Articles
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Citation: Virology Journal 2024 21:66
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Liver injury in COVID-19: an insight into pathobiology and roles of risk factors
COVID-19 is a complex disease that can lead to fatal respiratory failure with extrapulmonary complications, either as a direct result of viral invasion in multiple organs or secondary to oxygen supply shortage...
Citation: Virology Journal 2024 21:65 -
Development of a time-resolved fluorescence immunoassay kit for detecting canine coronavirus and parvovirus through double labeling
Canine enteric coronavirus (CCV) and canine parvovirus type 2 (CPV-2) are the main pathogens responsible for acute gastroenteritis in dogs, and both single and mixed infections are common. This study aimed to ...
Citation: Virology Journal 2024 21:64 -
Congenital CMV infection in a Brazilian neonatal intensive care unit: high prevalence among twin newborns
Cytomegalovirus (CMV) is one of the most important pathogens associated with congenital infection worldwide. Most congenital CMV-infected infants are asymptomatic at birth; however, some can develop delayed se...
Citation: Virology Journal 2024 21:63 -
Seasonality of respiratory syncytial virus infection in children hospitalized with acute lower respiratory tract infections in Hunan, China, 2013–2022
In China, respiratory syncytial virus (RSV) infections traditionally occur during the spring and winter seasons. However, a shift in the seasonal trend was noted in 2020–2022, during the coronavirus disease 20...
Citation: Virology Journal 2024 21:62 -
SARS-CoV-2 infection increases airway bleeding risk in patients after tracheostomies
Airway bleeding events are a rare incident in SARS-CoV-2-infected patients after tracheostomies. We aimed to explore the correlation between airway bleeding and SARS-CoV-2 infection and evaluate the consistency o...
Citation: Virology Journal 2024 21:61 -
RNA-seq analysis of chlorogenic acid intervention in duck embryo fibroblasts infected with duck plague virus
Chlorogenic acid, the primary active component in Chinese medicines like honeysuckle, exhibits anti-inflammatory and antiviral effects. It has been demonstrated that chlorogenic acid effectively prevents and t...
Citation: Virology Journal 2024 21:60 -
Epidemiology and diagnosis technologies of human metapneumovirus in China: a mini review
Human metapneumovirus (HMPV) is a newly identified pathogen causing acute respiratory tract infections in young infants worldwide. Since the initial document of HMPV infection in China in 2003, Chinese scienti...
Citation: Virology Journal 2024 21:59 -
Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cells
The novel coronavirus disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Data from the COVID-19 clinical control case studies showed tha...
Citation: Virology Journal 2024 21:58 -
Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
Non-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally. The absence of influenza has raised concerns of waning immunity, and p...
Citation: Virology Journal 2024 21:57 -
Bacterial isolation and genome analysis of a novel Klebsiella quasipneumoniae phage in southwest China’s karst area
Southwest China is one of the largest karst regions in the world. Karst environment is relatively fragile and vulnerable to human activities. Due to the discharge of sewage and domestic garbage, the karst syst...
Citation: Virology Journal 2024 21:56 -
Unraveling the genetic variations underlying virulence disparities among SARS-CoV-2 strains across global regions: insights from Pakistan
Over the course of the COVID-19 pandemic, several SARS-CoV-2 variants have emerged that may exhibit different etiological effects such as enhanced transmissibility and infectivity. However, genetic variations ...
Citation: Virology Journal 2024 21:55 -
The POU-HD TFs impede the replication efficiency of several human papillomavirus genomes
Human papillomavirus (HPV) is a double-stranded DNA virus that infects cutaneous and mucosal epithelial cells. HPV replication initiates at the origin (ori), located within a noncoding region near the major ea...
Citation: Virology Journal 2024 21:54 -
Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus
Atypical porcine pestivirus (APPV) is a newly discovered swine pestivirus, which can cause congenital tremor and high mortality in newborn piglets and subclinical infection in adult pigs, leading to significan...
Citation: Virology Journal 2024 21:53 -
Prevalence and genotype distribution of HPV infections among women in Chengdu,China
Human papilloma virus (HPV) infection among female is the cause of cervical cancer and genital warts. In China, the HPV vaccination rate and the target population screening rate among females are low, and the ...
Citation: Virology Journal 2024 21:52 -
Diversity of astroviruses in wild animals in Yunnan province, China
Astroviruses (AstVs) are single-stranded RNA viruses that have been detected in a wide range of mammals and birds. They are associated with numerous interspecies transmissions and viral recombination events, p...
Citation: Virology Journal 2024 21:51 -
Molecular epidemiology and phylogenetic analysis of feline calicivirus in Kunshan, China
Feline calicivirus (FCV) is a highly contagious virus in cats, which typically causes respiratory tract and oral infections. Despite vaccination against FCV being a regular practice in China, new FCV cases sti...
Citation: Virology Journal 2024 21:50 -
Identification and characterisation of Gamma-herpesviruses in zoo artiodactyla
Viruses within the γ-herpesviruses subfamily include the causative agents of Malignant Catarrhal Fever (MCF) in several species of the order Artiodactyla. MCF is a usually fatal lymphoproliferative disease affect...
Citation: Virology Journal 2024 21:49 -
Green synthesis of MnO2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1
The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and th...
Citation: Virology Journal 2024 21:48 -
A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment
HIV infection compromises both the peripheral and central immune systems due to its pathogenic and neuropathogenic features. The mechanisms driving HIV-1 pathogenesis and neuropathogenesis involve a series of ...
Citation: Virology Journal 2024 21:47 -
Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis
Azvudine has been approved for the treatment of coronavirus disease 2019 (COVID-19) patients in China, and this meta-analysis aims to illustrate the safety of azvudine and its effectiveness in reducing mortality.
Citation: Virology Journal 2024 21:46 -
Cytomegalovirus infection during pregnancy: cross-sectional survey of knowledge and prevention practices of healthcare professionals in French-speaking Switzerland
Lack of Cytomegalovirus (CMV) knowledge among healthcare professionals has been proven to be the main threat to pregnant women's awareness, preventing them from reducing the risk of infection. The aims of this...
Citation: Virology Journal 2024 21:45 -
Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E. coli accoun...
Citation: Virology Journal 2024 21:44 -
Correction: Role of human heterogeneous nuclear ribonucleoprotein C1/C2 in dengue virus replication
Citation: Virology Journal 2024 21:43 -
Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines
Aedes albopictus is the secondary vector for dengue virus (DENV) in the Philippines, and also harbors chikungunya (CHIKV) and Zika (ZIKV) viruses. This study aimed to determine the minimum infection rates (MIRs) ...
Citation: Virology Journal 2024 21:42 -
Recognizing the role of Epstein-Barr virus in gastric cancer: transcriptomic insights into malignancy modulation
Studies show that Epstein-Barr virus (EBV) infection can play a role in malignancy and increase the risk of gastric cancer (GC). The objective of this research was to pinpoint genes whose expression may be inf...
Citation: Virology Journal 2024 21:41 -
Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic: role of the Belgian National Reference Centre
Since the onset of the coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as the National Reference Centre (NRC) for respiratory pathogens, to be the first Belgian labor...
Citation: Virology Journal 2024 21:40 -
Prevalence and progression of pneumonia in immunocompetent adults with varicella
Pneumonia is the most common complication of varicella infections. Although previous studies have tended to focus mainly on immunocompromised patients, varicella pneumonia can also occur in healthy adults. The...
Citation: Virology Journal 2024 21:39 -
Mechanisms and consequences of mRNA destabilization during viral infections
During viral infection there is dynamic interplay between the virus and the host to regulate gene expression. In many cases, the host induces the expression of antiviral genes to combat infection, while the vi...
Citation: Virology Journal 2024 21:38 -
Novel neutralizing SARS-CoV-2-specific mAbs offer detection of RBD linear epitopes
To stop the spread of the COVID-19 disease, it is crucial to create molecular tools to investigate and diagnose COVID-19. Current efforts focus on developing specific neutralizing monoclonal antibodies (NmAbs)...
Citation: Virology Journal 2024 21:37 -
Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C
HIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir dynamics during antiretroviral therapy. The Intact Proviral DNA Assay (IPDA...
Citation: Virology Journal 2024 21:36 -
ZNF148 inhibits HBV replication by downregulating RXRα transcription
Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market are efficient in controlling HBV infection,...
Citation: Virology Journal 2024 21:35 -
A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection
Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular components found in exosomes released by tumor cells. They play an essential role in healthy and diseased cells as messengers of sho...
Citation: Virology Journal 2024 21:34 -
Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3
Influenza A virus (IAV) can cause severe and life-threatening illness in humans and animals. Therefore, it is important to search for host antiviral proteins and elucidate their antiviral mechanisms for the de...
Citation: Virology Journal 2024 21:33 -
Severe COVID-19 and chronic kidney disease: bidirectional mendelian randomization study
Traditional observational research has revealed an association between severe COVID-19 and chronic kidney disease (CKD). It is unclear whether there is a causative connection between them. Our goal was to dete...
Citation: Virology Journal 2024 21:32 -
Correction: Molecular epidemiology and phylodynamic analysis of enterovirus 71 in Beijing, China, 2009–2019
Citation: Virology Journal 2024 21:31 -
Exosome-mediated regulation of inflammatory pathway during respiratory viral disease
Viruses have developed many mechanisms by which they can stimulate or inhibit inflammation and cause various diseases, including viral respiratory diseases that kill many people every year. One of the mechanis...
Citation: Virology Journal 2024 21:30 -
Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2
Several in silico studies have determined that quercetin, a plant flavonol, could bind with strong affinity and low free energy to SARS-CoV-2 proteins involved in viral entry and replication, suggesting it could ...
Citation: Virology Journal 2024 21:29 -
Porcine epidemic diarrhea virus strain CH/HLJ/18 isolated in China: characterization and phylogenetic analysis
Porcine epidemic diarrhea (PED) is an infectious disease of the digestive tract caused by the porcine epidemic diarrhea virus (PEDV), characterized by vomiting, severe diarrhea, and high mortality rates in pig...
Citation: Virology Journal 2024 21:28 -
Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt
Since the emergence of the COVID-19 infection in China, it has caused considerable morbidity, mortality, and economic burden. It causes the vast majority of clinical manifestations, ranging from mild or even n...
Citation: Virology Journal 2024 21:27 -
A novel film spray containing curcumin inhibits SARS-CoV-2 and influenza virus infection and enhances mucosal immunity
Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza virus is still a major worldwide health concern. Plants are a good source of bioactive compounds to be used as preventive...
Citation: Virology Journal 2024 21:26 -
Interference of pseudorabies virus infection on functions of porcine granulosa cells via apoptosis modulated by MAPK signaling pathways
Pseudorabies virus (PRV) is one of the major viral pathogens leading to reproductive disorders in swine. However, little is known about the effects of PRV infection on porcine reproductive system. Ovarian gran...
Citation: Virology Journal 2024 21:25 -
Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily
The Corona Virus Disease 2019 (COVID-19) pandemic has raised concerns regarding its potential impact on male reproductive health. However, the impact of COVID-19 on sperm quality remains uncertain. This retros...
Citation: Virology Journal 2024 21:24 -
N6-methyladenosine modification positively regulate Japanese encephalitis virus replication
N6-methyladenosine (m6A) is present in diverse viral RNA and plays important regulatory roles in virus replication and host antiviral innate immunity. However, the role of m6A in regulating JEV replication has...
Citation: Virology Journal 2024 21:23 -
Correlation analysis of hepatic steatosis and hepatitis B virus: a cross-sectional study
The co-occurrence of chronic hepatitis B (CHB) and metabolic dysfunction-associated fatty liver disease (MAFLD) has drawn considerable attention due to its impact on disease outcomes. This study aimed to inves...
Citation: Virology Journal 2024 21:22 -
An unusual diarrheal outbreak in the community in Eastern Thailand caused by Norovirus GII.3[P25]
Sentinel laboratory surveillance for diarrheal disease determined norovirus to be the most common cause of non-bacterial gastroenteritis in people during the COVID-19 pandemic in Thailand. An increase in patie...
Citation: Virology Journal 2024 21:21 -
A bibliometric analysis of m6A methylation in viral infection from 2000 to 2022
N6-methyladenosine (m6A) methylation has become an active research area in viral infection, while little bibliometric analysis has been performed. In this study, we aim to visualize hotspots and trends using b...
Citation: Virology Journal 2024 21:20 -
Epidemiology and genotypes analysis of human papillomavirus infection in Beijing, China
This study aimed to investigate the epidemiology of high-risk human papillomavirus (HPV) in the female population in Beijing, China, and identify the relationship between HPV genotypes and host factors.
Citation: Virology Journal 2024 21:19 -
Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications
Viruses pose a constant threat to human well-being, necessitating the immune system to develop robust defenses. Natural killer (NK) cells, which play a crucial role in the immune system, have become recognized...
Citation: Virology Journal 2024 21:18 -
Recent advances in various adeno-associated viruses (AAVs) as gene therapy agents in hepatocellular carcinoma
Primary liver cancer, which is scientifically referred to as hepatocellular carcinoma (HCC), is a significant concern in the field of global health. It has been demonstrated that conventional chemotherapy, che...
Citation: Virology Journal 2024 21:17