Influenza viruses

Section Editor: Hualan Chen, Chinese Academy of Agricultural Sciences, China 
Deputy Section Editor: Chengjun Li, Chinese Academy of Agricultural Sciences, China

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  1. Research

    Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population

    IFITM3 has been suggested to be associated with infection in some ethnic groups. Diabetes and hypercholesterolemia are also important clinical conditions that can predispose individual...

    Parvaneh Mehrbod, Sana Eybpoosh, Fatemeh Fotouhi, Hadiseh Shokouhi Targhi, Vahideh Mazaheri and Behrokh Farahmand

    Virology Journal 2017 14:218

    Published on: 9 November 2017

  2. Research

    Investigation of antiviral state mediated by interferon-inducible transmembrane protein 1 induced by H9N2 virus and inactivated viral particle in human endothelial cells

    Endothelial cells are believed to play an important role in response to virus infection. Our previous microarray analysis showed that H9N2 virus infection and inactivated viral particle inoculation increased t...

    Bo Feng, Lihong Zhao, Wei Wang, Jianfang Wang, Hongyan Wang, Huiqin Duan, Jianjun Zhang and Jian Qiao

    Virology Journal 2017 14:213

    Published on: 3 November 2017

  3. Research

    Effective usage of cationic derivatives of polyprenols as carriers of DNA vaccines against influenza virus

    Cationic derivatives of polyprenols (trimethylpolyprenylammonium iodides – PTAI) with variable chain length between 6 and 15 isoprene units prepared from naturally occurring poly-cis-prenols were tested as DNA va...

    Anna Stachyra, Monika Rak, Patrycja Redkiewicz, Zbigniew Madeja, Katarzyna Gawarecka, Tadeusz Chojnacki, Ewa Świeżewska, Marek Masnyk, Marek Chmielewski, Agnieszka Sirko and Anna Góra-Sochacka

    Virology Journal 2017 14:168

    Published on: 2 September 2017

  4. Short Report

    Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

    Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010–2011 influenza seasons, nearly half o...

    Julie McAuley, Yi-Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr and Lorena Brown

    Virology Journal 2017 14:162

    Published on: 22 August 2017

  5. Research

    Avian influenza H9N2 virus isolated from air samples in LPMs in Jiangxi, China

    Recently, avian influenza virus has caused repeated worldwide outbreaks in humans. Live Poultry Markets (LPMs) play an important role in the circulation and reassortment of novel Avian Influenza Virus (AIVs). ...

    Xiaoxu Zeng, Mingbin Liu, Heng Zhang, Jingwen Wu, Xiang Zhao, Wenbing Chen, Lei Yang, Fenglan He, Guoyin Fan, Dayan Wang, Haiying Chen and Yuelong Shu

    Virology Journal 2017 14:136

    Published on: 24 July 2017

  6. Research

    Semi-quantitative Influenza A population averages from a multiplex respiratory viral panel (RVP): potential for reflecting target sequence changes affecting the assay

    Yearly influenza virus mutations potentially affect the performance of molecular assays, if nucleic acid changes involve the sequences in the assay. Because individual patient viral loads depend on variables s...

    Kenneth H. Rand, Maura Pieretti, Rodney Arcenas, Stacy G. Beal, Herbert Houck, Emma Boslet and John A. Lednicky

    Virology Journal 2017 14:128

    Published on: 14 July 2017

  7. Research

    Maternal antibodies protect offspring from severe influenza infection and do not lead to detectable interference with subsequent offspring immunization

    Various studies have shown that infants under the age of 6 months are especially vulnerable for complications due to influenza. Currently there are no vaccines licensed for use in this age group. Vaccination o...

    Joan E. M. van der Lubbe, Jessica Vreugdenhil, Sarra Damman, Joost Vaneman, Jaco Klap, Jaap Goudsmit, Katarina Radošević and Ramon Roozendaal

    Virology Journal 2017 14:123

    Published on: 26 June 2017

  8. Short Report

    Chorioallantoic membranes of embryonated chicken eggs as an alternative system for isolation of equine influenza virus

    Influenza virus isolation in embryonated chicken eggs (ECEs) is not applicable for rapid diagnosis, however it allows the recovery and propagation of the viable virus. A low number of infectious virus particle...

    Ilona Marcelina Gora, Malgorzata Kwasnik, Jan Franciszek Zmudzinski and Wojciech Rozek

    Virology Journal 2017 14:120

    Published on: 21 June 2017

  9. Short report

    Identification of Two novel reassortant avian influenza a (H5N6) viruses in whooper swans in Korea, 2016

    On November 20, 2016 two novel strains of H5N6 highly pathogenic avian influenza virus (HPAIVs) were isolated from three whooper swans (Cygnus cygnus) at Gangjin Bay in South Jeolla province, South Korea. Identif...

    Jipseol Jeong, Chanjin Woo, Hon S. Ip, Injung An, Youngsik Kim, Kwanghee Lee, Seong-Deok Jo, Kidong Son, Saemi Lee, Jae-Ku Oem, Seung-Jun Wang, Yongkwan Kim, Jeonghwa Shin, Jonathan Sleeman and Weonhwa Jheong

    Virology Journal 2017 14:60

    Published on: 21 March 2017

  10. Research

    A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity

    Influenza virus is still a huge threat to the world-wide public health. Host inosine-5’- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target ...

    Jin Hu, Linlin Ma, Huiqiang Wang, Haiyan Yan, Dajun Zhang, Zhuorong Li, Jiandong Jiang and Yuhuan Li

    Virology Journal 2017 14:55

    Published on: 15 March 2017

  11. Research article

    Surveillance of avian influenza viruses in South Korea between 2012 and 2014

    National surveillance of avian influenza virus (AIV) in South Korea has been annually conducted for the early detection of AIV and responses to the introduction of highly pathogenic avian influenza (HPAI) viru...

    Eun-Kyoung Lee, Hyun-Mi Kang, Byung-Min Song, Yu-NA Lee, Gyeong-Beum Heo, Hee-Soo Lee, Youn-Jeong Lee and Jae-Hong Kim

    Virology Journal 2017 14:54

    Published on: 14 March 2017

  12. Case report

    Isolation and genetic characterization of a novel 2.2.1.2a H5N1 virus from a vaccinated meat-turkeys flock in Egypt

    Vaccination of poultry to control highly pathogenic avian influenza virus (HPAIV) H5N1 is used in several countries. HPAIV H5N1 of clade 2.2.1 which is endemic in Egypt has diversified into two genetic clades....

    Ahmed H. Salaheldin, Jutta Veits, Hatem S. Abd El-Hamid, Timm C. Harder, Davud Devrishov, Thomas C. Mettenleiter, Hafez M. Hafez and Elsayed M. Abdelwhab

    Virology Journal 2017 14:48

    Published on: 9 March 2017

  13. Short report

    The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen

    Despite availability of annual influenza vaccines, influenza causes significant morbidity and mortality in the elderly. This is at least in part a result of immunosenescence; the age-dependent decrease in immu...

    Tina Falkeborn, Jorma Hinkula, Marie Olliver, Alf Lindberg and Anna-Karin Maltais

    Virology Journal 2017 14:44

    Published on: 3 March 2017

  14. Research

    New H6 influenza virus reassortment strains isolated from Anser fabalis in Anhui Province, China

    H6 subtype avian influenza viruses are globally distributed and, in recent years, have been isolated with increasing frequency from both domestic and wild bird species as well as infected humans. Many reports ...

    Ye Ge, Hongliang Chai, Zhiqiang Fan, Xianfu Wang, Qiucheng Yao, Jian Ma, Si Chen, Yuping Hua, Guohua Deng and Hualan Chen

    Virology Journal 2017 14:36

    Published on: 21 February 2017

  15. Research

    Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice

    H9N2 influenza viruses circulate globally and are considered to have pandemic potential. The hyper-inflammatory response elicited by these viruses is thought to contribute to disease severity. Calcitriol plays...

    Boxiang Gui, Qin Chen, Chuanxia Hu, Caihui Zhu and Guimei He

    Virology Journal 2017 14:10

    Published on: 23 January 2017

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