A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV). The vac...
Authors: Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li and Shuli Zhao
Echoviruses, a serotype of enteroviruses, infect millions of people globally and there is no specific drug treatment or vaccine available for its management. The screening of medicinal plants used locally for ...
Authors: Omonike O. Ogbole, Toluwanimi E. Akinleye, Peter A. Segun, Temitope C. Faleye and Adekunle J. Adeniji
Small hydrophobic (SH) gene is one of the mostly diverse genomic regions of human respiratory syncytial virus (HRSV). Its coding region constitutes less than 50% of the complete gene length, enabling SH gene t...
Authors: Jelena Ivancic-Jelecki, Anamarija Slovic, Sunčanica Ljubin-Sternak, Gordana Mlinarić Galinović and Dubravko Forcic
Serologic detection of Zika virus (ZIKV) infections is challenging because of antigenic similarities among flaviviruses.
Authors: Mariana Kikuti, Laura B. Tauro, Patrícia S. S. Moreira, Gúbio S. Campos, Igor A. D. Paploski, Scott C. Weaver, Mitermayer G. Reis, Uriel Kitron and Guilherme S. Ribeiro
A treatment of HCV infection depends on the genotype and sub-genotype. Therefore, accurate HCV genotyping is critical for selecting the appropriate treatment regimen.
Authors: Shrikant Dasharath Warkad, Satish Balasaheb Nimse, Keum-Soo Song, Wasun Chantratita, Viroj Pongthanapisith, Laxman Uddhav Nawale and Taisun Kim
Equid herpesviruses (EHVs) are widespread in equine populations worldwide. While the infection with equine α-herpesviruses (EHV-1 and EHV-4) has been linked to several clinical outcomes, the pathogenic potenti...
Authors: Karol Stasiak, Magdalena Dunowska and Jerzy Rola
Rice stripe virus (RSV) belongs to the genus Tenuivirus. It is transmitted by small brown planthoppers in a persistent and circulative-propagative manner and causes rice stripe disease (RSD). The NS3 protein of R...
Authors: Gentu Wu, Guixian Zheng, Qiao Hu, Mingge Ma, Mingjun Li, Xianchao Sun, Fei Yan and Ling Qing
Astroviruses (AstVs) are responsible for infection of a large diversity of mammalian and avian species, including bats, aquatic birds, livestock and humans. We investigated AstVs circulation in bats in Mozambi...
Authors: Flora Hoarau, Gildas Le Minter, Léa Joffrin, M. Corrie Schoeman, Erwan Lagadec, Beza Ramasindrazana, Andréa Dos Santos, Steven M. Goodman, Eduardo S. Gudo, Patrick Mavingui and Camille Lebarbenchon
Canine parvovirus (CPV) has been considered to be an important pathogen, which can cause acute infectious disease in canids. Although current vaccines are effective in preventing CPV infection, safety problems...
Authors: Liangliang Nan, Yunchao Liu, Pengchao Ji, Hua Feng, Chen Chen, Juan Wang, Dongmin Liu, Yinglei Cui, Yanwei Wang, Yafei Li, Enmin Zhou and Gaiping Zhang
Pig diarrhea causes high mortality and large economic losses in the swine industry. Transmissible gastroenteritis virus (TGEV) causes pig diarrhea, with 100% mortality in piglets less than 2 weeks old. No inve...
Authors: Lu Xia, Yunhan Yang, Jialu Wang, Yuchao Jing and Qian Yang
Chinese woodchucks (M. himalayana) were recently found to be susceptible to woodchuck hepatitis virus (WHV) infection. In this study, we aimed to determine the susceptibility to WHV infection of M. himalayana fro...
Authors: Bin Zhu, Zhenni Zhu, Junzhong Wang, Shunmei Huang, Fanghui Li, Lu Wang, Yanan Liu, Qi Yan, Shunchang Zhou, Mengji Lu, Dongliang Yang and Baoju Wang
Avian keratin disorder (AKD) is an epizootic of debilitating beak deformities, first documented in black-capped chickadees (Poecile atricapillus) in Alaska during the late 1990s. Similar deformities have now been...
Authors: Maxine Zylberberg, Caroline Van Hemert, Colleen M. Handel and Joseph L. DeRisi
Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenavirus...
Authors: Amélie D. Zaza, Cécile H. Herbreteau and Christophe N. Peyrefitte
In September 2009, a mumps outbreak originated in New York and spread to Northeastern USA and Canada. This study compares the performance of different diagnostic testing methods used in Ontario and describes m...
Authors: Arnaud G. L’Huillier, Alireza Eshaghi, C. Sarai Racey, Katherene Ogbulafor, Ernesto Lombos, Rachel R. Higgins, David C. Alexander, Erik Kristjanson, Jocelyn Maregmen, Jonathan B. Gubbay and Tony Mazzulli
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), a tick borne bunyavirus. However, Immunohistochemistry of SFTS patients are not well stud...
Authors: Shibo Li, Yang Li, Qiujing Wang, Xuewen Yu, Miaomiao Liu, Haibo Xie, Liyong Qian, Ling Ye, Zhejuan Yang, Jianjing Zhang, Huimin Zhu and Wenhong Zhang
Torque teno virus is a small chronically persisting circular negative ssDNA virus reaching near 100% prevalence. It is reported to be a marker for immune function in immunocompromised patients. The possibility...
Authors: Elena A. Tyschik, Anastasiya S. Rasskazova, Anna V. Degtyareva, Denis V. Rebrikov and Gennady T. Sukhikh
Emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) in North America, Asia and Europe has caused severe economic loss to the global swine industry. However, the virome of PEDV infected pigs an...
Authors: Qi Chen, Leyi Wang, Ying Zheng, Jianqiang Zhang, Baoqing Guo, Kyoung-Jin Yoon, Phillip C. Gauger, Karen M. Harmon, Rodger G. Main and Ganwu Li
Currently, the role of human papillomavirus (HPV)-58 in southwestern China has been unexplored. Although there is some controversy, it is proposed that the viral load of HPV correlates with the severity of int...
Authors: Wenbo Long, Zixi Yang, Xiabin Li, Ming Chen, Jie Liu, Yuanxue Zhang and Xingwang Sun
Cucurbit chlorotic yellows virus (CCYV), a bipartite crinivirus, causes chlorotic leaf spots and yellowing symptoms on cucurbit leaves. We previously developed an infectious clone of CCYV. Limited work has been c...
Authors: Ying Wei, Xiaoyu Han, Zhenyue Wang, Qinsheng Gu, Honglian Li, Linlin Chen, Bingjian Sun and Yan Shi
Grass carp (Ctenopharyngodon idella) hemorrhagic disease is caused by an acute infection with grass carp reovirus (GCRV). The frequent outbreaks of this disease have suppressed development of the grass carp farmi...
Authors: Hao Wang, Weisha Liu, Meng Sun, Dubo Chen, Lingbing Zeng, Liqun Lu and Jing Xie
Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe the effect of HMPV genotypes and/or viral load on di...
Authors: Xiang Yong Oong, Jack Bee Chook, Kim Tien Ng, Wei Zhen Chow, Kok Gan Chan, Nik Sherina Hanafi, Yong Kek Pang, Yoke Fun Chan, Adeeba Kamarulzaman and Kok Keng Tee
Maize lethal necrosis is caused by a synergistic co-infection of Maize chlorotic mottle virus (MCMV) and a specific member of the Potyviridae, such as Sugarcane mosaic virus (SCMV), Wheat streak mosaic virus (WSM...
Authors: Mwathi Jane Wamaitha, Deepti Nigam, Solomon Maina, Francesca Stomeo, Anne Wangai, Joyce Njoki Njuguna, Timothy A. Holton, Bramwel W. Wanjala, Mark Wamalwa, Tanui Lucas, Appolinaire Djikeng and Hernan Garcia-Ruiz
Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, causing a major risk of liver disease and hepatocellular carcinoma (HCC). Many mouse models have been tried to establish ...
Authors: Xian Wang, Jianmin Zhu, Yong Zhang, Yue Li, Tai Ma, Qun Li, Jiegou Xu and Long Xu
Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strain...
Authors: Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang and Yuhuan Li
N6-methyl-adenosine (m6A) is a prevalent RNA modification in many species. Abnormal m6A methylation levels can lead to RNA dysfunction and can cause diseases. Tobacco mosai...
Authors: Zhurui Li, Jing Shi, Lu Yu, Xiaozhen Zhao, Longlu Ran, Deyu Hu and Baoan Song
Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in...
Authors: Kasthuri Prakash, Gustaf E. Rydell, Simon B. Larsson, Maria Andersson, Gunnar Norkrans, Heléne Norder and Magnus Lindh
‘Rapid Apple Decline’ (RAD) is a newly emerging problem of young, dwarf apple trees in the Northeastern USA. The affected trees show trunk necrosis, cracking and canker before collapse in summer. In this study...
Authors: Huawei Liu, Liping Wu, Ekaterina Nikolaeva, Kari Peter, Zongrang Liu, Dimitre Mollov, Mengji Cao and Ruhui Li
Chikungunya virus (CHIKV) and dengue virus (DENV) are arboviruses that share the same Aedes mosquito vector, and there is much overlap in endemic areas. In India, co-infection with both viruses is often reported....
Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavi...
Adverse drug reactions (ADRs) are a significant problem for HIV patients, with the risk of developing ADRs increasing as the infection progresses to AIDS. However, the pathophysiology underlying ADRs remains u...
Authors: Kemi Adeyanju, John R. Bend, Michael J. Rieder and Gregory A. Dekaban
Human adenovirus (HAdV) serotypes 2, 3 and 7 are more prevalent than other serotypes and have been associated with severe pneumonia in pediatric children. Molecular typing of HAdV is not routinely performed in...
Authors: Fang-zhou Qiu, Xin-xin Shen, Meng-chuan Zhao, Li Zhao, Su-xia Duan, Chen Chen, Ju-Ju Qi, Gui-xia Li, Le Wang, Zhi-shan Feng and Xue-jun Ma
The human T-lymphotropic virus type 1 (HTLV-1) affects 2–5 million people worldwide, and is associated with a number of degenerative and infectious diseases. The Envelope glycoproteins (gp) are highly conserve...
Authors: Maria de Nazaré do Socorro de Almeida Viana, Akim Felipe Santos Nobre, Edivaldo Costa Jr, Ingrid Christiane Silva, Bruna Teles Pinheiro, Cássia Cristine Costa Pereira, Louise de Souza Canto Ferreira, Danilo Souza de Almeida, Marcos William Leão de Araújo, Mariza da Silva Borges, Carlos Araujo da Costa, Edna Aoba Yassui Ishikawa, Stephen Francis Ferrari and Maísa Silva de Sousa
Zika virus infection in new born is linked to congenital syndromes, especially microcephaly. Studies have shown that these neuropathies are the result of significant death of neuronal progenitor cells in the c...
Authors: Julie Gaburro, Asim Bhatti, Vinod Sundaramoorthy, Megan Dearnley, Diane Green, Saeid Nahavandi, Prasad N. Paradkar and Jean-Bernard Duchemin
Rotavirus infection is the most common cause of severe gastroenteritis in children under five years of age in both developed and developing countries. The World Health Organisation (WHO) recommends the surveil...
Authors: Catherine Boni-cisse, Sindou Meite, Alice Britoh Mlan, Flore Zaba, Rebecca N’Guessan, Nicaise Aka Lepri and Bélinda Lartey
The Oral Polio Vaccine (OPV or Sabin) is genetically unstable and may mutate to form vaccine-derived polioviruses (VDPVs).
Authors: Mary Bridget Nanteza, Barnabas Bakamutumaho, Annet Kisakye, Prossy Namuwulya, Henry Bukenya, Edson Katushabe, Josephine Bwogi, Charles Rutebarika Byabamazima, Raffaella Williams and Nicksy Gumede
Variations in HPV LCR/E6/E7 have been shown to be associated with the viral persistence and cervical cancer development. So far, there are few reports about the polymorphisms of the HPV-58 LCR/E6/E7 sequences ...
Authors: Juemin Xi, Junying Chen, Miaoling Xu, Hongying Yang, Songjiao Wen, Yue Pan, Xiaodan Wang, Chao Ye, Lijuan Qiu and Qiangming Sun
The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six...
Authors: Ameh S. James, Shawn Todd, Nina M. Pollak, Glenn A. Marsh and Joanne Macdonald
Infection with Parvovirus B19 (B19V), Cytomegalovirus (CMV) and Herpes Simplex Virus-1/2 (HSV-1/2) may cause fetal loses including spontaneous abortion, intrauterine fetal death and non-immune hydrops fetalis....
Authors: Ya-Ling Gao, Zhan Gao, Miao He and Pu Liao
To investigate the predictive capability of microRNAs (miRNAs) prior treatment for HBsAg clearance in chronic hepatitis B (CHB) treated with pegylated interferon α-2a (PEG-IFNα-2a).
Authors: Yanlin Yang, Ming Liu, Ying Deng, Yan Guo, Xuqing Zhang, Dedong Xiang, Li Jiang, Zhonglan You, Yi Wu, Maoshi Li and Qing Mao
In China, the rice pathogen Rice yellow stunt virus (RYSV), a member of the genus Nucleorhabdovirus in the family Rhabdoviridae, was a severe threat to rice production during the1960s and1970s. Fundamental aspect...
Authors: Haitao Wang, Juan Wang, Yunjie Xie, Zhijun Fu, Taiyun Wei and Xiao-Feng Zhang
Mosquitoes are the potential vectors for a variety of viruses that can cause diseases in the human and animal populations. Viruses in the order Picornavirales infect a broad range of hosts, including mosquitoes. ...
Authors: Harindranath Cholleti, Juliette Hayer, Jose Fafetine, Mikael Berg and Anne-Lie Blomström
Enteroviruses account for about one billion infections worldwide each year, the majority remain asymptomatic. Data on enterovirus infections during pregnancy appear to be very rare. Several cases have been rep...
Authors: Z. Khediri, C. Vauloup-Fellous, A. Benachi, J. M. Ayoubi, L. Mandelbrot and O. Picone
Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), an...
Authors: Nguyen Thi Thuy Chinh B’Krong, Ngo Ngoc Quang Minh, Phan Tu Qui, Tran Thi Hong Chau, Ho Dang Trung Nghia, Lien Anh Ha Do, Nguyen Ngoc Nhung, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan, H. Rogier van Doorn and Tran Tan Thanh
With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the ...
Authors: Tessa Slater, Isabella Eckerle and Kin-Chow Chang
Analysis of metagenomic sequences has become the principal approach for the study of the diversity of viruses. Many recent, extensive metagenomic studies on several classes of viruses have dramatically expande...
Authors: Natalya Yutin, Disa Bäckström, Thijs J. G. Ettema, Mart Krupovic and Eugene V. Koonin
Nucleo-cytoplasmic large DNA viruses are doubled stranded DNA viruses capable of infecting eukaryotic cells. Since the discovery of Mimivirus and Pandoravirus, there has been no doubt about their extraordinary...
Authors: Julien Andreani, Jonathan Verneau, Didier Raoult, Anthony Levasseur and Bernard La Scola
Endometrial cancer (EC) is one of the most common gynecological malignancies globally. Although progress has been made in surgical and other adjuvant therapies, there is still a great need to develop new appro...
Kadipiro virus (KDV) belongs to the Reoviridae family, which consists of segmented, non-enveloped, double-stranded RNA viruses. It has previously been isolated from Culex, Anopheles, Armigeres and Aedes mosquitoe...
Authors: Weijia Zhang, Fan Li, Aiguo Liu, Xiaojuan Lin, Shihong Fu, Jingdong Song, Guifang Liu, Nan Shao, Zexin Tao, Qianying Wang, Ying He, Wenwen Lei, Guodong Liang, Aiqiang Xu, Li Zhao and Huanyu Wang
Rift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon...
Authors: Serge Alain Sadeuh-Mba, Gide Martial Yonga Wansi, Maurice Demanou, Antoine Gessain and Richard Njouom
Iris yellow spot virus (IYSV) is an Orthotospovirus that infects most Allium species. Very few approaches for specific detection of IYSV from infected plants are available to date. We report the development of a ...
Authors: Cui Yu, Cuiyun Yang, Shaoyi Song, Zixiang Yu, Xueping Zhou and Jianxiang Wu
