Opriessnig T, Xiao CT, Halbur PG, Gerber PF, Matzinger SR, Meng XJ. A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naive pigs under experimental conditions. Vaccine. 2017;35:248–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gillespie J, Opriessnig T, Meng XJ, Pelzer K, Buechner-Maxwell V. Porcine circovirus type 2 and porcine circovirus-associated disease. J Vet Intern Med. 2009;23:1151–63.
Article
CAS
PubMed
Google Scholar
Nawagitgul P, Morozov I, Bolin SR, Harms PA, Sorden SD, Paul PS. Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein. J Gen Virol. 2000;81:2281–7.
Article
CAS
PubMed
Google Scholar
Liu J, Chen I, Kwang J. Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis. J Virol. 2005;79:8262–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
He J, Cao J, Zhou N, Jin Y, Wu J, Zhou J. Identification and functional analysis of the novel ORF4 protein encoded by porcine circovirus type 2. J Virol. 2013;87:1420–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Davies B, Wang X, Dvorak CM, Marthaler D, Murtaugh MP. Diagnostic phylogenetics reveals a new porcine circovirus 2 cluster. Virus Res. 2016;217:32–7.
Article
CAS
PubMed
Google Scholar
Huan C, Fan M, Cheng Q, Wang X, Gao Q, Wang W, et al. Evaluation of the efficacy and cross-protective immunity of live-attenuated chimeric PCV1-2b vaccine against PCV2b and PCV2d subtype challenge in pigs. Front Microbiol. 2018;9:455.
Article
PubMed
PubMed Central
Google Scholar
Li J, Shi JL, Wu XY, Fu F, Yu J, Yuan XY, et al. Improvement of the immunogenicity of porcine circovirus type 2 DNA vaccine by recombinant ORF2 gene and CpG motifs. Viral Immunol. 2015;28:290–6.
Article
CAS
PubMed
Google Scholar
Firth C, Charleston MA, Duffy S, Shapiro B, Holmes EC. Insights into the evolutionary history of an emerging livestock pathogen: porcine circovirus 2. J Virol. 2009;83:12813–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gerber PF, Johnson J, Shen H, Striegel D, Xiao CT, Halbur PG, et al. Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs. Res Vet Sci. 2013;95:775–81.
Article
CAS
PubMed
Google Scholar
Xiao CT, Harmon KM, Halbur PG, Opriessnig T. PCV2d-2 is the predominant type of PCV2 DNA in pig samples collected in the U.S. during 2014-2016, vet. Microbiol. 2016;197:72–7.
CAS
Google Scholar
Guo XQ, Wang LQ, Qiao H, Yang XW, Yang MF, Chen HY. Enhancement of the immunogenicity of a porcine circovirus type 2 DNA vaccine by a recombinant plasmid coexpressing capsid protein and porcine interleukin-6 in mice. Microbiol Immunol. 2015;59:174–80.
Article
CAS
PubMed
Google Scholar
Mitchell JA, Green TD, Bright RA, Ross TM. Induction of heterosubtypic immunity to influenza a virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins. Vaccine. 2003;21:902–14.
Article
CAS
PubMed
Google Scholar
Park C, Jeong J, Choi K, Park SJ, Kang I, Chae C. Development of porcine circovirus 2 (PCV2) open reading frame 2 DNA vaccine with different adjuvants and comparison with commercial PCV2 subunit vaccine in an experimental challenge. Can J Vet Res. 2017;81:171–7.
CAS
PubMed
PubMed Central
Google Scholar
Petrovsky N. Comparative safety of vaccine adjuvants: a summary of current evidence and future needs. Drug Saf. 2015;38:1059–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li L, Petrovsky N. Molecular adjuvants for DNA vaccines. Curr Issues Mol Biol. 2017;22:17–40.
Article
PubMed
Google Scholar
Zhang D, Xia Q, Wu J, Liu D, Wang X, Niu Z. Construction and immunogenicity of DNA vaccines encoding fusion protein of murine complement C3d-p28 and GP5 gene of porcine reproductive and respiratory syndrome virus. Vaccine. 2011;29:629–35.
Article
CAS
PubMed
Google Scholar
Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science. 1996;271:348–50.
Article
CAS
PubMed
Google Scholar
Yang S, Wang C, Fang X, Zhai L, Dong C, Ding L, et al. Fusion of C3d molecule with neutralization epitope(s) of hepatitis E virus enhances antibody avidity maturation and neutralizing activity following DNA immunization. Virus Res. 2010;151:162–9.
Article
CAS
PubMed
Google Scholar
Zhao K, Duan X, Hao L, Wang X, Wang Y. Immune effect of Newcastle disease virus DNA vaccine with C3d as a molecular adjuvant. J Microbiol Biotechnol. 2017;27:2060–9.
Article
CAS
PubMed
Google Scholar
Watanabe I, Ross TM, Tamura S, Ichinohe T, Ito S, Takahashi H, et al. Protection against influenza virus infection by intranasal administration of C3d-fused hemagglutinin. Vaccine. 2003;21:4532–8.
Article
CAS
PubMed
Google Scholar
Jeong J, Park C, Kim S, Park SJ, Kang I, Park KH, et al. Evaluation of the efficacy of a novel porcine circovirus type 2 synthetic peptide vaccine. Can J Vet Res. 2018;82:146–53.
PubMed
PubMed Central
Google Scholar
Fort M, Sibila M, Perez-Martin E, Nofrarias M, Mateu E, Segales J. One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model. Vaccine. 2009;27:4031–7.
Article
CAS
PubMed
Google Scholar
Alarcon P, Rushton J, Wieland B. Cost of post-weaning multi-systemic wasting syndrome and porcine circovirus type-2 subclinical infection in England - an economic disease model. Prev Vet Med. 2013;110:88–102.
Article
PubMed
PubMed Central
Google Scholar
Alarcon P, Rushton J, Nathues H, Wieland B. Economic efficiency analysis of different strategies to control post-weaning multi-systemic wasting syndrome and porcine circovirus type 2 subclinical infection in 3-weekly batch system farms. Prev Vet Med. 2013;110:103–18.
Article
PubMed
PubMed Central
Google Scholar
Karuppannan AK, Opriessnig T. Porcine circovirus type 2 (PCV2) vaccines in the context of current molecular epidemiology. Viruses. 2017;9:99.
Article
PubMed Central
Google Scholar
Chae C. Commercial porcine circovirus type 2 vaccines: efficacy and clinical application. Vet J. 2012;194:151–7.
Article
CAS
PubMed
Google Scholar
Seo HW, Han K, Park C, Chae C. Clinical, virological, immunological and pathological evaluation of four porcine circovirus type 2 vaccines. Vet J. 2014;200:65–70.
Article
CAS
PubMed
Google Scholar
Holvold LB, Myhr AI, Dalmo RA. Strategies and hurdles using DNA vaccines to fish. Vet Res. 2014;45:21.
Article
PubMed
PubMed Central
Google Scholar
Liu D, Niu ZX. Immunogenicity of a chicken viral Newcastle disease virus F gene-C3d fusion protein containing a chicken homologue of C3d. Viral Immunol. 2008;21:389–98.
Article
CAS
PubMed
Google Scholar
Wang L, Sunyer JO, Bello LJ. Fusion to C3d enhances the immunogenicity of the E2 glycoprotein of type 2 bovine viral diarrhea virus. J Virol. 2004;78:1616–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li GX, Tian ZJ, Yu H, Jin YY, Hou SH, Zhou YJ, et al. Fusion of C3d with hemagglutinin enhances protective immunity against swine influenza virus. Res Vet Sci. 2009;86:406–13.
Article
CAS
PubMed
Google Scholar