AshwaqAhmed A, KrishnanNair B, JamiluAbubakar B, FaezFirdausJesse A, ZeenatulAllaudin N, Rasedee A, et al. Cytomegalovirus replication steps and the actions of antiviral drugs. Anti-Infect Agents. 2018;16(2):80–95.
Article
CAS
Google Scholar
Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev. 2013;26(1):86–102.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lachmann R, Loenenbach A, Waterboer T, Brenner N, Pawlita M, Michel A, et al. Cytomegalovirus (CMV) seroprevalence in the adult population of Germany. PLoS ONE. 2018;13(7):e0200267-e.
Article
CAS
Google Scholar
Wurzer P, Guillory A, Parvizi D, Clayton RP, Branski LK, Kamolz L-P, et al. Human herpes viruses in burn patients: a systematic review. Burns. 2017;43(1):25–33.
Article
PubMed
Google Scholar
Vancíková Z, Dvorák P. Cytomegalovirus infection in immunocompetent and immunocompromised individuals—a review. Curr Drug Targets Immune Endocr Metabol Disord. 2001;1(2):179–87.
Article
PubMed
Google Scholar
Kim CS. Congenital and perinatal cytomegalovirus infection. Korean J Pediatr. 2010;53:14.
Article
Google Scholar
Malm G, Engman M-L. Congenital cytomegalovirus infections. Sem Fetal Neonatal Med. 2007;12(3):154–9.
Article
Google Scholar
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391(6669):806–11.
Article
CAS
PubMed
Google Scholar
Dana H, Chalbatani GM, Mahmoodzadeh H, Karimloo R, Rezaiean O, Moradzadeh A, et al. Molecular mechanisms and biological functions of siRNA. Int J Biomed Sci. 2017;13(2):48–57.
PubMed
PubMed Central
Google Scholar
Ahmadzada T, Reid G, McKenzie DR. Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer. Biophys Rev. 2018;10(1):69–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barik S. siRNA for influenza therapy. Viruses. 2010;2(7):1448–57.
Article
CAS
PubMed
PubMed Central
Google Scholar
Levanova A, Poranen MM. RNA interference as a prospective tool for the control of human viral infections. Front Microbiol. 2018;9:2151.
Article
PubMed
PubMed Central
Google Scholar
Chen J, Li F, Xu Y, Zhang W, Hu Y, Fu Y, et al. Cholesterol modification of SDF-1-specific siRNA enables therapeutic targeting of angiogenesis through Akt pathway inhibition. Exp Eye Res. 2019;184:64–71.
Article
CAS
PubMed
Google Scholar
Flisiak R, Jaroszewicz J, Łucejko M. siRNA drug development against hepatitis B virus infection. Expert Opin Biol Ther. 2018;18(6):609–17.
Article
CAS
PubMed
Google Scholar
Togtema M, Jackson R, Grochowski J, Villa PL, Mellerup M, Chattopadhyaya J, et al. Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches. Nanomedicine. 2018;13(4):455–74.
Article
CAS
PubMed
Google Scholar
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411(6836):494–8.
Article
CAS
PubMed
Google Scholar
Qureshi A, Tantray VG, Kirmani AR, Ahangar AG. A review on current status of antiviral siRNA. Rev Med Virol. 2018;28(4):e1976.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grimm D, Kay MA. Combinatorial RNAi: a winning strategy for the race against evolving targets? Mol Ther J Am Soc Gene Ther. 2007;15(5):878–88.
Article
CAS
Google Scholar
Boden D, Pusch O, Lee F, Tucker L, Ramratnam B. Human immunodeficiency virus type 1 escape from RNA interference. J Virol. 2003;77(21):11531–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gitlin L, Stone JK, Andino R. Poliovirus escape from RNA Interference: short Interfering RNA-target recognition and implications for therapeutic approaches. J Virol. 2005;79(2):1027–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wilson JA, Richardson CD. Hepatitis C virus replicons escape RNA interference induced by a short interfering RNA directed against the NS5b coding region. J Virol. 2005;79(11):7050–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang X, Zheng H, Xu M, Zhou Y, Li X, Yang F, et al. Evaluation of a combinatorial RNAi lentivirus vector targeting foot-and-mouth disease virus in vitro and in vivo. Mol Med Rep. 2015;12(5):6672–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mandal A, Ganta KK, Chaubey B. Combinations of siRNAs against La autoantigen with NS5B or hVAP-A have additive effect on inhibition of HCV replication. Hepatitis Res Treat. 2016. https://doi.org/10.1155/2016/9671031.
Article
Google Scholar
Braga ACS, Carneiro BM, Batista MN, Akinaga MM, Rahal P. Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90. Cell Stress Chaperones. 2017;22(1):113–22.
Article
CAS
PubMed
Google Scholar
McDonagh P, Sheehy PA, Norris JM. Combination siRNA therapy against feline coronavirus can delay the emergence of antiviral resistance in vitro. Vet Microbiol. 2015;176(1–2):10–8.
Article
CAS
PubMed
Google Scholar
Abdullah JM, Ahmad F, Ahmad KA, Ghazali MM, Jaafar H, Ideris A, et al. Molecular genetic analysis of BAX and cyclin D1 genes in patients with malignant glioma. Neurol Res. 2007;29(3):239–42.
Article
CAS
PubMed
Google Scholar
ShenNi L, Allaudin ZN, MohdLila MA, Othman AM, Othman F. Selective apoptosis induction in MCF-7 cell line by truncated minimal functional region of apoptin. BMC Cancer. 2013;13(1):488.
Article
CAS
Google Scholar
Hani H, Ibrahim TA, Othman AM, Lila MA, Allaudin ZN. Isolation, density purification, and in vitro culture maintenance of functional caprine islets of Langerhans as an alternative islet source for diabetes study. Xenotransplantation. 2010;17(6):469–80.
Article
PubMed
Google Scholar
Vakhshiteh F, Allaudin ZN, MohdLila MA, Hani H. Size-related assessment on viability and insulin secretion of caprine islets in vitro. Xenotransplantation. 2013;20(2):82–8.
Article
PubMed
Google Scholar
Loh HS, Mohd-Azmi ML, Lai KY, Sheikh-Omar AR, Zamri-Saad M. Characterization of a novel rat cytomegalovirus (RCMV) infecting placenta-uterus of Rattus rattus diardii. Arch Virol. 2003;148(12):2353–67.
Article
CAS
PubMed
Google Scholar
Loh H-S, Mohd-Lila M-A, Abdul-Rahman S-O, Kiew L-J. Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus. Virol J. 2006;3(1):42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Balakrishnan KN, Abdullah AA, Camalxaman SN, Quah YW, Abba Y, Hani H, et al. Complete genome sequence of rat cytomegalovirus strain ALL-03 (Malaysian Strain). Genome announcements: American Society for Microbiology; 2015. p. e00451-15.
Google Scholar
Balakrishnan KN, Abdullah AA, Bala J, Abba Y, Sarah SA, Jesse FFA, et al. Identification and comparison of RCMV ALL 03 open reading frame (ORF) among several different strains of cytomegalovirus worldwide. Infect Genet Evol. 2017;54:81–90.
Article
CAS
PubMed
Google Scholar
Reed LJ, Muench H. A simple method of estimating fifty per cent endpoints. Am J Epidemiol. 1938;27(3):493–7.
Article
Google Scholar
Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55(4):611–22.
Article
CAS
PubMed
Google Scholar
Haimes JD, Kelley MA. Demonstration of a ΔΔCq calculation method to compute relative gene expression from qPCR data. USA: Thermo Scientific; 2015.
Google Scholar
Torre-Cisneros J, Aguado JM, Caston JJ, Almenar L, Alonso A, Cantisán S, et al. Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations. Transpl Rev. 2016;30(3):119–43.
Article
CAS
Google Scholar
Schleiss MR, Permar SR, Plotkin SA. Progress toward development of a vaccine against congenital cytomegalovirus infection. Clin Vacc Immunol. 2017a;24(12):e00268-17.
Article
Google Scholar
Bruminhent J, Razonable RR. Management of cytomegalovirus infection and disease in liver transplant recipients. World J Hepatol. 2014;6(6):370–83.
Article
PubMed
PubMed Central
Google Scholar
Lawrence RS, Durch JS, Stratton KR. Vaccines for the 21st century: a tool for decisionmaking. New York: National Academies Press; 2001.
Google Scholar
Plotkin SA, Boppana SB. Vaccination against the human cytomegalovirus. Vaccine. 2019;37(50):7437–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schleiss MR, Permar SR, Plotkin SA. Progress toward development of a vaccine against congenital cytomegalovirus infection. Clin Vaccine Immunol. 2017b;24(12):e00268-e317.
Article
CAS
PubMed
PubMed Central
Google Scholar
Martin-Vicente M, Resino S, Martinez I. siRNA-mediated simultaneous regulation of the cellular innate immune response and human respiratory syncytial virus replication. Biomolecules. 2019;9(5):165.
Article
CAS
PubMed Central
Google Scholar
Xin X-M, Li G-Q, Jin Y-Y, Zhuang M, Li D. Combination of small interfering RNAs mediates greater suppression on hepatitis B virus cccDNA in HepG2. 2.15 cells. World J Gastroenterol. 2008;14(24):3849.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bian Z, Xiao A, Cao M, Liu M, Liu S, Jiao Y, et al. Anti-HBV efficacy of combined siRNAs targeting viral gene and heat shock cognate 70. Virol J. 2012;9(1):275.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vigne S, Duraffour S, Andrei G, Snoeck R, Garin D, Crance J-M. Inhibition of vaccinia virus replication by two small interfering RNAs targeting B1R and G7L genes and their synergistic combination with cidofovir. Antimicrob Agents Chemother. 2009;53(6):2579–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sohail M, Doran G, Riedemann J, Macaulay V, Southern EM. A simple and cost-effective method for producing small interfering RNAs with high efficacy. Nucleic Acids Res. 2003;31(7):e38-e.
Article
CAS
Google Scholar
Gaglione M, Mercurio ME, Potenza N, Mosca N, Russo A, Novellino E, et al. Synthesis and gene silencing properties of siRNAs containing terminal amide linkages. Biomed Res Int. 2014;2014:901617.
Article
PubMed
PubMed Central
Google Scholar
Potaczek DP, Garn H, Unger SD, Renz H. Antisense molecules: A new class of drugs. J Allergy Clin Immunol. 2016;137(5):1334–46.
Article
CAS
PubMed
Google Scholar
Saw PE, Song EW. siRNA therapeutics: a clinical reality. Sci China Life Sci. 2019;63:485.
Article
CAS
PubMed
Google Scholar
Hu B, Weng Y, Xia X-H, Liang X, Huang Y. Clinical advances of siRNA therapeutics. J Gene Med. 2019;21(7):e3097.
Article
PubMed
Google Scholar
Setten RL, Rossi JJ, Han S. The current state and future directions of RNAi-based therapeutics. Nature Rev Drug Discov. 2019;18(6):421–46.
Article
CAS
Google Scholar
Taylor SC, Laperriere G, Germain H. Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from variable nonsense to publication quality data. Sci Rep. 2017;7(1):2409.
Article
CAS
PubMed
PubMed Central
Google Scholar
Quan P-L, Sauzade M, Brouzes E. dPCR: a technology review. Sensors (Basel). 2018;18(4):1271.
Article
CAS
Google Scholar
Thomson BJ. Viruses and apoptosis. Int J Exp Pathol. 2001;82(2):65–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Çam M, Handke W, Picard-Maureau M, Brune W. Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins. Cell Death Differ. 2010;17(4):655–65.
Article
CAS
PubMed
Google Scholar
Richman DD, Nathanson N. Chapter 20—Antiviral therapy. In: Katze MG, Korth MJ, Law GL, Nathanson N, editors. Viral pathogenesis. 3rd ed. Boston: Academic Press; 2016. p. 271–87.
Chapter
Google Scholar
Koller E, Propp S, Murray H, Lima W, Bhat B, Prakash TP, et al. Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res. 2006;34(16):4467–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kurreck J. siRNA efficiency: structure or sequence-that is the question. J Biomed Biotechnol. 2006;2006(4):83757.
PubMed
PubMed Central
Google Scholar
He F, Han Y, Gong J, Song J, Wang H, Li Y. Predicting siRNA efficacy based on multiple selective siRNA representations and their combination at score level. Sci Rep. 2017;7(1):44836.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xiaofei E, Stadler BM, Debatis M, Wang S, Lu S, Kowalik TF. RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions. J Virol. 2012;86(10):5660–73.
Article
CAS
PubMed
Google Scholar
Bala JA, Balakrishnan KN, Abdullah AA, Adamu L, Noorzahari MS, May LK, et al. An association of Orf virus infection among sheep and goats with herd health programme in Terengganu state, eastern region of the peninsular Malaysia. BMC Vet Res. 2019;15(1):250.
Article
CAS
PubMed
PubMed Central
Google Scholar
Laere E, Ling APK, Wong YP, Koh RY, Mohd Lila MA, Hussein S. Plant-based vaccines: production and challenges. J Bot. 2016;2016:4928637.
Google Scholar