Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med. 2005;352:1749–59.
Article
CAS
PubMed
Google Scholar
Collins PL, Graham BS. Viral and host factors in human respiratory Syncytial virus pathogenesis. J Virol. 2008;82:2040–55.
Article
CAS
PubMed
Google Scholar
Borchers AT, Chang C, Gershwin ME, Gershwin LJ. Respiratory syncytial virus--a comprehensive review. Clin Rev Allergy Immunol. 2013;45:331–79.
Article
CAS
PubMed
Google Scholar
Houspie L, Lemey P, Keyaerts E, Reijmen E, Vergote V, Vankeerberghen A, et al. Circulation of HRSV in Belgium: from multiple genotype circulation to prolonged circulation of predominant genotypes. PLoS One. 2013;8:e60416.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang L, Peeples ME, Boucher RC, Collins PL, Pickles RJ. Respiratory Syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious Cytopathology. J Virol. 2002;76:5654–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Leung TF, Lam DSY, Miu TY, Hon KL, Chau CSK, Ku SW, et al. Epidemiology and risk factors for severe respiratory syncytial virus infections requiring pediatric intensive care admission in Hong Kong children. Infection. 2014;42:343–50.
Article
CAS
PubMed
Google Scholar
Graham BS. Vaccine development for respiratory syncytial virus. Curr Opin Virol Elsevier B V. 2017;23:107–12.
Article
CAS
Google Scholar
Meissner HC. Selected populations at increased risk from respiratory syncytial virus infection. Pediatr. Infect Dis J. 2003;22:S40–4. discussion S44–5
Google Scholar
Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet Elsevier Ltd. 2010;375:1545–55.
Article
Google Scholar
Graham BS, Modjarrad K, McLellan JS. Novel antigens for RSV vaccines. Curr Opin Immunol. 2015;35:30–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Johnson S, Oliver C, Prince GA, Hemming VG, Pfarr DS, Wang SC, et al. Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus. J Infect Dis. 1997;176:1215–24.
Article
CAS
PubMed
Google Scholar
Crim RL, Audet SA, Feldman SA, Mostowski HS, Beeler JA. Identification of linear heparin-binding peptides derived from human respiratory syncytial virus fusion glycoprotein that inhibit infectivity. J Virol. 2007;81:261–71.
Article
CAS
PubMed
Google Scholar
Guo Y, Wang Z, Dong L, Wu J, Zhai S, Liu D. Ability of low-molecular-weight heparin to alleviate proteinuria by inhibiting respiratory syncytial virus infection. Nephrology. 2008;13:545–53.
Article
CAS
PubMed
Google Scholar
Mastrangelo P, Hegele R. RSV fusion: time for a new model. Viruses. 2013;5:873–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krzyzaniak MA, Zumstein MT, Gerez JA, Picotti P, Helenius A. Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. PLoS Pathog. 2013;9:e1003309.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brown G, Aitken J, Rixon HWM, Sugrue RJ. Caveolin-1 is incorporated into mature respiratory syncytial virus particles during virus assembly on the surface of virus-infected cells. J. Gen. Virol. 2002;83:611–21.
Article
PubMed
Google Scholar
Geller R, Andino R, Frydman J. Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory Syncytial virus. PLoS One. 2013;8:13–20.
Article
Google Scholar
Ohol YM, Wang Z, Kemble G, Duke G. Direct inhibition of cellular fatty acid Synthase impairs replication of respiratory Syncytial virus and other respiratory viruses. PLoS One. 2015;10:e0144648.
Article
PubMed
PubMed Central
Google Scholar
Nishimura H, Yamaya M. A synthetic serine protease inhibitor, Nafamostat Mesilate, is a drug potentially applicable to the treatment of Ebola virus disease. Tohoku J Exp Med. 2015;237:45–50.
Article
PubMed
Google Scholar
Gallay PA, Bobardt MD, Chatterji U, Trepanier DJ, Ure D, Ordonez C, et al. The novel cyclophilin inhibitor CPI-431-32 concurrently blocks HCV and HIV-1 infections via a similar mechanism of action. PLoS One. 2015;10:1–18.
Article
Google Scholar
Yamaya M, Shimotai Y, Hatachi Y, Lusamba Kalonji N, Tando Y, Kitajima Y, et al. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells. Pulm Pharmacol Ther Elsevier Ltd. 2015;33:66–74.
Article
CAS
Google Scholar
Shirato K, Kawase M, Matsuyama S. Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2. J Virol. 2013;87:12552–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bolt G, Pedersen LØ, Birkeslund HH. Cleavage of the respiratory syncytial virus fusion protein is required for its surface expression: role of furin. Virus Res. 2000;68:25–33.
Article
CAS
PubMed
Google Scholar
Fernie BF, Dapolito G, Cote PJ, Gerin JL. Kinetics of synthesis of respiratory syncytial virus glycoproteins. J. Gen. Virol. 1985;66(Pt 9):1983–90.
Article
CAS
PubMed
Google Scholar
Gruber C, Levine S. Respiratory syncytial virus polypeptides. V. The kinetics of glycoprotein synthesis. J Gen Virol. 1985;66:1241–7.
Article
CAS
PubMed
Google Scholar
Collins PL, Mottet G. Post-translational processing and oligomerization of the fusion glycoprotein of human respiratory syncytial virus. J Gen Virol. 1991;72(Pt 12):3095–101.
Article
CAS
PubMed
Google Scholar
Begoña Ruiz-Argüello M, González-Reyes L, Calder LJ, Palomo C. Martı́n D, Saı́z MJ, et al. effect of Proteolytic processing at two distinct sites on shape and aggregation of an anchorless fusion protein of human respiratory Syncytial virus and fate of the intervening segment. Virology. 2002;298:317–26.
Article
PubMed
Google Scholar
Gonzalez-Reyes L, Ruiz-Arguello MB, Garcia-Barreno B, Calder L, Lopez JA, Albar JP, et al. Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion. Proc Natl Acad Sci U S A. 2001;98:9859–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Corry J, Johnson SM, Cornwell J, Peeples ME. Prevention of respiratory Syncytial virus attachment protein cleavage in Vero cells rescues infectivity of progeny Virions for primary human airway cultures. J Virol. 2015;90:1311–20.
Article
PubMed
Google Scholar
Schepens B, Sedeyn K, Vande Ginste L, De Baets S, Schotsaert M, Roose K, et al. Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein. EMBO Mol Med. 2014;6:1436–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hosoya M, Matsuyama S, Baba M, Suzuki H, Shigeta S. Effects of protease inhibitors on replication of various myxoviruses. Antimicrob Agents Chemother. 1992;36:1432–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Anantharam V, Kaul S, Song C, Kanthasamy A, Kanthasamy AG. Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology. 2007;28:988–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Megyeri P, Németh L, Pabst KM, Pabst MJ, Deli MA, Ábrahám CS. 4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-??-induced blood-brain barrier opening. Eur J Pharmacol. 1999;374:207–11.
Article
CAS
PubMed
Google Scholar
Saw S, Arora N. Protease inhibitor reduces airway response and underlying inflammation in cockroach allergen-induced Murine model. Inflammation. 2015;38:672–82.
Article
CAS
PubMed
Google Scholar
Saw S, Kale SL, Arora N. Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS One. 2012;7:e41107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS. The histopathology of fatal untreated human respiratory syncytial virus infection. Mod. Pathol. 2007;20:108–19.
Article
CAS
PubMed
Google Scholar
Welliver TP, Reed JL, Welliver RC Sr. Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases. Pediatr Infect Dis J. 2008;27:S92–6.
Article
PubMed
Google Scholar
Welliver RC. The immune response to respiratory syncytial virus infection: friend or foe? Clin Rev Allergy Immunol. 2008;34:163–73.
Article
CAS
PubMed
Google Scholar
Piedimonte G, Hegele RG, Auais A. Persistent airway inflammation after resolution of respiratory Syncytial virus infection in rats. Pediatr Res. 2004;55:657–65.
Article
CAS
PubMed
Google Scholar
Kadota Y, Sakai N, Fujikawa R, Aoyama E, Zhong M, Tanaka S, et al. Dextran sulfate-induced degradation of spontaneously apoptotic B cells. Int Immunopharmacol. 2013;15:581–7.
Article
CAS
PubMed
Google Scholar
Queiroz AFS, Silva RA, Moura RM, Dreyfuss JL, Paredes-Gamero EJ, Souza ACS, et al. Growth inhibitory activity of a novel lectin from Cliona Varians against K562 human erythroleukemia cells. Cancer Chemother Pharmacol. 2009;63:1023–33.
Article
CAS
PubMed
Google Scholar
Takashima T, Kawada N, Maeda N, Okuyama H, Uyama N, Seki S, et al. Pepstatin a attenuates the inhibitory effect of N-acetyl-L-cysteine on proliferation of hepatic myofibroblasts (stellate cells). Eur J Pharmacol. 2002;451:265–70.
Article
CAS
PubMed
Google Scholar
Sachse F, Von Eiff C, Stoll W, Becker K, Rudack C. Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases - a possible route for neutrophilic inflammation in chronic rhinosinusitis. Clin Exp Immunol. 2006;144:534–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Megyeri P, Pabst KM, Pabst MJ. Serine protease inhibitors block priming of monocytes for enhanced release of superoxide. Immunology. 1995;86:629–35.
CAS
PubMed
PubMed Central
Google Scholar
Iwata Y, Nicole O, Okamura T, Zurakowski D, Jonas RA. Aprotinin confers neuroprotection by reducing excitotoxic cell death. J Thorac Cardiovasc Surg. 2008;135:573–8.
Article
CAS
PubMed
Google Scholar
Forney JR, Yang S, Du C, Healey MC. Efficacy of serine protease inhibitors against Cryptosporidium Parvum infection in a bovine fallopian tube epithelial cell culture system. J Parasitol. 1996;82:638–40.
Article
CAS
PubMed
Google Scholar
Hwang I, Park JH, Park HS, Choi KA, Seol KC, Oh SI, et al. Neural stem cells inhibit melanin production by activation of Wnt inhibitors. J Dermatol Sci. 2013;72:274–83.
Article
CAS
PubMed
Google Scholar
Movsesyan VA, Yakovlev AG, Fan L, Faden A. Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis. Exp Neurol. 2001;167:366–75.
Article
CAS
PubMed
Google Scholar
Ikegami K, Kato S, Koike T. N-alpha-p-tosyl-l-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration. Brain Res. 2004;1030:81–93.
Article
CAS
PubMed
Google Scholar