Retroviruses

Section edited by Johnson Mak

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  1. Research

    Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein

    The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env), a Type 1 transmembrane protein, assembles into a trimeric spike complex that mediates virus entry into host cells. The high potential energ...

    Hanh T. Nguyen, Navid Madani, Haitao Ding, Emerald Elder, Amy Princiotto, Christopher Gu, Patrice Darby, James Alin, Alon Herschhorn, John C. Kappes, Youdong Mao and Joseph G. Sodroski

    Virology Journal 2017 14:33

    Published on: 16 February 2017

  2. Short report

    Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART

    HIV-1 is highly variable genetically and at protein level, a property it uses to subvert antiviral immunity and treatment. The aim of this study was to assess if HIV subtype differences were associated with va...

    Rose C. Kitawi, Carol W. Hunja, Rashid Aman, Bernhards R. Ogutu, Anne W. T. Muigai, Gilbert O. Kokwaro and Washingtone Ochieng

    Virology Journal 2017 14:29

    Published on: 14 February 2017

  3. Short report

    The sense behind retroviral anti-sense transcription

    Retroviruses are known to rely extensively on the expression of viral proteins from the sense proviral genomic strand. Yet, the production of regulatory retroviral proteins from antisense-encoded viral genes i...

    Mamneet Manghera, Alycia Magnusson and Renée N. Douville

    Virology Journal 2017 14:9

    Published on: 14 January 2017

  4. Research

    Construction of a molecular clone of ovine enzootic nasal tumor virus

    Enzootic nasal tumor virus (ENTV-1) is an ovine betaretrovirus that has been linked to enzootic nasal adenocarcinoma (ENA), a contagious tumor of the ethmoid turbinates of sheep. Transmission experiments perfo...

    Scott R. Walsh, María Carla Rosales Gerpe and Sarah K. Wootton

    Virology Journal 2016 13:209

    Published on: 30 December 2016

  5. Research

    Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques

    Increasing evidence suggests an unexpected potential for non-neutralizing antibodies to prevent HIV infection. Consequently, identification of functional linear B-cell epitopes for HIV are important for develo...

    Bapi Pahar, Carys S. Kenway-Lynch, Preston Marx, Sudesh K. Srivastav, Celia LaBranche, David C. Montefiori and Arpita Das

    Virology Journal 2016 13:200

    Published on: 1 December 2016

  6. Short report

    Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro

    During sexual transmission of human immunodeficiency virus (HIV), macrophages are initial targets for HIV infection. Secretory leukocyte protease inhibitor (SLPI) has been shown to protect against HIV infectio...

    Andrew W. Woodham, Adriana M. Sanna, Julia R. Taylor, Joseph G. Skeate, Diane M. Da Silva, Lodewijk V. Dekker and W. Martin Kast

    Virology Journal 2016 13:187

    Published on: 18 November 2016

  7. Research

    Analysis of HIV-1 intersubtype recombination breakpoints suggests region with high pairing probability may be a more fundamental factor than sequence similarity affecting HIV-1 recombination

    With increasing data on HIV-1, a more relevant molecular model describing mechanism details of HIV-1 genetic recombination usually requires upgrades. Currently an incomplete structural understanding of the cop...

    Lei Jia, Lin Li, Tao Gui, Siyang Liu, Hanping Li, Jingwan Han, Wei Guo, Yongjian Liu and Jingyun Li

    Virology Journal 2016 13:156

    Published on: 21 September 2016

  8. Research

    Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs

    Despite the successful inhibition of human immunodeficiency virus type 1 (HIV-1) replication by combination antiretroviral therapy, cells latently infected with HIV-1 remaining in patients are a major obstacle...

    YoungHyun Shin, Hoyong Lim, Byeong-Sun Choi, Kyung-Chang Kim, Chun Kang, Yong-Soo Bae and Cheol-Hee Yoon

    Virology Journal 2016 13:141

    Published on: 16 August 2016

  9. Research

    Avian leukosis virus subgroup J induces its receptor--chNHE1 up-regulation

    Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus which causes immunosuppression and neoplasia in meat-type and egg-type chickens. ALV-J infects host cells via specific interaction between the...

    Weiguo Feng, Wei Meng, Liming Cai, Xiyao Cui, Zhifang Pan, Guihua Wang and Ziqiang Cheng

    Virology Journal 2016 13:58

    Published on: 2 April 2016

  10. Research

    Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

    The interaction of the envelope glycoprotein of HIV-1 (gp120/gp41) with coreceptor molecules has important implications for specific cellular targeting and pathogenesis. Experimental and theoretical evidences ...

    Elena Pacheco-Martínez, Evangelina Figueroa-Medina, Carlos Villarreal, Germinal Cocho, José L. Medina-Franco, Oscar Méndez-Lucio and Leonor Huerta

    Virology Journal 2016 13:28

    Published on: 16 February 2016

  11. Short Report

    Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells

    SAMHD1 counteracts HIV-1 or HIV-2/SIVsmm that lacks Vpx by depleting the intracellular pool of nucleotides in myeloid cells and CD4+ quiescent T cells, thereby inhibiting the synthesis of retroviral DNA by rev...

    Loic Dragin, Soundasse Munir-Matloob, Jeanne Froehlich, Marina Morel, Adèle Sourisce, Hichem Lahouassa, Karine Bailly, Marianne Mangeney, Bertha Cecilia Ramirez and Florence Margottin-Goguet

    Virology Journal 2015 12:201

    Published on: 25 November 2015

  12. Research

    Rapid detection of the common avian leukosis virus subgroups by real-time loop-mediated isothermal amplification

    Subgroups A, B, E and J are the major subgroups of avian leukosis virus (ALV) infecting chickens. ALV infection has become endemic in China and has a significant negative effect on the poultry industry. Conseq...

    Hao Peng, Lili Qin, Yuyu Bi, Peikun Wang, Guangzhen Zou, Jun Li, Yongli Yang, Xingfu Zhong and Ping Wei

    Virology Journal 2015 12:195

    Published on: 24 November 2015

  13. Research

    Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns

    Highly active antiretroviral therapy (HAART) is recommended to control the infection of HIV-1. HIV-1 drug resistance becomes an obstacle to HAART due to the accumulation of specific mutations in the RT coding ...

    Wei Guo, Jingwan Han, Daomin Zhuang, Siyang Liu, Yongjian Liu, Lin Li, Hanping Li, Zuoyi Bao, Fujiang Wang and Jingyun Li

    Virology Journal 2015 12:187

    Published on: 14 November 2015

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