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Table 1 Synergism between SsnB and AZT

From: The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription

Expt no.

Concentration of:

CI at HIV-1 inhibition of:

 

AZT (μM)

SsnB (μg/ml)

50 %

75 %

90 %

95 %

1

0.04, 0.16, 0.64, 1.28

0.1, 0.5, 1, 10

0.87

0.63

0.47

0.38

2

0.0025, 0.005, 0.01, 0.02

0.5, 1, 10, 50

0.77

0.53

0.46

0.43

  1. 0.5 × 106/ml CEM-SS cells were exposed to pNL4.3 virus (p24 ~ 100 ng) as inoculum in flasks containing either single agent (four concentrations each) or four combinations of AZT and SsnB (for example, in Exp 1, 0.04 μM AZT + 0.1 μg/ml SsnB; 0.16 μM AZT+ 0.5 μg/ml SsnB, and so on) for 12 h. Fourty eight hours thereafter, the production of infectious virus in the supernatants was determined by the standard TZM-bl assay [8]. The calculation was done using the method described in [18, 19]. CIs of <1, 1, and >1 indicate synergism, additive effects, and antagonism, respectively.
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Virology Journal

ISSN: 1743-422X