The gut microbiome is closely associated with the health of the host; although the interaction between the bacterial microbiome and the whole virome has rarely been studied, it is likely of medical importance....
Authors: Heng Li, Hongzhe Li, Jingjing Wang, Lei Guo, Haitao Fan, Huiwen Zheng, Zening Yang, Xing Huang, Manman Chu, Fengmei Yang, Zhanlong He, Nan Li, Jinxi Yang, Qiongwen Wu, Haijing Shi and Longding Liu
The inflammatory or non-inflammatory changes caused by the virus entering the nervous system and related tissues are central nervous system virus infections. Viral infection is a common infectious disease of t...
The high genetic diversity of HIV-1 has been shown to influence the global distribution, disease progression, treatment success, and the development of an effective vaccine. Despite the low HIV prevalence in C...
Authors: Lem Edith Abongwa, Anthony Kebira Nyamache, Judith Ndongo Torimiro, Paul Okemo and Fokunang Charles
Dengue virus (DENV) infection is one of the biggest challenges for human health in the world. In addition, a secondary DENV infection sometimes causes dengue hemorrhagic fever (DHF), which frequently leads to ...
Authors: Keita Suzuki, Emi E. Nakayama, Akatsuki Saito, Akio Egawa, Tairyu Sato, Juthamas Phadungsombat, Rummana Rahim, Abu Hasan, Hisahiko Iwamoto, Mizanur Rahman and Tatsuo Shioda
Current HCV treatments are genotype specific although potential pan-genotype treatments have recently been described. Therefore, genotyping is an essential tool for the therapeutic management of HCV infection ...
Authors: Paul Alain Tagnouokam-Ngoupo, Marie Nicole Ngoufack, Sebastien Kenmoe, Simon Frédéric Lissock, Marie Amougou-Atsama, Robert Banai, Laure Ngono and Richard Njouom
Recombinant Modified Vaccinia Virus Ankara has been employed as a safe and potent viral vector vaccine against infectious diseases and cancer. We generated recMVAs encoding norovirus GII.4 genotype capsid prot...
Both vector borne and sexual transmission of Zika virus (ZIKV) involve infection of epithelial cells in the initial stages of infection. Epithelial cells are unique in their ability to form polarized monolayer...
Coxsackievirus A10 (CA10) constitutes one of the four major pathogens causing hand, foot and mouth disease in infants. Infectious clones are of great importance for studying viral gene functions and pathogenic...
Authors: Qiliang Liu, Hanliang Dan, Xiaoping Zhao, Huoying Chen, Yongbei Chen, Ning Zhang, Zhijing Mo and Hongbo Liu
Transmissible gastroenteritis virus (TGEV), a member of the family Coronaviridae, causes lethal watery diarrhea in piglets. Previous studies have revealed that the coronaviruses develop various strategies to evad...
Authors: Yanan Wang, Aoying Sun, Yu Sun, Sijia Zhang, Tian Xia, Tiantian Guo, Zhenye Hao, Li Sun, Yanping Jiang, Xinyuan Qiao, Wen Cui, Lijie Tang, Yigang Xu, Yijing Li and Li Wang
Human cytomegalovirus (HCMV) has been associated with malignant gliomas. The purpose of the present study was to investigate the presence of HCMV in common non-glial tumors of the central nervous system (CNS) ...
Authors: Daling Ding, Ailing Zhao, Zhi Sun, Lihua Zuo, Anhua Wu and Jianrui Sun
Swine-origin virus infection spreading widely could cause significant economic loss to porcine industry. Novel antiviral agents need to be developed to control this situation.
Authors: Han Hu, Nan Guo, Shuhua Chen, Xiaozhen Guo, Xiaoli Liu, Shiyi Ye, Qingqing Chai, Yang Wang, Binlei Liu and Qigai He
Although enterovirus 71 (EV71) is an important public health threat, especially in the Asia-Pacific region, there are still no effective drugs or vaccines to treat and prevent EV71 infection. Therefore, it is ...
Dengue fever is a febrile disease caused by dengue virus (DENV), which affects people throughout the tropical and subtropical regions of the world, including Indonesia. East Kalimantan (Borneo) province suffer...
Authors: R. Tedjo Sasmono, Lily Pertiwi Kalalo, Suryani Trismiasih, Dionisius Denis, Benediktus Yohan, Rahma F. Hayati and Sotianingsih Haryanto
Influenza A and B viruses mainly cause respiratory infectious disease. Till now, few tests are able to simultaneously detect both, especially in primary medical establishments.
Authors: Qingjun Pan, Weiquan Wu, Shuzhen Liao, Sijie Wang, Chunfei Zhao, Chen Li and Ping Wu
Nelson Bay orthoreovirus (NBV) was first isolated over 40 years ago from a fruit bat in Australia. Normally, NBV does not cause human diseases, but recently several NBV strains have been associated with human ...
Authors: Xiao-Li Tao, Wei Zhao, Wei Tong, Xiao-Fang Wang, Li-Li Dou, Jiang-Man Chen, Nian Liu, Ying Lu, Yi-Bo Zhang, Xu-Peng Jin, Yan-Fei Shen, Hong-Yan Zhao, Hong Jin and Yong-Gang Li
A tenuivirus, referred to here as JKI 29327, was isolated from a black medic (Medicago lupulina) plant collected in Austria. The virus was mechanically transmitted to Nicotiana benthamiana, M. lupulina, M. sativa
Authors: Yahya Z. A. Gaafar, Katja R. Richert-Pöggeler, Angelika Sieg-Müller, Petra Lüddecke, Kerstin Herz, Jonas Hartrick, Yvonne Seide, Heinrich-Josef Vetten and Heiko Ziebell
Human infection with avian influenza H7N9 virus was first reported in 2013. Since the fifth epidemic, a highly pathogenic avian influenza (HPAI) H7N9 virus has emerged and caused 33 human infections. Several p...
Authors: Jing Tang, Jing Zhang, Jianfang Zhou, Wenfei Zhu, Lei Yang, Shumei Zou, Hejiang Wei, Li Xin, Weijuan Huang, Xiyan Li, Yanhui Cheng and Dayan Wang
Human adenoviruses are a common group of viruses that cause acute infectious diseases. Human adenovirus (HAdV) 3 and HAdV 7 cause major outbreaks of severe pneumonia. A reliable and practical method for HAdV t...
Authors: Rui-huan Wang, Hong Zhang, Yi Zhang, Xin-na Li, Xin-xin Shen, Ju-ju Qi, Guo-hao Fan, Xing-yu Xiang, Zhi-fei Zhan, Zi-wei Chen and Xue-jun Ma
Type A influenza viruses (IAVs) cause significant infections in humans and multiple species of animals including pigs, horses, birds, dogs and some marine animals. They are of complicated phylogenetic diversit...
Advances in molecular laboratory techniques are changing the prospects for the diagnosis of viral infectious diseases. Multiplex polymerase chain reaction assay (multiplex-PCR) can detect dozens of pathogens s...
Authors: Le Wang, Shuo Yang, Xiaotong Yan, Teng Liu, Zhishan Feng and Guixia Li
Shenzhen City is a rapidly growing area with a large number of floating populations, thus making it difficult to control HIV. Serial cross-sectional studies are helpful for the prediction of epidemiological te...
Authors: Dijing Jia, Jin Zhao, Yongjian Liu, Xiaolin Wang, Lei Jia, Tao Gui, Lin Chen, Chenli Zheng, Jingwan Han, Tianyi Li, Jingyun Li, Hanping Li and Lin Li
Cucurbit chlorotic yellows virus (CCYV) is a bipartite cucurbit-infecting crinivirus within the family Closteroviridae. The crinivirus genome varies among genera. P4.9 is the first protein encoded by CCYV RNA2. P...
Authors: Ying Wei, Yajuan Shi, Xaioyu Han, Siyu Chen, Honglian Li, Linlin Chen, Bingjian Sun and Yan Shi
Pseudorabies virus (PRV) protein UL56 (pUL56) has been implicated in viral dissemination and virulence in vivo. However, the properties of PRV pUL56 remain largely unknown. In the present study, we aim to inve...
Rabies virus (RABV), a member of Lyssavirus of Rhabdoviridae family, is a kind of negative-strand RNA virus. The zoonosis caused by RABV leads to high mortality in animals and humans. Though with the extensive...
Authors: Jie Gao, Xinyu Wang, Mingxin Zhao, Enhua Liu, Ming Duan, Zhenhong Guan, Yidi Guo and Maolin Zhang
The increased levels of blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A, influenza B and people with influenza-like illness (ILI)...
Authors: Mohsen Keshavarz, Haideh Namdari, Mohammad Farahmand, Parvaneh Mehrbod, Talat Mokhtari-Azad and Farhad Rezaei
Human adenoviruses (HAdVs) cause a wide range of diseases. However, the genotype diversity and epidemiological information relating to HAdVs among hospitalized children with respiratory tract infections (RTIs)...
Authors: Li-hong Yao, Chao Wang, Tian-li Wei, Hao Wang, Fen-lian Ma and Li-shu Zheng
Influenza B virus is a main causative pathogen of annual influenza epidemics, however, research on influenza B virus in general lags behind that on influenza A viruses, one of the important reasons is studies ...
Authors: Bing Yuan, Chunguang Yang, Xueshan Xia, Mark Zanin, Sook-san Wong, Fan Yang, Jixiang Chang, Zhitong Mai, Jin Zhao, Yunhui Zhang, Runfeng Li, Nanshan Zhong and Zifeng Yang
Stratified mucin-producing intraepithelial lesion (SMILE) is a rare precursor lesion in the uterine cervix that is considered a variant of adenocarcinoma in situ (AIS). Although human papillomavirus (HPV) is t...
Porcine parvovirus (PPV) is a DNA virus that causes reproductive failure in gilts and sows, resulting in embryonic and fetal losses worldwide. Epitope mapping of PPV is important for developing new vaccines. I...
Authors: Ancelmo Rabelo de Souza, Marriam Yamin, Danielle Gava, Janice Reis Ciacci Zanella, Maria Sílvia Viccari Gatti, Carlos Francisco Sampaio Bonafe and Daniel Ferreira de Lima Neto
Patients with hepatitis C virus (HCV) genotype 3 infection remain a difficult-to-cure population. This study evaluated the efficacy and safety of sofosbuvir-based regimen in genotype 3 patients in a real-world...
Authors: Qunying Han, Xiude Fan, Xiaoyun Wang, Ye Wang, Huan Deng, Xiaoge Zhang, Kun Zhang, Na Li and Zhengwen Liu
The ubiquitin proteasome system (UPS) regulates the expression levels of cellular proteins by ubiquitination of protein substrates followed by their degradation via the proteasome. As a highly conserved cellul...
Human papillomavirus (HPV) E6 and E7 oncoproteins play a crucial role in HPV-related diseases, such as cervical cancer, and can be used as ideal targets for therapeutic vaccines. Human leukocyte antigen (HLA) ...
Authors: Jiaoyu He, Yasi Yang, Zuyi Chen, Yang Liu, Shanfei Bao, Yun Zhao and Xianping Ding
Lates calcarifer, known as seabass in Asia and barramundi in Australia, is a widely farmed species internationally and in Southeast Asia and any disease outbreak will have a great economic impact on the aquacultu...
A novel nepovirus was identified and characterised from caraway, and tentatively named caraway yellows virus (CawYV). Tubular structures with isomeric virus particles typical for nepoviruses were observed in i...
Authors: Yahya Z. A. Gaafar, Katja R. Richert-Pöggeler, Angelika Sieg-Müller, Petra Lüddecke, Kerstin Herz, Jonas Hartrick, Christina Maaß, Roswitha Ulrich and Heiko Ziebell
Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to be capable of infecting humans as well. The outbreak of severe acute respiratory syndro...
Shingles (localized zoster) and disseminated zoster are caused by the reactivation of latent varicella zoster virus (VZV). Reactivation of VZV is related to impaired cell-mediated immunity. Extensive burns aff...
Human papillomavirus (HPV) infection may lead to a series of lesions in the cervix. Distributions of HPV genotypes reveal that an increased prevalence of high-risk HPV (HR-HPV) is positively correlated with th...
Authors: C. Zhang, Wj Cheng, Q. Liu, Q. Guan and Qw Zhang
Bovine leukemia virus (BLV) causes enzootic bovine leukosis, the most common neoplastic disease of cattle. Previously, we reported the luminescence syncytium induction assay (LuSIA), an assay for BLV infectivi...
Yellow fever, Dengue, West Nile and Zika viruses are re-emerging mosquito-borne Flaviviruses of public health concern. However, the extent of human exposure to these viruses and associated disease burden in Kenya...
Authors: E. Chepkorir, D. P. Tchouassi, S. L. Konongoi, J. Lutomiah, C. Tigoi, Z. Irura, F. Eyase, M. Venter and R. Sang
Acute gastroenteritis (AGE) due to group A rotavirus (RVA) agent is one of the major causes of hospitalization in paediatric age. The G3P[8] RVA genotype has been usually considered as one of the major human g...
Authors: Susanna Esposito, Barbara Camilloni, Sonia Bianchini, Giovanni Ianiro, Ilaria Polinori, Edoardo Farinelli, Marina Monini and Nicola Principi
Hand, foot, and mouth disease (HFMD) is a common childhood disease, which is usually caused by enterovirus A (EV-A) serotypes. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the main etiologic ag...
Authors: Jie Zhang, Hongbo Liu, Yilin Zhao, Haihao Zhang, Hao Sun, Xiaoqin Huang, Zhaoqing Yang, Jiansheng Liu and Shaohui Ma
Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus gen...
Authors: Katherine Laiton-Donato, Diego A. Alvarez, Dioselina Peláez-Carvajal, Marcela Mercado, Nadim J. Ajami, Irene Bosch and José A. Usme-Ciro
In the original publication of the article [1], as the quotation below was included without specific permission from Dr. Gary Marty, which is against the Virology Journal guidelines for the citation of unpublishe...
Authors: Molly J. T. Kibenge, Yingwei Wang, Nick Gayeski, Alexandra Morton, Kurt Beardslee, Bill McMillan and Frederick S. B. Kibenge
Much evidence has demonstrated the influence of Hepatitis B virus (HBV) mutations on the clinical course of HBV infection. As large (L) protein plays a crucial role for viral entry, we hypothesized that mutati...
Authors: Suguru Ogura, Masahiko Tameda, Kazushi Sugimoto, Makoto Ikejiri, Masanobu Usui, Masaaki Ito and Yoshiyuki Takei
MicroRNAs (miRNAs) have gained much attention as cellular factors regulating hepatitis C virus (HCV) infection. miR-27b has been shown to regulate HCV infection in the hepatocytes via various mechanisms that h...
Porcine circovirus type 2 (PCV2) is an economically important viral pathogen for swine industry worldwide. However, current PCV2 vaccines provide incomplete protection against the PCV2d, which has recently eme...
Authors: Zhumei Hou, Honghua Wang, Yanni Feng, Qingwang Li and Junwei Li
Tetraparvovirus, formerly known as Partetravirus, is a newly discovered genus in the family Parvoviridae that is considered phylogenetically distinct from other parvoviruses. However, nothing is known about the p...
Authors: Yangyang Pan, Yun Wang, Meng Wang, Qian Zhang, Abdul Rasheed Baloch, Jun Zhou, Jing Ma, Jam Kashif, Gengquan Xu, Libin Wang, Jiangfeng Fan, Yan Cui and Sijiu Yu
