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Virology Journal

Negative-strand RNA viruses

Section Editor: Bert Rima, Queen’s University Belfast, UK
Deputy Section Editor: John Barr, University of Leeds, UK ​​​​​​​

The Negative-strand RNA viruses section of Virology Journal aims to publish research articles and reviews covering all aspects of segmented and non-segmented negative strand RNA viruses from all eukaryotes. Basic research topics of interest include aspects of the viral life cycle: viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress as wells as virus-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants. We also welcome basic and translational studies on the development of antiviral drugs and vaccines. Interdisciplinary research on these viruses using multiple approaches is particularly welcome.

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  1. Content type: Research

    The specific and dynamic interaction between the hemagglutinin (H) and fusion (F) proteins of morbilliviruses is a prerequisite for the conformational rearrangements and membrane fusion during infection proces...

    Authors: Xuelian Meng, Ruixue Deng, Xueliang Zhu and Zhidong Zhang

    Citation: Virology Journal 2018 15:21

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  2. Content type: Research

    Rodent borne viruses of the Orthohantavirus genus cause hemorrhagic fever with renal syndrome among people in Eurasia, and hantavirus cardiopulmonary syndrome in the Americas. At present, there are no specific tr...

    Authors: Julia Wigren Byström, Jonas Näslund, Fredrik Trulsson, Magnus Evander, Olivia Wesula Lwande, Clas Ahlm and Göran Bucht

    Citation: Virology Journal 2018 15:18

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  3. Content type: Research

    Newcastle disease viruses (NDV) are highly contagious and cause disease in both wild birds and poultry. A pigeon-adapted variant of genotype VI NDV, often termed pigeon paramyxovirus 1, is commonly isolated fr...

    Authors: Ying He, Tonya L. Taylor, Kiril M. Dimitrov, Salman L. Butt, James B. Stanton, Iryna V. Goraichuk, Heather Fenton, Rebecca Poulson, Jian Zhang, Corrie C. Brown, Hon S. Ip, Marcos Isidoro-Ayza and Claudio L. Afonso

    Citation: Virology Journal 2018 15:9

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  4. Content type: Methodology

    Newcastle disease is one of the most important infectious diseases of poultry, caused by Newcastle disease virus (NDV). This virus is distributed worldwide and it can cause severe economic losses in the poultr...

    Authors: Ana Chumbe, Ray Izquierdo-Lara, Katherine Calderón, Manolo Fernández-Díaz and Vikram N. Vakharia

    Citation: Virology Journal 2017 14:232

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  5. Content type: Methodology

    Virus infections often result in quasispecies of viral strains that can have dramatic impacts on disease outcomes. However, sequencing of viruses to determine strain composition is time consuming and often cos...

    Authors: Lina S. Franco, Susan A. Holechek, Michael R. Caplan and Joseph N. Blattman

    Citation: Virology Journal 2017 14:197

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  6. Content type: Short Report

    Newcastle disease virus (NDV) causes severe diseases in avian species. Its fusion protein cleavage site (Fcs) is a major contributor to virulence and membrane fusion. Previous studies showed that a change from...

    Authors: Yanhong Wang, Youkun Bi, Wanqi Yu, Ning Wei, Wenbin Wang, Qiaolin Wei, Xinglong Wang, Shuxia Zhang, Zengqi Yang and Sa Xiao

    Citation: Virology Journal 2017 14:185

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  7. Content type: Research

    As rabies still represents a major public threat with tens of thousands of deaths per year, particularly in developing countries, adequate surveillance based on rapid and reliable rabies diagnosis for both hum...

    Authors: Kore Schlottau, Conrad M. Freuling, Thomas Müller, Martin Beer and Bernd Hoffmann

    Citation: Virology Journal 2017 14:184

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    The Correction to this article has been published in Virology Journal 2017 14:225

  8. Content type: Research

    Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. Therefore, these cellular proteases are putative target...

    Authors: Winke Van der Gucht, Annelies Leemans, Marjorie De Schryver, Annick Heykers, Guy Caljon, Louis Maes, Paul Cos and Peter L. Delputte

    Citation: Virology Journal 2017 14:157

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  9. Content type: Research

    Hantaan and Seoul viruses, in the Hantavirus genus, are known to cause hemorrhagic fever with renal syndrome (HFRS). The plaque reduction neutralization test (PRNT), as conventional neutralization test for han...

    Authors: Weihong Li, Shouchun Cao, Quanfu Zhang, Jiandong Li, Shuo Zhang, Wei Wu, Jing Qu, Chuan Li, Mifang Liang and Dexin Li

    Citation: Virology Journal 2017 14:133

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  10. Content type: Short Paper

    Borna disease virus (BoDV), which has a negative-sense, single-stranded RNA genome, causes persistent infection in the cell nucleus. The nuclear export signal (NES) of the viral nucleoprotein (N) consisting of...

    Authors: Mako Yanai, Madoka Sakai, Akiko Makino and Keizo Tomonaga

    Citation: Virology Journal 2017 14:126

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  11. Content type: Research

    Rabies is an important viral zoonosis that causes acute encephalitis and death in mammals. To date, several recombinant vaccines have been developed based on G protein, which is considered to be the main antig...

    Authors: Ha-Hyun Kim, Dong-Kun Yang, Jin-Ju Nah, Jae-Young Song and In-Soo Cho

    Citation: Virology Journal 2017 14:122

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  12. Content type: Research

    Rabies is an important but underestimated threat to public health, with most cases reported in Asia. Since 2000, a new epidemic wave of rabies has emerged in Yunnan Province, southwestern China, which borders ...

    Authors: Yuzhen Zhang, Bram Vrancken, Yun Feng, Simon Dellicour, Qiqi Yang, Weihong Yang, Yunzhi Zhang, Lu Dong, Oliver G. Pybus, Hailin Zhang and Huaiyu Tian

    Citation: Virology Journal 2017 14:102

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  13. Content type: Methodology

    Next-generation sequencing (NGS) allows ultra-deep sequencing of nucleic acids. The use of sequence-independent amplification of viral nucleic acids without utilization of target-specific primers provides adva...

    Authors: Kiril M. Dimitrov, Poonam Sharma, Jeremy D. Volkening, Iryna V. Goraichuk, Abdul Wajid, Shafqat Fatima Rehmani, Asma Basharat, Ismaila Shittu, Tony M. Joannis, Patti J. Miller and Claudio L. Afonso

    Citation: Virology Journal 2017 14:72

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  14. Content type: Short report

    Infectious salmon anemia virus (ISAV) is an important fish pathogen that causes high mortality in farmed Atlantic salmon. The ISAV genome consists of eight single-stranded, negative-sense RNA segments. The six la...

    Authors: Wenting Zhang, Chengzhi Cai, Li Lin, Yizhi Jane Tao and Meilin Jin

    Citation: Virology Journal 2017 14:30

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  15. Content type: Methodology

    Peste des petits ruminants (PPR) is an economically important, Office International des Epizooties (OIE) notifiable, transboundary viral disease of small ruminants such as sheep and goat. PPR virus (PPRV), a n...

    Authors: Yang Yang, Xiaodong Qin, Yiming Song, Wei Zhang, Gaowei Hu, Yongxi Dou, Yanmin Li and Zhidong Zhang

    Citation: Virology Journal 2017 14:24

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  16. Content type: Research

    Hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus infection is characterized by fever, renal dysfunction and hemorrhage. An animal model mimicking symptoms of HFRS remains to be established. In...

    Authors: Kenta Shimizu, Takaaki Koma, Kumiko Yoshimatsu, Yoshimi Tsuda, Yuji Isegawa and Jiro Arikawa

    Citation: Virology Journal 2017 14:13

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  17. Content type: Research

    The viral hemorrhagic septicemia virus (VHSV) is one of the most serious fish pathogens. In 2003, a novel sublineage (genotype IVb) of this deadly virus emerged in the Great Lakes basin causing serious fish ki...

    Authors: Isaac F. Standish, Elena V. Millard, Travis O. Brenden and Mohamed Faisal

    Citation: Virology Journal 2016 13:203

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  18. Content type: Research

    The canonical genome organization of measles virus (MV) is characterized by total size of 15 894 nucleotides (nts) and defined length of every genomic region, both coding and non-coding. Only rarely have repor...

    Authors: Jelena Ivancic-Jelecki, Anamarija Slovic, Maja Šantak, Goran Tešović and Dubravko Forcic

    Citation: Virology Journal 2016 13:134

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