From: HBx inhibits DNA sensing signaling pathway via ubiquitination and autophagy of cGAS
Full name: Abbreviations |
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cGAS: Cyclic GMP-AMP synthase |
HBV: Hepatitis B virus |
HBx: Hepatitis B virus X protein |
PRRs: Pathogen recognition receptors |
IFN-I: Type I interferon |
IRF3: Interferon regulatory factor-3 |
ISGs: IFN stimulated genes |
HSV-1: Herpes simplex virus 1 |
DENV: Dengue virus |
KSHV: Kaposi's sarcoma-associated herpesvirus |
LANA: Latency-associated nuclear antigen |
DMEM: Dulbecco's modified Eagle's medium |
pRL-TK: Renilla luciferase |
DOC: Deoxycholate |
DLR: Dual-luciferase reporter |
dsDNA: Double-stranded DNA |
K48: Lysine 48 |
LC3: microtubule-associated protein-Light-chain 3 |
pcDNA-HBV1.3: HBV 1.3-fold genome plasmid |
IFN-β: Interferon beta |
TBK1: Tank-binding kinase 1 |
3-MA: 3-methyladenine |
ISG: Interferon-inducible Protein 6–16 |
ISG56: IFN-stimulated gene 56 |
ISG54: IFN-stimulated gene 54 |
WB: Western-Blot |