Hepatitis viruses

Section edited by Alan McLachlan

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  1. Research

    Effect of 48-week pegylated interferon α-2a or nucleos(t)ide analogue therapy on renal function in Chinese patients with chronic hepatitis B

    Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal functio...

    Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu and Jian-Qi Lian

    Virology Journal 2017 14:49

    Published on: 9 March 2017

  2. Research

    Community seroprevalence of hepatitis B, C and human immunodeficiency virus in adult population in gojjam zones, northwest Ethiopia

    In Ethiopia, there is lack of data on the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) infections in adult population at community level. This study ai...

    Bayeh Abera, Yesuf Adem, Mulat Yimer, Wondemagegn Mulu, Yohannes Zenebe and Zewdie Mekonnen

    Virology Journal 2017 14:21

    Published on: 6 February 2017

  3. Research

    HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients

    This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course...

    Song Yang, Huichun Xing, Yuming Wang, Jinlin Hou, Duande Luo, Qing Xie, Qin Ning, Hong Ren, Huiguo Ding, Jifang Sheng, Lai Wei, Shijun Chen, Xiaoling Fan, Wenxiang Huang, Chen Pan, Zhiliang Gao…

    Virology Journal 2016 13:180

    Published on: 28 October 2016

  4. Research

    Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon

    HBV and HIV share similar transmission routes. Concurrent infection with the two viruses usually results in more severe and progressive liver disease, and a higher incidence of cirrhosis, liver cancer and mort...

    Tshifhiwa Magoro, George Gachara, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal Bessong

    Virology Journal 2016 13:178

    Published on: 21 October 2016

  5. Research

    Characterization of differential antibody production against hepatitis C virus in different HCV infection status

    The Centers for Disease Control and Prevention (CDC) issued an update on hepatitis C virus (HCV) testing approach, in which it omitted the use of recombinant immunoblot assay (RIBA) in the diagnostic algorithm...

    Mona Rafik, Salwa Bakr, Dina Soliman, Nesrine Mohammed, Dina Ragab, Walid Abd ElHady and Nancy Samir

    Virology Journal 2016 13:116

    Published on: 30 June 2016

  6. Research

    Changing etiologies and outcome of liver failure in Southwest China

    The prognosis of liver failure depends greatly on the underlying cause, and there were few data about the prognosis, etiologies or trigger factors of liver failure in China based on long-term and large samples...

    Gui-Juan Xie, Hui-Yan Zhang, Qing Chen, Hui-Min Liu, Jian-Ping You, Sha Yang, Qing Mao and Xu-Qing Zhang

    Virology Journal 2016 13:89

    Published on: 4 June 2016

  7. Research

    Occult Hepatitis B virus infection in previously screened, blood donors in Ile-Ife, Nigeria: implications for blood transfusion and stem cell transplantation

    Hepatitis B virus (HBV) transmission through blood transfusion is reduced by screening for hepatitis B surface antigen (HBsAg). However this method cannot detect the presence of occult hepatitis B virus infect...

    Amadin A. Olotu, Adesola O. Oyelese, Lateef Salawu, Rosemary A. Audu, Azuka P. Okwuraiwe and Aaron O. Aboderin

    Virology Journal 2016 13:76

    Published on: 5 May 2016

  8. Research

    Increased CD56bright NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype

    HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infect...

    Suvercha Bhardwaj, Fareed Ahmad, Heiner Wedemeyer, Marcus Cornberg, Julian Schulze zur Wiesch, Jan van Lunzen, Shiv K. Sarin, Reinhold E. Schmidt and Dirk Meyer-Olson

    Virology Journal 2016 13:67

    Published on: 18 April 2016

  9. Research

    Molecular epidemiology of hepatitis D virus circulating in Southwestern Nigeria

    Hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major public health problems in sub-Saharan Africa. Whereas it is known that HBV infection is endemic in Nigeria, there is only little data ab...

    Oluyinka Oladele Opaleye, Oluwatoyin Margaret Japhet, Olubusuyi Moses Adewumi, Ewean Chukwuma Omoruyi, Olusola Anuoluwapo Akanbi, Adeolu Sunday Oluremi, Bo Wang, Hoang van Tong, Thirumalaisamy P. Velavan and C.-Thomas Bock

    Virology Journal 2016 13:61

    Published on: 5 April 2016

  10. Research

    Alanine aminotransferase, HCV RNA levels and pro-inflammatory and pro-fibrogenic cytokines/chemokines during acute hepatitis C virus infection

    This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to prov...

    Behzad Hajarizadeh, François MJ Lamoury, Jordan J. Feld, Janaki Amin, Elizabeth Keoshkerian, Gail V. Matthews, Margaret Hellard, Gregory J. Dore, Andrew R. Lloyd, Jason Grebely and Tanya L. Applegate

    Virology Journal 2016 13:32

    Published on: 24 February 2016

  11. Research

    T-bet expression in CD8+ T cells associated with chronic hepatitis B virus infection

    The mechanisms leading to virus-specific CD8+ T cell dysfuction in chronic hepatitis B virus (HBV) infection remain to be elucidated. Our study focused on the role of transcription factor T-bet in HBV infectio...

    Rongshan Fan, Yinghua Lan, Jiwang Chen, Yanxin Huang, Qin Yan, Lisheng Jiang, Shupeng Song and Yongguo Li

    Virology Journal 2016 13:14

    Published on: 25 January 2016

  12. Research

    Occult hepatitis B virus infection: influence of S protein variants

    In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape ...

    Zhenhua Zhang, Ling Zhang, Yu Dai, Yafei Zhang, Jun Li and Xu Li

    Virology Journal 2016 13:10

    Published on: 19 January 2016

  13. Research

    Long-term effects of peginterferon alfa-2a therapy in Japanese patients with chronic hepatitis B virus infection

    There is no information on the long-term effects of peginterferon (PEG-IFN) alfa-2a therapy for chronic hepatitis B (CHB) in Japan. This double-blind, randomized trial investigated the efficacy of PEG-IFN ther...

    Keiichi Masaki, Fumitaka Suzuki, Tasuku Hara, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi and Hiromitsu Kumada

    Virology Journal 2015 12:225

    Published on: 23 December 2015

  14. Research

    Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

    Amino acid (aa) 70 substitution (R70Q/H) in the core protein of hepatitis C virus (HCV) genotype 1b has been shown to be one of the key factors in determining resistance for pegylated interferon-α plus ribavir...

    Zhongjie Hu, Ying Liu, Lixia Qiu, Zuopeng Fan, Wei Nie, Shan Liang and Ronghua Jin

    Virology Journal 2015 12:220

    Published on: 18 December 2015

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