Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–20.
Article
CAS
Google Scholar
Schneider W, Chevillotte M, Rice C. Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol. 2014;32:513–45.
Article
CAS
Google Scholar
Sun L, Wu J, Du F, Chen X, Chen Z. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (New York, NY). 2013;339(6121):786–91.
Article
CAS
Google Scholar
Kato K, Omura H, Ishitani R, Nureki O. Cyclic GMP-AMP as an endogenous second messenger in innate immune signaling by cytosolic DNA. Annu Rev Biochem. 2017;86:541–66.
Article
CAS
Google Scholar
Diner B, Lum K, Toettcher J, Cristea I: Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection. mBio 2016, 7(6).
Kao Y, Lai M, Yu C. How dengue virus circumvents innate immunity. Front Immunol. 2018;9:2860.
Article
CAS
Google Scholar
Gao D, Wu J, Wu Y, Du F, Aroh C, Yan N, Sun L, Chen Z. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science (New York, NY). 2013;341(6148):903–6.
Article
CAS
Google Scholar
Dansako H, Ueda Y, Okumura N, Satoh S, Sugiyama M, Mizokami M, Ikeda M, Kato N. The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly. FEBS J. 2016;283(1):144–56.
Article
CAS
Google Scholar
He J, Hao R, Liu D, Liu X, Wu S, Guo S, Wang Y, Tien P, Guo D. Inhibition of hepatitis B virus replication by activation of the cGAS-STING pathway. J Gen Virol. 2016;97(12):3368–78.
Article
CAS
Google Scholar
Guo F, Tang L, Shu S, Sehgal M, Sheraz M, Liu B, Zhao Q, Cheng J, Zhao X, Zhou T et al. Activation of stimulator of interferon genes in hepatocytes suppresses the replication of hepatitis B virus. Antimicrobial Agents Chemotherapy 2017, 61(10).
Zhang D, Su C, Zheng C. Herpes simplex virus 1 serine protease VP24 blocks the DNA-sensing signal pathway by abrogating activation of interferon regulatory factor 3. J Virol. 2016;90(12):5824–9.
Article
CAS
Google Scholar
Su C, Zheng C. Herpes simplex virus 1 abrogates the cGAS/STING-mediated cytosolic DNA-sensing pathway via its virion host shutoff protein, UL41. J. Virol. 2017, 91(6).
Xu H, Su C, Pearson A, Mody C, Zheng C. Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-κB activation. J Virol. 2017, 91(7).
You H, Zheng S, Huang Z, Lin Y, Shen Q, Zheng C. Herpes simplex virus 1 tegument protein UL46 Inhibits TANK-binding kinase 1-mediated signaling. mBio 2019, 10(3).
Ye R, Su C, Xu H, Zheng C: Herpes simplex virus 1 ubiquitin-specific protease UL36 abrogates NF-κB activation in DNA sensing signal pathway. J Virol. 2017;91(5).
You H, Lin Y, Lin F, Yang M, Li J, Zhang R, Huang Z, Shen Q, Tang R, Zheng C: β-Catenin is required for the cGAS/STING signaling pathway but antagonized by the herpes simplex virus 1 US3 protein. J Virol. 2020, 94(5).
Huang J, You H, Su C, Li Y, Chen S, Zheng C. Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/STING-mediated antiviral innate immunity. J Virol. 2018, 92(15).
Wu J, Li W, Shao Y, Avey D, Fu B, Gillen J, Hand T, Ma S, Liu X, Miley W, et al. Inhibition of cGAS DNA sensing by a herpesvirus virion protein. Cell Host Microbe. 2015;18(3):333–44.
Article
CAS
Google Scholar
Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann M, Schulz T. Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci USA. 2016;113(8):E1034-1043.
CAS
PubMed
PubMed Central
Google Scholar
Verrier E, Yim S, Heydmann L, El Saghire H, Bach C, Turon-Lagot V, Mailly L, Durand S, Lucifora J, Durantel D, et al. Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes. Hepatology (Baltimore, MD). 2018;68(5):1695–709.
Article
CAS
Google Scholar
Lok A, McMahon B. Chronic hepatitis B. Hepatology (Baltimore, MD). 2007;45(2):507–39.
Article
CAS
Google Scholar
Lee S, Cha E, Lim J, Kwon S, Kim D, Cho H, Han K. Structural characterization of an intrinsically unfolded mini-HBX protein from hepatitis B virus. Mol Cells. 2012;34(2):165–9.
Article
CAS
Google Scholar
Jiang J, Tang H. Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein. Protein Cell. 2010;1(12):1106–17.
Article
CAS
Google Scholar
Tao J, Zhang X, Jin J, Du X, Lian T, Yang J, Zhou X, Jiang Z, Su X: Nonspecific DNA Binding of cGAS N terminus promotes cGAS activation. J Immunol. (Baltimore, Md : 1950) 2017, 198(9):3627–36.
Wang X, Li Y, Mao A, Li C, Li Y, Tien P. Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol. 2010;7(5):341–8.
Article
CAS
Google Scholar
Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang R, et al. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Mol Cell. 2016;64(1):105–19.
Article
CAS
Google Scholar
Park S, Rehermann B. Immune responses to HCV and other hepatitis viruses. Immunity. 2014;40(1):13–24.
Article
CAS
Google Scholar
Xiong M, Wang S, Wang Y, Ran Y. The regulation of cGAS. Virol Sin. 2018;33(2):117–24.
Article
CAS
Google Scholar
Murphy CM, Xu Y, Li F, Nio K, Reszka-Blanco N, Li X, Wu Y, Yu Y, Xiong Y, Su L. Hepatitis B Virus X protein promotes degradation of SMC5/6 to enhance HBV replication. Cell Rep. 2016;16(11):2846–54.
Article
CAS
Google Scholar
Zhang HT, Chen GG, Hu BG, Zhang ZY, Yun JP, He ML, Lai PB. Hepatitis B virus x protein induces autophagy via activating death-associated protein kinase. J Viral Hepatitis. 2014;21(9):642–9.
Article
CAS
Google Scholar
Gao P, Ascano M, Wu Y, Barchet W, Gaffney B, Zillinger T, Serganov A, Liu Y, Jones R, Hartmann G, et al. Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 2013;153(5):1094–107.
Article
CAS
Google Scholar
Zhao B, Xu P, Rowlett C, Jing T, Shinde O, Lei Y, West A, Liu W, Li P. The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature. 2020;587(7835):673–7.
Article
CAS
Google Scholar
Chen H, Chen H, Zhang J, Wang Y, Simoneau A, Yang H, Levine A, Zou L, Chen Z, Lan L. cGAS suppresses genomic instability as a decelerator of replication forks. Sci Adv. 2020, 6(42).