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  1. Nonstructural protein 1 (NS1) is a virulence factor encoded by influenza A virus (IAV) that is expressed in the nucleus and cytoplasm of host cells during the earliest stages of infection. NS1 is a multifuncti...

    Authors: Jinghua Cheng, Jie Tao, Benqiang Li, Ying Shi and Huili Liu

    Citation: Virology Journal 2019 16:152

    Content type: Research

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  2. Bluetongue virus (BTV), an emerging insect vector mediated pathogen affecting both wild ruminants and livestock, has a genome consisting of 10 linear double-stranded RNA genome segments. BTV has a severe econo...

    Authors: Qingyuan Xu, Jinying Ge, Maolin Li, Encheng Sun, Yawei Zhou, Yunze Guo, Donglai Wu and Zhigao Bu

    Citation: Virology Journal 2019 16:151

    Content type: Methodology

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  3. Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses i...

    Authors: Vladimir Berezin, Diyora Abdukhakimova, Lyudmila Trenozhnikova, Andrey Bogoyavlenskiy, Aizhan Turmagambetova, Alpamys Issanov and Azliyati Azizan

    Citation: Virology Journal 2019 16:150

    Content type: Research

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  4. Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be a...

    Authors: Natalia A. Ilyushina, Takashi E. Komatsu, William L. Ince, Eric F. Donaldson, Nicolette Lee, Julian J. O’Rear and Raymond P. Donnelly

    Citation: Virology Journal 2019 16:149

    Content type: Research

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  5. About 23% of patients develop CIN2+ after LEEP treatment due to residual or recurrent lesions. The majority of patients with HPV infection were HPV negative before treatment, but 16,4% were still HPV 16 positi...

    Authors: Maria Teresa Bruno, Nazzario Cassaro, Salvatore Garofalo and Sara Boemi

    Citation: Virology Journal 2019 16:148

    Content type: Research

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  6. Adenoviruses play an important role as human pathogens, though most infections are believed to be asymptomatic. The over 100 human adenovirus types are classified into seven species (A-G), some of which includ...

    Authors: Christian E. Lange, Fabien R. Niama, Kenneth Cameron, Sarah H. Olson, Rock Aime Nina, Alain Ondzie, Gerard Bounga, Brett R. Smith, Jasmine Pante, Patricia Reed, Ubald Tamufe, Anne Laudisoit, Tracey Goldstein, Romain Bagamboula MPassi and Damien O. Joly

    Citation: Virology Journal 2019 16:147

    Content type: Research

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  7. This study was performed to evaluate the use of high-risk HPV (hrHPV) viral load in screening tests for cervical cancer to predict persistent infection and presence of cervical intraepithelial neoplasia grade ...

    Authors: Malin Berggrund, Inger Gustavsson, Riina Aarnio, Julia Hedlund-Lindberg, Karin Sanner, Ingrid Wikström, Stefan Enroth, Matts Olovsson and Ulf Gyllensten

    Citation: Virology Journal 2019 16:146

    Content type: Research

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  8. Rice stripe mosaic virus (RSMV) is a tentative new Cytorhabdovirus species in family Rhabdoviridae transmitted by the leafhopper Recilia dorsalis. Although the virus was first detected in southern China in 2015, ...

    Authors: Siping Chen, Weilin Li, Xiuqin Huang, Biao Chen, Tong Zhang and Guohui Zhou

    Citation: Virology Journal 2019 16:145

    Content type: Research

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  9. MicroRNAs (miRNAs) is increasingly recognized as an important element in regulating virus-host interactions. Our previous results showed that cellular miR-30a-5p was significantly downregulated after duck ente...

    Authors: Xianglong Wu, Renyong Jia, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Qiao Yang, Ying Wu, Zhongqiong Yin, Shaqiu Zhang, Juan Huang, Ling Zhang, Yunya Liu, Yanling Yu, Leichang Pan…

    Citation: Virology Journal 2019 16:144

    Content type: Research

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  10. We evaluated the prognostic and diagnostic ability of p16/Ki-67 immunocytochemistry, HPV E6/E7 mRNA testing and HPV DNA assay in triaging ASCUS to find a way to manage cervical lesions more effectively.

    Authors: Chenchen Ren, Yuanhang Zhu, Li Yang, Xiaoan Zhang, Ling Liu, Zhaoxin Wang and Dongyuan Jiang

    Citation: Virology Journal 2019 16:143

    Content type: Research

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  11. Avian hepatitis E virus (aHEV) has been associated with hepatitis-splenomegaly syndrome (HSS) in chickens along with asymptomatic subclinical infection in many cases. So far, four genotypes have been described...

    Authors: Tahir Iqbal, Umer Rashid, Muhammad Idrees, Amber Afroz, Saleem Kamili and Michael A. Purdy

    Citation: Virology Journal 2019 16:142

    Content type: Research

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  12. Rice stripe virus (RSV) causes one of the most important rice virus diseases of plants in East Asia. However, the molecular mechanisms controlling rice resistance to RSV infection are largely unknown. Recently, s...

    Authors: Rongfei Lu, Zhiyang Liu, Yudong Shao, Feng Sun, Yali Zhang, Jin Cui, Yijun Zhou, Wenbiao Shen and Tong Zhou

    Citation: Virology Journal 2019 16:141

    Content type: Short report

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  13. Next generation sequencing (NGS) is becoming widely used among diagnostics and research laboratories, and nowadays it is applied to a variety of disciplines, including veterinary virology. The NGS workflow com...

    Authors: Gianpiero Zamperin, Pierrick Lucas, Irene Cano, David Ryder, Miriam Abbadi, David Stone, Argelia Cuenca, Estelle Vigouroux, Yannick Blanchard and Valentina Panzarin

    Citation: Virology Journal 2019 16:140

    Content type: Research

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  14. HIV-1 hijacks the cellular machinery for its own replication through protein-protein interactions between viral and host cell factors. One strategy against HIV-1 infection is thus to target these key protein c...

    Authors: Fadila Larguet, Clément Caté, Benoit Barbeau, Eric Rassart and Elsy Edouard

    Citation: Virology Journal 2019 16:138

    Content type: Research

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  15. Goose parvovirus (GPV) is the etiological agent of Derzsy’s disease and is fatal for gosling. Research on the molecular basis of GPV pathogenicity has been hampered by the lack of a reliable reverse genetics s...

    Authors: Peng Liu, Liqin Yang, Jingyue Zhang, Tao Wang, Yuanyuan Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang…

    Citation: Virology Journal 2019 16:136

    Content type: Research

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  16. H9N2 influenza viruses continuously circulate in multiple avian species and are repeatedly transmitted to humans, posing a significant threat to public health. To investigate the adaptation ability of H9N2 avi...

    Authors: Zhe Hu, Yiran Zhang, Zhen Wang, Jingjing Wang, Qi Tong, Mingyang Wang, Honglei Sun, Juan Pu, Changqing Liu, Jinhua Liu and Yipeng Sun

    Citation: Virology Journal 2019 16:135

    Content type: Short report

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  17. Duck tembusu virus (DTMUV, genus Flaviviruses, family Flaviviridae) is an emerging flavivirus that can infect a wide range of cells and cell lines in vitro, though the initial step of virus invasion remains ob...

    Authors: Shaoxiong Wu, Zhen Wu, Yuanyuan Wu, Tao Wang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Yunya Liu, Ling Zhang, Yanling Yu, Leichang Pan…

    Citation: Virology Journal 2019 16:134

    Content type: Research

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  18. N6-methyladenosine (m6A) modification is the most prevalent internal modification of eukaryotic mRNA modulating gene expression. m6A modification is a dynamic reversible process regulated by three protein grou...

    Authors: Fang Wu, Wenzhao Cheng, Feiyuan Zhao, Mingqing Tang, Yong Diao and Ruian Xu

    Citation: Virology Journal 2019 16:133

    Content type: Review

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  19. Human pegivirus (HPgV) is structurally similar to hepatitis C virus (HCV) and was discovered 20 years ago. Its distribution, natural history and exact rule of this viral group in human hosts remain unclear. Ou...

    Authors: Hany K. Soliman, Mohamed Abouelhoda, Mahmoud N. El Rouby, Ola S. Ahmed, G. Esmat, Zeinab K. Hassan, Mohammed M. Hafez, Dina Ahmed Mehaney, Manojkumar Selvaraju, Rania Kamal Darwish, Yehia A. Osman and Abdel-Rahman N. Zekri

    Citation: Virology Journal 2019 16:132

    Content type: Case Report

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  20. In Oman tobacco (Nicotiana tabacum; family Solanaceae) is a minor crop, which is produced only for local consumption. In 2015, tobacco plants exhibiting severe downward leaf curling, leaf thickening, vein swellin...

    Authors: Muhammad Shafiq Shahid, Muhammad Shafiq, Amir Raza, Abdullah M. Al-Sadi and Rob W. Briddon

    Citation: Virology Journal 2019 16:131

    Content type: Research

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  21. MicroRNAs (miRNAs) are a class of 21–24 nucleotide endogenous non-coding small RNAs that play important roles in plant development and defense responses to biotic and abiotic stresses. Tobacco curly shoot viru...

    Authors: Jiang Du, Gentu Wu, Zhongpiao Zhou, Jiayuan Zhang, Mingjun Li, Miao Sun, Kairong Jiang and Ling Qing

    Citation: Virology Journal 2019 16:130

    Content type: Research

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  22. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SF...

    Authors: Yi Sun, Bin Guo, Hao Yan, Ai Lan Wu, Wen Wu Yao, Kang Chen, Jun Hang Pan, Zhao Xia Li, Hai Yan Mao and Yan Jun Zhang

    Citation: Virology Journal 2019 16:129

    Content type: Case Report

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  23. Capsid (C) protein plays an important role in the replication of classical swine fever virus (CSFV). The ubiquitin proteasome system (UPS) involves in replication of many viruses via modulation of viral protei...

    Authors: Yuming Chen, Erpeng Zhu, Shuangqi Fan, Hongxing Ding, Shengming Ma, Mengjiao Zhu, Shaofeng Deng, Jinding Chen and Mingqiu Zhao

    Citation: Virology Journal 2019 16:127

    Content type: Research

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  24. Since the discovery of mimivirus, numerous giant viruses associated with free-living amoebae have been described. The genome of giant viruses can be more than 2.5 megabases, and virus particles can exceed the ...

    Authors: Graziele Oliveira, Bernard La Scola and Jônatas Abrahão

    Citation: Virology Journal 2019 16:126

    Content type: Review

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  25. Dengue is an important mosquito-borne disease. There is currently only one licensed vaccine for dengue prevention. The vaccine provides higher efficacy in pre-vaccination dengue-seropositive persons but a high...

    Authors: Chukiat Sirivichayakul, Kriengsak Limkittikul, Pornthep Chanthavanich, Sutee Yoksan, Anuttarasakdi Ratchatatat, Jacqueline Kyungah Lim, Watcharee Arunsodsai and Arunee Sabchareon

    Citation: Virology Journal 2019 16:125

    Content type: Research

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  26. Despite the high yearly prevalence of Influenza, the pathogenesis mechanism and involved genes have not been fully known. Finding the patterns and mapping the complex interactions between different genes help ...

    Authors: Mohadeseh Zarei Ghobadi, Sayed-Hamidreza Mozhgani, Mahdieh Farzanehpour and Farida Behzadian

    Citation: Virology Journal 2019 16:124

    Content type: Research

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  27. Conventional assays to titrate polioviruses usually test serial dilutions inoculated into replicate cell cultures to determine a 50% cytopathic endpoint, a process that is both time-consuming and laborious. Su...

    Authors: Hasmik Manukyan, Elvira Rodionova, Tatiana Zagorodnyaya, Tsai-Lien Lin, Konstantin Chumakov and Majid Laassri

    Citation: Virology Journal 2019 16:122

    Content type: Methodology

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  28. Porcine epidemic diarrhea virus (PEDV) has caused enormous economic losses to the global pig industry. Currently available PEDV vaccine strains have limited protective effects against PEDV variant strains.

    Authors: Yu Wu, Wei Li, Qingfeng Zhou, Qunhui Li, Zhichao Xu, Hanqin Shen and Feng Chen

    Citation: Virology Journal 2019 16:121

    Content type: Research

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  29. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is a novel target and molecule in the negative regulation of immune homeostasis. The present study aimed to investigate the dynamic expression of TI...

    Authors: Yi Liu, Jia Jin, Jian Ji, Xi-Mei Gao and Yu-Chen Fan

    Citation: Virology Journal 2019 16:120

    Content type: Research

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  30. In 2017–2018, a new highly pathogenic H5N6 avian influenza virus (AIV) variant appeared in poultry and wild birds in Asian and European countries and caused multiple outbreaks. These variant strains are differ...

    Authors: Lin Liu, Ying Zhang, Pengfei Cui, Congcong Wang, Xianying Zeng, Guohua Deng and Xiurong Wang

    Citation: Virology Journal 2019 16:119

    Content type: Research

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  31. Mycoviruses were recently discovered in the white pine blister rust (WPBR) fungus Cronartium ribicola (J.C. Fisch.). Detection and characterization of their double stranded RNA (dsRNA) would facilitate understand...

    Authors: Jun-Jun Liu, Yu Xiang, Richard A. Sniezko, Anna W. Schoettle, Holly Williams and Arezoo Zamany

    Citation: Virology Journal 2019 16:118

    Content type: Research

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  32. Human Papilloma Virus (HPV) DNA tests are highly sensitive and can triage women with mild lesions, improving the prognosis and diagnosis of cervical lesions. However, additional efficient strategies should be ...

    Authors: Yuejie Li, Jie Liu, Li Gong, Xingwang Sun and Wenbo Long

    Citation: Virology Journal 2019 16:117

    Content type: Research

    Published on:

  33. Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In this study, we aimed to evaluate the expression level of potential biomarkers in progression of c...

    Authors: Mahdieh Farzanehpour, Sayed-Hamidreza Mozhgani, Somayeh Jalilvand, Ebrahim Faghihloo, Setareh Akhavan, Vahid Salimi and Talat Mokhtari Azad

    Citation: Virology Journal 2019 16:116

    Content type: Research

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  34. Hepatitis B virus-related decompensated cirrhosis is difficult to cure but has a high readmission rate due to multiple complications. Our aim was to investigate the diagnostic potential value of plasma diamine...

    Authors: Feng-Cai Li, Yu-Chen Fan, Yue-Kai Li and Kai Wang

    Citation: Virology Journal 2019 16:115

    Content type: Research

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  35. Human papillomavirus type-6 (HPV6) is the major etiological agent of anogenital warts both men and women. The present study aimed to characterize the genetic diversity among HPV6 in Southwest China, and to inv...

    Authors: Zuyi Chen, Qiongyao Li, Jian Huang, Jin Li, Feng Yang, Xun Min and Zehui Chen

    Citation: Virology Journal 2019 16:114

    Content type: Research

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  36. Trichoderma spp. are used extensively in agriculture as biological control agents to prevent soil-borne plant diseases. In recent years, mycoviruses from fungi have attracted increasing attention due to their eff...

    Authors: Chenchen Liu, Mei Li, Estifanos Tsegaye Redda, Jie Mei, Jiantai Zhang, Beilei Wu and Xiliang Jiang

    Citation: Virology Journal 2019 16:113

    Content type: Research

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  37. Reverse genetics systems enable the manipulation of viral genomes and therefore serve as robust reverse genetic tools to study RNA viruses. A DNA-launched rescue system initiates the transcription of viral gen...

    Authors: Ruihua Zhang, Jingjing Lan, Haie Li, Junhao Chen, Yupeng Yang, Shaoli Lin, Zhijing Xie and Shijin Jiang

    Citation: Virology Journal 2019 16:112

    Content type: Research

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  38. Viral respiratory tract infections are common during early childhood. How they impact cystic fibrosis lung disease history in young children is poorly known. The principal aim o...

    Authors: Mathilde Eymery, Florence Morfin, Anne Doleans-Jordheim, Marie Perceval, Camille Ohlmann, Catherine Mainguy and Philippe Reix

    Citation: Virology Journal 2019 16:111

    Content type: Research

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  39. Iridoviruses are large DNA viruses that cause diseases in fish, amphibians and insects. Singapore grouper iridovirus (SGIV) is isolated from cultured grouper and characterized as a ranavirus. ICP46 is defined ...

    Authors: Li-Qun Xia, Jian-Lin Chen, Hong-Lian Zhang, Jia Cai, Sheng Zhou and Yi-Shan Lu

    Citation: Virology Journal 2019 16:110

    Content type: Research

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  40. The aim of this article is to summarise the virology content presented at the 9th Lorne Infection and Immunity Conference, Australia, in February 2019. The broad program included virology as a key theme, and t...

    Authors: Gregor Ebert, Prasad N. Paradkar and Sarah L. Londrigan

    Citation: Virology Journal 2019 16:109

    Content type: Meeting report

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  41. Bovine leukemia virus (BLV) causes enzootic bovine leucosis and is widely spread worldwide, except several European countries, Australia and New Zealand. Although BLV is highly prevalent in China, information ...

    Authors: Yi Yang, Lina Chen, Maoli Dong, Wenjiang Huang, Xiaoli Hao, Yalan Peng, Zaicheng Gong, Aijian Qin, Shaobin Shang and Zhangping Yang

    Citation: Virology Journal 2019 16:108

    Content type: Short report

    Published on:

  42. The indicating FTA card is a dry medium used for collection of cervical samples. HPVIR is a multiplex real-time PCR test that detects 12 high-risk human papillomavirus types (hrHPV) and provides single genotyp...

    Authors: Inger Gustavsson, Riina Aarnio, Mattias Myrnäs, Julia Hedlund-Lindberg, Ongeziwe Taku, Tracy Meiring, Ingrid Wikström, Stefan Enroth, Anna-Lise Williamson, Matts Olovsson and Ulf Gyllensten

    Citation: Virology Journal 2019 16:107

    Content type: Research

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  43. Plant viruses can affect vector’s behaviors in order to enhance viral transmission. Cucurbit chlorotic yellows virus (CCYV) (genus Crinivirus) is an emergent RNA plant virus and is transmitted specifically by bio...

    Authors: Shaohua Lu, Mingshun Chen, Jingjing Li, Yan Shi, Qinsheng Gu and Fengming Yan

    Citation: Virology Journal 2019 16:106

    Content type: Research

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  44. The gut microbiome is closely associated with the health of the host; although the interaction between the bacterial microbiome and the whole virome has rarely been studied, it is likely of medical importance....

    Authors: Heng Li, Hongzhe Li, Jingjing Wang, Lei Guo, Haitao Fan, Huiwen Zheng, Zening Yang, Xing Huang, Manman Chu, Fengmei Yang, Zhanlong He, Nan Li, Jinxi Yang, Qiongwen Wu, Haijing Shi and Longding Liu

    Citation: Virology Journal 2019 16:105

    Content type: Research

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