. The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR...

    Authors: Huiqiang Wang, Ke Li, Linlin Ma, Shuo Wu, Jin Hu, Haiyan Yan, Jiandong Jiang and Yuhuan Li

    Citation: Virology Journal 2017 14:2

    Content type: Research

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  17. We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN recept...

    Authors: Priya Dhole, Emi E. Nakayama, Akatsuki Saito, Kriengsak Limkittikul, Supranee Phanthanawiboon, Tatsuo Shioda and Takeshi Kurosu

    Citation: Virology Journal 2016 13:199

    Content type: Research

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  18. Hand, foot and mouth disease is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. EV-A71 infection is associated with high fever, rashes and ulcers but more severe symptoms such as cardiopulmonary failur...

    Authors: Pinn Tsin Isabel Yee, Kuan Onn Tan, Iekhsan Othman and Chit Laa Poh

    Citation: Virology Journal 2016 13:194

    Content type: Research

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  19. Quantitation of HIV-RNA is critically important for diagnosis, prognosis, treatment, monitoring and assessment of infectivity in HIV-1 infection. The objective of this study was to assess performance character...

    Authors: Angelos. Hatzakis, Helen Papachristou, Sangeetha J. Nair, Jacqueline Fortunko, Tracy Foote, HeeCheol Kim, Tashi L. Peling and Andrew J. Worlock

    Citation: Virology Journal 2016 13:176

    Content type: Methodology

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  20. Coxsackievirus A9 (CV-A9) is a pathogenic enterovirus type within the family Picornaviridae. CV-A9 infects A549 human epithelial lung carcinoma cells by attaching to the αVβ6 integrin receptor through a highly co...

    Authors: Outi Heikkilä, Pirjo Merilahti, Marika Hakanen, Eveliina Karelehto, Jonna Alanko, Maria Sukki, Saija Kiljunen and Petri Susi

    Citation: Virology Journal 2016 13:171

    Content type: Research

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  21. Four vaccine-related polioviruses (VRPV) were isolated from aseptic encephalitis cases in Yunnan, China in 2010. The genomic sequences of these VRPVs were investigated to gain a better understanding of their m...

    Authors: Jiansheng Liu, Haihao Zhang, Yilin Zhao, Longhui Xia, Chen Guo, Huai Yang, Na Luo, Zhanlong He and Shaohui Ma

    Citation: Virology Journal 2016 13:162

    Content type: Research

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  22. Culex Flavivirus (CxFV) is an insect-specific virus that is widely distributed and primarily infects mosquito species from the genus Culex. Its hosts include Culex tritaeniorhynchus, Culex quinquefasciatus, and A...

    Authors: Cíntia Bittar, Daiane Cristina Machado, Danila Vedovello, Leila Sabrina Ullmann, Paula Rahal, João Pessoa Araújo Junior and Maurício Lacerda Nogueira

    Citation: Virology Journal 2016 13:158

    Content type: Research

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  23. Chikungunya virus (CHIKV) is a prevalent mosquito-borne pathogen that is emerging in many parts of the globe causing significant human morbidity. Here, we report the isolation and characterization of an infect...

    Authors: Pattra Chalaem, Sarunyou Chusri, Stefan Fernandez, Wilaiwan Chotigeat, Juan Anguita, Utpal Pal and Kamoltip Promnares

    Citation: Virology Journal 2016 13:150

    Content type: Research

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  24. Dengue virus is circulating in Pakistan since 1994, which causes major and minor outbreaks in many areas of the country. The incidence of dengue in Pakistan in past years mainly restricted to parts of Sindh an...

    Authors: Amjad Ali, Habib Ahmad, Muhammad Idrees, Fazli Zahir and Ijaz Ali

    Citation: Virology Journal 2016 13:144

    Content type: Short report

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  25. About half of the world’s population are living in the endemic area of dengue viruses implying that a rapid-mass vaccination may be required. In addition, a major target of dengue vaccine are children, thus, a...

    Authors: Nattika Nantachit, Panya Sunintaboon and Sukathida Ubol

    Citation: Virology Journal 2016 13:142

    Content type: Short report

    Published on:

  26. Rotavirus is one of the leading causes of childhood diarrhoea worldwide. The highest disease burden is seen in resource-constrained settings of sub-Saharan Africa. Recently, commercial multiplex PCR panels pro...

    Authors: Amelie Leva, Daniel Eibach, Ralf Krumkamp, Julia Käsmaier, Dennis Rubbenstroth, Yaw Adu-Sarkodie, Jürgen May, Egbert Tannich and Marcus Panning

    Citation: Virology Journal 2016 13:132

    Content type: Short report

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  27. Flaviviruses are emerging arthropod-borne viruses representing an immense global health problem. The prominent viruses of this group include dengue virus, yellow fever virus, Japanese encephalitis virus, West ...

    Authors: Meghana Rastogi, Nikhil Sharma and Sunit Kumar Singh

    Citation: Virology Journal 2016 13:131

    Content type: Review

    Published on:

  28. Hand, foot and mouth disease (HFMD) has become a major public health problem across the Asia-Pacific region, and is commonly caused by enterovirus A71 (EV-A71) and coxsackievirus A6 (CV-A6), CV-A10 and CV-A16....

    Authors: Anh To Nguyen, Thanh Tan Tran, Van Minh Tu Hoang, Ngoc My Nghiem, Nhu Nguyen Truc Le, Thanh Thi My Le, Qui Tu Phan, Khanh Huu Truong, Nhan Nguyen Thanh Le, Viet Lu Ho, Viet Chau Do, Tuan Manh Ha, Hung Thanh Nguyen, Chau Van Vinh Nguyen, Guy Thwaites, H. Rogier van Doorn…

    Citation: Virology Journal 2016 13:125

    Content type: Methodology

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  29. Enterovirus A71 (EV-A71) is the main pathogen responsible for large outbreaks of hand, foot, and mouth disease (HFMD) in mainland China, and the dominant EV-A71 strains belong to subgenotype C4. To date, only ...

    Authors: Qian Yang, Yong Zhang, Dongmei Yan, Shuangli Zhu, Dongyan Wang, Tianjiao Ji, Wei Huang, Hongqiu An and Wenbo Xu

    Citation: Virology Journal 2016 13:115

    Content type: Short report

    Published on:

  30. Recurrence of hand, foot and mouth disease (HFMD) pandemics continues to threaten public health. Despite increasing awareness and efforts, effective vaccine and drug treatment have yet to be available. Probiot...

    Authors: Lei Yin Emily Ang, Horng Khit Issac Too, Eng Lee Tan, Tak-Kwong Vincent Chow, Pei-Chi Lynette Shek, Elizabeth Tham and Sylvie Alonso

    Citation: Virology Journal 2016 13:111

    Content type: Research

    Published on:

    The Erratum to this article has been published in Virology Journal 2016 13:186

  31. Enterovirus 71 (EV71) is a major causative agent of hand-foot-mouth disease (HFMD) and also causes severe neurological complications, leading to fatality in young children. However, no effective therapy is cur...

    Authors: Chonsaeng Kim, Hyunju Kang, Dong-eun Kim, Jae-Hyoung Song, Miri Choi, Mingu Kang, Kyungjin Lee, Hae Soo Kim, Jin Soo Shin, Hyejeong Jeong, Sunhee Jung, Sang-Bae Han, Jong Heon Kim, Hyun-Jeong Ko, Chong-Kyo Lee, Meehyein Kim…

    Citation: Virology Journal 2016 13:99

    Content type: Research

    Published on:

  32. Among all known picornaviruses, only two species, equine rhinitis A virus and equine rhinitis B virus (ERBV) are known to infect horses, causing respiratory infections. No reports have described the detection ...

    Authors: Patrick C. Y. Woo, Susanna K. P. Lau, Garnet K. Y. Choi, Yi Huang, Renate Wernery, Sunitha Joseph, Emily Y. M. Wong, Shyna K. Elizabeth, Nissy Annie Georgy Patteril, Tong Li, Ulrich Wernery and Kwok-Yung Yuen

    Citation: Virology Journal 2016 13:94

    Content type: Research

    Published on:

  33. We report the isolation and characterization of dengue virus (DENV) serotype 4 from a resident of Santa Fé, state of Paraná, South Brazil, in March 2013. This patient presented with hemorrhagic manifestations,...

    Authors: Diogo Kuczera, Lorena Bavia, Ana Luiza Pamplona Mosimann, Andrea Cristine Koishi, Giovanny Augusto Camacho Antevere Mazzarotto, Mateus Nóbrega Aoki, Ana Maria Ferrari Mansano, Ediléia Inês Tomeleri, Wilson Liuti Costa Junior, Milena Menegazzo Miranda, Maria Lo Sarzi, Wander Rogério Pavanelli, Ivete Conchon-Costa, Claudia Nunes Duarte dos Santos and Juliano Bordignon

    Citation: Virology Journal 2016 13:93

    Content type: Case Report

    Published on:

  34. RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon...

    Authors: Jaspreet Jain, Kalika Mathur, Jatin Shrinet, Raj K. Bhatnagar and Sujatha Sunil

    Citation: Virology Journal 2016 13:86

    Content type: Research

    Published on:

  35. The family Flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity and mortality. There are neither vaccines nor antivirals for m...

    Authors: Lorena Bavia, Ana Luiza Pamplona Mosimann, Mateus Nóbrega Aoki and Claudia Nunes Duarte dos Santos

    Citation: Virology Journal 2016 13:84

    Content type: Review

    Published on:

  36. Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodical...

    Authors: Noelia Carmona-Vicente, David J. Allen, Jesús Rodríguez-Díaz, Miren Iturriza-Gómara and Javier Buesa

    Citation: Virology Journal 2016 13:82

    Content type: Research

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  37. Hepatitis C virus (HCV) could induce chronic liver diseases and hepatocellular carcinoma in human. The use of primary human hepatocyte as a viral host is restrained with the scarcity of tissue supply. A cultur...

    Authors: Khanit Sa-ngiamsuntorn, Adisak Wongkajornsilp, Phetcharat Phanthong, Suparerk Borwornpinyo, Narisorn Kitiyanant, Wasun Chantratita and Suradej Hongeng

    Citation: Virology Journal 2016 13:59

    Content type: Research

    Published on:

  38. Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus infecting pigs of all ages with high morbidity and mortality among newborn piglets. Currently, there is no effective vaccine available to pro...

    Authors: Niraj Makadiya, Robert Brownlie, Jan van den Hurk, Nathalie Berube, Brenda Allan, Volker Gerdts and Alexander Zakhartchouk

    Citation: Virology Journal 2016 13:57

    Content type: Research

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  39. Brevicoryne brassicae virus (BrBV) is a positive-strand genomic RNA virus which is unassigned tentative member of the genus Iflavirus. BrBv was first identified and characterized in th...

    Authors: Neta Luria, Victoria Reingold, Oded Lachman, Noa Sela and Aviv Dombrovsky

    Citation: Virology Journal 2016 13:50

    Content type: Short report

    Published on:

  40. Dengue virus (DENV) is a member of the Flaviviridae family, transmitted to human via mosquito. DENV infection is common in tropical areas and occasionally causes life-threatening symptoms. DENV contains a relativ...

    Authors: Warobon Noppakunmongkolchai, Teera Poyomtip, Thichakorn Jittawuttipoka, Natthanej Luplertlop, Anavaj Sakuntabhai, Sarin Chimnaronk, Siwanon Jirawatnotai and Rutaiwan Tohtong

    Citation: Virology Journal 2016 13:35

    Content type: Research

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  41. Despite the worldwide circulation of human coronavirus OC43 (HCoV-OC43) and HKU1 (HCoV-HKU1), data on their molecular epidemiology and evolutionary dynamics in the tropical Southeast Asia region is lacking.

    Authors: Maryam Nabiel Al-Khannaq, Kim Tien Ng, Xiang Yong Oong, Yong Kek Pang, Yutaka Takebe, Jack Bee Chook, Nik Sherina Hanafi, Adeeba Kamarulzaman and Kok Keng Tee

    Citation: Virology Journal 2016 13:33

    Content type: Research

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  42. Rubella virus (RV) infection is usually a mild illness in children and adults. However, maternal infection during the first trimester of pregnancy can lead to congenital rubella syndrome (CRS) in the infant. F...

    Authors: Henriette Geyer, Michael Bauer, Jennifer Neumann, Amy Lüdde, Paul Rennert, Nicole Friedrich, Claudia Claus, Ludmilla Perelygina and Annette Mankertz

    Citation: Virology Journal 2016 13:21

    Content type: Research

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  43. Human Coronaviruses (HCoV) are a common cause of respiratory illnesses and are responsible for considerable morbidity and hospitalization across all age groups especially in individuals with compromised immuni...

    Authors: Lenata A. Sipulwa, Juliette R. Ongus, Rodney L. Coldren and Wallace D. Bulimo

    Citation: Virology Journal 2016 13:18

    Content type: Research

    Published on: