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Herpes viruses

Section Editor: Blossom Damania, University of North Carolina at Chapel Hill, USA​​​​​​​ 
Deputy Section Editor: Anthony Nicola, Washington State University, USA​​​​​​​

The Herpes viruses section of Virology Journal includes research articles and reviews on both human and animal herpes viruses. This includes basic, mechanistic, and translational studies of herpes virus biology and pathogenesis. Topics include, but are not limited to, virus biology, virus entry, virus-host interactions, viral pathogenesis, viral cancers, antivirals and vaccines.

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  1. Content type: Research

    Pseudorabies virus (PRV) protein UL56 (pUL56) has been implicated in viral dissemination and virulence in vivo. However, the properties of PRV pUL56 remain largely unknown. In the present study, we aim to inve...

    Authors: Chuang Lyu and Xuehui Cai

    Citation: Virology Journal 2019 16:81

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  2. Content type: Case Report

    Shingles (localized zoster) and disseminated zoster are caused by the reactivation of latent varicella zoster virus (VZV). Reactivation of VZV is related to impaired cell-mediated immunity. Extensive burns aff...

    Authors: Yoshitaka Kubota, Kentaro Kosaka, Toshinori Hokazono, Yoshihisa Yamaji, Takafumi Tezuka, Shinsuke Akita, Motone Kuriyama and Nobuyuki Mitsukawa

    Citation: Virology Journal 2019 16:68

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  3. Content type: Research

    Elephant endotheliotropic herpesviruses (EEHV) can cause an acute highly fatal hemorrhagic disease in young Asian elephants (Elephas maximus), both ex situ and in situ. Amongst eight EEHV types described so far, ...

    Authors: Taweepoke Angkawanish, Mirjam Nielen, Hans Vernooij, Janine L. Brown, Peter J. S. van Kooten, Petra B. van den Doel, Willem Schaftenaar, Kannika Na Lampang and Victor P. M. G. Rutten

    Citation: Virology Journal 2019 16:33

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  4. Content type: Research

    Alternative splicing (AS) is an important mRNA maturation step that allows increased variability and diversity of proteins in eukaryotes. AS is dysregulated in numerous diseases, and its implication in the car...

    Authors: Simon Boudreault, Victoria E. S. Armero, Michelle S. Scott, Jean-Pierre Perreault and Martin Bisaillon

    Citation: Virology Journal 2019 16:29

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  5. Content type: Research

    Haploidentical hematopoietic stem cell transplant (haplo-HSCT) recipients are at high risk for Epstein Barr virus (EBV)-related diseases. EBV-specific CD8+ cytotoxic T cells can control EBV-infected B cell expans...

    Authors: Ling Zhou and Dao-pei Lu

    Citation: Virology Journal 2019 16:19

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  6. Content type: Short report

    Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky’s disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occ...

    Authors: Chao Ye, Jiqiang Wu, Wu Tong, Tongling Shan, Xuefei Cheng, Jingjing Xu, Chao Liang, Hao Zheng, Guoxin Li and Guangzhi Tong

    Citation: Virology Journal 2018 15:195

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  7. Content type: Research

    The pattern recognition receptors (PPRs) are the earliest phase of the host defense against pathogens in genital epithelium, and toll-like receptors (TLRs) are best characterized PPRs mediating innate immune r...

    Authors: Xiaowen Lv, Huanru Wang, Airong Su, Shijie Xu and Ying Chu

    Citation: Virology Journal 2018 15:173

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  8. Content type: Research

    The results of our previous study showed that impaired cellular energy metabolism contributes to duck enteritis virus-induced autophagy via the 5`-adenosine monophosphate-activated protein kinase (AMPK)/tubero...

    Authors: Haichang Yin, Lili Zhao, Yiping Wang, Siqi Li, Hong Huo and Hongyan Chen

    Citation: Virology Journal 2018 15:120

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  9. Content type: Research

    The alphaherpesvirus virion host shutoff (vhs) gene, UL41, can induce degradation of host mRNAs and shut off host protein synthesis. The roles of vhs in HSV-1 and HSV-2 have been studied extensively in previou...

    Authors: Chao Ye, Jing Chen, Tao Wang, Jingjing Xu, Hao Zheng, Jiqiang Wu, Guoxin Li, Zhiqing Yu, Wu Tong, Xuefei Cheng, Shasha Zhou and Guangzhi Tong

    Citation: Virology Journal 2018 15:119

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  10. Content type: Research

    Duck enteritis virus (DEV) belongs to the subfamily Alphaherpesvirinae, and information on the DEV UL41 gene is limited.

    Authors: Tianqiong He, Mingshu Wang, Xuelian Cao, Anchun Cheng, Ying Wu, Qiao Yang, Mafeng Liu, Dekang Zhu, Renyong Jia, Shun Chen, Kunfeng Sun, Xinxin Zhao and Xiaoyue Chen

    Citation: Virology Journal 2018 15:12

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  11. Content type: Research

    Hemophagocytic lymphohistiocytosis (HLH) is a rare immunological disorder caused by unbridled activation of T cells and macrophages, culminating in a life-threatening cytokine storm. A genetic and acquired sub...

    Authors: Ellen Brisse, Maya Imbrechts, Tania Mitera, Jessica Vandenhaute, Carine H. Wouters, Robert Snoeck, Graciela Andrei and Patrick Matthys

    Citation: Virology Journal 2017 14:240

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  12. Content type: Research

    Epstein-Barr virus (EBV) exhibits both lytic and latent (Lat. I, II, and III) phases in an infected individual. It’s during the latent phase of EBV that all EBV-associated cancers, including Burkitt’s lymphoma...

    Authors: Gina Pisano, Arunava Roy, Mairaj Ahmed Ansari, Binod Kumar, Leela Chikoti and Bala Chandran

    Citation: Virology Journal 2017 14:221

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  13. Content type: Short Report

    Gliomas are the most common brain tumors and include a variety of histologic types and grades of malignancy. They arise from glial cells and represent approximately 70% of the primary brain tumors. According t...

    Authors: Araceli Garcia-Martinez, Cristina Alenda, Esperanza Irles, Enrique Ochoa, Teresa Quintanar, Alvaro Rodriguez-Lescure, Jose L. Soto and Victor M. Barbera

    Citation: Virology Journal 2017 14:216

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  14. Content type: Research

    Epstein–Barr virus (EBV) is closely associated with many human diseases, including a variety of deadly human malignant tumours. However, due to the lack of ideal animal models,the biological characteristics of...

    Authors: Zhi Wang, Xiang Yi, Long Du, Hong Wang, Jie Tang, Menglin Wang, Chenglin Qi, Heng Li, Yongjing Lai, Wei Xia and Anzhou Tang

    Citation: Virology Journal 2017 14:193

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  15. Content type: Research

    There is little information regarding the duck enteritis virus (DEV) US10 gene and its molecular characterization.

    Authors: Daixi Zhang, Maoyin Lai, Anchun Cheng, Mingshu Wang, Ying Wu, Qiao Yang, Mafeng Liu, Dekang Zhu, Renyong Jia, Shun Chen, Kunfeng Sun, Xinxin Zhao and Xiaoyue Chen

    Citation: Virology Journal 2017 14:183

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  16. Content type: Short Report

    Rift Valley fever virus (RVFV) is an arthropod-borne bunyavirus that can cause serious and fatal disease in humans and animals. RVFV is a negative-sense RNA virus of the Phlebovirus genus in the Bunyaviridae fami...

    Authors: Abdelrahman Said, Mona Elmanzalawy, Guanggang Ma, Armando Mario Damiani and Nikolaus Osterrieder

    Citation: Virology Journal 2017 14:154

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  17. Content type: Research

    Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.

    Authors: Shimos A. Alshareef, Ahmed M. Eltom, Abubakr M. Nasr, Hamdan Z. Hamdan and Ishag Adam

    Citation: Virology Journal 2017 14:142

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  18. Content type: Research

    Cytomegalovirus (CMV) infection occurs frequently and is widespread globally. Numerous studies have shown that various types of immune cells play roles in mediating the response to CMV infection. CD11c, a comm...

    Authors: Yi Liao, Xinglou Liu, Yuan Huang, Heyu Huang, Yuanyuan Lu, Yanan Zhang, Sainan Shu and Feng Fang

    Citation: Virology Journal 2017 14:132

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  19. Content type: Research

    Epstein-Barr Virus (EBV) is associated with hematopoietic malignancies, such as Burkitt’s lymphoma, post-transplantation lymphoproliferative disorder, and diffuse large B-cell lymphoma. The current approach fo...

    Authors: Qinyan Yin, Mark Sides, Christopher H. Parsons, Erik K. Flemington and Joseph A. Lasky

    Citation: Virology Journal 2017 14:121

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  20. Content type: Case Report

    Primary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possi...

    Authors: Mónica Parra, Adoración Alcala, Cristina Amoros, Anna Baeza, Antonio Galiana, David Tarragó, Miguel Ángel García-Quesada and Victoria Sánchez-Hellín

    Citation: Virology Journal 2017 14:97

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  21. Content type: Research

    Human cytomegalovirus (HCMV) is the most common cause of intrauterine infections worldwide. The toll-like receptors (TLRs) have been reported as important factors in immune response against HCMV. Particularly,...

    Authors: Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński and Dorota Nowakowska

    Citation: Virology Journal 2017 14:64

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  22. Content type: Research

    Acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) infections are concern in immunocompromised patients. Most clinical ACVr HSV-1 isolates have mutations in the viral thymidine kinase (vTK) g...

    Authors: Natsumi Omura, Hikaru Fujii, Tomoki Yoshikawa, Souichi Yamada, Shizuko Harada, Takuya Inagaki, Miho Shibamura, Haruko Takeyama and Masayuki Saijo

    Citation: Virology Journal 2017 14:59

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  23. Content type: Research

    Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) infections are environmental risk factors affecting the outcome of cancer due to an impairment in the cell-mediated immunity. Therefore, this study aime...

    Authors: Samah Aly Loutfy, Maha A. Abo-Shadi, Mohamed Fawzy, Mohamed El-Wakil, Shimaa A. Metwally, Manar M. Moneer, Nasra F. Abdel Fattah, Sara Kassem and Ahmed Elgebaly

    Citation: Virology Journal 2017 14:46

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  24. Content type: Research

    Herpes simplex virus type 1 (HSV-1) cause not only mild symptoms but also blindness and encephalitis. It was previously shown that the immune response against HSV-1 occurs mainly in the trigeminal ganglia (TG)...

    Authors: Natália Lucinda, Maria Marta Figueiredo, Natália Lima Pessoa, Beatriz Senra Álvares da Silva Santos, Graciela Kunrath Lima, Arthur Molinari Freitas, Alexandre Magalhães Vieira Machado, Erna Geessien Kroon, Lis Ribeiro do Valle Antonelli and Marco Antônio Campos

    Citation: Virology Journal 2017 14:37

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  25. Content type: Research

    Herpes simplex virus 1 (HSV-1) is an archetypal member of the alphaherpesvirus subfamily with a large genome encoding over 80 proteins, many of which play a critical role in virus-host interactions and immune ...

    Authors: Chunfu Zheng and Chenhe Su

    Citation: Virology Journal 2017 14:35

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  26. Content type: Research

    AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its role in human cytomegalovirus (HCMV) infection remains unclear. Previously, we ...

    Authors: Yuan Huang, Di Ma, Heyu Huang, Yuanyuan Lu, Yi Liao, Lingling Liu, Xinglou Liu and Feng Fang

    Citation: Virology Journal 2017 14:34

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  27. Content type: Research

    Human cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of...

    Authors: Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński and Dorota Nowakowska

    Citation: Virology Journal 2017 14:12

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  28. Content type: Short report

    Human herpesviruses have been hypothesized as environmental triggers in the development of autoimmune thyroid diseases (AITD), and in particular active human herpesvirus 6A (HHV-6A) infection was detected in t...

    Authors: Elisabetta Caselli, Maria D’Accolti, Irene Soffritti, Maria Chiara Zatelli, Roberta Rossi, Ettore degli Uberti and Dario Di Luca

    Citation: Virology Journal 2017 14:3

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  29. Content type: Research

    Human cytomegalovirus (HCMV) is an opportunistic pathogen leading to severe and even fatal diseases in ‘at-risk’ categories of individuals upon primary infection or the symptomatic reactivation of the endogeno...

    Authors: Maria-Cristina Arcangeletti, Rosita Vasile Simone, Isabella Rodighiero, Flora De Conto, Maria-Cristina Medici, Clara Maccari, Carlo Chezzi and Adriana Calderaro

    Citation: Virology Journal 2016 13:179

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  30. Content type: Research

    Herpes simplex virus type 1 (HSV1), a member of the alphaherpesvirinae, can cause recurrent facial lesions and encephalitis. Two membrane envelopment processes, one at the inner nuclear membrane and a second a...

    Authors: Melanie Ott, Débora Marques, Christina Funk and Susanne M. Bailer

    Citation: Virology Journal 2016 13:175

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  31. Content type: Research

    HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins. However, the me...

    Authors: Yalan Liu, Mei Li, Di Zhang, Mudan Zhang and Qinxue Hu

    Citation: Virology Journal 2016 13:154

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  32. Content type: Research

    UL7, a tegument protein of Herpes Simplex Virus type I (HSV-1), is highly conserved in viral infection and proliferation and has an unknown mechanism of action.

    Authors: Xingli Xu, Shengtao Fan, Jienan Zhou, Ying Zhang, Yanchun Che, Hongzhi Cai, Lichun Wang, Lei Guo, Longding Liu and Qihan Li

    Citation: Virology Journal 2016 13:152

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  33. Content type: Short report

    The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that transforms B cells and causes several malignancies including Burkitt’s lymphoma. EBV differentially expresses at least 49 mature microRNAs (miRNAs)...

    Authors: Cecelia Harold, Diana Cox and Kasandra J. Riley

    Citation: Virology Journal 2016 13:145

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  34. Content type: Research

    One of the most important functions of long noncoding RNAs (lncRNAs) is to control protein coding gene transcription by acting locally in cis, or remotely in trans. Herpes Simplex Virus type I (HSV-1) latently...

    Authors: Benxia Hu, Yongxia Huo, Guijun Chen, Liping Yang, Dongdong Wu and Jumin Zhou

    Citation: Virology Journal 2016 13:137

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  35. Content type: Case Report

    Herpes simplex virus (HSV) is the most common identified cause of focal encephalitis worldwide. However, postoperative HSV encephalitis (HSVE) is a rare complication of neurosurgical procedures and a significa...

    Authors: David A. Jaques, Spyridoula Bagetakou, Arnaud G. L’Huillier, Andrea Bartoli, Maria-Isabel Vargas, Joel Fluss and Laurent Kaiser

    Citation: Virology Journal 2016 13:83

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  36. Content type: Research

    Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...

    Authors: Zhuoran Li, Ce Fang, Yuanyuan Su, Hongmei Liu, Fengchao Lang, Xin Li, Guijun Chen, Danfeng Lu and Jumin Zhou

    Citation: Virology Journal 2016 13:65

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  37. Content type: Methodology

    Investigating the neutralizing antibody (NAb) titer against HSV-1 is essential for monitoring the immune protection against HSV-1 in susceptible populations, which would facilitate the development of vaccines ...

    Authors: Yong Luo, Dan Xiong, Huan-Huan Li, Sheng-Ping Qiu, Chao-Long Lin, Qin Chen, Cheng-Hao Huang, Quan Yuan, Jun Zhang and Ning-Shao Xia

    Citation: Virology Journal 2016 13:44

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  38. Content type: Research

    Herpes simplex virus type-2 is the common cause of genital ulcer disease worldwide. Genital herpes infection is a major concern in pregnancy due to the risk of neonatal transmission.

    Authors: Antehun Alemayehu Anjulo, Tamrat Abebe, Feleke Hailemichael and Adane Mihret

    Citation: Virology Journal 2016 13:43

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  39. Content type: Review

    Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...

    Authors: Chenhe Su, Guoqing Zhan and Chunfu Zheng

    Citation: Virology Journal 2016 13:38

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  40. Content type: Short report

    Marek’s disease is a virus disease with worldwide distribution that causes major losses to poultry production. Vaccines against Marek’s disease virus, an oncogenic alphaherpesvirus, reduce tumour formation but...

    Authors: Mathilde Couteaudier, Katia Courvoisier, Laetitia Trapp-Fragnet, Caroline Denesvre and Jean-François Vautherot

    Citation: Virology Journal 2016 13:7

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  41. Content type: Research

    Epstein-Barr virus (EBV) was the first virus identified to encode microRNAs (miRNAs). Both of viral and human cellular miRNAs are important in EBV infection. However, the dynamic expression profile of miRNAs d...

    Authors: Liwei Gao, Junhong Ai, Zhengde Xie, Chen Zhou, Chunyan Liu, Hui Zhang and Kunling Shen

    Citation: Virology Journal 2015 12:208

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