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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Chronic infection with hepatitis B virus (HBV) has been proved highly associated with the development of hepatocellular carcinoma (HCC).

    Authors: Jian-an Jia, Shuqin Zhang, Xin Bai, Meng Fang, Shipeng Chen, Xiaotao Liang, Shanfeng Zhu, Danny Ka-Ho Wong, Anye Zhang, Jianfeng Feng, Fengzhu Sun and Chunfang Gao
    Citation: Virology Journal 2022 19:114
  2. Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribut...

    Authors: Bin Cheng, Qiong Wang, Zhiqiang Wei, Yulin He, Ruiming Li, Guohua Liu, Shaobo Zeng and Zhongji Meng
    Citation: Virology Journal 2022 19:110
  3. Hepatitis C virus (HCV) infection is a blood borne infection that remains potentially transmissible through blood transfusions. Sickle cell disease (SCD) is a common inheritable haemoglobinopathy in Ghana that...

    Authors: Gifty Mawuli, Bartholomew Dzudzor, Kenneth Tachi, Amma Anima Benneh-Akwasi Kuma, James Odame-Aboagye, Billal Musah Obeng, Anthony Twumasi Boateng, Elijah Paa Edu-Quansah, Keren Okyerebea Attiku, Esinam Agbosu, Augustina Arjarquah and Joseph Humphrey Kofi Bonney
    Citation: Virology Journal 2022 19:73
  4. Soluble programmed death-1 (sPD-1) is a novel immune markers and possibly predictive of chronic hepatitis B (CHB) outcome. However, results were inconsistent by different ELISA kits. This study aims to compare...

    Authors: Wen-Juei Jeng, Chien-Hung Chen, Yi-Wen Wang, Mei-Hung Pan, Chia-Wei Lin, Chun-Yen Lin and Hwai-I Yang
    Citation: Virology Journal 2022 19:59
  5. Cyclic GMP-AMP synthase (cGAS) is a crucial DNA sensor and plays an important role in host antiviral innate immune responses. During hepatitis B virus (HBV) infection, the cGAS signaling pathway can suppress H...

    Authors: Hong Chen, Linshan Jiang, Shu Chen, Qin Hu, Ying Huang, Ying Wu and Weixian Chen
    Citation: Virology Journal 2022 19:55
  6. Hepatitis B virus (HBV) infection is a particular concern in human immunodeficiency virus (HIV) infected individuals. In Ethiopia, detailed clinical and virological descriptions of HBV prevailing during HIV co...

    Authors: Yeshambel Belyhun, Uwe Gerd Liebert and Melanie Maier
    Citation: Virology Journal 2022 19:53
  7. Human pegivirus 1 (HPgV-1) is a Positive-sense single-stranded RNA (+ ssRNA) virus, discovered in 1995 as a Flaviviridae member, and the closest human virus linked to HCV. In comparison to HCV, HPgV-1 seems to...

    Authors: Mehdi Samadi, Vahid Salimi, Mohammad Reza Haghshenas, Seyed Mohammad Miri, Seyed Reza Mohebbi and Amir Ghaemi
    Citation: Virology Journal 2022 19:41
  8. Some cytokine signaling pathways can interact with interferon (IFN)-α pathway and thus regulate cell responses to IFN-α. Levels of the pro-inflammatory cytokine interleukin-17A (IL-17A) were found to be elevat...

    Authors: Jiaxuan Zhang, Kai Liu, Gaoli Zhang, Ning Ling and Min Chen
    Citation: Virology Journal 2022 19:28
  9. Serum hepatitis B virus (HBV) RNA is a surrogate biomarker for intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity and persistence. In this retrospective study, we investigated its pr...

    Authors: Andreas Laras, Margarita Papatheodoridi, Eleni Panopoulou, George V. Papatheodoridis, Stephanos J. Hadziyannis and Emilia Hadziyannis
    Citation: Virology Journal 2022 19:22
  10. Kaposi’s sarcoma-associated herpes virus (KSHV) prevalence and risk factors exhibit considerable variations across populations in different geographic regions. Determinants and the transmission routes of KSHV ...

    Authors: Xin Zhang, Yiyun Xu, Yi Li, Huangbo Yuan, Zhenqiu Liu and Tiejun Zhang
    Citation: Virology Journal 2022 19:5
  11. Vaccination against HCV is an effective measure in reduction of virus-related public health burden and mortality. However, no prophylactic vaccine is available as of yet. DNA-based immunization is a promising ...

    Authors: Ali Shayeghpour, Roya Kianfar, Parastoo Hosseini, Mehdi Ajorloo, Sepehr Aghajanian, Mojtaba Hedayat Yaghoobi, Tayebeh Hashempour and Sayed-Hamidreza Mozhgani
    Citation: Virology Journal 2021 18:248
  12. Despite the five decades having passed since discovery of the hepatitis B virus (HBV), together with development of an effective anti-HBV vaccine, infection with the virus remains a serious public health probl...

    Authors: Njabulo Mnyandu, Shonisani Wendy Limani, Patrick Arbuthnot and Mohube Betty Maepa
    Citation: Virology Journal 2021 18:247
  13. The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liver-failure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirr...

    Authors: Anabella Fantilli, Sarah Daniela López Villa, Alina Zerega, Guadalupe Di Cola, Luis López, Maribel Wassaf Martínez, María Belén Pisano and Viviana Elizabeth Ré
    Citation: Virology Journal 2021 18:245
  14. Chronic hepatitis B virus (HBV) infection (CHB) is a significant public health problem that could benefit from treatment with immunomodulators. Here we describe a set of therapeutic HBV vaccines that target th...

    Authors: Mohadeseh Hasanpourghadi, Mikhail Novikov, Dakota Newman, ZhiQuan Xiang, Xiang Yang Zhou, Colin Magowan and Hildegund C. J. Ertl
    Citation: Virology Journal 2021 18:242
  15. Previous works have observed that younger infants with chronic hepatitis B virus (HBV) infection are more responsive to antiviral treatment. However, the underlying mechanism remains unclear. In this study, th...

    Authors: Yi Li, Yiwei Xiao, Lili Li, Yarong Song, Xiangjun Zhai, Jianxun Liu, Zhongping Duan, Ling Yan, Feng Ding, Jia Liu, Liguo Zhu, Jie Jiang, Huaibin Zou, Lingxiang Li, Caihong Liang, Jie Wang…
    Citation: Virology Journal 2021 18:236
  16. Hepatitis B virus (HBV) serum markers during typical acute self-limited infection are usually depicted as a composite of traditional HBV markers. The current study updates and expands our knowledge of acute he...

    Authors: Mary C. Kuhns, Vera Holzmayer, Anne L. McNamara, Mark Anderson and Gavin A. Cloherty
    Citation: Virology Journal 2021 18:235
  17. Given that many pregnant women have chronic hepatitis B virus (HBV) infection and that gestational diabetes mellitus (GDM) is linked to poor maternal and neonatal outcomes, we looked into the relationship betw...

    Authors: Wanchang Yin, Bingjun Chen, Yilin Yang, Xiuzi Li, Ruirui Li, Jiangnan Xie, Guixian Chen, Fang He and Dunjin Chen
    Citation: Virology Journal 2021 18:226
  18. Recent genome sequence technology has revealed a novel type of genetic rearrangement referred to as complex structural variations (SVs). Previous studies have elucidated the complex SVs in human hepatitis B vi...

    Authors: Yoshihito Nagura, Kei Fujiwara, Kentaro Matsuura, Etsuko Iio, Yasuhito Tanaka and Hiromi Kataoka
    Citation: Virology Journal 2021 18:200
  19. Chronic hepatitis C (CHC) is one of the most important comorbidities in patients with hereditary bleeding disorders (HBD). The present study aimed at evaluating the effectiveness of direct-acting antiviral age...

    Authors: Heidar Sharafi, Bita Behnava, Alireza Azizi-saraji, Ali Namvar, Ali Anvar, Shima Salimi and Seyed Moayed Alavian
    Citation: Virology Journal 2021 18:199
  20. GATA binding protein 4 (GATA4) has been reported as a potential target of gene therapy for hepatocellular carcinoma (HCC). It is well known that the main cause of HCC is the chronic infection of hepatitis B vi...

    Authors: Xiaoqin Lv, Xia Xiang, Yue Wu, Yang Liu, Ruqing Xu, Qin Xiang and Guoqi Lai
    Citation: Virology Journal 2021 18:196
  21. Hepatitis E is an enteric and zoonotic disease caused by hepatitis E virus (HEV) that is mainly transmitted via the faecal-oral route through contaminated food or the environment. The virus is an emerging infe...

    Authors: Fufa Dawo Bari, Haimanot Belete Wodaje, Umer Said, Hika Waktole, Melaku Sombo, Samson Leta, Tesfaye Rufael Chibsa and Paul Plummer
    Citation: Virology Journal 2021 18:160
  22. Limited data is available on the efficacy of direct acting anti-viral drugs on hepatitis C in drug users. The aim of this meta-analysis was to comprehensively analyze the efficacy and safety of LDV/SOF in drug...

    Authors: Xue Yang, Yang Tang, Di Xu, Guang Zhang, Peng Xu, Houlin Tang and Lin Pang
    Citation: Virology Journal 2021 18:156
  23. Hepatitis E virus (HEV) is a nonenveloped RNA virus causing hepatitis E worldwide. The increase in transfusion-transmitted cases of HEV infections from asymptomatic blood donors causing serious illnesses among...

    Authors: Ping Fu, Baochai Lin, Bingting Wu, Ling Ke, Tianfu Yang, Yue’e Du, Lishan Cheng, Zhou Li, Tiancheng Li and Yu Liu
    Citation: Virology Journal 2021 18:141
  24. All commercial Hepatitis C virus antibody (anti-HCV) assays use a combination of recombinant antigens to detect antibody response. Antibody responses to individual antigenic regions (core, NS3/4 and NS5) used ...

    Authors: Xinyi Jiang, Le Chang, Ying Yan, Huimin Ji, Huizhen Sun, Fei Guo and Lunan Wang
    Citation: Virology Journal 2021 18:137
  25. Recent studies suggest that lncRNAs may play significant roles in the development of hepatitis B virus (HBV) infection. However, as a special stage of HBV infection, the lncRNA expression in occult HBV infecti...

    Authors: Qingqin Hao, Zheng Wang, Qinghui Wang, Bo Chen, Huizhong Qian, Xiao Liu, Hong Cao, Wei Xia, Jian Jiang and Zhonghua Lu
    Citation: Virology Journal 2021 18:125
  26. Hepatitis B virus (HBV) is a DNA virus belonging to the Hepadnaviridae family that has limited tissue and species specificity. Due to the persistence of HBV covalently closed circular DNA (cccDNA) in host cell...

    Authors: Ruirui Xu, Pingping Hu, Yuwen Li, Anran Tian, Jun Li and Chuanlong Zhu
    Citation: Virology Journal 2021 18:105
  27. Gene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and persist is a promising approach for the next generation of antiviral therapies. Recombinant adeno-associated viruses (AA...

    Authors: Rossana Colón-Thillet, Keith R. Jerome and Daniel Stone
    Citation: Virology Journal 2021 18:85
  28. Liver cancer has become one of the most common cancers and has a high mortality rate. Hepatocellular carcinoma is one of the most common liver cancers, and its occurrence and development process are associated...

    Authors: Jinyan Xie, Mingshu Wang, Anchun Cheng, Renyong Jia, Dekang Zhu, Mafeng Liu, Shun Chen, XinXin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Qihui Luo, Yin Wang, Zhiwen Xu, Zhengli Chen, Ling Zhu…
    Citation: Virology Journal 2021 18:74
  29. Hepatitis B virus (HBV) infection is difficult to cure. HBV-specific immune tolerance plays a key role in HBV persistence, and enhancing cellular and humoral immunity will improve the control of HBV infection....

    Authors: Tingyu Lan, Zhiqiang Wei, Yulin He, Song Wan, Li Liu, Bin Cheng, Ruimin Li, Hongxia Chen, Guohua Liu and Zhongji Meng
    Citation: Virology Journal 2021 18:37
  30. Coinfections of HIV-positive individuals with Hepatitis B and D virus (HBV and HDV) are common and can be associated with rapid liver damage. Several antiretroviral drugs for HIV exhibit anti-HBV effect; howev...

    Authors: Oluyinka Oladele Opaleye, Olusola Anuoluwapo Akanbi, Folakemi Abiodun Osundare, Bo Wang, Olufisayo Adesina, Adeolu Sunday Oluremi, Sola Thomas Sunday, Abiodun Akeem Akindele, Patrycja Klink and C. Thomas Bock
    Citation: Virology Journal 2021 18:20
  31. In China, more than 20 million patients with chronic hepatitis B need antiviral treatment. Side effects of antiviral treatment such as renal complications can be problematic, particularly in an aging population.

    Authors: Jueqing Gu, Guodong Yu, Xiaoli Zhang, Shanyan Zhang, Huan Cai, Chanyuan Ye, Yida Yang, Dezhou Li, Zhaowei Tong, Huajiang Shen, Huazhong Chen, Feng Ding, Xijie Lai, Junyan Liu, Meiling Xu and Weiti Wu
    Citation: Virology Journal 2021 18:19
  32. The hepatitis B virus (HBV) is one of the leading causes of acute, chronic and occult hepatitis (OBI) representing a serious public health threat. Cytokines are known to be important chemical mediators that re...

    Authors: Camilla Rodrigues de Almeida Ribeiro, Nathalia Alves Araújo de Almeida, Katrini Guidolini Martinelli, Marcia Amendola Pires, Carlos Eduardo Brandao Mello, José J. Barros and Vanessa Salete de Paula
    Citation: Virology Journal 2021 18:15
  33. Serum hepatitis B virus RNA (HBV RNA) has been reported to be a surrogate marker of intrahepatic cccDNA during nucleos(t)ide analogs therapy. However, in HBeAg-positive patients treated with peg-interferon (pe...

    Authors: Xiaomei Wang, Xiumei Chi, Ruihong Wu, Hongqin Xu, Xiuzhu Gao, Lei Yu, Longgen Liu, Mingxiang Zhang, Youwen Tan, Junqi Niu and Qinglong Jin
    Citation: Virology Journal 2021 18:4
  34. Hepatitis B virus (HBV) causes significant morbidity and mortality globally primarily due to its ability to cause hepatitis, liver cirrhosis and hepatocellular carcinoma. The Kenya National Blood Transfusion S...

    Authors: Patrick Okoti Aluora, Margaret Wangui Muturi and George Gachara
    Citation: Virology Journal 2020 17:176
  35. Despite available treatments, a prophylactic HCV vaccine is needed to achieve elimination targets. HCV vaccine development has faltered largely because the extreme diversity of the virus limits the protective ...

    Authors: Alexander I. Mosa, Mounir G. AbouHaidar, Richard A. Urbanowicz, John E. Tavis, Jonathan K. Ball and Jordan J. Feld
    Citation: Virology Journal 2020 17:140
  36. Chronic hepatitis B has become a major public health problem in China. An accurate depiction of the disease burden has not yet been thoroughly conducted. We aimed to project the disease burden of chronic hepat...

    Authors: Yang Zheng, Jie Wu, Cheng Ding, Kaijin Xu, Shigui Yang and Lanjuan Li
    Citation: Virology Journal 2020 17:132
  37. There has been little published data on estimates of HBV and/or HCV coinfection in HIV-positive patients in China or an understanding of how this coinfection varies with different factors. Therefore, this stud...

    Authors: Songxia Yu, Chengbo Yu, Jian Li, Shiming Liu, Haowen Wang and Min Deng
    Citation: Virology Journal 2020 17:127
  38. HIV-infected patients have immunological and clinical features that might affect the pathogenesis, as well as the outcome of the HIV/HEV co-infection. The current study aimed to determine the seroprevalence of...

    Authors: Reza Shahriarirad, Amirhossein Erfani, Mohammad Rastegarian, Ali Zeighami, Nasir Arefkhah, Fariba Ghorbani, Jamal Sarvari and Bahador Sarkari
    Citation: Virology Journal 2020 17:109
  39. Notwithstanding the efforts of direct-acting antivirals (DAAs) for the treatment of chronically infected hepatitis C virus (HCV) patients, concerns exist regarding the emergence of resistance-associated substi...

    Authors: Valeria Caputo, Roberta Antonia Diotti, Enzo Boeri, Hamid Hasson, Michela Sampaolo, Elena Criscuolo, Sabrina Bagaglio, Emanuela Messina, Caterina Uberti-Foppa, Matteo Castelli, Roberto Burioni, Nicasio Mancini, Massimo Clementi and Nicola Clementi
    Citation: Virology Journal 2020 17:103
  40. SLC10A1 gene codes NTCP, a receptor through which the hepatitis B virus (HBV) gets access into hepatocytes - a stage of the viral cycle necessary for replication. Polymorphism variants of SLC10A1 play roles in...

    Authors: Eric Nyarko, Christian Obirikorang, W. K. B. A. Owiredu, Evans Asamoah Adu, Emmanuel Acheampong, Freeman Aidoo, Emmanuel Ofori, Bright Selorm Addy and Henry Asare-Anane
    Citation: Virology Journal 2020 17:91
  41. Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy. This clinical ph...

    Authors: Jie Ruan, Shuo Sun, Xin Cheng, Pengyu Han, Yinge Zhang and Dianxing Sun
    Citation: Virology Journal 2020 17:89
  42. LIN28B is involved in multiple cellular developmental processes, tissue inflammatory response and tumourigenesis. The association of LIN28B polymorphisms with hepatitis B virus (HBV) infection remains unknown.

    Authors: Qunying Han, Jiao Sang, Xiude Fan, Xiaoyun Wang, Lu Zeng, Xiaoge Zhang, Kun Zhang, Na Li, Yi Lv and Zhengwen Liu
    Citation: Virology Journal 2020 17:81
  43. Hepatitis D virus (HDV) infection is a major global health issue around the world. There are approximately 15–20 million individuals infected with HDV worldwide. HDV infection usually causes increased mortalit...

    Authors: Guan-Yu Lin, Yi-Le Wu, Cheng-Si Wang, Chia-Yun Ko, Chien-Hung Chen, Pei-Jer Chen, Po-Hsin Peng and Chao-Wei Hsu
    Citation: Virology Journal 2020 17:76
  44. The genetic variation and origin of Hepatitis B Virus (HBV) in Qinghai-Tibet Plateau were poorly studied. The coexistence of HBsAg and anti-HBs has been described as a puzzle and has never been reported in the...

    Authors: He Liu, Liping Shen, Shuang Zhang, Feng Wang, Guomin Zhang, Zundong Yin, Feng Qiu, Xiaofeng Liang, Fuzhen Wang and Shengli Bi
    Citation: Virology Journal 2020 17:75
  45. Hepatitis E virus (HEV) generally causes self-limiting viral hepatitis. However, in pregnant women, HEV infection can be severe and has been associated with up to 30% mortality in the third trimester. Addition...

    Authors: Chunchen Wu, Xiaoxue Wu and Jianbo Xia
    Citation: Virology Journal 2020 17:73
  46. Hepatitis B virus (HBV) infection remains as one of the major public health problems in the world. Type I interferon (IFN) plays an essential role in antiviral defense by induced expression of a few hundred in...

    Authors: Yujia Li, Min Yao, Xiaoqiong Duan, Haiyan Ye, Shilin Li, Limin Chen, Chunhui Yang and Yongjun Chen
    Citation: Virology Journal 2020 17:47