Ekiert DC, Friesen RHE, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJWM, Brandenburg B, et al. A highly conserved neutralizing epitope on group 2 influenza a viruses. Science. 2011;333:843–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang Y, Zhang Q, Kong H, Jiang Y, Gao Y, Deng G, Shi J, Tian G, Liu L, Liu J, et al. H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in Guinea pigs by respiratory droplet. Science. 2013;340:1459–63.
Article
CAS
PubMed
Google Scholar
Li C, Bu Z, Chen H. Avian influenza vaccines against H5N1 ‘bird flu’. Trends Biotechnol. 2014;32:147–56.
Article
CAS
PubMed
Google Scholar
Chen H. H5N1 avian influenza in China. Sci China C Life Sci. 2009;52:419–27.
Article
PubMed
Google Scholar
Yamayoshi S, Uraki R, Ito M, Kiso M, Nakatsu S, Yasuhara A, Oishi K, Sasaki T, Ikuta K, Kawaoka Y. A broadly reactive human anti-hemagglutinin stem monoclonal antibody that inhibits influenza a virus particle release. EBioMedicine. 2017;17:182–91.
Article
PubMed
PubMed Central
Google Scholar
Bommakanti G, Lu X, Citron MP, Najar TA, Heidecker GJ, ter Meulen J, Varadarajan R, Liang X. Design of Escherichia coli-expressed stalk domain immunogens of H1N1 hemagglutinin that protect mice from lethal challenge. J Virol. 2012;86:13434–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang Y, Xu C, Zhang H, Liu GD, Xue C, Cao Y. Targeting hemagglutinin: approaches for broad protection against the influenza A virus. Viruses. 2019;11:405.
Article
CAS
PubMed Central
Google Scholar
Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen LM, Recuenco S, Ellison JA, Davis CT, York IA, et al. A distinct lineage of influenza a virus from bats. Proc Natl Acad Sci U S A. 2012;109:4269–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tong S, Zhu X, Li Y, Shi M, Zhang J, Bourgeois M, Yang H, Chen X, Recuenco S, Gomez J, et al. New World Bats Harbor diverse influenza a viruses. Plos Pathog. 2013;9:e1003657.
Article
PubMed
PubMed Central
CAS
Google Scholar
Plotch SJ, O’Hara B, Morin J, Palant O, LaRocque J, Bloom JD, Lang SA, DiGrandi MJ, Bradley M, Nilakantan R, Gluzman Y. Inhibition of influenza a virus replication by compounds interfering with the Fusogenic function of the viral hemagglutinin. J Virol. 1999;73:140–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo G, Colonno R, Krystal M. Characterization of a hemagglutinin-specific inhibitor of influenza a virus. Virology. 1996;226:66–76.
Article
CAS
PubMed
Google Scholar
Zhu L, Li Y, Li S, Li H, Qiu Z, Lee C, Lu H, Lin X, Zhao R, Chen L, et al. Inhibition of influenza a virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin. PLoS One. 2011;6:e29120.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen HL, Yuen KY, Kao RY. Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics. J Virol. 2015;90:2690–701.
Article
PubMed
CAS
Google Scholar
Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ. Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci. 2008;105:17736–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bodian DL, Yamasaki RB, Buswell RL, Stearns JF, White JM, Kuntz ID. Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochemistry. 1993;32:2967–78.
Article
CAS
PubMed
Google Scholar
Hoffman LR, Kuntz ID, White JM. Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity. J Virol. 1997;71:8808–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Anice CL, Peter P. Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic. Infect Disord Drug Targets. 2007;7:318–28.
Article
Google Scholar
Bright RA, Shay DK, Shu B, Cox NJ, Klimov AI. Adamantane Resistance Among Influenza A Viruses Isolated Early During the 2005-2006 Influenza season in the United States. JAMA. 2006;295:891–4.
Article
CAS
PubMed
Google Scholar
Kiso M, Mitamura K, Sakai-Tagawa Y, Shiraishi K, Kawakami C, Kimura K, Hayden FG, Sugaya N, Kawaoka Y. Resistant influenza a viruses in children treated with oseltamivir: descriptive study. Lancet. 2004;364:759–65.
Article
CAS
PubMed
Google Scholar
Russell CA, Jones TC, Barr IG, Cox NJ, Garten RJ, Gregory V, Gust ID, Hampson AW, Hay AJ, Hurt AC. The global circulation of seasonal influenza a (H3N2) viruses. Science. 2008;320:340–6.
Article
CAS
PubMed
Google Scholar
Lee JKH, Lam GKL, Shin T, Kim J, Krishnan A, Greenberg DP, Chit A. Efficacy and effectiveness of high-dose versus standard-dose influenza vaccination for older adults: a systematic review and meta-analysis. Expert Rev Vaccin. 2018;17:435–43.
Article
CAS
Google Scholar
Fouchier RA, Munster V, Wallensten A, Bestebroer TM, Herfst S, Smith D, Rimmelzwaan GF, Olsen B, Osterhaus AD. Characterization of a novel influenza a virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol. 2005;79:2814–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Raymond DD, Bajic G, Ferdman J, Suphaphiphat P, Settembre EC, Moody MA, Schmidt AG, Harrison SC. Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. Proc Natl Acad Sci. 2018;115:168–73.
Article
CAS
PubMed
Google Scholar
Ekiert DC, Bhabha G, Elsliger M-A, Friesen RHE, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus epitope. Science. 2009;324:246–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Throsby M, van den Brink E, Jongeneelen M, Poon LL, Alard P, Cornelissen L, Bakker A, Cox F, van Deventer E, Guan Y, et al. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. Plos One. 2008;3:e3942.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sui J, Hwang WC, Perez S, Wei G, Aird D, Chen LM, Santelli E, Stec B, Cadwell G, Ali M, et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza a viruses. Nat Struct Mol Biol. 2009;16:265–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wyrzucki A, Dreyfus C, Kohler I, Steck M, Wilson IA, Hangartner L. Alternative recognition of the conserved stem epitope in influenza a virus hemagglutinin by a VH3-30-encoded Heterosubtypic antibody. J Virol. 2014;88:7083–92.
Article
PubMed
PubMed Central
CAS
Google Scholar
Corti D, Suguitan AL Jr, Pinna D, Silacci C, Fernandez-Rodriguez BM, Vanzetta F, Santos C, Luke CJ, Torres-Velez FJ, Temperton NJ, et al. Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine. J Clin Invest. 2010;120:1663–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kashyap AK, Steel J, Rubrum A, Estelles A, Briante R, Ilyushina NA, Xu L, Swale RE, Faynboym AM, Foreman PK, et al. Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. Plos Pathog. 2010;6:e1000990.
Article
PubMed
PubMed Central
CAS
Google Scholar
De Marco D, Clementi N, Mancini N, Solforosi L, Moreno GJ, Sun X, Tumpey TM, Gubareva LV, Mishin V, Clementi M, Burioni R. A non-VH1-69 heterosubtypic neutralizing human monoclonal antibody protects mice against H1N1 and H5N1 viruses. Plos One. 2012;7:e34415.
Article
PubMed
PubMed Central
CAS
Google Scholar
Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, et al. A common solution to group 2 influenza virus neutralization. Proc Natl Acad Sci U S A. 2014;111:445–50.
Article
CAS
PubMed
Google Scholar
Tan GS, Lee PS, Hoffman RM, Mazel-Sanchez B, Krammer F, Leon PE, Ward AB, Wilson IA, Palese P. Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza a virus hemagglutinin. J Virol. 2014;88:13580–92.
Article
PubMed
PubMed Central
CAS
Google Scholar
Henry Dunand CJ, Leon PE, Kaur K, Tan GS, Zheng NY, Andrews S, Huang M, Qu X, Huang Y, Salgado-Ferrer M, et al. Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. J Clin Invest. 2015;125:1255–68.
Article
PubMed
PubMed Central
Google Scholar
Laursen NS, Friesen RHE, Zhu X, Jongeneelen M, Blokland S, Vermond J, van Eijgen A, Tang C, van Diepen H, Obmolova G, et al. Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science. 2018;362:598–602.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, et al. Highly conserved protective epitopes on influenza B viruses. Science. 2012;337:1343–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Corti D, Voss J, Gamblin SJ, Codoni G, Macagno A, Jarrossay D, Vachieri SG, Pinna D, Minola A, Vanzetta F, et al. A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza a hemagglutinins. Science. 2011;333:850–6.
Article
CAS
PubMed
Google Scholar
Wu Y, Cho M, Shore D, Song M, Choi J, Jiang T, Deng YQ, Bourgeois M, Almli L, Yang H, et al. A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza a virus. Nat Commun. 2015;6:7708.
Article
CAS
PubMed
Google Scholar
Clementi N, De Marco D, Mancini N, Solforosi L, Moreno GJ, Gubareva LV, Mishin V, Di Pietro A, Vicenzi E, Siccardi AG, et al. A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes. Plos One. 2011;6:e28001.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tharakaraman K, Subramanian V, Viswanathan K, Sloan S, Yen H-L, Barnard DL, Leung YHC, Szretter KJ, Koch TJ, Delaney JC, et al. A broadly neutralizing human monoclonal antibody is effective against H7N9. Proc Natl Acad Sci. 2015;112:10890–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kallewaard NL, Corti D, Collins PJ, Neu U, McAuliffe JM, Benjamin E, Wachter-Rosati L, Palmer-Hill FJ, Yuan AQ, Walker PA, et al. Structure and function analysis of an antibody recognizing all influenza a subtypes. Cell. 2016;166:596–608.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jacobsen H, Rajendran M, Choi A, Sjursen H, Brokstad KA, Cox RJ, Palese P, Krammer F, Nachbagauer R. Influenza virus hemagglutinin stalk-specific antibodies in human serum are a surrogate marker for in vivo protection in a serum transfer mouse challenge model. MBio. 2017;8:e01463–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Neumann G, Watanabe T, Ito H, Watanabe S, Goto H, Gao P, Hughes M, Perez DR, Donis R, Hoffmann E, et al. Generation of influenza a viruses entirely from cloned cDNAs. Proc Natl Acad Sci. 1999;96:9345–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xie S, Shi Y, Gong R, Cui W, Jiang Y, Liu M, Wang L, Zhou H, Qiao X, Li Y, et al. Identification of antigenic epitopes of monoclonal antibodies against the VP2 protein of the 25 serotype of bluetongue virus. Vet Microbiol. 2018;219:136–43.
Article
CAS
PubMed
Google Scholar
Chiu C, Ellebedy AH, Wrammert J, Ahmed R. B cell responses to influenza infection and vaccination. Curr Top Microbiol Immunol. 2014;386:381–98.
Google Scholar
Li C, Yu K, Tian G, Yu D, Liu L, Jing B, Ping J, Chen H. Evolution of H9N2 influenza viruses from domestic poultry in mainland China. Virology. 2005;340:70–83.
Article
CAS
PubMed
Google Scholar
Li X, Shi J, Guo J, Deng G, Zhang Q, Wang J, He X, Wang K, Chen J, Li Y, et al. Genetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 avian influenza viruses. PLoS Pathog. 2014;10:e1004508.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sano K, Ainai A, Suzuki T, Hasegawa H. The road to a more effective influenza vaccine: up to date studies and future prospects. Vaccine. 2017;35:5388–95.
Article
CAS
PubMed
Google Scholar
Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12:36–44.
Article
PubMed
Google Scholar
Okuno Y, Isegawa Y, Sasao F, Ueda S. A common neutralizing epitope conserved between the hemagglutinins of influenza a virus H1 and H2 strains. J Virol. 1993;67:2552–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Corti D, Cameroni E, Guarino B, Kallewaard NL, Zhu Q, Lanzavecchia A. Tackling influenza with broadly neutralizing antibodies. Curr Opin Virol. 2017;24:60–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu NC, Wilson IA. Structural insights into the design of novel anti-influenza therapies. Nat Struct Mol Biol. 2018;25:115–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bangaru S, Lang S, Schotsaert M, Vanderven HA, Zhu X, Kose N, Bombardi R, Finn JA, Kent SJ, Gilchuk P, et al. A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell. 2019;177:1136–1152.e1118.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, et al. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nat Med. 2016;22:1456–64.
Article
CAS
PubMed
PubMed Central
Google Scholar