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  1. Research

    Membrane-anchored CCL20 augments HIV Env-specific mucosal immune responses

    Induction of broad immune responses at mucosal site remains a primary goal for most vaccines against mucosal pathogens. Abundance of evidence indicates that the co-delivery of mucosal adjuvants, including cyto...

    Xianliang Sun, Han Zhang, Shuiling Xu, Lili Shi, Jingjian Dong, Dandan Gao, Yan Chen and Hao Feng

    Virology Journal 2017 14:163

    Published on: 23 August 2017

  2. Research

    Prevalence of hepatitis-C virus genotypes and potential transmission risks in Malakand Khyber Pakhtunkhwa, Pakistan

    Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...

    Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam

    Virology Journal 2017 14:160

    Published on: 22 August 2017

  3. Research

    New insights into HCV replication in original cells from Aedes mosquitoes

    The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glyco...

    Catherine Fallecker, Alban Caporossi, Yassine Rechoum, Frederic Garzoni, Sylvie Larrat, Olivier François, Pascal Fender, Patrice Morand, Imre Berger, Marie-Anne Petit and Emmanuel Drouet

    Virology Journal 2017 14:161

    Published on: 22 August 2017

  4. Research

    ORF1a of highly pathogenic PRRS attenuated vaccine virus plays a key role in neutralizing antibody induction in piglets and virus neutralization in vitro

    Currently, porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens in swine in most countries, especially China. Two PRRSV attenuated live vaccine ...

    Chaoliang Leng, Wuchao Zhang, Hongliang Zhang, Yunchao Kan, Lunguang Yao, Hongyue Zhai, Mingliang Li, Zhen Li, Chunxiao Liu, Tongqing An, Jinmei Peng, Qian Wang, Yumin Leng, Xuehui Cai, Zhijun Tian and Guangzhi Tong

    Virology Journal 2017 14:159

    Published on: 22 August 2017

  5. Short Report

    Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

    Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010–2011 influenza seasons, nearly half o...

    Julie McAuley, Yi-Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr and Lorena Brown

    Virology Journal 2017 14:162

    Published on: 22 August 2017

  6. Research

    Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies

    Adenoviruses are common pathogens infecting animals and humans. They are classified based on serology, or genome sequence information. These methods have limitations due to lengthy procedures or lack of infect...

    Martin Pacesa, Rodinde Hendrickx, Manuela Bieri, Justin W. Flatt, Urs F. Greber and Silvio Hemmi

    Virology Journal 2017 14:158

    Published on: 18 August 2017

  7. Research

    Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection

    Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. Therefore, these cellular proteases are putative target...

    Winke Van der Gucht, Annelies Leemans, Marjorie De Schryver, Annick Heykers, Guy Caljon, Louis Maes, Paul Cos and Peter L. Delputte

    Virology Journal 2017 14:157

    Published on: 17 August 2017

  8. Short Report

    Detection and genetic characterization of canine astroviruses in pet dogs in Guangxi, China

    Astroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species. Human AstVs were regarded the causative agent of viral diarrhea in children. In dogs, little is known about t...

    Huabo Zhou, Lin Liu, Ruikai Li, Yifeng Qin, Qingli Fang, Vinod RMT Balasubramaniam, Guojun Wang, Zuzhang Wei, Kang Ouyang, Weijian Huang and Ying Chen

    Virology Journal 2017 14:156

    Published on: 17 August 2017

  9. Short Report

    An equine herpesvirus type 1 (EHV-1) vector expressing Rift Valley fever virus (RVFV) Gn and Gc induces neutralizing antibodies in sheep

    Rift Valley fever virus (RVFV) is an arthropod-borne bunyavirus that can cause serious and fatal disease in humans and animals. RVFV is a negative-sense RNA virus of the Phlebovirus genus in the Bunyaviridae fami...

    Abdelrahman Said, Mona Elmanzalawy, Guanggang Ma, Armando Mario Damiani and Nikolaus Osterrieder

    Virology Journal 2017 14:154

    Published on: 14 August 2017

  10. Research

    The impact of p53 on the early stage replication of retrovirus

    The function of p53 in cancer biology has been studied extensively, but its role in anti-retrovirus infection has been elusive for many years. The restriction of retrovirus early stage replication by p53 was i...

    Michaela Kinnetz, Faris Alghamdi, Michael Racz, Wenwei Hu and Binshan Shi

    Virology Journal 2017 14:151

    Published on: 9 August 2017

  11. Research

    A novel bladder cancer - specific oncolytic adenovirus by CD46 and its effect combined with cisplatin against cancer cells of CAR negative expression

    Conditionally replicative oncolytic adenoviruses (CRAds) display significant anti-tumor effects. However, the traditional adenovirus of serotype 5 (Ad5) entering cancer cells via coxsackie virus and adenovirus...

    Wenjuan Cao, Junqiang Tian, Chong Li, Yanjun Gao, Xingchen Liu, Jianzhong Lu, Yuhan Wang, Zhiping Wang, Robert S. Svatek and Ronald Rodriguez

    Virology Journal 2017 14:149

    Published on: 8 August 2017

  12. Research

    Co-infection of two reoviruses increases both viruses accumulation in rice by up-regulating of viroplasm components and movement proteins bilaterally and RNA silencing suppressor unilaterally

    Synergism between southern rice black-streaked dwarf virus (SRBSDV) and rice ragged stunt virus (RRSV) not only aggravates disease symptoms but also enhances their vector acquisition efficiencies by increasing...

    Shu Li, Tong Zhang, Yingzhi Zhu and Guohui Zhou

    Virology Journal 2017 14:150

    Published on: 8 August 2017

  13. Research

    Association of the tandem polymorphisms (rs148314165, rs200820567) in TNFAIP3 with chronic hepatitis B virus infection in Chinese Han population

    Chronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene, is complicated in HB...

    Na Li, Ying Shi, Pingping Zhang, Jiao Sang, Fang Li, Huan Deng, Yi Lv, Qunying Han and Zhengwen Liu

    Virology Journal 2017 14:148

    Published on: 7 August 2017

  14. Research

    Crimean Congo hemorrhagic fever among the one-humped camel (Camelus dromedaries) in Central Sudan

    Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonotic disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the genus Nairovirus in the family Bunyaviridae. CCHF is typicall...

    Hajer M. Suliman, Ibrahim A. Adam, Shamseldin I. Saeed, Sanaa A. Abdelaziz, Eltahir M. Haroun and Imadeldin E. Aradaib

    Virology Journal 2017 14:147

    Published on: 3 August 2017

  15. Research

    3-(2-Chloropropyl amide)-4-methoxy-N-phenylbenzamide inhibits expression of HPV oncogenes in human cervical cancer cell

    Human papillomaviruses (HPVs) are the primary causative agents for cervical cancer, and HPV oncoproteins E6 and E7 are known to be the main reason for the onset and maintenance of the malignancies. Therefore, ...

    Fang Han, Yanping Li, Qiaoni Lu, Linlin Ma, Huiqiang Wang, Jiandong Jiang, Zhuorong Li and Yuhuan Li

    Virology Journal 2017 14:145

    Published on: 28 July 2017

  16. Research

    Occurrence of a novel mastrevirus in sugarcane germplasm collections in Florida, Guadeloupe and Réunion

    In Africa and Asia, sugarcane is the host of at least seven different virus species in the genus Mastrevirus of the family Geminiviridae. However, with the exception of Sugarcane white streak virus in Barbados, n...

    Wardatou Boukari, Ricardo I. Alcalá-Briseño, Simona Kraberger, Emmanuel Fernandez, Denis Filloux, Jean-Heinrich Daugrois, Jack C. Comstock, Jean-Michel Lett, Darren P. Martin, Arvind Varsani, Philippe Roumagnac, Jane E. Polston and Philippe C. Rott

    Virology Journal 2017 14:146

    Published on: 28 July 2017

  17. Research

    Rubella, herpes simplex virus type 2 and preeclampsia

    Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.

    Shimos A. Alshareef, Ahmed M. Eltom, Abubakr M. Nasr, Hamdan Z. Hamdan and Ishag Adam

    Virology Journal 2017 14:142

    Published on: 26 July 2017

  18. Research

    Molecular evolution of two asymptomatic echovirus 6 strains that constitute a novel branch of recently epidemic echovirus 6 in China

    Echovirus 6 (E6) infections are associated with aseptic meningitis and acute flaccid paralysis (AFP). But some infections, sometimes most of them, are asymptomatic. The mechanism of E6 virulence is unknown. An...

    Hao Sun, Xiaoqin Huang, Keqin Lin, Kai Huang, Jiayou Chu, Zhaoqing Yang and Shaohui Ma

    Virology Journal 2017 14:140

    Published on: 25 July 2017

  19. Research

    Avian influenza H9N2 virus isolated from air samples in LPMs in Jiangxi, China

    Recently, avian influenza virus has caused repeated worldwide outbreaks in humans. Live Poultry Markets (LPMs) play an important role in the circulation and reassortment of novel Avian Influenza Virus (AIVs). ...

    Xiaoxu Zeng, Mingbin Liu, Heng Zhang, Jingwen Wu, Xiang Zhao, Wenbing Chen, Lei Yang, Fenglan He, Guoyin Fan, Dayan Wang, Haiying Chen and Yuelong Shu

    Virology Journal 2017 14:136

    Published on: 24 July 2017

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