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Positive-strand RNA viruses

Section Editor: Jason Mackenzie, The University of Melbourne, Australia
Deputy Section Editor: Rushika Perera, Colorado State University, USA
 

The Positive-strand RNA viruses section of Virology Journal invites submissions of research articles and reviews covering all aspects of positive-strand RNA virus biology. Basic research topics of interest include all facets of the viral life cycle from viral attachment and entry, viral RNA replication and translation, viral gene expression/regulation, viral protein processing, viral particle assembly and secretion. We welcome studies that investigate interactions between the virus and host that impact viral replication and the cellular response to infection. Other topics include but are not limited to viral pathogenesis, epidemiology, and viral immunology. We also welcome basic and translational studies on the development of novel model systems, antiviral drugs and vaccines.

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  1. Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This virus affects the respiratory tract and usua...

    Authors: Soheila Montazersaheb, Seyed Mahdi Hosseiniyan Khatibi, Mohammad Saeid Hejazi, Vahideh Tarhriz, Afsaneh Farjami, Faramarz Ghasemian Sorbeni, Raheleh Farahzadi and Tohid Ghasemnejad
    Citation: Virology Journal 2022 19:92
  2. The new coronavirus (COVID-19) has been transmitted exponentially. Numerous studies have been performed in recent years that have shown the inhibitory effect of plant extracts or plant-derived compounds on the...

    Authors: Mina Mobini Kesheh, Sara Shavandi, Niloofar Haeri Moghaddam, Moazzameh Ramezani and Fatemeh Ramezani
    Citation: Virology Journal 2022 19:87
  3. The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well esta...

    Authors: Fenfen Si, Dongyan Wang, Tianjiao Ji, Yong Zhang, Shuangli Zhu, Junhan Li, Wenbo Xu, Zexin Tao and Dongmei Yan
    Citation: Virology Journal 2022 19:83
  4. Human rhinovirus C (HRV-C) accounts for a large proportion of HRV-related illnesses, but the immune response to HRV-C infection has not been elucidated. Our objective was to assess the effect of HRV-C on cytok...

    Authors: Xin-hui Yuan, Li-li Pang, Jing Yang and Yu Jin
    Citation: Virology Journal 2022 19:81
  5. Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), and pancreatitis, and is a heavy burden on public health. However, CVB3 has ...

    Authors: Qian Yang, Dongmei Yan, Yang Song, Shuangli Zhu, Yun He, Zhenzhi Han, Dongyan Wang, Tianjiao Ji, Yong Zhang and Wenbo Xu
    Citation: Virology Journal 2022 19:69
  6. The newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and four seasonal human coronaviruses (HCoVs) (HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1) still circulate worldwide. The ea...

    Authors: Mengchuan Zhao, Yi Xu, Dijun Zhang, Guixia Li, Huixia Gao, Xianping Zeng, Yanqing Tie, Yong Wu, Erhei Dai and Zhishan Feng
    Citation: Virology Journal 2022 19:67
  7. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered the worldwide coronavirus disease 2019 (COVID-19) pandemic. Serological assays for the detection of SARS-CoV-2 infections are impo...

    Authors: Ji Luo, Alexandra Brakel, Andor Krizsan, Tobias Ludwig, Marina Mötzing, Daniela Volke, Nicole Lakowa, Thomas Grünewald, Claudia Lehmann, Johannes Wolf, Stephan Borte, Sanja Milkovska-Stamenova, Jörg Gabert, Felix Fingas, Markus Scholz and Ralf Hoffmann
    Citation: Virology Journal 2022 19:50
  8. The dengue epidemic in Guangzhou has imposed a rising burden on society and health infrastructure. Here, we present the genotype data for dengue virus serotype 2 (DENV-2) to improve understanding of this dengu...

    Authors: Liyun Jiang, Yuan Liu, Wenzhe Su, Yimin Cao, Qinlong Jing, Xinwei Wu and Zhicong Yang
    Citation: Virology Journal 2022 19:47
  9. Enteroviruses (EVs) are considered the main causative agents responsible for aseptic meningitis worldwide. This study was conducted in the Monastir region of Tunisia in order to know the prevalence of EV infec...

    Authors: Yosra Rmadi, Aida Elargoubi, Rubén González-Sanz, Maha Mastouri, Maria Cabrerizo and Mahjoub Aouni
    Citation: Virology Journal 2022 19:45
  10. Despite the clinical burden attributable to rhinovirus (RV) infections, the RV transmission dynamics and the impact of interventions on viral transmission remain elusive.

    Authors: Kim Tien Ng, Liang Jie Ng, Xiang Yong Oong, Jack Bee Chook, Kok Gan Chan, Yutaka Takebe, Adeeba Kamarulzaman and Kok Keng Tee
    Citation: Virology Journal 2022 19:36
  11. Rubella virus (RV) is the causative agent of rubella or German measles. Although most infections cause only mild self-limited measles-like illness, the infection in pregnant women can cause severe foetal malfo...

    Authors: Wenyue Xing, Li Li, Jingnan Zhang, Chunli Ma, Xin Xue, Shumei Ye, Huiting Xue, Ruiping Hu, Yanhua Ma and Hong Yuan
    Citation: Virology Journal 2022 19:33
  12. Ultraviolet (UV) light has previously been established as useful method of disinfection, with demonstrated efficacy to inactivate a broad range of microorganisms. The advent of ultraviolet light-emitting diode...

    Authors: Arvin T. Persaud, Jonathan Burnie, Laxshaginee Thaya, Liann DSouza, Steven Martin and Christina Guzzo
    Citation: Virology Journal 2022 19:29
  13. Coronavirus disease-19 (COVID-19) is a communicable disease caused by a virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pandemics are associated with the high level of mental stress. I...

    Authors: Munam Raza Jafri, Anna Zaheer, Sahar Fatima, Taiba Saleem and Atif Sohail
    Citation: Virology Journal 2022 19:3
  14. Although interferon regulatory factor 2 (IRF2) was reported to stimulate virus replication by suppressing the type I interferon signaling pathway, because cell cycle arrest was found to promote viral replicati...

    Authors: Kai Ren, Ya Zhu, Honggang Sun, Shilin Li, Xiaoqiong Duan, Shuang Li, Yujia Li, Bin Li and Limin Chen
    Citation: Virology Journal 2021 18:256
  15. Enterovirus 71 (EV71) usually infects infants causing hand-foot-mouth disease (HFMD), even fatal neurological disease like aseptic meningitis. Effective drug for preventing and treating EV71 infection is unava...

    Authors: Zhuoran Li, Ya’ni Wu, Hui Li, Wenqian Li, Juan Tan and Wentao Qiao
    Citation: Virology Journal 2021 18:255
  16. The uncontrollable spread of Zika virus (ZIKV) in the Americas during 2015–2017, and its causal link to microcephaly in newborns and Guillain-Barré syndrome in adults, led the World Health Organisation to decl...

    Authors: Julio Carrera, Alice M. Trenerry, Cameron P. Simmons and Jason M. Mackenzie
    Citation: Virology Journal 2021 18:251
  17. Parechoviruses (PeV-As), which constitute a new genus within the family Picornaviridae, have been associated with numerous localized outbreaks of serious diseases, such as coryza, pneumonia, maculopapular exanthe...

    Authors: Huanhuan Lu, Jinbo Xiao, Keyi Zhang, Zhenzhi Han, Yang Song, Dongyan Wang, Tianjiao Ji, Dongmei Yan, Shuangli Zhu, Wenbo Xu and Yong Zhang
    Citation: Virology Journal 2021 18:227
  18. With the advancement of sequencing technologies, a plethora of noncoding RNA (ncRNA) species have been widely discovered, including microRNAs (miRNAs), circular RNAs (circRNAs), and long ncRNAs (lncRNAs). Howe...

    Authors: Junzhuo Si, Xia Tang, Lei Xu, Huichao Fu, Huayi Li, Yonglin He, Jiajia Bao, Jialing Tang, Anlong Li, Nan Lu and Chun Yang
    Citation: Virology Journal 2021 18:216
  19. Foot-and-mouth disease (FMD) is a devastating animal disease. Anti-non-structural protein (NSP) antibody detection is very important for confirming suspected cases, evaluating the prevalence of infection, cert...

    Authors: Wei Liu, Guanglei Zhang, Sicheng Yang, Junhui Li, Zhan Gao, Sudan Ge, Huihui Yang, Junjun Shao and Huiyun Chang
    Citation: Virology Journal 2021 18:193
  20. Flaviviruses are representative arboviruses carried by arthropods and/or vertebrates; these viruses can pose a public health concern in many countries. By contrast, it is known that a novel virus group called ...

    Authors: Tomo Daidoji, Ronald Enrique Morales Vargas, Katsuro Hagiwara, Yasuha Arai, Yohei Watanabe, Keisuke Nishioka, Fumi Murakoshi, Kotaro Garan, Hiroki Sadakane and Takaaki Nakaya
    Citation: Virology Journal 2021 18:187
  21. Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronaviru...

    Authors: Chuanxiong Nie, Jakob Trimpert, Sooyeon Moon, Rainer Haag, Kerry Gilmore, Benedikt B. Kaufer and Peter H. Seeberger
    Citation: Virology Journal 2021 18:182
  22. Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in...

    Authors: Natália Lima Pessoa, Aline Almeida Bentes, Andrea Lucchesi de Carvalho, Thaís Bárbara de Souza Silva, Pedro Augusto Alves, Erik Vinicius de Sousa Reis, Tayse Andrade Rodrigues, Erna Geessien Kroon and Marco Antônio Campos
    Citation: Virology Journal 2021 18:180
  23. The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest i...

    Authors: Jalen Singh, Pranav Pandit, Andrew G. McArthur, Arinjay Banerjee and Karen Mossman
    Citation: Virology Journal 2021 18:166
  24. Enterovirus 71 (EV-A71) is a highly infectious pathogen associated with hand, foot and mouth disease, herpangina, and various neurological complications, so it is important for the early detection and treatmen...

    Authors: Xinran Zou, Jing Wu, Jiaqi Gu, Li Shen and Lingxiang Mao
    Citation: Virology Journal 2021 18:164
  25. As frequent viral outbreaks continue to pose threat to public health, the unavailability of antiviral drugs and challenges associated with vaccine development underscore the need for antiviral drugs discovery ...

    Authors: Omonike O. Ogbole, Toluwanimi E. Akinleye, Abraham O. Nkumah, Aminat O. Awogun, Alfred F. Attah, Moses O. Adewumi and Adekunle J. Adeniji
    Citation: Virology Journal 2021 18:161
  26. The numbers of confirmed cases of coronavirus disease 2019 (COVID-19) and COVID-19 related deaths are still increasing, so it is very important to determine the risk factors of COVID-19. Dyslipidemia is a comm...

    Authors: Yanli Liu, Yilong Pan, Yuyao Yin, Wenhao Chen and Xiaodong Li
    Citation: Virology Journal 2021 18:157
  27. Acute flaccid paralysis (AFP) surveillance was conducted as part of the World Health Organization’s strategy for completely eradicating poliomyelitis and leaving non-polio enteroviruses NPEVs as one of the mai...

    Authors: Napa Onvimala, Nathamon Kosoltanapiwat, Pornpan Pumirat, Muthita Vanaporn, Suchitra Nimmanitya, Ratana Tacharoenmuang, Ratigorn Guntapong and Pornsawan Leaungwutiwong
    Citation: Virology Journal 2021 18:153
  28. Zika virus is becoming one of the most widely transmitted arboviruses in the world. Development of antiviral inhibitor and vaccine requires an experimental system that allows rapid monitoring of the virus infe...

    Authors: Jing Gao, Jiayi Chen, Weizhi Lu, Jintai Cai, Linjuan Shi, Wei Zhao and Bao Zhang
    Citation: Virology Journal 2021 18:151
  29. Mosquito-borne flaviviruses are prime pathogens and have been a major hazard to humans and animals. They comprise several arthropod-borne viruses, including dengue virus, yellow fever virus, Japanese encephali...

    Authors: Shilpa Chatterjee, Choon-Mee Kim, Na Ra Yun, Dong-Min Kim, Hyeon Je Song and Kyeoung A Chung
    Citation: Virology Journal 2021 18:150

    The Correction to this article has been published in Virology Journal 2021 18:172

  30. On the detection and identification of enteroviruses circulating in children with acute gastroenteritis in Brazil: reply to Luchs, A. Comments on Detection and identification of enteroviruses circulating in ch...

    Authors: Raiana Scerni Machado, Ivanildo Pedro de Sousa Jr., Jacqueline Cortinhas Monteiro, James Lima Ferreira, Jainara Cristina dos Santos Alves and Fernando Neto Tavares
    Citation: Virology Journal 2021 18:148

    The original article was published in Virology Journal 2021 18:133

    The Short report to this article has been published in Virology Journal 2020 17:156

  31. The international SARS-CoV-2 pandemic has resulted in an urgent need to identify new anti-viral drugs for treatment of COVID-19. The initial step to identifying potential candidates usually involves in vitro s...

    Authors: Kexin Yan, Daniel J. Rawle, Thuy T. Le and Andreas Suhrbier
    Citation: Virology Journal 2021 18:123
  32. Although more than a year past since COVID-19 was defined, there is no specific treatment yet. Since COVID-19 management differs over time, it is hard to determine which therapy is more efficacious. In this st...

    Authors: Anıl Ucan, Pamir Cerci, Serdar Efe, Hakan Akgun, Ahmet Ozmen, Aysel Yagmuroglu, Muzaffer Bilgin and Deniz Avci
    Citation: Virology Journal 2021 18:102
  33. Sensitive, rapid, and accessible diagnostics continue to be critical to track the COVID-19 pandemic caused by the SARS-CoV-2 virus. RT-qPCR is the gold standard test, and comparison of methodologies and reagen...

    Authors: Joel D. Pearson, Daniel Trcka, Suying Lu, Sharon J. Hyduk, Mark Jen, Marie-Ming Aynaud, J. Javier Hernández, Philippos Peidis, Miriam Barrios-Rodiles, Kin Chan, Jim Woodgett, Tony Mazzulli, Liliana Attisano, Laurence Pelletier, Myron I. Cybulsky, Jeffrey L. Wrana…
    Citation: Virology Journal 2021 18:99
  34. A novel coronavirus (SARS-CoV-2) emerging has put global public health institutes on high alert. Little is known about the epidemiology and clinical characteristics of human coronaviruses infections in relatio...

    Authors: Yanjun Zhang, Lingxuan Su, Yin Chen, Sicong Yu, Dan Zhang, Haiyan Mao and Lei Fang
    Citation: Virology Journal 2021 18:89
  35. Although most enterovirus (EV) infections can be asymptomatic, these viral agents can cause serious conditions associated with central nervous system, respiratory disease and uncommon manifestations of hand, f...

    Authors: Ivanildo Pedro de Sousa Jr, Heloísa Ihle Giamberardino, Sonia Mara Raboni, Maria Carmo Debur, Maria de Lourdes Aguiar Oliveira, Fernanda Marcicano Burlandy and Edson Elias da Silva
    Citation: Virology Journal 2021 18:88
  36. Coxsackievirus A16 (CA16) is one of the neurotropic pathogen that has been associated with severe neurological forms of hand, foot, and mouth disease (HFMD), but its pathogenesis is not yet clear. The limited ...

    Authors: Yanli Chen, Heng Li, Jinxi Yang, Huiwen Zheng, Lei Guo, Weiyu Li, Zening Yang, Jie Song and Longding Liu
    Citation: Virology Journal 2021 18:84
  37. Sacbrood is an infectious disease of the honey bee caused by Scbrood virus (SBV) which belongs to the family Iflaviridae and is especially lethal for Asian honeybee Apis cerana. Chinese Sacbrood virus (CSBV) is a...

    Authors: Liping Sun, Xueqi Zhang, Shufa Xu, Chunsheng Hou, Jin Xu, Dongxiang Zhao and Yanping Chen
    Citation: Virology Journal 2021 18:83
  38. Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 has infected more than 111 mi...

    Authors: Zachary A. Krumm, Grace M. Lloyd, Connor P. Francis, Lith H. Nasif, Duane A. Mitchell, Todd E. Golde, Benoit I. Giasson and Yuxing Xia
    Citation: Virology Journal 2021 18:66
  39. Chikungunya virus (CHIKV), a serious health problem in several tropical countries, is the causative agent of chikungunya fever. Approved antiviral therapies or vaccines for the treatment or prevention of CHIKV...

    Authors: Poonam Patil, Megha Agrawal, Shahdab Almelkar, Manish Kumar Jeengar, Ashwini More, Kalichamy Alagarasu, Naveen V. Kumar, Prathama S. Mainkar, Deepti Parashar and Sarah Cherian
    Citation: Virology Journal 2021 18:47
  40. The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of infections worldwide. While the search for an effective antiviral is still ongoing, experimental ...

    Authors: Mohamed Mahdi, János András Mótyán, Zsófia Ilona Szojka, Mária Golda, Márió Miczi and József Tőzsér
    Citation: Virology Journal 2020 17:190
  41. Transmissible gastroenteritis virus (TGEV) causes enteric infection in piglets, characterized by vomiting, severe diarrhea and dehydration, and the mortality in suckling piglets is often high up to 100%. Vacci...

    Authors: Fujie Zhao, Lintao Liu, Menglong Xu, Xiangli Shu, Lanlan Zheng and Zhanyong Wei
    Citation: Virology Journal 2020 17:163
  42. Although acute gastroenteritis (AGE) has been reported as a common infectious disease in children, there is scarce information about enterovirus (EV) circulating associated with AGE cases in Brazil. The purpos...

    Authors: Raiana Scerni Machado, Ivanildo Pedro de Sousa Jr., Jacqueline Cortinhas Monteiro, James Lima Ferreira, Jainara Cristina dos Santos Alves and Fernando Neto Tavares
    Citation: Virology Journal 2020 17:156

    The Commentary to this article has been published in Virology Journal 2021 18:133

    The Commentary to this article has been published in Virology Journal 2021 18:148

  43. Human pegivirus (HPgV)—formerly known as GBV-C—is a member of the Flaviviridae family and belongs to the species Pegivirus C. It is a non-pathogenic virus and is transmitted among humans mainly through the exposu...

    Authors: Aniel de Sarom Negrão Silva, Clayton Pereira Silva, Rafael Ribeiro Barata, Pedro Victor Reis da Silva, Patrícia Danin Jordão Monteiro, Letícia Lamarão, Rommel Mário Rodríguez Burbano, Márcio Roberto Teixeira Nunes and Patrícia Danielle Lima de Lima
    Citation: Virology Journal 2020 17:153
  44. Coronaviruses (CoVs) were long thought to only cause mild respiratory and gastrointestinal symptoms in humans but outbreaks of Middle East Respiratory Syndrome (MERS)-CoV, Severe Acute Respiratory Syndrome (SA...

    Authors: Johanna Signer, Hulda R. Jonsdottir, Werner C. Albrich, Marc Strasser, Roland Züst, Sarah Ryter, Rahel Ackermann-Gäumann, Nicole Lenz, Denise Siegrist, Andreas Suter, Roland Schoop and Olivier B. Engler
    Citation: Virology Journal 2020 17:136

    The Author Correction to this article has been published in Virology Journal 2020 17:172