Forrest HL, Webster RG. Perspectives on influenza evolution and the role of research. Anim Health Res Rev. 2010;11:3–18.
Article
PubMed
Google Scholar
Braber S, Verheijden KA, Henricks PA, Kraneveld AD, Folkerts G. A comparison of fixation methods on lung morphology in a murine model of emphysema. Am J Physiol Lung Cell Mol Physiol. 2010;299:L843-851.
Article
CAS
PubMed
Google Scholar
Szretter KJ, Gangappa S, Lu X, Smith C, Shieh WJ, Zaki SR, Sambhara S, Tumpey TM, Katz JM. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol. 2007;81:2736–44.
Article
CAS
PubMed
Google Scholar
Zhang RH, Li CH, Wang CL, Xu MJ, Xu T, Wei D, Liu BJ, Wang GH, Tian SF. N-acetyl-l-cystine (NAC) protects against H9N2 swine influenzavirus-induced acute lung injury. Int Immunopharmacol. 2014;22:1–8.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang R, Ai X, Duan Y, Xue M, He W, Wang C, Xu T, Xu M, Liu B, Li C, et al. Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways. Biomed Pharmacother. 2017;89:660–72.
Article
CAS
PubMed
Google Scholar
Xu MJ, Liu BJ, Wang CL, Wang GH, Tian Y, Wang SH, Li J, Li PY, Zhang RH, Wei D, et al. Epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa laminin receptor and effectively alleviates acute lung injury induced by H9N2 swine influenza virus. Int Immunopharmacol. 2017;52:24–33.
Article
CAS
PubMed
Google Scholar
Jung KI, Pyo CW, Choi SY. Influenza A virus-induced autophagy contributes to enhancement of virus infectivity by SOD1 downregulation in alveolar epithelial cells. Biochem Biophys Res Commun. 2018;498:960–6.
Article
CAS
PubMed
Google Scholar
Xu T, Wang C, Zhang R, Xu M, Liu B, Wei D, Wang G, Tian S. Carnosine markedly ameliorates H9N2 swine influenza virus-induced acute lung injury. J Gen Virol. 2015;96:2939–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Galluzzi L, Pietrocola F, Levine B, Kroemer G. Metabolic control of autophagy. Cell. 2014;159:1263–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Res. 2014;24:42–57.
Article
CAS
PubMed
Google Scholar
Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 2011;27:107–32.
Article
CAS
PubMed
Google Scholar
Mizushima N. Autophagy: process and function. Genes Dev. 2007;21:2861–73.
Article
CAS
PubMed
Google Scholar
Yoshimori T. Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Commun. 2004;313:453–8.
Article
CAS
PubMed
Google Scholar
Zhou Z, Jiang X, Liu D, Fan Z, Hu X, Yan J, Wang M, Gao GF. Autophagy is involved in influenza A virus replication. Autophagy. 2009;5:321–8.
Article
CAS
PubMed
Google Scholar
Tran AT, Cortens JP, Du Q, Wilkins JA, Coombs KM. Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. J Virol. 2013;87:1049–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sun Y, Li C, Shu Y, Ju X, Zou Z, Wang H, Rao S, Guo F, Liu H, Nan W, et al. Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection. Sci Signal. 2012;5:ra16.
Article
PubMed
Google Scholar
Gannagé M, Dormann D, Albrecht R, Dengjel J, Torossi T, Rämer PC, Lee M, Strowig T, Arrey F, Conenello G, et al. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe. 2009;6:367–80.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ludwig S, Pleschka S, Wolff T. A fatal relationship-influenza virus interactions with the host cell. Viral Immunol. 1999;12:175–96.
Article
CAS
PubMed
Google Scholar
Yoshimura A, Ohnishi S. Uncoating of influenza virus in endosomes. J Virol. 1984;51:497–504.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bui M, Whittaker G, Helenius A. Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. J Virol. 1996;70:8391–401.
Article
CAS
PubMed
PubMed Central
Google Scholar
Comber JD, Robinson TM, Siciliano NA, Snook AE, Eisenlohr LC. Functional macroautophagy induction by influenza A virus without a contribution to major histocompatibility complex class II-restricted presentation. J Virol. 2011;85:6453–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Law AH, Lee DC, Yuen KY, Peiris M, Lau AS. Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction. Cell Mol Immunol. 2010;7:263–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yeganeh B, Ghavami S, Kroeker AL, Mahood TH, Stelmack GL, Klonisch T, Coombs KM, Halayko AJ. Suppression of influenza A virus replication in human lungepithelial cells by noncytotoxic concentrations bafilomycin A1. Am J Physiol Lung Cell Mol Physiol. 2015;308:L270–86.
Article
CAS
PubMed
Google Scholar
Dai JP, Li WZ, Zhao XF, Wang GF, Yang JC, Zhang L, Chen XX, Xu YX, Li KS. A drug screening method based on the autophagy pathway and studies of the mechanism of evodiamine against influenza A virus. PLoS ONE. 2012;7:e42706.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ma J, Sun Q, Mi R, Zhang H. Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling. J Genet Genomics. 2011;38:533–7.
Article
CAS
PubMed
Google Scholar
Yoshimura K, Shibata M, Koike M, Gotoh K, Fukaya M, Watanabe M, Uchiyama Y. Effects of RNA interference of Atg4B o n the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues. Autophagy. 2006;2:200–8.
Article
CAS
PubMed
Google Scholar
Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy. 2007;3:542–5.
Article
CAS
PubMed
Google Scholar
Romanov J, Walczak M, Ibiricu I, Schüchner S, Ogris E, Kraft C, Martens S. Mechanism and functions of membrane binding by the Atg5–Atg12/Atg16 complex during autophagosome formation. EMBO J. 2012;31:4304–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pyo CW, Shin N, Jung KI, Choi JH, Choi SY. Alteration of copper–zinc superoxide dismutase 1 expression by influenza A virus is correlated with virus replication. Biochem Biophys Res Commun. 2014;450:711–6.
Article
CAS
PubMed
Google Scholar
DíazTroya S, PérezPérez ME, Florencio FJ, Crespo JL. The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy. 2008;4:851–65.
Article
Google Scholar
Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P. Regulation of macroautophagy by mTOR and Beclin1 complexes. Biochimie. 2008;90:313–23.
Article
CAS
PubMed
Google Scholar
Adachi N, Kanazawa I, Tanaka KI, Takeno A, Notsu M, Tanaka S, Sugimoto T. Insulin-like growth factor-i protects against the detrimental effects of advanced glycation end products and high glucosein myoblastic C2C12 cells. Calcif Tissue Int. 2019;105:89–96.
Article
CAS
PubMed
Google Scholar
Wang H, He J, Luo Y, Mu M, Guo S, Shen L, Qian Z, Fang Q, Song C. IGF-1 Promotes endocytosis of alveolar epithelial cells through PI3K signaling. Ann Clin Lab Sci. 2019;49:3–8.
CAS
PubMed
Google Scholar
Tang W, Feng X, Zhang S, Ren Z, Liu Y, Yang B, Lv B, Cai Y, Xia J, Ge N. Caveolin-1 confers resistance of hepatoma cells to anoikis by activating IGF-1 pathway. Cell Physiol Biochem. 2015;36:1223–36.
Article
CAS
PubMed
Google Scholar
Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol. 2005;6:505–10.
Article
CAS
PubMed
Google Scholar
Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol. 2005;26:523–8.
Article
CAS
PubMed
Google Scholar
Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8:931–7.
Article
CAS
PubMed
Google Scholar
Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu Rev Pathol. 2008;3:499–522.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zou SM, Zhou JF, Li Z, Zhu WF, Zhang Y, Wen LY, Zhu Y, Li XD, Wang W, Shu YL. The proliferation of H1N1 subtype influenza viruses in A549 and BEAS-2B cells. Zhonghua Shi Yan He Lin Chuang Bing Du XueZaZhi. 2011;25:205–7.
Google Scholar
Seng LG, Daly J, Chang KC, Kuchipudi SV. High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistance. PLoS ONE. 2014;9:e109023.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhirnov OP, Klenk HD. Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells. J Virol. 2013;87:13107–13014.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang R, Zhu Y, Zhao J, Ren C, Li P, Chen H, Jin M, Zhou H. Autophagy promotes replication of influenza A virus in vitro. J Virol. 2019;93:e01984-e2018.
CAS
PubMed
PubMed Central
Google Scholar
Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP. Inhibition of influenza infection by glutathione. Free Radic Biol Med. 2003;34:928–36.
Article
CAS
PubMed
Google Scholar
Babizhayev MA, Deyev AI, Yegorov YE. L-carnosine modulates respiratory burst and reactive oxygenspecies production in neutrophil biochemistry and function: may oral dosage form of non-hydrolized dipeptide L-carnosinecomplement anti-infective anti-influenza flu treatment, prevention and self-care as an alternative to the conventional vaccination? Curr Clin Pharmacol. 2014;9:93–115.
Article
CAS
PubMed
Google Scholar
Amatore D, Sgarbanti R, Aquilano K, Baldelli S, Limongi D, Civitelli L, Nencioni L, Garaci E, Ciriolo MR, Palamara AT. Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS. Cell Microbiol. 2015;17:131–45.
Article
CAS
PubMed
Google Scholar
Vlahos R, Stambas J, Bozinovski S, Broughton BR, Drummond GR, Selemidis S. Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation. PLoS Pathog. 2017;7:e1001271.
Article
CAS
Google Scholar
Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87:245–313.
Article
CAS
PubMed
Google Scholar
Inoki K, Li Y, Xu T, Guan KL. RhebGTPase is a direct target of TSC2GAP activity and regulates mTOR signaling. Genes Dev. 2003;17:1829–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115:577–90.
Article
CAS
PubMed
Google Scholar
Mao XY, Zhou HH, Li X, Liu ZQ. Huperzinea alleviates oxidative glutamate toxicity in hippocampal HT22 cells via activating BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway. Cell Mol Neurobiol. 2016;36:915–25.
Article
CAS
PubMed
Google Scholar
Huang H, Kang R, Wang J, Luo G, Yang W, Zhao Z. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. Autophagy. 2013;9:175–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 2018;558:136–40.
Article
PubMed
PubMed Central
CAS
Google Scholar
Potter LE, Paylor JW, Suh JS, Tenorio G, Caliaperumal J, Colbourne F, Baker G, Winship I, Kerr BJ. Altered excitatory–inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis. J Neuroinflammation. 2016;13:142–62.
Article
PubMed
PubMed Central
CAS
Google Scholar
Uiprasertkul M, Kitphati R, Puthavathana P, Kriwong R, Kongchanagul A, Ungchusak K, Angkasekwinai S, Chokephaibulkit K, Srisook K, Vanprapar N, et al. Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans. Emerg Infect Dis. 2007;13:708–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu G, Zhong M, Guo C, Komatsu M, Xu J, Wang Y, Kitazato K. Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway. Int J Biochem Cell Biol. 2016;72:100–8.
Article
CAS
PubMed
Google Scholar
Hu XF, Liu QZ, Li C, Dong J, Zhou JF, Wang M, Shu YL, Liu HT, Liang MF, Li DX. The differential expression of the human lung carcinoma cells infected with high pathogenic avian influenza virus A/Anhui/1/2005 (H5N1). Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008;22:180–2.
CAS
PubMed
Google Scholar