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Emerging viruses

Section Editor: Tom Geisbert, University of Texas Medical Branch, USA 
Deputy Section Editor: Chad Mire, University of Texas Medical Branch at Galveston, USA 

The Emerging viruses section of Virology Journal includes studies covering all aspects of new and reemerging viruses that cause severe and/or lethal diseases in humans and animals. Examples of these viruses include filoviruses (Ebola, Marburg), henipaviruses (Nipah, Hendra), Lassa virus, Lujo virus, South American hemorrhagic fever viruses (Junin, Machupo, Guanarito, Chapare, Sabia), Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, hantaviruses, SARS coronavirus, MERS coronavirus, tick-borne encephalitis viruses, and Zika virus. Topics of interest include but are not limited to virus discovery, mechanisms of virus entry, assembly, protein translation, transcription and replication, pathogenesis, immunology, ecology, and epidemiology. Basic and translational research on the development of preventive vaccines and antiviral drugs and therapeutic interventions is particularly welcome.

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  1. Content type: Meeting report

    The aim of this article is to summarise the virology content presented at the 9th Lorne Infection and Immunity Conference, Australia, in February 2019. The broad program included virology as a key theme, and t...

    Authors: Gregor Ebert, Prasad N. Paradkar and Sarah L. Londrigan

    Citation: Virology Journal 2019 16:109

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  2. Content type: Research

    Yellow fever, Dengue, West Nile and Zika viruses are re-emerging mosquito-borne Flaviviruses of public health concern. However, the extent of human exposure to these viruses and associated disease burden in Kenya...

    Authors: E. Chepkorir, D. P. Tchouassi, S. L. Konongoi, J. Lutomiah, C. Tigoi, Z. Irura, F. Eyase, M. Venter and R. Sang

    Citation: Virology Journal 2019 16:65

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  3. Content type: Research

    Zika virus (ZIKV) has become a global threat with immediate need for accurate diagnostics, efficacious vaccines and therapeutics. Several ZIKV envelope (Env)-based vaccines have been developed recently. Howeve...

    Authors: Young Chan Kim, Cesar Lopez-Camacho, Joanne E. Nettleship, Nahid Rahman, Michelle L. Hill, Laura Silva-Reyes, Georgina Ortiz-Martinez, Gloria Figueroa-Aguilar, María Antonieta Mar, Héctor Vivanco-Cid, Christine S. Rollier, Nicole Zitzmann, Martha Eva Viveros-Sandoval, Raymond J. Owens and Arturo Reyes-Sandoval

    Citation: Virology Journal 2018 15:193

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  4. Content type: Short report

    Here we propose a strategy allowing implementing efficient and practicable large-scale seroepidemiological studies for Zika Virus (ZIKV). It combines screening by a commercial NS1 protein-based Zika IgG ELISA,...

    Authors: Elif Nurtop, Paola Mariela Saba Villarroel, Boris Pastorino, Laetitia Ninove, Jan Felix Drexler, Yelin Roca, Bouba Gake, Audrey Dubot-Peres, Gilda Grard, Christophe Peyrefitte, Stéphane Priet, Xavier de Lamballerie and Pierre Gallian

    Citation: Virology Journal 2018 15:192

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    The Correction to this article has been published in Virology Journal 2019 16:12

  5. Content type: Research

    African swine fever virus (ASFV) causes an acute hemorrhagic infection in suids with a mortality rate of up to 100%. No vaccine is available and the potential for catastrophic disease in Europe remains elevate...

    Authors: Jason Farlow, Marina Donduashvili, Maka Kokhreidze, Adam Kotorashvili, Nino G. Vepkhvadze, Nato Kotaria and Ana Gulbani

    Citation: Virology Journal 2018 15:190

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  6. Content type: Short report

    Usutu virus (USUV) is a mosquito-born flavivirus that can infect multiple avian and mammalian species. The viral surface envelope (E) protein functions to initiate the viral infection by recognizing cellular r...

    Authors: Zimin Chen, Fei Ye, Sheng Lin, Fanli Yang, Yanwei Cheng, Yu Cao, Zhujun Chen and Guangwen Lu

    Citation: Virology Journal 2018 15:183

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  7. Content type: Research

    Retinoic acid-inducible gene I (RIG-I) is a key cytosolic receptor of the innate immune system. Seneca valley virus (SVV) is a newly emerging RNA virus that infects pigs causing significant economic losses in ...

    Authors: Pengfei Li, Xiangle Zhang, Weijun Cao, Fan Yang, Xiaoli Du, Zhengwang Shi, Miaotao Zhang, Xiangtao Liu, Zixiang Zhu and Haixue Zheng

    Citation: Virology Journal 2018 15:162

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  8. Content type: Research

    Hand, foot and mouth disease (HFMD) is endemic among population of young children in Thailand. The disease is mostly caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16).

    Authors: Hatairat Lerdsamran, Jarunee Prasertsopon, Anek Mungaomklang, Chompunuch Klinmalai, Pirom Noisumdaeng, Kantima Sangsiriwut, Boonrat Tassaneetrithep, Ratigorn Guntapong, Sopon Iamsirithaworn and Pilaipan Puthavathana

    Citation: Virology Journal 2018 15:158

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  9. Content type: Research

    Tembusu virus is a newly emerging flavivirus that caused egg-drop syndrome in ducks in China. TMUV envelope protein is a major structural protein locates at the surface of tembusu virus particle. During tembus...

    Authors: Dongmin Zhao, Kaikai Han, Xinmei Huang, Lijiao Zhang, Huili Wang, Na Liu, Yujie Tian, Qingtao Liu, Jing Yang, Yuzhuo Liu and Yin Li

    Citation: Virology Journal 2018 15:142

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  10. Content type: Research

    Currently, no FDA-approved vaccines or treatments are available for Ebola virus disease (EVD), and therapy remains largely supportive. Ebola virus (EBOV) has broad tissue tropism and can infect a variety of ce...

    Authors: Manasi Tamhankar, Dawn M. Gerhardt, Richard S. Bennett, Nicole Murphy, Peter B. Jahrling and Jean L. Patterson

    Citation: Virology Journal 2018 15:135

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  11. Content type: Methodology

    Chikungunya (CHIKV) virus is an important mosquito-borne virus causing outbreaks of acute febrile illness with arthropathy. The detection of specific antibodies against CHIKV is used for diagnosis after the ac...

    Authors: Marcílio Jorge Fumagalli, William Marciel de Souza, Danillo Lucas Alves Espósito, Angélica Silva, Marilia Farignoli Romeiro, Edson Zangiacomi Martinez, Benedito Antônio Lopes da Fonseca and Luiz Tadeu Moraes Figueiredo

    Citation: Virology Journal 2018 15:112

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  12. Content type: Research

    Serologic detection of Zika virus (ZIKV) infections is challenging because of antigenic similarities among flaviviruses.

    Authors: Mariana Kikuti, Laura B. Tauro, Patrícia S. S. Moreira, Gúbio S. Campos, Igor A. D. Paploski, Scott C. Weaver, Mitermayer G. Reis, Uriel Kitron and Guilherme S. Ribeiro

    Citation: Virology Journal 2018 15:108

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  13. Content type: Short report

    Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenavirus...

    Authors: Amélie D. Zaza, Cécile H. Herbreteau and Christophe N. Peyrefitte

    Citation: Virology Journal 2018 15:99

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  14. Content type: Research

    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), a tick borne bunyavirus. However, Immunohistochemistry of SFTS patients are not well stud...

    Authors: Shibo Li, Yang Li, Qiujing Wang, Xuewen Yu, Miaomiao Liu, Haibo Xie, Liyong Qian, Ling Ye, Zhejuan Yang, Jianjing Zhang, Huimin Zhu and Wenhong Zhang

    Citation: Virology Journal 2018 15:97

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  15. Content type: Research

    ‘Rapid Apple Decline’ (RAD) is a newly emerging problem of young, dwarf apple trees in the Northeastern USA. The affected trees show trunk necrosis, cracking and canker before collapse in summer. In this study...

    Authors: Huawei Liu, Liping Wu, Ekaterina Nikolaeva, Kari Peter, Zongrang Liu, Dimitre Mollov, Mengji Cao and Ruhui Li

    Citation: Virology Journal 2018 15:85

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  16. Content type: Research

    Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavi...

    Authors: Vololoniaina Raharinosy, Marie-Marie Olive, Fehivola Mandanirina Andriamiarimanana, Soa Fy Andriamandimby, Jean-Pierre Ravalohery, Seta Andriamamonjy, Claudia Filippone, Danielle Aurore Doll Rakoto, Sandra Telfer and Jean-Michel Heraud

    Citation: Virology Journal 2018 15:83

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  17. Content type: Research

    The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six...

    Authors: Ameh S. James, Shawn Todd, Nina M. Pollak, Glenn A. Marsh and Joanne Macdonald

    Citation: Virology Journal 2018 15:75

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  18. Content type: Research

    Mosquitoes are the potential vectors for a variety of viruses that can cause diseases in the human and animal populations. Viruses in the order Picornavirales infect a broad range of hosts, including mosquitoes. ...

    Authors: Harindranath Cholleti, Juliette Hayer, Jose Fafetine, Mikael Berg and Anne-Lie Blomström

    Citation: Virology Journal 2018 15:71

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  19. Content type: Short report

    Rift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon...

    Authors: Serge Alain Sadeuh-Mba, Gide Martial Yonga Wansi, Maurice Demanou, Antoine Gessain and Richard Njouom

    Citation: Virology Journal 2018 15:63

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  20. Content type: Research

    The 4 dengue serotypes (DENV) are mosquito-borne pathogens that are associated with severe hemorrhagic disease. DENV particles have a lipid bilayer envelope that anchors two membrane glycoproteins prM and E. T...

    Authors: Stefan W. Metz, Ashlie Thomas, Laura White, Mark Stoops, Markus Corten, Holger Hannemann and Aravinda M. de Silva

    Citation: Virology Journal 2018 15:60

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  21. Content type: Research

    Bats are natural reservoirs for several highly pathogenic and novel viruses including coronaviruses (CoVs) (mainly Alphacoronavirus and Betacoronavirus). Lyle’s flying fox (Pteropus lylei)‘s roosts and foraging s...

    Authors: Supaporn Wacharapluesadee, Prateep Duengkae, Aingorn Chaiyes, Thongchai Kaewpom, Apaporn Rodpan, Sangchai Yingsakmongkon, Sininat Petcharat, Patcharakiti Phengsakul, Pattarapol Maneeorn and Thiravat Hemachudha

    Citation: Virology Journal 2018 15:38

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  22. Content type: Research

    Rhabdoviridae is one of the most ecologically diverse families of RNA viruses which can infect a wide range of vertebrates and invertebrates. Bats, among mammals, are pointed to harbor a significantly higher p...

    Authors: Davide Lelli, Alice Prosperi, Ana Moreno, Chiara Chiapponi, Anna Maria Gibellini, Paola De Benedictis, Stefania Leopardi, Enrica Sozzi and Antonio Lavazza

    Citation: Virology Journal 2018 15:37

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  23. Content type: Case report

    Zika virus is an emerging arbovirus of the family Flaviviridae and genus Flavivirus that until 2007 was restricted to a few cases of mild illness in Africa and Asia.

    Authors: Ligia Fernandes Abdalla, João Hugo Abdalla Santos, Renata Teodora Jales Barreto, Erick Martins e Souza, Fabrício Fonseca D’Assunção, Márcio Aurélio Borges, Valdinete Alves Nascimento, George Allan Villarouco da Silva, Victor Costa de Souza, Rajendranath Ramasawmy, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho and Felipe Gomes Naveca

    Citation: Virology Journal 2018 15:23

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  24. Content type: Research

    Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogeneti...

    Authors: Ana Moreno, Davide Lelli, Luca de Sabato, Guendalina Zaccaria, Arianna Boni, Enrica Sozzi, Alice Prosperi, Antonio Lavazza, Eleonora Cella, Maria Rita Castrucci, Massimo Ciccozzi and Gabriele Vaccari

    Citation: Virology Journal 2017 14:239

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    The Correction to this article has been published in Virology Journal 2018 15:10

  25. Content type: Review

    The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a ...

    Authors: Joachim Denner

    Citation: Virology Journal 2017 14:171

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  26. Content type: Research

    Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonotic disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the genus Nairovirus in the family Bunyaviridae. CCHF is typicall...

    Authors: Hajer M. Suliman, Ibrahim A. Adam, Shamseldin I. Saeed, Sanaa A. Abdelaziz, Eltahir M. Haroun and Imadeldin E. Aradaib

    Citation: Virology Journal 2017 14:147

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  27. Content type: Research

    The appearance of severe Zika virus (ZIKV) disease in the most recent outbreak has prompted researchers to respond through the development of tools to quickly characterize transmission and pathology. We descri...

    Authors: Anna B. Kawiecki, E. Handly Mayton, M. Fausta Dutuze, Brad A. Goupil, Ingeborg M. Langohr, Fabio Del Piero and Rebecca C. Christofferson

    Citation: Virology Journal 2017 14:82

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  28. Content type: Review

    Pakistan has faced a number of significant healthcare challenges over the past decade. In 2000, one of these events - a deadly epidemic of Crimean Congo Haemorrhagic Fever (CCHF) - struck Pakistan. The people ...

    Authors: Muhammad Atif, Anum Saqib, Raazeyah Ikram, Muhammad Rehan Sarwar and Shane Scahill

    Citation: Virology Journal 2017 14:63

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  29. Content type: Research

    Inkoo virus (INKV) is a less known mosquito-borne virus belonging to Bunyaviridae, genus Orthobunyavirus, California serogroup. Studies indicate that INKV infection is mainly asymptomatic, but can cause mild ence...

    Authors: Olivia Wesula Lwande, Göran Bucht, Clas Ahlm, Kristoffer Ahlm, Jonas Näslund and Magnus Evander

    Citation: Virology Journal 2017 14:61

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  30. Content type: Research

    In recent years, novel hepadnaviruses, hepeviruses, hepatoviruses, and hepaciviruses have been discovered in various species of bat around the world, indicating that bats may act as natural reservoirs for thes...

    Authors: Bo Wang, Xing-Lou Yang, Wen Li, Yan Zhu, Xing-Yi Ge, Li-Biao Zhang, Yun-Zhi Zhang, Claus-Thomas Bock and Zheng-Li Shi

    Citation: Virology Journal 2017 14:40

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  31. Content type: Research

    Japanese encephalitis virus (JEV) is a neurotropic flavivirus causing mortality and morbidity in humans. Severe Japanese encephalitis cases display strong inflammatory responses in the central nervous system a...

    Authors: Nils Lannes, Viviane Neuhaus, Brigitte Scolari, Solange Kharoubi-Hess, Michael Walch, Artur Summerfield and Luis Filgueira

    Citation: Virology Journal 2017 14:8

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  32. Content type: Case report

    Reporting new cases of enterovirus (EV)-D68-associated acute flaccid myelitis (AFM) is essential to understand how the virus causes neurological damage and to characterize EV-D68 strains associated with AFM.

    Authors: Susanna Esposito, Giovanna Chidini, Claudia Cinnante, Luisa Napolitano, Alberto Giannini, Leonardo Terranova, Hubert Niesters, Nicola Principi and Edoardo Calderini

    Citation: Virology Journal 2017 14:4

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  33. Content type: Research

    Anelloviruses (TTV, TTMV, and TTMDV) have been associated with non A-G hepatitis. The goal of the current study was to estimate the prevalence of these anelloviruses in Qatar.

    Authors: Ahmed A. Al-Qahtani, Enas S. Alabsi, Raed AbuOdeh, Lukman Thalib, Mohamed E El Zowalaty and Gheyath K. Nasrallah

    Citation: Virology Journal 2016 13:208

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    The Erratum to this article has been published in Virology Journal 2017 14:143

  34. Content type: Research

    Dengue fever, a mosquito-borne disease, is associated with illness of varying severity in countries in the tropics and sub tropics. Dengue cases continue to be detected more frequently and its geographic range...

    Authors: Limbaso Konongoi, Victor Ofula, Albert Nyunja, Samuel Owaka, Hellen Koka, Albina Makio, Edith Koskei, Fredrick Eyase, Daniel Langat, Randal J. Schoepp, Cynthia Ann Rossi, Ian Njeru, Rodney Coldren and Rosemary Sang

    Citation: Virology Journal 2016 13:182

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  35. Content type: Research

    Sub-Saharan Africa is home to a variety of pathogens, but disease surveillance and the healthcare infrastructure necessary for proper management and control are severely limited. Lassa virus, the cause of Lass...

    Authors: Aileen E. O’Hearn, Matthew A. Voorhees, David P. Fetterer, Nadia Wauquier, Moinya R. Coomber, James Bangura, Joseph N. Fair, Jean-Paul Gonzalez and Randal J. Schoepp

    Citation: Virology Journal 2016 13:163

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  36. Content type: Research

    Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes albopictus, which also inhabits temperate region...

    Authors: Lisa Henß, Simon Beck, Tatjana Weidner, Nadine Biedenkopf, Katja Sliva, Christopher Weber, Stephan Becker and Barbara S. Schnierle

    Citation: Virology Journal 2016 13:149

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  37. Content type: Short report

    Mammalian Orthoreoviruses 3 (MRV3) have been described in diarrheic pigs from USA and Asia. We firstly detected MRV3 in Europe (Italy) in piglets showing severe diarrhea associated with Porcine Epidemic Diarrh...

    Authors: Davide Lelli, Maria Serena Beato, Lara Cavicchio, Antonio Lavazza, Chiara Chiapponi, Stefania Leopardi, Laura Baioni, Paola De Benedictis and Ana Moreno

    Citation: Virology Journal 2016 13:139

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  38. Content type: Short report

    Bats have been implicated as the main reservoir of coronavirus (CoV). Thus the role of these hosts on the evolution and spread of CoVs currently deserve the attention of emerging diseases surveillance programs...

    Authors: Karen Miyuki Asano, Aline Santana Hora, Karin Côrrea Scheffer, Willian Oliveira Fahl, Keila Iamamoto, Enio Mori and Paulo Eduardo Brandão

    Citation: Virology Journal 2016 13:110

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    The Erratum to this article has been published in Virology Journal 2016 13:124

  39. Content type: Research

    West Nile virus (WNV) is an emerging zoonotic pathogen which is harmful to human and animal health. Effective vaccination in susceptible hosts should protect against WNV infection and significantly reduce vira...

    Authors: Jinliang Wang, Jie Yang, Jinying Ge, Ronghong Hua, Renqiang Liu, Xiaofeng Li, Xijun Wang, Yu Shao, Encheng Sun, Donglai Wu, Chengfeng Qin, Zhiyuan Wen and Zhigao Bu

    Citation: Virology Journal 2016 13:109

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  40. Content type: Short report

    Saliva and urine have been used for arthropod-borne viruses molecular detection but not yet for chikungunya virus (CHIKV). We investigated the use of saliva and urine for molecular detection of CHIKV during th...

    Authors: Didier Musso, Anita Teissier, Eline Rouault, Sylviane Teururai, Jean-Jacques de Pina and Tu-Xuan Nhan

    Citation: Virology Journal 2016 13:102

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    The Erratum to this article has been published in Virology Journal 2016 13:120

  41. Content type: Research

    The novel Malawi polyomavirus (MWPyV) was initially detected in stool specimens from healthy children and children with gastrointestinal symptoms, mostly diarrhea, indicating that MWPyV might play a role in hu...

    Authors: N. Papa, N. Zanotta, A. Knowles, E. Orzan and M. Comar

    Citation: Virology Journal 2016 13:97

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  42. Content type: Short report

    Rift Valley fever virus (RVFV) remains heavily neglected in humans in Mozambique, even though recent outbreaks were reported in neighboring countries in humans and several cases of RVFV in cattle were reported...

    Authors: Eduardo Samo Gudo, Gabriela Pinto, Jacqueline Weyer, Chantel le Roux, Arcildo Mandlaze, Américo Feriano José, Argentina Muianga and Janusz Tadeusz Paweska

    Citation: Virology Journal 2016 13:96

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