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Positive-strand RNA viruses

Section Editor: Alexander A Khromykh, University of Queensland, Australia
Deputy Section Editor: Michael Beard, University of Adelaide, Australia

The Positive-strand RNA viruses section of Virology Journal invites submissions of research articles and reviews covering all aspects of positive-strand RNA virus biology. Basic research topics of interest include all facets of the viral life cycle from viral attachment and entry, viral RNA replication and translation, viral gene expression/regulation, viral protein processing, viral particle assembly and secretion. We welcome studies that investigate interactions between the virus and host that impact viral replication and the cellular response to infection. Other topics include but are not limited to viral pathogenesis, epidemiology, and viral immunology. We also welcome basic and translational studies on the development of novel model systems, antiviral drugs and vaccines.

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  1. Content type: Research

    Porcine Epidemic Diarrhea (PED) is an acute and highly contagious enteric disease caused by PED virus (PEDV), characterized by vomitting, watery diarrhea and fatal dehydration with high mortality in sucking pi...

    Authors: Yifeng Chen, Zhibang Zhang, Jie Li, Yueyi Gao, Lei Zhou, Xinna Ge, Jun Han, Xin Guo and Hanchun Yang

    Citation: Virology Journal 2018 15:170

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  2. Content type: Short report

    Zika virus (ZIKV) became a global human health concern owing to its rapid spread worldwide and its association with congenital and neurological disorders. The current epidemiological profile of arboviruses in ...

    Authors: Lívia Sacchetto, Danielle Alves Gomes Zauli, Galileu Barbosa Costa, Sarah Anne J Guagliardo, Luige Biciati Alvim, Feliciana Lage de Oliveira Marinho, Jônatas Santos Abrahão, Giliane de Souza Trindade, Erna Geessien Kroon, Elvis Cristian Cueva Mateo and Betânia Paiva Drumond

    Citation: Virology Journal 2018 15:155

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  3. Content type: Research

    Porcine epidemic diarrhea virus (PEDV) is emerging as a pathogenic coronavirus that causes a huge economic burden to the swine industry. Interaction of the viral spike (S) surface glycoprotein with the host ce...

    Authors: Lang Gong, Ying Lin, Jianru Qin, Qianniu Li, Chunyi Xue and Yongchang Cao

    Citation: Virology Journal 2018 15:133

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  4. Content type: Research

    Viral infection activates innate immune pathways and interferons (IFNs) play a pivotal role in the outcome of a viral infection. Ubiquitin modifications of host and viral proteins significantly influence the p...

    Authors: Tingting Feng, Lei Deng, Xiaochuan Lu, Wen Pan, Qihan Wu and Jianfeng Dai

    Citation: Virology Journal 2018 15:132

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  5. Content type: Research

    Dengue is the most common mosquito-borne infection worldwide and a serious threat to global public health. Sporadic dengue virus serotype 2 (DENV-2) imported cases from Myanmar have been documented almost ever...

    Authors: Zhaoping Zeng, Jiandong Shi, Xiaofang Guo, Ling Mo, Ningzhu Hu, Jing Sun, Meini Wu, Hongning Zhou and Yunzhang Hu

    Citation: Virology Journal 2018 15:131

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  6. Content type: Research

    Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus within the family Togaviridae, which has attracted global attention due to its recent re-emergence. In one of our previous studies, we successfully i...

    Authors: Xiaomin Zhang, Yalan Huang, Miao Wang, Fan Yang, Chunli Wu, Dana Huang, Linghong Xiong, Chengsong Wan, Jinquan Cheng and Renli Zhang

    Citation: Virology Journal 2018 15:130

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  7. Content type: Research

    Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in imm...

    Authors: Ju Kim, Ye Lin Yang, Sun-Hee Jang and Yong-Suk Jang

    Citation: Virology Journal 2018 15:124

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  8. Content type: Research

    Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), which is sometimes associated with severe central nervous system disease in children. There is currently no s...

    Authors: Chenguang Yao, Caili Xi, Kanghong Hu, Wa Gao, Xiaofeng Cai, Jinlan Qin, Shiyun Lv, Canghao Du and Yanhong Wei

    Citation: Virology Journal 2018 15:116

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  9. Content type: Research

    Previous work indicated that an ultrashort pulse (USP) 425 nm laser is capable of inactivating murine norovirus (MNV: Virol. J. 11:20), perhaps via an impulsive stimulated Raman scattering (ISRS) mechanism, an...

    Authors: David Kingsley, Robinson Kuis, Rafael Perez, Isaac Basaldua, Paul Burkins, Aristides Marcano and Anthony Johnson

    Citation: Virology Journal 2018 15:117

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  10. Content type: Research

    Dengue virus (DENV) infection caused by international visitors has become a public health concern in China. Although sporadic imported cases of DENV have been documented in Yunnan, China since 2000, a complete...

    Authors: Ling Mo, Jiandong Shi, Xiaofang Guo, Zhaoping Zeng, Ningzhu Hu, Jing Sun, Meini Wu, Hongning Zhou and Yunzhang Hu

    Citation: Virology Journal 2018 15:113

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  11. Content type: Research

    Echoviruses, a serotype of enteroviruses, infect millions of people globally and there is no specific drug treatment or vaccine available for its management. The screening of medicinal plants used locally for ...

    Authors: Omonike O. Ogbole, Toluwanimi E. Akinleye, Peter A. Segun, Temitope C. Faleye and Adekunle J. Adeniji

    Citation: Virology Journal 2018 15:110

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  12. Content type: Short report

    Astroviruses (AstVs) are responsible for infection of a large diversity of mammalian and avian species, including bats, aquatic birds, livestock and humans. We investigated AstVs circulation in bats in Mozambi...

    Authors: Flora Hoarau, Gildas Le Minter, Léa Joffrin, M. Corrie Schoeman, Erwan Lagadec, Beza Ramasindrazana, Andréa Dos Santos, Steven M. Goodman, Eduardo S. Gudo, Patrick Mavingui and Camille Lebarbenchon

    Citation: Virology Journal 2018 15:104

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  13. Content type: Research

    Chikungunya virus (CHIKV) and dengue virus (DENV) are arboviruses that share the same Aedes mosquito vector, and there is much overlap in endemic areas. In India, co-infection with both viruses is often reported....

    Authors: Jaspreet Jain, Tamaki Okabayashi, Navjot Kaur, Emi Nakayama, Tatsuo Shioda, Rajni Gaind, Takeshi Kurosu and Sujatha Sunil

    Citation: Virology Journal 2018 15:84

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  14. Content type: Research

    The Oral Polio Vaccine (OPV or Sabin) is genetically unstable and may mutate to form vaccine-derived polioviruses (VDPVs).

    Authors: Mary Bridget Nanteza, Barnabas Bakamutumaho, Annet Kisakye, Prossy Namuwulya, Henry Bukenya, Edson Katushabe, Josephine Bwogi, Charles Rutebarika Byabamazima, Raffaella Williams and Nicksy Gumede

    Citation: Virology Journal 2018 15:77

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  15. Content type: Research

    Zika virus infection in new born is linked to congenital syndromes, especially microcephaly. Studies have shown that these neuropathies are the result of significant death of neuronal progenitor cells in the c...

    Authors: Julie Gaburro, Asim Bhatti, Vinod Sundaramoorthy, Megan Dearnley, Diane Green, Saeid Nahavandi, Prasad N. Paradkar and Jean-Bernard Duchemin

    Citation: Virology Journal 2018 15:79

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  16. Content type: Research

    Endometrial cancer (EC) is one of the most common gynecological malignancies globally. Although progress has been made in surgical and other adjuvant therapies, there is still a great need to develop new appro...

    Authors: Yanzhen Lin, Wei Wang, Junkai Wan, Ying Yang, Wenkun Fu, Dequan Pan, Linli Cai, Tong Cheng, Xiumin Huang and Yifeng Wang

    Citation: Virology Journal 2018 15:65

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  17. Content type: Short report

    Cardioviruses cause severe illnesses in rodents and humans. In recent years, novel cardioviruses have been frequently found, which promoted further studies of the genetic diversity of cardioviruses. Using vira...

    Authors: Yan Wang, Jing Zhao, Min Zheng, Zhijian Liu, Wang Li, Xingli Fu, Yuan Lin, Jiaqi Yuan, Jieji Zhao, Quan Shen, Xiaochun Wang, Hua Wang and Shixing Yang

    Citation: Virology Journal 2018 15:58

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  18. Content type: Research

    Genotype 3 hepatitis E virus (HEV) infection is generally associated with mild disease. However, recently eight genotype 3 HEV isolates were identified from patients with severe hepatitis. Importantly, three m...

    Authors: Dianjun Cao, Yan-Yan Ni and Xiang-Jin Meng

    Citation: Virology Journal 2018 15:32

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  19. Content type: Methodology

    Dengue, caused by one of the four serologically distinct dengue viruses (DENV-1 to − 4), is a mosquito-borne disease of serious global health significance. Reliable and cost-effective diagnostic tests, along w...

    Authors: Tesfaye Gelanew and Elizabeth Hunsperger

    Citation: Virology Journal 2018 15:30

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  20. Content type: Research

    Recreational water contaminated with fecal pollution poses a great public health concern, as fecal waste may cause serious waterborne illnesses. Current recreational water standards using fecal indicator bacte...

    Authors: Hui Zhu, Fang Yuan, Zhaokang Yuan, Rong Liu, Fei Xie, Ling Huang, Xiaojun Liu, Xiaoqing Jiang, Jian Wang, Qunying Xu, Zhiqiang Shen, Donghan Liu, Ronghao Zhang and Yuanan Lu

    Citation: Virology Journal 2018 15:3

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  21. Content type: Research

    Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and...

    Authors: Meichun Yuan, Jingjing Yan, Jingna Xun, Chong Chen, Yuling Zhang, Min Wang, Wenqi Chu, Zhigang Song, Yunwen Hu, Shuye Zhang and Xiaoyan Zhang

    Citation: Virology Journal 2018 15:1

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  22. Content type: Research

    Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly...

    Authors: Yuefei Jin, Chao Zhang, Rongguang Zhang, Jingchao Ren, Shuaiyin Chen, Meili Sui, Guangyuan Zhou, Dejian Dang, Jiehui Zhu, Huifen Feng, Yuanlin Xi, Haiyan Yang and Guangcai Duan

    Citation: Virology Journal 2017 14:243

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  23. Content type: Review

    This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines.

    Authors: Hong Yuan, Pinghua Li, Xueqing Ma, Zengjun Lu, Pu Sun, Xingwen Bai, Jing Zhang, Huifang Bao, Yimei Cao, Dong Li, Yuanfang Fu, Yingli Chen, Qifeng Bai, Jie Zhang and Zaixin Liu

    Citation: Virology Journal 2017 14:233

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  24. Content type: Research

    More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR of China in 2002, there is still no reoccurrence, but the evolution and recombination of the co...

    Authors: Peilin Liu, Lei Shi, Wei Zhang, Jianan He, Chunxiao Liu, Chunzhong Zhao, Siu Kai Kong, Jacky Fong Chuen Loo, Dayong Gu and Longfei Hu

    Citation: Virology Journal 2017 14:230

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  25. Content type: Research

    The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study ...

    Authors: Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Miaw Fang Chew, Hong Wai Tham and Sharifah Syed Hassan

    Citation: Virology Journal 2017 14:229

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  26. Content type: Review

    Norovirus (NoV) is considered the second leading cause of viral acute gastroenteritis (AGE). To our knowledge, there are no systematic reviews assessing the role of NoV in AGE in the Middle East and North Afri...

    Authors: Khalil Kreidieh, Rana Charide, Ghassan Dbaibo and Nada M. Melhem

    Citation: Virology Journal 2017 14:220

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  27. Content type: Research

    The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we a...

    Authors: Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, Minhua Luo, Jinlong Yang and Jumin Zhou

    Citation: Virology Journal 2017 14:217

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  28. Content type: Research

    Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease, which mostly affects infants and children and leads to severe neurological diseases. Vaccination offers the best option for...

    Authors: Ting Yang, Hua Li, Lei Yue, Xia Song, Tianhong Xie, Shaohui Ma, Huaqing Meng, Ye Zhang, Xin He, Runxiang Long, Rong Yang, Fangyu Luo, Zhongping Xie and Qihan Li

    Citation: Virology Journal 2017 14:206

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  29. Content type: Research

    The need to investigate the contribution of non-polio enteroviruses to acute flaccid paralysis (AFP) cannot be over emphasized as we move towards a poliovirus free world. Hence, we aim to identify non-polio en...

    Authors: T. O. C. Faleye, M. O. Adewumi, M. O. Japhet, O. M. David, A. O. Oluyege, J. A. Adeniji and O. Famurewa

    Citation: Virology Journal 2017 14:175

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  30. Content type: Research

    Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principl...

    Authors: Yakov Vitrenko, Iryna Kostenko, Kateryna Kulebyakina and Khrystyna Sorochynska

    Citation: Virology Journal 2017 14:167

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  31. Content type: Research

    Echovirus 30 (E30) causes acute aseptic meningitis. Viral replication requires energy and macromolecular precursors derived from the metabolic network of the host cell. The effect of viral infection within a h...

    Authors: Sarika Tiwari and Tapan N. Dhole

    Citation: Virology Journal 2017 14:144

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    The Erratum to this article has been published in Virology Journal 2017 14:182

  32. Content type: Research

    Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeut...

    Authors: Chris M. Cirimotich, Eric M. Vela, Jennifer Garver, Roy E. Barnewall, Brian D. Miller, Gabriel T. Meister and James V. Rogers

    Citation: Virology Journal 2017 14:135

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  33. Content type: Research

    Bovine coronavirus (BCoV) belong to the genus Betacoronavirus of the family Coronaviridae. BCoV are widespread around the world and cause enteric or respiratory infections among cattle, leading to important econo...

    Authors: Matías Castells, Matías Victoria, Rodney Colina, Héctor Musto and Juan Cristina

    Citation: Virology Journal 2017 14:115

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  34. Content type: Research

    We previously reported the discovery of a novel, putative flavivirus designated T’Ho virus in Culex quinquefasciatus mosquitoes in the Yucatan Peninsula of Mexico. A 1358-nt region of the NS5 gene was amplified a...

    Authors: Thomas Briese, Maria A. Loroño-Pino, Julian E. Garcia-Rejon, Jose A. Farfan-Ale, Carlos Machain-Williams, Karin S. Dorman, W. Ian Lipkin and Bradley J. Blitvich

    Citation: Virology Journal 2017 14:110

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  35. Content type: Research

    Zika virus is an emerging pathogen of global importance. It has been responsible for recent outbreaks in the Americas and in the Pacific region. This study assessed five different mosquito species from the tem...

    Authors: Jean-Bernard Duchemin, Peter T. Mee, Stacey E. Lynch, Ravikiran Vedururu, Lee Trinidad and Prasad Paradkar

    Citation: Virology Journal 2017 14:108

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  36. Content type: Research

    Rodents represent the most diverse mammals on the planet and are important reservoirs of human pathogens. Coronaviruses infect various animals, but to date, relatively few coronaviruses have been identified in...

    Authors: Xing-Yi Ge, Wei-Hong Yang, Ji-Hua Zhou, Bei Li, Wei Zhang, Zheng-Li Shi and Yun-Zhi Zhang

    Citation: Virology Journal 2017 14:98

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  37. Content type: Review

    Flaviviruses are small viruses with single-stranded RNA, which include the yellow fever virus, dengue virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus; and are...

    Authors: Leidy L. García, Leonardo Padilla and Jhon C. Castaño

    Citation: Virology Journal 2017 14:95

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  38. Content type: Research

    Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemic of Zika virus (ZIKV). Here we report that immunocompetent guinea pigs are susceptible to infection by a ...

    Authors: Mukesh Kumar, Keeton K. Krause, Francine Azouz, Eileen Nakano and Vivek R. Nerurkar

    Citation: Virology Journal 2017 14:75

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  39. Content type: Short report

    Zika virus is a mosquito-borne flavivirus that causes clinical symptoms similar to those observed in dengue and chikungunya virus infections. The Korea Centers for Disease Control and Prevention initiated labo...

    Authors: Young Eui Jeong, Go-Woon Cha, Jung Eun Cho, Eun Ju Lee, Youngmee Jee and Won-Ja Lee

    Citation: Virology Journal 2017 14:70

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  40. Content type: Research

    The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) continues to pose one of the greatest threats to the swine industry. M protein is the most conserved and important structura...

    Authors: Qian Wang, Yanwei Li, Hong Dong, Li Wang, Jinmei Peng, Tongqing An, Xufu Yang, Zhijun Tian and Xuehui Cai

    Citation: Virology Journal 2017 14:39

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  41. Content type: Research

    The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular li...

    Authors: Natthida Tongluan, Suwipa Ramphan, Phitchayapak Wintachai, Janthima Jaresitthikunchai, Sarawut Khongwichit, Nitwara Wikan, Supoth Rajakam, Sutee Yoksan, Nuttaporn Wongsiriroj, Sittiruk Roytrakul and Duncan R. Smith

    Citation: Virology Journal 2017 14:28

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  42. Content type: Research

    Life-threatening infections with type B Coxsackieviruses (CV-B) are frequently encountered among newborns and are partly attributed to vertically-transmitted virus. Our current study investigates this alternat...

    Authors: Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Moncef Mokni and Mahjoub Aouni

    Citation: Virology Journal 2017 14:16

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  43. Content type: Research

    The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of MEK-ERK signaling pathway and autophagy is shown to impair EV71 replication. Berberine (BBR...

    Authors: Huiqiang Wang, Ke Li, Linlin Ma, Shuo Wu, Jin Hu, Haiyan Yan, Jiandong Jiang and Yuhuan Li

    Citation: Virology Journal 2017 14:2

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  44. Content type: Research

    We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN recept...

    Authors: Priya Dhole, Emi E. Nakayama, Akatsuki Saito, Kriengsak Limkittikul, Supranee Phanthanawiboon, Tatsuo Shioda and Takeshi Kurosu

    Citation: Virology Journal 2016 13:199

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  45. Content type: Research

    Hand, foot and mouth disease is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. EV-A71 infection is associated with high fever, rashes and ulcers but more severe symptoms such as cardiopulmonary failur...

    Authors: Pinn Tsin Isabel Yee, Kuan Onn Tan, Iekhsan Othman and Chit Laa Poh

    Citation: Virology Journal 2016 13:194

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  46. Content type: Methodology

    Quantitation of HIV-RNA is critically important for diagnosis, prognosis, treatment, monitoring and assessment of infectivity in HIV-1 infection. The objective of this study was to assess performance character...

    Authors: Angelos. Hatzakis, Helen Papachristou, Sangeetha J. Nair, Jacqueline Fortunko, Tracy Foote, HeeCheol Kim, Tashi L. Peling and Andrew J. Worlock

    Citation: Virology Journal 2016 13:176

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  47. Content type: Research

    Coxsackievirus A9 (CV-A9) is a pathogenic enterovirus type within the family Picornaviridae. CV-A9 infects A549 human epithelial lung carcinoma cells by attaching to the αVβ6 integrin receptor through a highly co...

    Authors: Outi Heikkilä, Pirjo Merilahti, Marika Hakanen, Eveliina Karelehto, Jonna Alanko, Maria Sukki, Saija Kiljunen and Petri Susi

    Citation: Virology Journal 2016 13:171

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