The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
© Deng et al. 2015
Received: 18 February 2015
Accepted: 3 July 2015
Published: 25 July 2015
The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection.
We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT.
These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV infection.
Despite the success of highly active antiretroviral therapy (HAART) in containing human immunodeficiency virus (HIV) infection, there has been an urgent demand for cheaper and alternative drugs in developing countries. Moreover, HIV persists in stable reservoirs harboring chromosomally integrated latent HIV-1 proviruses, where continuous viral production and reactivation of transcription from these reservoirs are not affected by current drugs [1–4]. As such, novel classes of antivirals are needed to inhibit these processes. In this regard, a drug that blocks HIV transcription would be of great value because it offers the potential to shut down the transcription in HIV latent reservoirs.
Synergism between SsnB and AZT
CI at HIV-1 inhibition of:
0.04, 0.16, 0.64, 1.28
0.1, 0.5, 1, 10
0.0025, 0.005, 0.01, 0.02
0.5, 1, 10, 50
This study was sponsored by National Natural Science Foundation of China Grant 2014DFA30580, The Ministry of Education of the People’s Republic of China grant NCET-13-0745, Guangxi Science and Technology key projects 1298003-1-1, 1355006–7, and 14124004-2-2. J. L. is a Guangxi Bagui Scholar.
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