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  1. Research

    Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein

    The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env), a Type 1 transmembrane protein, assembles into a trimeric spike complex that mediates virus entry into host cells. The high potential energ...

    Hanh T. Nguyen, Navid Madani, Haitao Ding, Emerald Elder, Amy Princiotto, Christopher Gu, Patrice Darby, James Alin, Alon Herschhorn, John C. Kappes, Youdong Mao and Joseph G. Sodroski

    Virology Journal 2017 14:33

    Published on: 16 February 2017

  2. Research

    The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation

    Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular D...

    Martyn K. White, Anna Bellizzi, Gabriele Ibba, Valeria Pietropaolo, Anna T. Palamara and Hassen S. Wollebo

    Virology Journal 2017 14:31

    Published on: 15 February 2017

  3. Short report

    Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART

    HIV-1 is highly variable genetically and at protein level, a property it uses to subvert antiviral immunity and treatment. The aim of this study was to assess if HIV subtype differences were associated with va...

    Rose C. Kitawi, Carol W. Hunja, Rashid Aman, Bernhards R. Ogutu, Anne W. T. Muigai, Gilbert O. Kokwaro and Washingtone Ochieng

    Virology Journal 2017 14:29

    Published on: 14 February 2017

  4. Research

    Involvement of fatty acid synthase in dengue virus infection

    The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular li...

    Natthida Tongluan, Suwipa Ramphan, Phitchayapak Wintachai, Janthima Jaresitthikunchai, Sarawut Khongwichit, Nitwara Wikan, Supoth Rajakam, Sutee Yoksan, Nuttaporn Wongsiriroj, Sittiruk Roytrakul and Duncan R. Smith

    Virology Journal 2017 14:28

    Published on: 13 February 2017

  5. Research

    Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China

    The implementation of phage therapy is re-emerging with the increase in widespread antibiotic-resistant bacteria.

    Zelin Cui, Tingting Feng, Feifei Gu, Qingtian Li, Ke Dong, Yan Zhang, Yongzhang Zhu, Lizhong Han, Jinhong Qin and Xiaokui Guo

    Virology Journal 2017 14:26

    Published on: 8 February 2017

  6. Research

    Characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (Callithrix jacchus)

    Licensed antiviral therapeutics and vaccines to protect against eastern equine encephalitis virus (EEEV) in humans currently do not exist. Animal models that faithfully recapitulate the clinical characteristic...

    Aimee I. Porter, Rebecca A. Erwin-Cohen, Nancy Twenhafel, Taylor Chance, Steven B. Yee, Steven J. Kern, David Norwood, Laurie J. Hartman, Michael D. Parker, Pamela J. Glass and Luis DaSilva

    Virology Journal 2017 14:25

    Published on: 7 February 2017

  7. Methodology

    Development of real-time and lateral flow strip reverse transcription recombinase polymerase Amplification assays for rapid detection of peste des petits ruminants virus

    Peste des petits ruminants (PPR) is an economically important, Office International des Epizooties (OIE) notifiable, transboundary viral disease of small ruminants such as sheep and goat. PPR virus (PPRV), a n...

    Yang Yang, Xiaodong Qin, Yiming Song, Wei Zhang, Gaowei Hu, Yongxi Dou, Yanmin Li and Zhidong Zhang

    Virology Journal 2017 14:24

    Published on: 7 February 2017

  8. Research

    Community seroprevalence of hepatitis B, C and human immunodeficiency virus in adult population in gojjam zones, northwest Ethiopia

    In Ethiopia, there is lack of data on the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) infections in adult population at community level. This study ai...

    Bayeh Abera, Yesuf Adem, Mulat Yimer, Wondemagegn Mulu, Yohannes Zenebe and Zewdie Mekonnen

    Virology Journal 2017 14:21

    Published on: 6 February 2017

  9. Research

    miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA

    Cervical cancer (CC) is the second most common cancer in females in developing countries. The two viral oncoproteins E6 and E7 mediate the oncogenic activities of high-risk human papillomavirus (HR-HPV), and H...

    Yu-Fang Xia, Gui-Hua Pei, Ning Wang, Yan-Ci Che, Feng-Sheng Yu, Fu-Fen Yin, Hai-Xia Liu, Bing Luo and Yan-Kui Wang

    Virology Journal 2017 14:20

    Published on: 4 February 2017

  10. Research

    Coxsackievirus B4 vertical transmission in a murine model

    Life-threatening infections with type B Coxsackieviruses (CV-B) are frequently encountered among newborns and are partly attributed to vertically-transmitted virus. Our current study investigates this alternat...

    Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Moncef Mokni and Mahjoub Aouni

    Virology Journal 2017 14:16

    Published on: 31 January 2017

  11. Research

    Molecular characterization of infectious pancreatic necrosis virus strains isolated from the three types of salmonids farmed in Chile

    The infectious pancreatic necrosis virus (IPNV) causes significant economic losses in Chilean salmon farming. For effective sanitary management, the IPNV strains present in Chile need to be fully studied, char...

    René A. Manríquez, Tamara Vera, Melina V. Villalba, Alejandra Mancilla, Vikram N. Vakharia, Alejandro J. Yañez and Juan G. Cárcamo

    Virology Journal 2017 14:17

    Published on: 31 January 2017

  12. Research

    TLR2 2258 G>A single nucleotide polymorphism and the risk of congenital infection with human cytomegalovirus

    Human cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of...

    Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński and Dorota Nowakowska

    Virology Journal 2017 14:12

    Published on: 24 January 2017

  13. Research

    Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice

    H9N2 influenza viruses circulate globally and are considered to have pandemic potential. The hyper-inflammatory response elicited by these viruses is thought to contribute to disease severity. Calcitriol plays...

    Boxiang Gui, Qin Chen, Chuanxia Hu, Caihui Zhu and Guimei He

    Virology Journal 2017 14:10

    Published on: 23 January 2017

  14. Research

    Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication

    The essential role of copper in eukaryotic cellular physiology is known, but has not been recognized as important in the context of influenza A virus infection. In this study, we investigated the effect of cel...

    Jonathan C. Rupp, Manon Locatelli, Alexis Grieser, Andrea Ramos, Patricia J. Campbell, Hong Yi, John Steel, Jason L. Burkhead and Eric Bortz

    Virology Journal 2017 14:11

    Published on: 23 January 2017

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