Hepatitis viruses

Section edited by Alan McLachlan

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  1. Case report

    Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure

    The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resist...

    Andreas Walker, Sandra Filke, Nadine Lübke, Martin Obermeier, Rolf Kaiser, Dieter Häussinger, Jörg Timm and Hans H. Bock

    Virology Journal 2017 14:106

    Published on: 8 June 2017

  2. Research

    Virology analysis in HCV genotype 1-infected patients treated with the combination of simeprevir and TMC647055/ritonavir, with and without ribavirin, and JNJ-56914845

    In study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir (SMV), non-nucleoside NS5B inhibitor TMC647055/ritonavir (RTV) and NS5A inhibitor JNJ-5691484...

    Leen Vijgen, Kim Thys, An Vandebosch, Pieter Van Remoortere, René Verloes and Sandra De Meyer

    Virology Journal 2017 14:101

    Published on: 31 May 2017

  3. Review

    Hepatitis C virus management: potential impact of nanotechnology

    Around 170–200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3–5 million people in the USA. According to the WHO regional office in the Middle Eas...

    Mostafa H. Elberry, Noureldien H. E. Darwish and Shaker A. Mousa

    Virology Journal 2017 14:88

    Published on: 2 May 2017

  4. Research

    Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants

    The amino acid substitution at position 181 of the Hepatitis B virus (HBV) polymerase is a multi-drug resistance affecting both the L-nucleoside and acyclic phosphonate nucleotide groups. Data is limited on th...

    Ping Li, Jiabao Geng, Wei Li, Xiaobing Xu, Xin Zhang, Wenkai Zheng, Yuecheng Yu, Zhiguo Yang and Maorong Wang

    Virology Journal 2017 14:68

    Published on: 4 April 2017

  5. Methodology

    Analytical characteristics and comparative evaluation of Aptima HCV quant Dx assay with the Abbott RealTime HCV assay and Roche COBAS AmpliPrep/COBAS TaqMan HCV quantitative test v2.0

    The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of diagnosis and monitoring of HCV RNA in plasma and serum s...

    A. Worlock, D. Blair, M. Hunsicker, T. Le-Nguyen, C. Motta, C. Nguyen, E. Papachristou, J. Pham, A. Williams, M. Vi, B. Vinluan and A. Hatzakis

    Virology Journal 2017 14:66

    Published on: 4 April 2017

  6. Research

    SVR Rates of HCV-infected population under PEG-IFN-α/R treatment in Northwest China

    Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as HCV genotype, IL-28B si...

    Yanhua Li, Jiuping Wang, Juan Wang, Yunfeng Xiao, Bin Xu, Hongwei Li, Liu Yang, Xiaoke Hao and Yueyun Ma

    Virology Journal 2017 14:62

    Published on: 23 March 2017

  7. Research

    Effect of 48-week pegylated interferon α-2a or nucleos(t)ide analogue therapy on renal function in Chinese patients with chronic hepatitis B

    Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal functio...

    Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu and Jian-Qi Lian

    Virology Journal 2017 14:49

    Published on: 9 March 2017

  8. Research

    Community seroprevalence of hepatitis B, C and human immunodeficiency virus in adult population in gojjam zones, northwest Ethiopia

    In Ethiopia, there is lack of data on the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) infections in adult population at community level. This study ai...

    Bayeh Abera, Yesuf Adem, Mulat Yimer, Wondemagegn Mulu, Yohannes Zenebe and Zewdie Mekonnen

    Virology Journal 2017 14:21

    Published on: 6 February 2017

  9. Research

    HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients

    This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course...

    Song Yang, Huichun Xing, Yuming Wang, Jinlin Hou, Duande Luo, Qing Xie, Qin Ning, Hong Ren, Huiguo Ding, Jifang Sheng, Lai Wei, Shijun Chen, Xiaoling Fan, Wenxiang Huang, Chen Pan, Zhiliang Gao…

    Virology Journal 2016 13:180

    Published on: 28 October 2016

  10. Research

    Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon

    HBV and HIV share similar transmission routes. Concurrent infection with the two viruses usually results in more severe and progressive liver disease, and a higher incidence of cirrhosis, liver cancer and mort...

    Tshifhiwa Magoro, George Gachara, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal Bessong

    Virology Journal 2016 13:178

    Published on: 21 October 2016

  11. Research

    Characterization of differential antibody production against hepatitis C virus in different HCV infection status

    The Centers for Disease Control and Prevention (CDC) issued an update on hepatitis C virus (HCV) testing approach, in which it omitted the use of recombinant immunoblot assay (RIBA) in the diagnostic algorithm...

    Mona Rafik, Salwa Bakr, Dina Soliman, Nesrine Mohammed, Dina Ragab, Walid Abd ElHady and Nancy Samir

    Virology Journal 2016 13:116

    Published on: 30 June 2016

  12. Research

    Changing etiologies and outcome of liver failure in Southwest China

    The prognosis of liver failure depends greatly on the underlying cause, and there were few data about the prognosis, etiologies or trigger factors of liver failure in China based on long-term and large samples...

    Gui-Juan Xie, Hui-Yan Zhang, Qing Chen, Hui-Min Liu, Jian-Ping You, Sha Yang, Qing Mao and Xu-Qing Zhang

    Virology Journal 2016 13:89

    Published on: 4 June 2016

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