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Herpes viruses

Section Editor: Blossom Damania, University of North Carolina at Chapel Hill, USA​​​​​​​ 
Deputy Section Editor: Anthony Nicola, Washington State University, USA​​​​​​​

The Herpes viruses section of Virology Journal includes research articles and reviews on both human and animal herpes viruses. This includes basic, mechanistic, and translational studies of herpes virus biology and pathogenesis. Topics include, but are not limited to, virus biology, virus entry, virus-host interactions, viral pathogenesis, viral cancers, antivirals and vaccines.

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  1. Selectively replicating herpes simplex virus-2 (HSV-2) vector is a promising treatment for cancer therapy. The insertion of multiple transgenes into the viral genome has been performed to improve its oncolytic...

    Authors: Han Hu, Siqi Zhang, Linkang Cai, Haixiao Duan, Yuying Li, Junhan Yang, Yang Wang, Biao Liu, Shuang Dong, Zhizheng Fang and Binlei Liu
    Citation: Virology Journal 2022 19:74
    Content type: Research Published on:

  2. Idiopathic CD4 + T lymphocytopenia (ICL) is a rare immunodeficiency syndrome, unaccompanied by various opportunistic infections. Cryptococcus and varicella-zoster viruse are the most common opportunistic infec...

    Authors: Li Fang, Junli Zhang and Fangfang Lv
    Citation: Virology Journal 2022 19:38
    Content type: Review Published on:

  3. Nuclear factor E2-related factor 2 (Nrf2) is an important transcription factor which plays a pivotal role in detoxifying reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory ...

    Authors: Li Zhang, Jiao Wang, Zhan Wang, Ying Li, Hui Wang and Hongtu Liu
    Citation: Virology Journal 2022 19:23
    Content type: Research Published on:

  4. Equine herpesvirus-8 (EHV-8) is one of the most economically significant viruses that infect mammals of the genus Equus worldwide, which cause severe respiratory diseases and abortion in horses. However, there...

    Authors: Tongtong Wang, Leyu Hu, Yonghui Wang, Wenqiang Liu, Guiqin Liu, Mingxia Zhu, Wei Zhang, Changfa Wang, Huiying Ren and Liangliang Li
    Citation: Virology Journal 2022 19:10
    Content type: Case Report Published on:

  5. Epstein–Barr virus (EBV) is an important human pathogenic gammaherpesvirus with carcinogenic potential. The EBV transcriptome has previously been analyzed using both Illumina-based short read-sequencing and Pa...

    Authors: Ádám Fülöp, Gábor Torma, Norbert Moldován, Kálmán Szenthe, Ferenc Bánáti, Islam A. A. Almsarrhad, Zsolt Csabai, Dóra Tombácz, János Minárovits and Zsolt Boldogkői
    Citation: Virology Journal 2022 19:7
    Content type: Research Published on:

  6. Elephant endotheliotropic herpesvirus haemorrhagic disease (EEHV HD) is the leading cause of death in captive Asian elephant calves in Asia, North America, and Europe with a mortality rate of ~ 65% in calves t...

    Authors: Mei-Ho Lee, Senthilvel K. S. S. Nathan, Laura Benedict, Pakeeyaraj Nagalingam, Erin Latimer, Tom Hughes, Diana Ramirez and Jum Rafiah Abd Sukor
    Citation: Virology Journal 2021 18:231
    Content type: Case Report Published on:

  7. B-cell proliferative disorders, such as post-transplant lymphoproliferative disease (PTLD), are increased among persons afflicted by T-cell compromise. Most are Epstein–Barr virus (EBV) + and can first present...

    Authors: Elham Ahmadi, Mehrdad Ravanshad, Jun Xie, Rajesh Panigrahi, Sandeep S. Jubbal, Santosh Kumar Guru, Gao Guangping, Mazyar Ziyaeyan and Joyce Fingeroth
    Citation: Virology Journal 2021 18:223
    Content type: Research Published on:

  10. Regard to this fact that the main transmission route of HPV and HHV-8 is via sexual activity, it is reasonable to speculate that coinfection of HPV and HHV-8 may have been played an important role in the devel...

    Authors: Sara Chavoshpour-Mamaghani, Zabihollah Shoja, Yaghoub Mollaei-Kandelous, Kimia Sharifian and Somayeh Jalilvand
    Citation: Virology Journal 2021 18:144
    Content type: Research Published on:

  11. The advent of whole genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts. In particular, tr...

    Authors: Ahmed Al Qaffas, Salvatore Camiolo, Mai Vo, Alexis Aguiar, Amine Ourahmane, Myrna Sorono, Andrew J. Davison, Michael A. McVoy and Laura Hertel
    Citation: Virology Journal 2021 18:112
    Content type: Short report Published on:

  12. The emergence of drug resistance and cross-resistance to existing drugs has warranted the development of new antivirals for Herpes simplex viruses (HSV). Hence, we have designed this study to evaluate the anti...

    Authors: Abhishek Kumar, Saikat De, Alok Kumar Moharana, Tapas Kumar Nayak, Tanuja Saswat, Ankita Datey, Prabhudutta Mamidi, Priyadarsee Mishra, Bharat Bhusan Subudhi and Soma Chattopadhyay
    Citation: Virology Journal 2021 18:103
    Content type: Research Published on:

  13. DNA vaccine is one of the research hotspots in veterinary vaccine development. Several advantages, such as cost-effectiveness, ease of design and production, good biocompatibility of plasmid DNA, attractive bi...

    Authors: Xing-Bo Liu, Guo-Wei Yu, Xin-Yu Gao, Jin-Long Huang, Li-Ting Qin, Hong-Bo Ni and Chuang Lyu
    Citation: Virology Journal 2021 18:60
    Content type: Research Published on:

  14. Membrane-associated RING-CH (MARCH) ubiquitin ligases belong to a RING finger domain E3 ligases family. Recent studies have demonstrated that MARCH proteins play critical roles during various viral infections....

    Authors: Chunfu Zheng and Yan-Dong Tang
    Citation: Virology Journal 2021 18:49
    Content type: Review Published on:

  16. Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus. Cohesin, a major constituent of interphase and mi...

    Authors: Xin Li, Yafen Yu, Fengchao Lang, Guijun Chen, Erlin Wang, Lihong Li, Zhuoran Li, Liping Yang, Xia Cao, Nigel W. Fraser and Jumin Zhou
    Citation: Virology Journal 2021 18:26
    Content type: Research Published on:

  17. In the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequentl...

    Authors: Wenjin Zheng, Qing Xu, Yiyuan Zhang, Xiaofei E, Wei Gao, Mogen Zhang, Weijie Zhai, Ronaldjit Singh Rajkumar and Zhijun Liu
    Citation: Virology Journal 2020 17:192
    Content type: Review Published on:

    The Correction to this article has been published in Virology Journal 2020 17:199

  18. Chronic active Epstein–Barr virus (CAEBV) infection is a type of lymphoproliferative disorder characterized by chronic or recurrent infectious mononucleosis (IM)-like symptoms, which can have less-frequent cli...

    Authors: Haijuan Xiao, Bing Hu, Rongmu Luo, Huili Hu, Junmei Zhang, Weiying Kuang, Rui Zhang, Li Li and Gang Liu
    Citation: Virology Journal 2020 17:166
    Content type: Case Report Published on:

  19. Cytomegalovirus (CMV) is an opportunistic pathogen that causes severe complications in congenitally infected newborns and non-immunocompetent individuals. Developing an effective vaccine is a major public heal...

    Authors: Krishnan Nair Balakrishnan, Ashwaq Ahmed Abdullah, Jamilu Abubakar Bala, Faez Firdaus Abdullah Jesse, Che Azurahanim Che Abdullah, Mustapha Mohamed Noordin and Mohd Lila Mohd-Azmi
    Citation: Virology Journal 2020 17:164
    Content type: Research Published on:

  20. Bilateral herpes zoster (BHZ) is an atypical presentation of herpes zoster (HZ), with few cases reported before. Ramsay Hunt syndrome (RHS) is an uncommon complication of VZV infection. Cases of BHZ with RHS i...

    Authors: Siqi Dai, Xiaowen Huang, Yuxiang Chen, Menglei Wang, Huanxin Zheng, Kang Zeng and Li Li
    Citation: Virology Journal 2020 17:123
    Content type: Case Report Published on:

  21. Human cytomegalovirus (HCMV) causes asymptomatic infections, but also causes congenital infections when women were infected with HCMV during pregnancy, and life-threatening diseases in immunocompromised patien...

    Authors: Miho Shibamura, Tomoki Yoshikawa, Souichi Yamada, Takuya Inagaki, Phu Hoang Anh Nguyen, Hikaru Fujii, Shizuko Harada, Shuetsu Fukushi, Akira Oka, Masashi Mizuguchi and Masayuki Saijo
    Citation: Virology Journal 2020 17:120
    Content type: Research Published on:

  22. Herpes simplex virus (HSV) can cause encephalitis. Its infected cell polypeptide 47 (ICP47), encoded by immediate-early gene US12, promotes immune escape. ICP47 was modified in the clinically approved oncolytic H...

    Authors: Jun-Ting Cheng, Ying-Ying Wang, Lin-Zhong Zhu, Ying Zhang, Wen-Qi Cai, Zi-Wen Han, Yang Zhou, Xian-Wang Wang, Xiao-Chun Peng, Ying Xiang, Hui-Yu Yang, Shu-Zhong Cui, Zhaowu Ma, Bing-Rong Liu and Hong-Wu Xin
    Citation: Virology Journal 2020 17:101
    Content type: Research Published on:

  23. Following acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of trigeminal ganglia (TG). Infected tree shrew differs from mouse and s...

    Authors: Erlin Wang, Yunshuang Ye, Ke Zhang, Jinlong Yang, Daohua Gong, Jianhua Zhang, Renjun Hong, Huan Zhang, Lihong Li, Guijun Chen, Liping Yang, Jianmei Liu, Hanyu Cao, Ting Du, Nigel W. Fraser, Le Cheng…
    Citation: Virology Journal 2020 17:95
    Content type: Research Published on:

    The Correction to this article has been published in Virology Journal 2020 17:150

  24. Host shutoff refers to the widespread downregulation of host gene expression and has emerged as a key process that facilitates the reallocation of cellular resources for viral replication and evasion of host a...

    Authors: Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Ying Wu, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Shaqiu Zhang, Xin-Xin Zhao, Juan Huang, Di Sun, Sai Mao, Xuming Ou, Yin Wang…
    Citation: Virology Journal 2020 17:68
    Content type: Review Published on:

  25. The Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus related to various types of cancers, including epithelial nasopharyngeal carcinoma, gastric carcinoma, and lymphoma. Long noncoding RNAs (lncRNAs) are...

    Authors: Jing Zhang, Xiaohan Li, Jingjin Hu, Pengfei Cao, Qijia Yan, Siwei Zhang, Wei Dang and Jianhong Lu
    Citation: Virology Journal 2020 17:51
    Content type: Review Published on:

  26. Antibody neutralization of cytomegalovirus (CMV) entry into diverse cell types is a key consideration for development of vaccines and immunotherapeutics. CMV entry into fibroblasts differs significantly from e...

    Authors: Ying Qi, Li He, Xiaohong Cui, Laura Hertel, Daniel C. Freed, Tong-Ming Fu, Lawrence M. Kauvar, Michael A. McVoy and Qiang Ruan
    Citation: Virology Journal 2020 17:50
    Content type: Short report Published on:

  27. Herpes simplex virus 1, an enveloped DNA virus belonging to the Herpesviridae family, spreads to neurons and causes pathological changes in the central nervous system. The purpose of this study was to investig...

    Authors: Zhaoyang Wang, Jiaoyan Jia, Lu Wang, Feng Li, Yiliang Wang, Yuzhou Jiang, Xiaowei Song, Shurong Qin, Kai Zheng, Ju Ye, Zhe Ren, Yifei Wang and Shuhua Qi
    Citation: Virology Journal 2020 17:41
    Content type: Research Published on:

    The Correction to this article has been published in Virology Journal 2020 17:45

  29. Human herpesviruses (HHVs) remain latent after primary infection and can be reactivated in response to immunosuppression and chemotherapy. Little is known about their incidence, potential relationships, risk f...

    Authors: Imene Handous, Bechir Achour, Manel Marzouk, Sana Rouis, Olfa Hazgui, Ines Brini, Abderrahim Khelif, Naila Hannachi and Jalel Boukadida
    Citation: Virology Journal 2020 17:37
    Content type: Research Published on:

  30. MicroRNAs (miRNAs) are small non-coding RNAs about 22 nucleotides in length, which play an important role in gene regulation of both eukaryotes and viruses. They can promote RNA cleavage and repress translatio...

    Authors: Lichen Zhang, Jiaqi Yu and Zhijun Liu
    Citation: Virology Journal 2020 17:34
    Content type: Review Published on:

  31. Standardized and sensitive assays for Epstein Barr Virus (EBV) are needed to define universal cutoff for treatment initiation in allogeneic hematopoietic stem cells transplant recipients. In a context of accre...

    Authors: Maud Salmona, Karl Stefic, Nadia Mahjoub, Flore Sicre de Fontbrune, Sarah Maylin, François Simon, Catherine Scieux, Gérard Socié, Marie-Christine Mazeron and Jérôme LeGoff
    Citation: Virology Journal 2020 17:20
    Content type: Research Published on:

  32. Porcine parvovirus (PPV) and pseudorabies virus (PRV) are the important etiological agents of swine infectious diseases, resulting in huge economic losses to the Chinese swine industry. Interleukin-6 (IL-6) ha...

    Authors: Hui-Hua Zheng, Lin-Qing Wang, Peng-Fei Fu, Lan-Lan Zheng, Hong-Ying Chen and Fang Liu
    Citation: Virology Journal 2020 17:19
    Content type: Research Published on:

  33. Porcine β-defensin 2 (PBD-2), produced by host cells, is an antimicrobial cysteine-rich cationic peptide with multi-functions. Previous studies have demonstrated that PBD-2 can kill various bacteria, regulate ...

    Authors: Jing Huang, Yanhua Qi, Antian Wang, Chao Huang, Xiao Liu, Xi Yang, Lu Li and Rui Zhou
    Citation: Virology Journal 2020 17:18
    Content type: Research Published on:

  34. MicroRNAs (miRNAs) is increasingly recognized as an important element in regulating virus-host interactions. Our previous results showed that cellular miR-30a-5p was significantly downregulated after duck ente...

    Authors: Xianglong Wu, Renyong Jia, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Qiao Yang, Ying Wu, Zhongqiong Yin, Shaqiu Zhang, Juan Huang, Ling Zhang, Yunya Liu, Yanling Yu, Leichang Pan…
    Citation: Virology Journal 2019 16:144
    Content type: Research Published on:

  36. Pseudorabies virus (PRV) protein UL56 (pUL56) has been implicated in viral dissemination and virulence in vivo. However, the properties of PRV pUL56 remain largely unknown. In the present study, we aim to inve...

    Authors: Chuang Lyu and Xuehui Cai
    Citation: Virology Journal 2019 16:81
    Content type: Research Published on:

  37. Shingles (localized zoster) and disseminated zoster are caused by the reactivation of latent varicella zoster virus (VZV). Reactivation of VZV is related to impaired cell-mediated immunity. Extensive burns aff...

    Authors: Yoshitaka Kubota, Kentaro Kosaka, Toshinori Hokazono, Yoshihisa Yamaji, Takafumi Tezuka, Shinsuke Akita, Motone Kuriyama and Nobuyuki Mitsukawa
    Citation: Virology Journal 2019 16:68
    Content type: Case Report Published on:

  38. Elephant endotheliotropic herpesviruses (EEHV) can cause an acute highly fatal hemorrhagic disease in young Asian elephants (Elephas maximus), both ex situ and in situ. Amongst eight EEHV types described so far, ...

    Authors: Taweepoke Angkawanish, Mirjam Nielen, Hans Vernooij, Janine L. Brown, Peter J. S. van Kooten, Petra B. van den Doel, Willem Schaftenaar, Kannika Na Lampang and Victor P. M. G. Rutten
    Citation: Virology Journal 2019 16:33
    Content type: Research Published on:

  39. Alternative splicing (AS) is an important mRNA maturation step that allows increased variability and diversity of proteins in eukaryotes. AS is dysregulated in numerous diseases, and its implication in the car...

    Authors: Simon Boudreault, Victoria E. S. Armero, Michelle S. Scott, Jean-Pierre Perreault and Martin Bisaillon
    Citation: Virology Journal 2019 16:29
    Content type: Research Published on:

  40. Haploidentical hematopoietic stem cell transplant (haplo-HSCT) recipients are at high risk for Epstein Barr virus (EBV)-related diseases. EBV-specific CD8+ cytotoxic T cells can control EBV-infected B cell expans...

    Authors: Ling Zhou and Dao-pei Lu
    Citation: Virology Journal 2019 16:19
    Content type: Research Published on:

  41. Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky’s disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occ...

    Authors: Chao Ye, Jiqiang Wu, Wu Tong, Tongling Shan, Xuefei Cheng, Jingjing Xu, Chao Liang, Hao Zheng, Guoxin Li and Guangzhi Tong
    Citation: Virology Journal 2018 15:195
    Content type: Short report Published on:

  42. The pattern recognition receptors (PPRs) are the earliest phase of the host defense against pathogens in genital epithelium, and toll-like receptors (TLRs) are best characterized PPRs mediating innate immune r...

    Authors: Xiaowen Lv, Huanru Wang, Airong Su, Shijie Xu and Ying Chu
    Citation: Virology Journal 2018 15:173
    Content type: Research Published on:

  43. The results of our previous study showed that impaired cellular energy metabolism contributes to duck enteritis virus-induced autophagy via the 5`-adenosine monophosphate-activated protein kinase (AMPK)/tubero...

    Authors: Haichang Yin, Lili Zhao, Yiping Wang, Siqi Li, Hong Huo and Hongyan Chen
    Citation: Virology Journal 2018 15:120
    Content type: Research Published on:

  44. The alphaherpesvirus virion host shutoff (vhs) gene, UL41, can induce degradation of host mRNAs and shut off host protein synthesis. The roles of vhs in HSV-1 and HSV-2 have been studied extensively in previou...

    Authors: Chao Ye, Jing Chen, Tao Wang, Jingjing Xu, Hao Zheng, Jiqiang Wu, Guoxin Li, Zhiqing Yu, Wu Tong, Xuefei Cheng, Shasha Zhou and Guangzhi Tong
    Citation: Virology Journal 2018 15:119
    Content type: Research Published on:

  47. Duck enteritis virus (DEV) belongs to the subfamily Alphaherpesvirinae, and information on the DEV UL41 gene is limited.

    Authors: Tianqiong He, Mingshu Wang, Xuelian Cao, Anchun Cheng, Ying Wu, Qiao Yang, Mafeng Liu, Dekang Zhu, Renyong Jia, Shun Chen, Kunfeng Sun, Xinxin Zhao and Xiaoyue Chen
    Citation: Virology Journal 2018 15:12
    Content type: Research Published on:

  49. Hemophagocytic lymphohistiocytosis (HLH) is a rare immunological disorder caused by unbridled activation of T cells and macrophages, culminating in a life-threatening cytokine storm. A genetic and acquired sub...

    Authors: Ellen Brisse, Maya Imbrechts, Tania Mitera, Jessica Vandenhaute, Carine H. Wouters, Robert Snoeck, Graciela Andrei and Patrick Matthys
    Citation: Virology Journal 2017 14:240
    Content type: Research Published on:

  50. Epstein-Barr virus (EBV) exhibits both lytic and latent (Lat. I, II, and III) phases in an infected individual. It’s during the latent phase of EBV that all EBV-associated cancers, including Burkitt’s lymphoma...

    Authors: Gina Pisano, Arunava Roy, Mairaj Ahmed Ansari, Binod Kumar, Leela Chikoti and Bala Chandran
    Citation: Virology Journal 2017 14:221
    Content type: Research Published on:
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  • ISSN: 1743-422X (electronic)

Virology Journal

ISSN: 1743-422X