Skip to main content

Positive-strand RNA viruses

Section Editor: Alexander A Khromykh, University of Queensland, Australia
Deputy Section Editor: Michael Beard, University of Adelaide, Australia

The Positive-strand RNA viruses section of Virology Journal invites submissions of research articles and reviews covering all aspects of positive-strand RNA virus biology. Basic research topics of interest include all facets of the viral life cycle from viral attachment and entry, viral RNA replication and translation, viral gene expression/regulation, viral protein processing, viral particle assembly and secretion. We welcome studies that investigate interactions between the virus and host that impact viral replication and the cellular response to infection. Other topics include but are not limited to viral pathogenesis, epidemiology, and viral immunology. We also welcome basic and translational studies on the development of novel model systems, antiviral drugs and vaccines.

Page 2 of 4

  1. Cardioviruses cause severe illnesses in rodents and humans. In recent years, novel cardioviruses have been frequently found, which promoted further studies of the genetic diversity of cardioviruses. Using vira...

    Authors: Yan Wang, Jing Zhao, Min Zheng, Zhijian Liu, Wang Li, Xingli Fu, Yuan Lin, Jiaqi Yuan, Jieji Zhao, Quan Shen, Xiaochun Wang, Hua Wang and Shixing Yang

    Citation: Virology Journal 2018 15:58

    Content type: Short report

    Published on:

  2. Genotype 3 hepatitis E virus (HEV) infection is generally associated with mild disease. However, recently eight genotype 3 HEV isolates were identified from patients with severe hepatitis. Importantly, three m...

    Authors: Dianjun Cao, Yan-Yan Ni and Xiang-Jin Meng

    Citation: Virology Journal 2018 15:32

    Content type: Research

    Published on:

  3. Dengue, caused by one of the four serologically distinct dengue viruses (DENV-1 to − 4), is a mosquito-borne disease of serious global health significance. Reliable and cost-effective diagnostic tests, along w...

    Authors: Tesfaye Gelanew and Elizabeth Hunsperger

    Citation: Virology Journal 2018 15:30

    Content type: Methodology

    Published on:

  4. Recreational water contaminated with fecal pollution poses a great public health concern, as fecal waste may cause serious waterborne illnesses. Current recreational water standards using fecal indicator bacte...

    Authors: Hui Zhu, Fang Yuan, Zhaokang Yuan, Rong Liu, Fei Xie, Ling Huang, Xiaojun Liu, Xiaoqing Jiang, Jian Wang, Qunying Xu, Zhiqiang Shen, Donghan Liu, Ronghao Zhang and Yuanan Lu

    Citation: Virology Journal 2018 15:3

    Content type: Research

    Published on:

  5. Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and...

    Authors: Meichun Yuan, Jingjing Yan, Jingna Xun, Chong Chen, Yuling Zhang, Min Wang, Wenqi Chu, Zhigang Song, Yunwen Hu, Shuye Zhang and Xiaoyan Zhang

    Citation: Virology Journal 2018 15:1

    Content type: Research

    Published on:

  6. Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly...

    Authors: Yuefei Jin, Chao Zhang, Rongguang Zhang, Jingchao Ren, Shuaiyin Chen, Meili Sui, Guangyuan Zhou, Dejian Dang, Jiehui Zhu, Huifen Feng, Yuanlin Xi, Haiyan Yang and Guangcai Duan

    Citation: Virology Journal 2017 14:243

    Content type: Research

    Published on:

  7. This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines.

    Authors: Hong Yuan, Pinghua Li, Xueqing Ma, Zengjun Lu, Pu Sun, Xingwen Bai, Jing Zhang, Huifang Bao, Yimei Cao, Dong Li, Yuanfang Fu, Yingli Chen, Qifeng Bai, Jie Zhang and Zaixin Liu

    Citation: Virology Journal 2017 14:233

    Content type: Review

    Published on:

  8. More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR of China in 2002, there is still no reoccurrence, but the evolution and recombination of the co...

    Authors: Peilin Liu, Lei Shi, Wei Zhang, Jianan He, Chunxiao Liu, Chunzhong Zhao, Siu Kai Kong, Jacky Fong Chuen Loo, Dayong Gu and Longfei Hu

    Citation: Virology Journal 2017 14:230

    Content type: Research

    Published on:

  9. The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study ...

    Authors: Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Miaw Fang Chew, Hong Wai Tham and Sharifah Syed Hassan

    Citation: Virology Journal 2017 14:229

    Content type: Research

    Published on:

  10. Norovirus (NoV) is considered the second leading cause of viral acute gastroenteritis (AGE). To our knowledge, there are no systematic reviews assessing the role of NoV in AGE in the Middle East and North Afri...

    Authors: Khalil Kreidieh, Rana Charide, Ghassan Dbaibo and Nada M. Melhem

    Citation: Virology Journal 2017 14:220

    Content type: Review

    Published on:

  11. The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we a...

    Authors: Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, Minhua Luo, Jinlong Yang and Jumin Zhou

    Citation: Virology Journal 2017 14:217

    Content type: Research

    Published on:

    The Correction to this article has been published in Virology Journal 2019 16:17

  12. Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease, which mostly affects infants and children and leads to severe neurological diseases. Vaccination offers the best option for...

    Authors: Ting Yang, Hua Li, Lei Yue, Xia Song, Tianhong Xie, Shaohui Ma, Huaqing Meng, Ye Zhang, Xin He, Runxiang Long, Rong Yang, Fangyu Luo, Zhongping Xie and Qihan Li

    Citation: Virology Journal 2017 14:206

    Content type: Research

    Published on:

  13. The need to investigate the contribution of non-polio enteroviruses to acute flaccid paralysis (AFP) cannot be over emphasized as we move towards a poliovirus free world. Hence, we aim to identify non-polio en...

    Authors: T. O. C. Faleye, M. O. Adewumi, M. O. Japhet, O. M. David, A. O. Oluyege, J. A. Adeniji and O. Famurewa

    Citation: Virology Journal 2017 14:175

    Content type: Research

    Published on:

  14. Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principl...

    Authors: Yakov Vitrenko, Iryna Kostenko, Kateryna Kulebyakina and Khrystyna Sorochynska

    Citation: Virology Journal 2017 14:167

    Content type: Research

    Published on:

  15. Echovirus 30 (E30) causes acute aseptic meningitis. Viral replication requires energy and macromolecular precursors derived from the metabolic network of the host cell. The effect of viral infection within a h...

    Authors: Sarika Tiwari and Tapan N. Dhole

    Citation: Virology Journal 2017 14:144

    Content type: Research

    Published on:

    The Erratum to this article has been published in Virology Journal 2017 14:182

  16. Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeut...

    Authors: Chris M. Cirimotich, Eric M. Vela, Jennifer Garver, Roy E. Barnewall, Brian D. Miller, Gabriel T. Meister and James V. Rogers

    Citation: Virology Journal 2017 14:135

    Content type: Research

    Published on:

  17. Bovine coronavirus (BCoV) belong to the genus Betacoronavirus of the family Coronaviridae. BCoV are widespread around the world and cause enteric or respiratory infections among cattle, leading to important econo...

    Authors: Matías Castells, Matías Victoria, Rodney Colina, Héctor Musto and Juan Cristina

    Citation: Virology Journal 2017 14:115

    Content type: Research

    Published on:

  18. We previously reported the discovery of a novel, putative flavivirus designated T’Ho virus in Culex quinquefasciatus mosquitoes in the Yucatan Peninsula of Mexico. A 1358-nt region of the NS5 gene was amplified a...

    Authors: Thomas Briese, Maria A. Loroño-Pino, Julian E. Garcia-Rejon, Jose A. Farfan-Ale, Carlos Machain-Williams, Karin S. Dorman, W. Ian Lipkin and Bradley J. Blitvich

    Citation: Virology Journal 2017 14:110

    Content type: Research

    Published on:

  19. Zika virus is an emerging pathogen of global importance. It has been responsible for recent outbreaks in the Americas and in the Pacific region. This study assessed five different mosquito species from the tem...

    Authors: Jean-Bernard Duchemin, Peter T. Mee, Stacey E. Lynch, Ravikiran Vedururu, Lee Trinidad and Prasad Paradkar

    Citation: Virology Journal 2017 14:108

    Content type: Research

    Published on:

  20. Rodents represent the most diverse mammals on the planet and are important reservoirs of human pathogens. Coronaviruses infect various animals, but to date, relatively few coronaviruses have been identified in...

    Authors: Xing-Yi Ge, Wei-Hong Yang, Ji-Hua Zhou, Bei Li, Wei Zhang, Zheng-Li Shi and Yun-Zhi Zhang

    Citation: Virology Journal 2017 14:98

    Content type: Research

    Published on:

  21. Flaviviruses are small viruses with single-stranded RNA, which include the yellow fever virus, dengue virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus; and are...

    Authors: Leidy L. García, Leonardo Padilla and Jhon C. Castaño

    Citation: Virology Journal 2017 14:95

    Content type: Review

    Published on:

  22. Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemic of Zika virus (ZIKV). Here we report that immunocompetent guinea pigs are susceptible to infection by a ...

    Authors: Mukesh Kumar, Keeton K. Krause, Francine Azouz, Eileen Nakano and Vivek R. Nerurkar

    Citation: Virology Journal 2017 14:75

    Content type: Research

    Published on:

  23. Zika virus is a mosquito-borne flavivirus that causes clinical symptoms similar to those observed in dengue and chikungunya virus infections. The Korea Centers for Disease Control and Prevention initiated labo...

    Authors: Young Eui Jeong, Go-Woon Cha, Jung Eun Cho, Eun Ju Lee, Youngmee Jee and Won-Ja Lee

    Citation: Virology Journal 2017 14:70

    Content type: Short report

    Published on:

  24. The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) continues to pose one of the greatest threats to the swine industry. M protein is the most conserved and important structura...

    Authors: Qian Wang, Yanwei Li, Hong Dong, Li Wang, Jinmei Peng, Tongqing An, Xufu Yang, Zhijun Tian and Xuehui Cai

    Citation: Virology Journal 2017 14:39

    Content type: Research

    Published on:

  25. The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular li...

    Authors: Natthida Tongluan, Suwipa Ramphan, Phitchayapak Wintachai, Janthima Jaresitthikunchai, Sarawut Khongwichit, Nitwara Wikan, Supoth Rajakam, Sutee Yoksan, Nuttaporn Wongsiriroj, Sittiruk Roytrakul and Duncan R. Smith

    Citation: Virology Journal 2017 14:28

    Content type: Research

    Published on:

  26. Life-threatening infections with type B Coxsackieviruses (CV-B) are frequently encountered among newborns and are partly attributed to vertically-transmitted virus. Our current study investigates this alternat...

    Authors: Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Moncef Mokni and Mahjoub Aouni

    Citation: Virology Journal 2017 14:16

    Content type: Research

    Published on:

  27. The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR...

    Authors: Huiqiang Wang, Ke Li, Linlin Ma, Shuo Wu, Jin Hu, Haiyan Yan, Jiandong Jiang and Yuhuan Li

    Citation: Virology Journal 2017 14:2

    Content type: Research

    Published on:

  28. We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN recept...

    Authors: Priya Dhole, Emi E. Nakayama, Akatsuki Saito, Kriengsak Limkittikul, Supranee Phanthanawiboon, Tatsuo Shioda and Takeshi Kurosu

    Citation: Virology Journal 2016 13:199

    Content type: Research

    Published on:

  29. Hand, foot and mouth disease is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. EV-A71 infection is associated with high fever, rashes and ulcers but more severe symptoms such as cardiopulmonary failur...

    Authors: Pinn Tsin Isabel Yee, Kuan Onn Tan, Iekhsan Othman and Chit Laa Poh

    Citation: Virology Journal 2016 13:194

    Content type: Research

    Published on:

  30. Quantitation of HIV-RNA is critically important for diagnosis, prognosis, treatment, monitoring and assessment of infectivity in HIV-1 infection. The objective of this study was to assess performance character...

    Authors: Angelos. Hatzakis, Helen Papachristou, Sangeetha J. Nair, Jacqueline Fortunko, Tracy Foote, HeeCheol Kim, Tashi L. Peling and Andrew J. Worlock

    Citation: Virology Journal 2016 13:176

    Content type: Methodology

    Published on:

  31. Coxsackievirus A9 (CV-A9) is a pathogenic enterovirus type within the family Picornaviridae. CV-A9 infects A549 human epithelial lung carcinoma cells by attaching to the αVβ6 integrin receptor through a highly co...

    Authors: Outi Heikkilä, Pirjo Merilahti, Marika Hakanen, Eveliina Karelehto, Jonna Alanko, Maria Sukki, Saija Kiljunen and Petri Susi

    Citation: Virology Journal 2016 13:171

    Content type: Research

    Published on:

  32. Four vaccine-related polioviruses (VRPV) were isolated from aseptic encephalitis cases in Yunnan, China in 2010. The genomic sequences of these VRPVs were investigated to gain a better understanding of their m...

    Authors: Jiansheng Liu, Haihao Zhang, Yilin Zhao, Longhui Xia, Chen Guo, Huai Yang, Na Luo, Zhanlong He and Shaohui Ma

    Citation: Virology Journal 2016 13:162

    Content type: Research

    Published on:

  33. Culex Flavivirus (CxFV) is an insect-specific virus that is widely distributed and primarily infects mosquito species from the genus Culex. Its hosts include Culex tritaeniorhynchus, Culex quinquefasciatus, and A...

    Authors: Cíntia Bittar, Daiane Cristina Machado, Danila Vedovello, Leila Sabrina Ullmann, Paula Rahal, João Pessoa Araújo Junior and Maurício Lacerda Nogueira

    Citation: Virology Journal 2016 13:158

    Content type: Research

    Published on:

  34. Chikungunya virus (CHIKV) is a prevalent mosquito-borne pathogen that is emerging in many parts of the globe causing significant human morbidity. Here, we report the isolation and characterization of an infect...

    Authors: Pattra Chalaem, Sarunyou Chusri, Stefan Fernandez, Wilaiwan Chotigeat, Juan Anguita, Utpal Pal and Kamoltip Promnares

    Citation: Virology Journal 2016 13:150

    Content type: Research

    Published on:

  35. Dengue virus is circulating in Pakistan since 1994, which causes major and minor outbreaks in many areas of the country. The incidence of dengue in Pakistan in past years mainly restricted to parts of Sindh an...

    Authors: Amjad Ali, Habib Ahmad, Muhammad Idrees, Fazli Zahir and Ijaz Ali

    Citation: Virology Journal 2016 13:144

    Content type: Short report

    Published on:

  36. About half of the world’s population are living in the endemic area of dengue viruses implying that a rapid-mass vaccination may be required. In addition, a major target of dengue vaccine are children, thus, a...

    Authors: Nattika Nantachit, Panya Sunintaboon and Sukathida Ubol

    Citation: Virology Journal 2016 13:142

    Content type: Short report

    Published on:

  37. Rotavirus is one of the leading causes of childhood diarrhoea worldwide. The highest disease burden is seen in resource-constrained settings of sub-Saharan Africa. Recently, commercial multiplex PCR panels pro...

    Authors: Amelie Leva, Daniel Eibach, Ralf Krumkamp, Julia Käsmaier, Dennis Rubbenstroth, Yaw Adu-Sarkodie, Jürgen May, Egbert Tannich and Marcus Panning

    Citation: Virology Journal 2016 13:132

    Content type: Short report

    Published on:

  38. Flaviviruses are emerging arthropod-borne viruses representing an immense global health problem. The prominent viruses of this group include dengue virus, yellow fever virus, Japanese encephalitis virus, West ...

    Authors: Meghana Rastogi, Nikhil Sharma and Sunit Kumar Singh

    Citation: Virology Journal 2016 13:131

    Content type: Review

    Published on:

  39. Hand, foot and mouth disease (HFMD) has become a major public health problem across the Asia-Pacific region, and is commonly caused by enterovirus A71 (EV-A71) and coxsackievirus A6 (CV-A6), CV-A10 and CV-A16....

    Authors: Anh To Nguyen, Thanh Tan Tran, Van Minh Tu Hoang, Ngoc My Nghiem, Nhu Nguyen Truc Le, Thanh Thi My Le, Qui Tu Phan, Khanh Huu Truong, Nhan Nguyen Thanh Le, Viet Lu Ho, Viet Chau Do, Tuan Manh Ha, Hung Thanh Nguyen, Chau Van Vinh Nguyen, Guy Thwaites, H. Rogier van Doorn…

    Citation: Virology Journal 2016 13:125

    Content type: Methodology

    Published on:

  40. Enterovirus A71 (EV-A71) is the main pathogen responsible for large outbreaks of hand, foot, and mouth disease (HFMD) in mainland China, and the dominant EV-A71 strains belong to subgenotype C4. To date, only ...

    Authors: Qian Yang, Yong Zhang, Dongmei Yan, Shuangli Zhu, Dongyan Wang, Tianjiao Ji, Wei Huang, Hongqiu An and Wenbo Xu

    Citation: Virology Journal 2016 13:115

    Content type: Short report

    Published on:

  41. Recurrence of hand, foot and mouth disease (HFMD) pandemics continues to threaten public health. Despite increasing awareness and efforts, effective vaccine and drug treatment have yet to be available. Probiot...

    Authors: Lei Yin Emily Ang, Horng Khit Issac Too, Eng Lee Tan, Tak-Kwong Vincent Chow, Pei-Chi Lynette Shek, Elizabeth Tham and Sylvie Alonso

    Citation: Virology Journal 2016 13:111

    Content type: Research

    Published on:

    The Erratum to this article has been published in Virology Journal 2016 13:186

  42. Enterovirus 71 (EV71) is a major causative agent of hand-foot-mouth disease (HFMD) and also causes severe neurological complications, leading to fatality in young children. However, no effective therapy is cur...

    Authors: Chonsaeng Kim, Hyunju Kang, Dong-eun Kim, Jae-Hyoung Song, Miri Choi, Mingu Kang, Kyungjin Lee, Hae Soo Kim, Jin Soo Shin, Hyejeong Jeong, Sunhee Jung, Sang-Bae Han, Jong Heon Kim, Hyun-Jeong Ko, Chong-Kyo Lee, Meehyein Kim…

    Citation: Virology Journal 2016 13:99

    Content type: Research

    Published on:

  43. Among all known picornaviruses, only two species, equine rhinitis A virus and equine rhinitis B virus (ERBV) are known to infect horses, causing respiratory infections. No reports have described the detection ...

    Authors: Patrick C. Y. Woo, Susanna K. P. Lau, Garnet K. Y. Choi, Yi Huang, Renate Wernery, Sunitha Joseph, Emily Y. M. Wong, Shyna K. Elizabeth, Nissy Annie Georgy Patteril, Tong Li, Ulrich Wernery and Kwok-Yung Yuen

    Citation: Virology Journal 2016 13:94

    Content type: Research

    Published on:

  44. We report the isolation and characterization of dengue virus (DENV) serotype 4 from a resident of Santa Fé, state of Paraná, South Brazil, in March 2013. This patient presented with hemorrhagic manifestations,...

    Authors: Diogo Kuczera, Lorena Bavia, Ana Luiza Pamplona Mosimann, Andrea Cristine Koishi, Giovanny Augusto Camacho Antevere Mazzarotto, Mateus Nóbrega Aoki, Ana Maria Ferrari Mansano, Ediléia Inês Tomeleri, Wilson Liuti Costa Junior, Milena Menegazzo Miranda, Maria Lo Sarzi, Wander Rogério Pavanelli, Ivete Conchon-Costa, Claudia Nunes Duarte dos Santos and Juliano Bordignon

    Citation: Virology Journal 2016 13:93

    Content type: Case Report

    Published on: