Influenza viruses

Section edited by Hualan Chen

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  1. Short report

    Identification of Two novel reassortant avian influenza a (H5N6) viruses in whooper swans in Korea, 2016

    On November 20, 2016 two novel strains of H5N6 highly pathogenic avian influenza virus (HPAIVs) were isolated from three whooper swans (Cygnus cygnus) at Gangjin Bay in South Jeolla province, South Korea. Identif...

    Jipseol Jeong, Chanjin Woo, Hon S. Ip, Injung An, Youngsik Kim, Kwanghee Lee, Seong-Deok Jo, Kidong Son, Saemi Lee, Jae-Ku Oem, Seung-Jun Wang, Yongkwan Kim, Jeonghwa Shin, Jonathan Sleeman and Weonhwa Jheong

    Virology Journal 2017 14:60

    Published on: 21 March 2017

  2. Research

    A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity

    Influenza virus is still a huge threat to the world-wide public health. Host inosine-5’- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target ...

    Jin Hu, Linlin Ma, Huiqiang Wang, Haiyan Yan, Dajun Zhang, Zhuorong Li, Jiandong Jiang and Yuhuan Li

    Virology Journal 2017 14:55

    Published on: 15 March 2017

  3. Research article

    Surveillance of avian influenza viruses in South Korea between 2012 and 2014

    National surveillance of avian influenza virus (AIV) in South Korea has been annually conducted for the early detection of AIV and responses to the introduction of highly pathogenic avian influenza (HPAI) viru...

    Eun-Kyoung Lee, Hyun-Mi Kang, Byung-Min Song, Yu-NA Lee, Gyeong-Beum Heo, Hee-Soo Lee, Youn-Jeong Lee and Jae-Hong Kim

    Virology Journal 2017 14:54

    Published on: 14 March 2017

  4. Case report

    Isolation and genetic characterization of a novel 2.2.1.2a H5N1 virus from a vaccinated meat-turkeys flock in Egypt

    Vaccination of poultry to control highly pathogenic avian influenza virus (HPAIV) H5N1 is used in several countries. HPAIV H5N1 of clade 2.2.1 which is endemic in Egypt has diversified into two genetic clades....

    Ahmed H. Salaheldin, Jutta Veits, Hatem S. Abd El-Hamid, Timm C. Harder, Davud Devrishov, Thomas C. Mettenleiter, Hafez M. Hafez and Elsayed M. Abdelwhab

    Virology Journal 2017 14:48

    Published on: 9 March 2017

  5. Short report

    The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen

    Despite availability of annual influenza vaccines, influenza causes significant morbidity and mortality in the elderly. This is at least in part a result of immunosenescence; the age-dependent decrease in immu...

    Tina Falkeborn, Jorma Hinkula, Marie Olliver, Alf Lindberg and Anna-Karin Maltais

    Virology Journal 2017 14:44

    Published on: 3 March 2017

  6. Research

    New H6 influenza virus reassortment strains isolated from Anser fabalis in Anhui Province, China

    H6 subtype avian influenza viruses are globally distributed and, in recent years, have been isolated with increasing frequency from both domestic and wild bird species as well as infected humans. Many reports ...

    Ye Ge, Hongliang Chai, Zhiqiang Fan, Xianfu Wang, Qiucheng Yao, Jian Ma, Si Chen, Yuping Hua, Guohua Deng and Hualan Chen

    Virology Journal 2017 14:36

    Published on: 21 February 2017

  7. Research

    Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice

    H9N2 influenza viruses circulate globally and are considered to have pandemic potential. The hyper-inflammatory response elicited by these viruses is thought to contribute to disease severity. Calcitriol plays...

    Boxiang Gui, Qin Chen, Chuanxia Hu, Caihui Zhu and Guimei He

    Virology Journal 2017 14:10

    Published on: 23 January 2017

  8. Research

    Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication

    The essential role of copper in eukaryotic cellular physiology is known, but has not been recognized as important in the context of influenza A virus infection. In this study, we investigated the effect of cel...

    Jonathan C. Rupp, Manon Locatelli, Alexis Grieser, Andrea Ramos, Patricia J. Campbell, Hong Yi, John Steel, Jason L. Burkhead and Eric Bortz

    Virology Journal 2017 14:11

    Published on: 23 January 2017

  9. Research

    Codon optimization of antigen coding sequences improves the immune potential of DNA vaccines against avian influenza virus H5N1 in mice and chickens

    Highly pathogenic avian influenza viruses are a serious threat to domestic poultry and can be a source of new human pandemic and annual influenza strains. Vaccination is the main strategy of protection against...

    Anna Stachyra, Patrycja Redkiewicz, Piotr Kosson, Anna Protasiuk, Anna Góra-Sochacka, Grzegorz Kudla and Agnieszka Sirko

    Virology Journal 2016 13:143

    Published on: 26 August 2016

  10. Research

    First outbreaks and phylogenetic analyses of avian influenza H9N2 viruses isolated from poultry flocks in Morocco

    H9N2 avian influenza viruses continue to spread in poultry and wild birds worldwide. Morocco just faced its first H9N2 influenza virus outbreaks early 2016 affecting different types of poultry production. Afte...

    Mohammed EL Houadfi, Siham Fellahi, Saadia Nassik, Jean-Luc Guérin and Mariette F. Ducatez

    Virology Journal 2016 13:140

    Published on: 15 August 2016

  11. Research

    G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology

    The nonstructural protein 1 (NS1) of influenza A viruses can act as a viral replication enhancer by antagonizing type I interferon (IFN) induction and response in infected cells. We previously reported that A/...

    Challika Kaewborisuth, Mark Zanin, Hans Häcker, Richard J. Webby and Porntippa Lekcharoensuk

    Virology Journal 2016 13:127

    Published on: 12 July 2016

  12. Research

    Evaluation of custom multiplex real - time RT - PCR in comparison to fast - track diagnostics respiratory 21 pathogens kit for detection of multiple respiratory viruses

    Severe acute respiratory infections in children can be fatal, rapid identification of the causative agent and timely treatment can be life saving. Multiplex real time RT-PCR helps in simultaneous detection of ...

    Bharti Malhotra, M. Anjaneya Swamy, P. V. Janardhan Reddy, Neeraj Kumar and Jitendra Kumar Tiwari

    Virology Journal 2016 13:91

    Published on: 6 June 2016

  13. Short report

    Expression of importin-α isoforms in human nasal mucosa: implication for adaptation of avian influenza A viruses to human host

    Transportation into the host cell nucleus is crucial for replication and transcription of influenza virus. The classical nuclear import is regulated by specific cellular factor, importin-α. Seven isoforms of i...

    Khwansiri Ninpan, Ornpreya Suptawiwat, Chompunuch Boonarkart, Peerayuht Phuangphung, Sakda Sathirareuangchai, Mongkol Uiprasertkul and Prasert Auewarakul

    Virology Journal 2016 13:90

    Published on: 4 June 2016

  14. Research

    Pre-immune state induced by chicken interferon gamma inhibits the replication of H1N1 human and H9N2 avian influenza viruses in chicken embryo fibroblasts

    Interferon gamma (IFN-γ), an immunoregulatory cytokine, is known to control many microbial infections. In a previous study, chicken interferon gamma (chIFN-γ) was found to be up-regulated following avian influ...

    Seong-Su Yuk, Dong-Hun Lee, Jae-Keun Park, Erdene-Ochir Tseren-Ochir, Jung-Hoon Kwon, Jin-Yong Noh, Joong-Bok Lee, Seung-Yong Park, In-Soo Choi and Chang-Seon Song

    Virology Journal 2016 13:71

    Published on: 27 April 2016

  15. Short report

    Surveillance for Eurasian-origin and intercontinental reassortant highly pathogenic influenza A viruses in Alaska, spring and summer 2015

    Eurasian-origin and intercontinental reassortant highly pathogenic (HP) influenza A viruses (IAVs) were first detected in North America in wild, captive, and domestic birds during November–December 2014. Detec...

    Andrew M. Ramey, John M. Pearce, Andrew B. Reeves, Rebecca L. Poulson, Jennifer Dobson, Brian Lefferts, Kyle Spragens and David E. Stallknecht

    Virology Journal 2016 13:55

    Published on: 31 March 2016

  16. Research

    A heat-inactivated H7N3 vaccine induces cross-reactive cellular immunity in HLA-A2.1 transgenic mice

    Cross-reactive immunity against heterologous strains of influenza virus has the potential to provide partial protection in individuals that lack the proper neutralizing antibodies. In particular, the boosting ...

    Giuseppina Di Mario, Bruno Garulli, Ester Sciaraffia, Marzia Facchini, Isabella Donatelli and Maria R. Castrucci

    Virology Journal 2016 13:56

    Published on: 31 March 2016

  17. Research

    Phylodynamics of avian influenza clade 2.2.1 H5N1 viruses in Egypt

    Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are widely distributed within poultry populations in Egypt and have caused multiple human infections. Linking the epidemiological and sequen...

    Abdelsatar Arafa, Ihab El-Masry, Shereen Kholosy, Mohammed K. Hassan, Gwenaelle Dauphin, Juan Lubroth and Yilma J. Makonnen

    Virology Journal 2016 13:49

    Published on: 22 March 2016

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