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Association of dyslipidemia with the severity and mortality of coronavirus disease 2019 (COVID-19): a meta-analysis

Virology Journal volume 18, Article number: 157 (2021) Cite this article

Abstract

Background

The numbers of confirmed cases of coronavirus disease 2019 (COVID-19) and COVID-19 related deaths are still increasing, so it is very important to determine the risk factors of COVID-19. Dyslipidemia is a common complication in patients with COVID-19, but the association of dyslipidemia with the severity and mortality of COVID-19 is still unclear. The aim of this study is to analyze the potential association of dyslipidemia with the severity and mortality of COVID-19.

Methods

We searched the PubMed, Embase, MEDLINE, and Cochrane Library databases for all relevant studies up to August 24, 2020. All the articles published were retrieved without language restriction. All analysis was performed using Stata 13.1 software and Mantel–Haenszel formula with fixed effects models was used to compare the differences between studies. The Newcastle Ottawa scale was used to assess the quality of the included studies.

Results

Twenty-eight studies involving 12,995 COVID-19 patients were included in the meta-analysis, which was consisted of 26 cohort studies and 2 case–control studies. Dyslipidemia was associated with the severity of COVID-19 (odds ratio [OR] = 1.27, 95% confidence interval [CI] 1.11–1.44, P = 0.038, I2 = 39.8%). Further, patients with dyslipidemia had a 2.13-fold increased risk of death compared to patients without dyslipidemia (95% CI 1.84–2.47, P = 0.001, I2 = 66.4%).

Conclusions

The results proved that dyslipidemia is associated with increased severity and mortality of COVID-19. Therefore, we should monitor blood lipids and administer active treatments in COVID-19 patients with dyslipidemia to reduce the severity and mortality.

Introduction

Coronavirus disease 2019 (COVID-19) swept the world by manifestation as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease initially appeared in Wuhan, China in December 2019 and then spread rapidly worldwide in early 2020. On January 30, 2020, the World Health Organization (WHO) announced that COVID-19 was a public health emergency of international concern. Due to the continuous and rapid transmission of SARS-CoV-2, COVID-19 has caused a global health crisis that has drastically affected normal life, the economy, and politics. Although some preventative measures have been taken, the numbers of confirmed cases and deaths is still rising worldwide. On April 22, 2021, the WHO reported 143,184,614 confirmed cases and 3,047,322 deaths [1].

SARS-CoV-2 is the third highly pathogenic coronavirus found to infect humans, following the severe acute respiratory syndrome coronavirus in 2003 and the Middle East respiratory syndrome coronavirus in 2012 [2]. SARS-CoV-2 can be transmitted through respiratory droplets into the mucous membranes of the eyes or oral cavity and travel to important organs such as the heart and lungs. Patients infected with SARS-CoV-2 show different clinical symptoms, ranging from mild symptoms such as fever and cough to more serious symptoms such as bilateral interstitial pneumonia, and severe infection may cause acute respiratory distress syndrome and terminal organ failure [3].

Dyslipidemia is a common complication in patients with COVID-19. Reduction in total cholesterol and low-density lipoprotein cholesterol (LDL-C) in patients with COVID-19 has been reported [4, 5], indicating that there may be a pathophysiological interaction between lipid metabolism and vascular disease in the progression of COVID-19. However, the association between dyslipidemia and COVID-19 has not been established. Therefore, we conducted a meta-analysis of current studies to the possible interplay between dyslipidemia and the severity and mortality of COVID-19. This assessment will be helpful to further understand the characteristics of COVID-19 in patients with dyslipidemia.

Materials and methods

Study protocol and registration

This systematic review and meta-analysis was conducted in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [6]. The International Prospective Register of Systematic Reviews has reported this protocol (PROSPERO identifier: CRD42020222400).

Search strategy

To discern high-quality evidence, we conducted a comprehensive search in a wide spectrum of databases, namely the PubMed, Embase, MEDLINE, and Cochrane Library databases for all relevant studies up to August 24, 2020. The search terms were as follows: “Corona Virus Disease-2019” or “2019 novel coronavirus” or “SARS-CoV-2” or “COVID-19” or “2019-ncov” or “new coronavirus pneumonia” and “hyperlipemia” or “hyperlipidemia” or “dyslipidemia” or “dyslipidaemia” or “hypolipidemia” or “clinical characteristics” or “comorbidities” or “risk factors” and “cohort” or “case control”. The retrieved studies were also manually searched to ensure other related studies.

Selection criteria

The included studies were characterized as follows: (1) study design: case–control study or cohort study; (2) COVID-19 cases: all COVID-19 cases were confirmed on positive result of real-time reverse transcriptase–polymerase chain reaction for SARS-CoV-2 in swab samples and hospitalized; (3) parameters: COVID-19 patients with a history of dyslipidemia; (4) clinical outcomes: infection severity or mortality of COVID-19 reported; (5) "severe disease" was defined clearly; and (6) study sample size: at least 10 cases. In this analysis definition of severe disease was defined as COVID-19 confirmed patients with one of conditions: (1) arterial oxygen partial pressure/fraction of inspired oxygen ≤ 300 mmHg; (2) oxygen saturation ≤ 93% of indoor air at rest; (3) respiratory distress, respiratory rate ≥ 30 breaths/min; (4) patients requiring mechanical ventilation or vital life support or intensive care unit admission; (5) death. In this meta-analysis dyslipidemia included hyperlipidemia (hypertriglyceridemia or hypercholestromia) or hypolipidemia. When the information in the study was incomplete, we contacted the corresponding author to get the complete information.

Outcomes of interest

The primary outcome was the relationship between dyslipidemia and the severity of COVID-19. The secondary outcome was the association between dyslipidemia and COVID-19 mortality. Therefore, two separate meta-analyses were conducted.

Data extraction

Two authors (YLL and YLP) withdrew the useful data from all the included studies, and any disagreement was reconciled via discussion with the third author YYY. The following data were extracted from the included studies: (1) the name of the first author; (2) study type, study location, and study date; and (3) the general characteristics of the participants (age, body mass index and sample size in the non-severe cases, severe cases, death cases and survived cases).

Quality assessment

The Newcastle Ottawa scale was used to assess the quality of the included studies, including COVID-19 case selection, comparability, and outcome of disease severity or mortality. Case selection included four items: (1) representativeness of cases; (2) appropriate determination of severe cases; (3) appropriate determination of non-severe cases; and (4) appropriate determination of blood lipid levels. The comparability factor assessed whether the comparability between patients with and without dyslipidemia was considered in the design and statistical analysis. The lowest score and the highest was 0 and 9 points, respectively. Studies with scores of 0 to 3 points, 4 to 6 points, and 7 to 9 points were considered to be of low, medium, and high quality, respectively [7].

Data synthesis and analysis

All analysis was performed using Stata 13.1 software. Forest plots were employed to illustrate the severity and mortality of COVID-19 patients with and without dyslipidemia. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to describe the statistical significance (P ≤ 0.05), which provided a quantitative estimate of the associations of dyslipidemia with the severity and mortality of COVID-19. The statistical heterogeneity of the included studies was expressed by I2, whose value is stratified as low (< 25%), moderate(25–50%), high(> 50%). Fixed effects models were used to compare the differences between studies. In this study, funnel plot and Egger’s test were used to evaluate the possibility of publication bias. A P value < 0.05 in the Egger’s test was considered to indicate publication bias.

Results

Search results

A total of 2280 studies were retrieved, of which 972 were duplicate studies. Nine hundred and seventy-nine studies were excluded after reading the titles and abstracts. Three hundred and one studies with inconsistent primary and secondary outcomes were excluded after reading the full text. Finally, 28 studies involving 12,995 patients with COVID-19 were included for this meta-analysis, including 9 studies on COVID-19 mortality risk, 17 studies on COVID-19 severity, and 2 studies on both severity and mortality [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. The study selection flow diagram and exclusion reasons are shown in Fig. 1. All 28 included studies were published in 2020. The sample sizes ranged from 23 to 3988.

Fig. 1
figure 1

Flow chart showing the study selection

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Patient characteristics

The patient characteristics based on severity of COVID-19 are shown in Table 1. The patient characteristics based on mortality from COVID-19 are shown in Table 2.

Table 1 Patient characteristics based on COVID-19 severity
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Table 2 Patient characteristics based on COVID-19 mortality
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Data analysis

In the pooled analysis, dyslipidemia was significantly associated with the severity of COVID-19 (OR = 1.27, 95% CI 1.11–1.44, P = 0.038). In this analysis, moderate heterogeneity was observed (I2 = 39.8%; Fig. 2). There was no evidence of publication bias by Egger’s test (P = 0.856) or funnel plot (Fig. 3). In addition, compared to patients without dyslipidemia, patients with dyslipidemia had a higher risk of death (OR = 2.13, 95% CI 1.84–2.47, P = 0.001), and the heterogeneity was significant (I2 = 66.4%; Fig. 4). Then the sensitivity analysis demonstrating the association of dyslipidemia with COVID-19 mortality showed that the study [35] estimated OR was lower than 95% confidence interval lower limit (Additional file 3: Fig. S1). Get rid of this study, dyslipidemia was also associated with the mortality of COVID-19 (OR = 1.44, 95% CI 1.13–1.82, P = 0.153, I2 = 32.0%). Perhaps it was because there was unclear cut-off value for hypercholestromial in dyslipidemia. Similarly, Egger's test (P = 0.485) and funnel plot (Fig. 5) showed no potential publication bias in the analysis of mortality. The quality assessment of studies was shown in the Additional files 1, 2 Tables SI and SII.

Fig. 2
figure 2

Forest plot demonstrating the association of dyslipidemia with COVID-19 severity. COVID-19 coronavirus disease, RR risk ratio, CI confidence interval

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Fig. 3
figure 3

Funnel plot for the analysis of the association of dyslipidemia with COVID-19 severity. COVID-19 coronavirus disease

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Fig. 4
figure 4

Forest plot demonstrating the association of dyslipidemia with COVID-19 mortality. COVID-19 coronavirus disease; RR, risk ratio; CI, confidence interval

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Fig. 5
figure 5

Funnel plot for the analysis of the association of dyslipidemia with COVID-19 mortality. COVID-19 coronavirus disease

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Discussion

This meta-analysis included 28 studies involving 12,995 patients with COVID-19. To our knowledge, this meta-analysis is based on the study that dyslipidemia is associated with severe COVID-19 infection by Hariyanto Ti et al. to assess the potential relationship between dyslipidemia and severity and mortality risk of COVID-19 [36].

Previous studies have shown that dyslipidemia is accountable for the increased severity and mortality of COVID-19, which is of great significance in clinical practice. Hypercholesterolemia is an independent risk factor of cardiovascular disease and chronic inflammation. An epidemiological study showed that total cholesterol (TC) is positively correlated with mortality in cardiovascular disease [37]. The LDL-C concentration in COVID-19 patients with dyslipidemia is high. With increased oxidative stress, low-density lipoprotein (LDL) forms oxidized LDL (oxLDL) after crossing the endothelial barrier. OxLDL can form immune complexes and contribute significantly to the initiation and transmission of inflammatory processes. OxLDL is also a powerful stimulator that can activate endothelial cells and monocytes, so it can increase the expression of a variety of inflammatory proteins and receptors [38]. OxLDL can also induce endothelial cell apoptosis through LDL receptor-1-mediated NF-κB signaling, caspase-3, caspase-9, and Fas, thus increasing monocyte levels, platelet activation, and vascular smooth muscle cell migration induced by collagen exposure [39,40,41]. The pathological results showed that the lung injury of COVID-19 patients was caused by endothelial cell pyroptosis and apoptosis [42]. Hyperlipidemia is an important factor leading to endothelial dysfunction. Lowering cholesterol levels will reduce the degree of vascular disease, thus protecting the integrity of endothelial cells from SARS-CoV-2. Further, the level of high-density lipoprotein cholesterol (HDL-C) is low in COVID-19 patients with dyslipidemia. High-density lipoprotein (HDL) can inhibit atherosclerosis through adenosine triphosphate binding cassette A1 [43]. HDL also induces cyclooxygenase-2, which is responsible for producing anti-inflammatory prostaglandins [44]. HDL even directly inhibits the expression of NF-κB in macrophages by inhibiting CD40 [45]. These chronic inflammatory states increase the risk of cardiovascular disease. HDL also is proved to be an anti-inflammatory lipoprotein [46]. It has been reported that inflammation leads to the structural changes of HDL granules and the accumulation of serum amyloid A (SAA). The HDL granules rich in SAA lose their anti-inflammatory properties. Recent the study showed that SAA levels increased dynamically with the severity of COVID-19 disease. SAA may be considered as a biomarker to evaluate the severity and prognosis of COVID-19 [47, 48]. In the experimental model, infusion of recombinant HDL reduced inflammation and the number of bacteria, alleviated organ damage and improved survival rate [49]. In the study C-reactive protein (CRP) levels were higher in patients with low HDL-C, which indicated that HDL-C may hamper inflammation and thus have a protective effect against COVID-19. Based on these, we speculate that HDL loses its anti-inflammatory properties and consumes cholesterol during COVID-19 infection. This may further explain the significant decrease of HDL-C concentration in patients with COVID-19 infection [50]. A retrospective study of 597 patients with COVID-19 demonstrated that patients with COVID-19 developed hypolipidemia at the earliest onset of mild symptoms. The decrease of LDL-C level was positively correlated with CRP level. Reduced lipid levels are likely the result of complex biological and pathological processes caused by SARS-CoV-2 infection [51]. Although LDL-C synthesis is increased, serum LDL-C decreases due to the simultaneous increase in LDL receptor expression [6]. This may be explained by the characteristic changes in the acute phase response seen in many other inflammatory processes, such as acute coronary syndromes [52]. In addition, some studies attributed this low lipid status to increased lipid exosmosis and liver synthetic dysfunction [51].

SARS-CoV-2 is a single-stranded RNA virus with an envelope and can enter host cells through endocytosis or membrane fusion. SARS-CoV-2 binds to ACE2 on the host cell membrane [53]. In addition, it has been suggested that SARS-CoV-2 leads to excessive activation of the immune system through activation of the Toll-like receptor-MyD88-NF-κB pathway, which induces a proinflammatory response, a so-called "cytokine storm," by releasing proinflammatory cytokines such as interferons, interleukins, and tumor necrosis factor [54]. This cytokine storm can cause severe organ damage. Furthermore, studies have indicated that endothelial cells of patients with herpes virus infection indicated thrombin formation. These patients also had increased adhesion of platelets and granulocytes [55, 56]. Span et al. studied endothelial cells infected with cytomegalovirus (CMV) and found that leukocytes and platelets adhere to these endothelial cells, and CMV can also increase cytokine expression [56, 57]. Dyslipidemia promotes the activation of interleukin 1 (IL-1) dependent pathway by activating nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome, which is conducive to IL-1 cleavage and secretion, and modifie-LDL via scavenger receptors upregulates interleukin 6 (IL-6) in endothelial cells. Dyslipidemia promotes endothelial dysfunction and activation, which leads to the increase of pro-inflammatory cytokines and reactive oxygen species. These observations support that dyslipidemia promotes systemic inflammation by inducing multiple mediators [58,59,60]. Additionally, it is known that hyperlipidemia damages the immune response and may lead to persistent chronic inflammation, which leads to cardiovascular disease risk [61]. A meta-analysis suggested that an underlying or prior history of cardiovascular disease was directly associated with poor outcomes and severity in patients with COVID-19. Cardiovascular disease was found to be associated with an approximately three-fold increase in the risk of severe COVID-19 infection and an 11-fold increase in all-cause mortality in patients with COVID-19 [62]. Based on what has been observed in cardiovascular disease caused by dyslipidemia and chronic inflammation, it is possible that the SARS-CoV-2 acute inflammatory reaction aggravates the severity of the disease and increases the risk of mortality. Obesity may be key factors for COVID-19 in patients infected with SARS-CoV-2. The tissue expression of angiotensin converting enzyme 2 may play a important role in the disease development of COVID-19 obese patients, because the amount of adipose tissue in obese patients increases, resulting in an increase in the number of cells expressing angiotensin converting enzyme 2, thus increasing the risk of SARS-CoV-2 infection. Adipose tissue hypertrophy and hyperplasia promote triglyceride, phospholipid oxide, tumor necrosis factor-α, and adipocytokines contribute to obesit [63].

Lipids are the structural basis of both the cell membrane and the viral membrane, which play key roles in viral infection. Lipids are also involved in viral membrane fusion, encapsulation, and transformation. Lipid metabolism also plays an important role in the viral infection cycle, including virus entry, release, and replication, which may be prevented by changing the membrane lipid composition or lipid metabolism [64]. The lipid of virus is rich in cholesterol, so the consumption of cholesterol leads to decrease cholesterol content on virus membrane, and inhibit the infectivity of virus. In 2014, it was reported that statins, a limiting step in cholesterol biosynthesis, could inhibit the infectivity of Ebola virus disease [65]. Thus, hypolipidemic therapy has a dual beneficial effect in patients with hyperlipidemia by reducing the risk of cardiovascular disease and interfering with SARS-CoV-2 entry into cells. Therefore, patients with dyslipidemia should be advised to take preventive measures to minimize the risk of exposure to the virus. Patients with cardiovascular disease are at particular risk from COVID-19, as the infection will be more serious and the virus itself can cause cardiovascular damage. Thus dyslipidemia should be considered an important factor in the mortality of COVID-19. Additionally, reducing dietary cholesterol intake, increasing soluble fiber and soy protein intake and regular aerobic exercise, especially at least 120 min a week, have beneficial effects on blood lipid levels for reducing the risk of complications if COIVD is contracted [66].

As we know, this meta-analysis showed that dyslipidemia interconnects with the severity and mortality of COVID-19. However, the meta-analysis also has some limitations. First, unknown factors might interfere with the final result. Previous studies have shown that gender, age, nutritional status, smoking and diabetes can be implicated in the prognosis of patients with COVID-19, but other potential confounding factors were not excluded. In the future, the number of included studies will be increased, and it may be possible to analyze these potential confounding factors according to risk factors. Second, this meta-analysis only includes cohort studies and case–control studies. The lack of large-scale randomized controlled trials is the main limitation. In the future, more randomized controlled studies should be included. Third, hyperlipidemia and hypolipidemia were classified into dyslipidemia for analysis. None of the studies clearly indicated the accurate cut-off value of the diagnosis and definition of dyslipidemia, which may lead to error in the summary results and affect their accuracy. However, all included studies followed national or international guidelines for the diagnosis of dyslipidemia, and these studies were peer-reviewed. Fourth, the timing of the measurement of serum lipids and lipid-lowering drugs in each individual study were unclear, which may affect the true difference in severity and mortality of COVID-19 infection between patients with and without dyslipidemia. In addition, it is worth noting that funnel plots are a useful test for detecting bias in meta-analyses, but the ability to detect bias is limited when analyzing small trials. In the paper, most of the included studies were small, so the analysis should be treated with caution, which may affect the accuracy.

Conclusion

In conclusion, the meta-analysis showed that dyslipidemia as a predictor might foretell the severity and mortality of COVID-19. Active management of blood lipids and monitoring of lipid levels may be beneficial for COVID-19 patients.

Availability of data and materials

The data in the current paper are publicly available since this a meta-analysis conducted on the basis of the cited literature.

Abbreviations

COVID-19:

2019 Coronavirus disease

RR:

Risk ratio

CI:

Confidence inerval

SARS-CoV-2:

Severe acute respiratory syndrome coronavirus 2

WHO:

World Health Organization

LDL-C:

Low density lipoprotein cholesterol

TC:

Total cholesterol

LDL:

Low density lipoprotein

oxLDL:

Oxidized low density lipoprotein

HDL-C:

High density lipoprotein cholesterol

HDL:

High density lipoprotein

NF-κB:

Nuclear factor kappa-B

SAA:

Serum amyloid A

CRP:

C-reactive protein

CMV:

Cytomegalovirus

IL-1:

Interleukin 1

NLRP3:

Nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3

IL-6:

Interleukin 6

References:

  1. https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed April 22, 2021.

  2. Zhou J, Chu H, Chan JF, Yuen KY. Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis. Virol J. 2015;12:218.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (Lond, Eng). 2020;395(10223):497–506.

    Article  CAS  Google Scholar 

  4. Fan J, Wang H, Ye G, Cao X, Xu X, Tan W, et al. Letter to the editor: low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019. Metab Clin Exp. 2020;107:154243.

    Article  CAS  PubMed  Google Scholar 

  5. Wei X, Zeng W, Su J, Wan H, Yu X, Cao X, et al. Hypolipidemia is associated with the severity of COVID-19. J Clin Lipidol. 2020;14(3):297–304.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Liberati A, Altman DG, Tetzlaff J. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62:e1-34.

    Article  PubMed  Google Scholar 

  7. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.

    Article  PubMed  Google Scholar 

  8. Maeda T, Obata R, Rizk Do D, Kuno T. The association of interleukin-6 value, interleukin inhibitors and outcomes of patients with COVID-19 in New York City. J Med Virol. 2020.

  9. Ferguson J, Rosser JI, Quintero O, Scott J, Subramanian A, Gumma M, et al. Characteristics and outcomes of coronavirus disease patients under nonsurge conditions, Northern California, USA, March–April 2020. Emerg Infect Dis. 2020;26(8):1679–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020;75(7):1730–41.

    Article  CAS  PubMed  Google Scholar 

  11. To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020;20(5):565–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Rastrelli G, Di Stasi V, Inglese F, Beccaria M, Garuti M, Di Costanzo D, et al. Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. Andrology 2020.

  13. Almazeedi S, Al-Youha S, Jamal MH, Al-Haddad M, Al-Muhaini A, Al-Ghimlas F, et al. Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait. EClinicalMedicine 2020; 24:100448.

  14. Chen Q, Zheng Z, Zhang C, Zhang X, Wu H, Wang J, et al. Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection. 2020;48(4):543–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Jurado A, Martín MC, Abad-Molina C, Orduña A, Martínez A, Ocaña E, et al. COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. Immun Ageing I & A. 2020;17:22.

    Article  CAS  Google Scholar 

  16. Wu G, Yang P, Xie Y, Woodruff HC, Rao X, Guiot J, et al. Development of a clinical decision support system for severity risk prediction and triage of COVID-19 patients at hospital admission: an international multicenter study. Eur Respir J 2020.

  17. Urra JM, Cabrera CM, Porras L, Ródenas I. Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients. Clin Immunol (Orlando, Fla) 2020; 217:108486.

  18. Gidari A, De Socio GV, Sabbatini S, Francisci D. Predictive value of National Early Warning Score 2 (NEWS2) for intensive care unit admission in patients with SARS-CoV-2 infection. Infect Dis (Lond, Engl). 2020;52(10):698–704.

    Article  Google Scholar 

  19. Zhang C, Qin L, Li K, Wang Q, Zhao Y, Xu B, et al. A novel scoring system for prediction of disease severity in COVID-19. Front Cell Infect Microbiol. 2020;10:318.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. de la Rica R, Borges M, Aranda M, Del Castillo A, Socias A, Payeras A, et al. Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in spain: a retrospective cohort study. Microorganisms 2020; 8(8).

  21. Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195–9.

    Article  CAS  PubMed  Google Scholar 

  22. Petrilli CM, Jones SA, Yang J, Rajagopalan H, O'Donnell L, Chernyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ (Clinical research ed) 2020; 369:m1966.

  23. Li C, Ye J, Chen Q, Hu W, Wang L, Fan Y, et al. Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19. Aging. 2020;12(15):15670–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Chang MC, Park Y-K, Kim B-O, Park D. Risk factors for disease progression in COVID-19 patients. BMC Infect Dis. 2020;20(1):445.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Kong M, Zhang H, Cao X, Mao X, Lu Z. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol Infection. 2020;148:e139.

    Article  Google Scholar 

  26. Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Khalil K, Agbontaen K, McNally D, Love A, Mandalia S, Banya W, et al. Clinical characteristics and 28-day mortality of medical patients admitted with COVID-19 to a central London teaching hospital. J Infect. 2020;81(3):e85–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Gayam V, Chobufo MD, Merghani MA, Lamichhane S, Garlapati PR, Adler MK. Clinical characteristics and predictors of mortality in African-Americans with COVID-19 from an inner-city community teaching hospital in New York. J Med Virol. 2020.

  29. Goicoechea M, Sánchez Cámara LA, Macías N, Muñoz de Morales A, Rojas ÁG, Bascuñana A, et al. COVID-19: clinical course and outcomes of 36 hemodialysis patients in Spain. Kidney Int. 2020;98(1):27–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Santos CS, Morales CM, Álvarez ED, Castro C, Robles AL, Sandoval TP. Determinants of COVID-19 disease severity in patients with underlying rheumatic disease. Clin Rheumatol. 2020;39(9):2789–96.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Wang B, Van Oekelen O, Mouhieddine TH, Del Valle DM, Richter J, Cho HJ, et al. A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward. J Hematol Oncol. 2020;13(1):94.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Ferrando C, Mellado-Artigas R, Gea A, Arruti E, Aldecoa C, Bordell A, et al. Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: a prospective, cohort, multicentre study. Rev Esp Anestesiol Reanim. 2020;67(8):425–37.

    Article  CAS  PubMed Central  Google Scholar 

  33. Hwang JM, Kim JH, Park JS, Chang MC, Park D. Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study. Neurol Sci. 2020;41(9):2317–24.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Smith AA, Fridling J, Ibhrahim D, Porter PS. Identifying patients at greatest risk of mortality due to COVID-19: a new england perspective. West J Emerg Med. 2020;21(4):785–9.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Grasselli G, Greco M, Zanella A, Albano G, Antonelli M, Bellani G, et al. Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Int Med. 2020;180(10):1–11.

    Article  CAS  Google Scholar 

  36. Hariyanto TI, Kurniawan A. Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection. Diabetes Metab Syndr. 2020;14(5):1463–5.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation. 1990;82(2):495–506.

    Article  CAS  PubMed  Google Scholar 

  38. Trpkovic A, Resanovic I, Stanimirovic J, Radak D, Mousa SA, Cenic-Milosevic D, et al. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit Rev Clin Lab Sci. 2015;52(2):70–85.

    Article  CAS  PubMed  Google Scholar 

  39. Chen L, Yang G, Zhang X, Wu J, Gu Q, Wei M, et al. Induction of MIF expression by oxidized LDL via activation of NF-kappaB in vascular smooth muscle cells. Atherosclerosis. 2009;207(2):428–33.

    Article  CAS  PubMed  Google Scholar 

  40. Lievens D, Eijgelaar WJ, Biessen EA, Daemen MJ, Lutgens E. The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 2009;102(2):206–14.

    Article  CAS  PubMed  Google Scholar 

  41. Lee T, Chau L. Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2001;280(3):C709-718.

    Article  CAS  PubMed  Google Scholar 

  42. Li S, Jiang L, Li X, Lin F, Wang Y, Li B, et al. Clinical and pathological investigation of patients with severe COVID-19. JCI Insight. 2020; 5(12).

  43. Yu XH, Fu YC, Zhang DW, Yin K, Tang CK. Foam cells in atherosclerosis. Clin Chim Acta. 2013;424:245–52.

    Article  CAS  PubMed  Google Scholar 

  44. Zhang QH, Zu XY, Cao RX, Liu JH, Mo ZC, Zeng Y, et al. An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase 2 expression and prostacyclin production in endothelial cells. Biochem Biophys Res Commun. 2012;420(1):17–23.

    Article  CAS  PubMed  Google Scholar 

  45. Yin K, Chen WJ, Zhou ZG, Zhao GJ, Lv YC, Ouyang XP, et al. Apolipoprotein A-I inhibits CD40 proinflammatory signaling via ATP-binding cassette transporter A1-mediated modulation of lipid raft in macrophages. J Atheroscler Thromb. 2012;19(9):823–36.

    Article  CAS  PubMed  Google Scholar 

  46. Taborda NA, Blanquiceth Y, Urcuqui-Inchima S, Latz E, Hernandez JC. High-density lipoproteins decrease proinflammatory activity and modulate the innate immune response. J Interf Cytokine Res. 2019;39(12):760–70.

    Article  CAS  Google Scholar 

  47. Zewinger S, Drechsler C, Kleber ME, Dressel A, Riffel J, Triem S, et al. Serum amyloid a: high-density lipoproteins interaction and cardiovascular risk. Eur Heart J. 2015;36(43):3007–16.

    CAS  PubMed  Google Scholar 

  48. Li H, Xiang X, Ren H, Xu L, Zhao L, Chen X, et al. Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis. J Infect. 2020;80(6):646–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Tanaka S, Couret D, Tran-Dinh A, Duranteau J, Montravers P, Schwendeman A, et al. High-density lipoproteins during sepsis: from bench to bedside. Crit Care (Lond, Engl). 2020;24(1):134.

    Article  Google Scholar 

  50. Wang G, Zhang Q, Zhao X, Dong H, Wu C, Wu F, et al. Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study. Lipids Health Dis. 2020;19(1):204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Gierens H, Nauck M, Roth M, Schinker R, Schürmann C, Scharnagl H, et al. Interleukin-6 stimulates LDL receptor gene expression via activation of sterol-responsive and Sp1 binding elements. Arterioscler Thromb Vasc Biol. 2000;20(7):1777–83.

    Article  CAS  PubMed  Google Scholar 

  52. Balci B. The modification of serum lipids after acute coronary syndrome and importance in clinical practice. Curr Cardiol Rev. 2011;7(4):272–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181(2):281-292.e286.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Sun X, Wang T, Cai D, Hu Z, Chen J, Liao H, et al. Cytokine storm intervention in the early stages of COVID-19 pneumonia. Cytokine Growth Factor Rev. 2020;53:38–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Jacob HS, Visser M, Key NS, Goodman JL, Moldow CF, Vercellotti GM. Herpes virus infection of endothelium: new insights into atherosclerosis. Trans Am Clin Climatol Assoc. 1992;103:95–104.

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Span AH, van Dam-Mieras MC, Mullers W, Endert J, Muller AD, Bruggeman CA. The effect of virus infection on the adherence of leukocytes or platelets to endothelial cells. Eur J Clin Invest. 1991;21(3):331–8.

    Article  CAS  PubMed  Google Scholar 

  57. Geist LJ, Dai LY. Cytomegalovirus modulates interleukin-6 gene expression. Transplantation. 1996;62(5):653–8.

    Article  CAS  PubMed  Google Scholar 

  58. Lubrano V, Gabriele M, Puntoni MR, Longo V, Pucci L. Relationship among IL-6, LDL cholesterol and lipid peroxidation. Cell Mol Biol Lett. 2015;20(2):310–22.

    Article  CAS  PubMed  Google Scholar 

  59. Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE. 2010;5(7):e11765.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  60. van Diepen JA, Berbée JF, Havekes LM, Rensen PC. Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. Atherosclerosis. 2013;228(2):306–15.

    Article  PubMed  CAS  Google Scholar 

  61. Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V, et al. Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week. J Am Coll Cardiol. 2018;72(17):2071–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Aggarwal G, Cheruiyot I, Aggarwal S, Wong J, Lippi G, Lavie CJ, et al. Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis. Curr Probl Cardiol. 2020;45(8):100617.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Kassir R. Risk of COVID-19 for patients with obesity. Obes Rev. 2020;21(6):e13034.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Lorizate M, Kräusslich HG. Role of lipids in virus replication. Cold Spring Harbor Perspect Biol. 2011;3(10):e004820.

    Article  CAS  Google Scholar 

  65. Fedson DS. A practical treatment for patients with Ebola virus disease. J Infect Dis. 2015;211(4):661–2.

    Article  PubMed  Google Scholar 

  66. Kelly RB. Diet and exercise in the management of hyperlipidemia. Am Fam Physician. 2010;81(9):1097–102.

    PubMed  Google Scholar 

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Acknowledgements

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Funding

This study was funded by the foundation for Young Core Scientists of China Medical University, China (Grant No. QGZ2018059).

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Authors and Affiliations

  1. Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang, Liaoning, 110004, People’s Republic of China

    Yanli Liu, Yilong Pan, Yuyao Yin, Wenhao Chen & Xiaodong Li

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  1. Yanli Liu
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  2. Yilong Pan
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  3. Yuyao Yin
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  4. Wenhao Chen
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  5. Xiaodong Li
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Contributions

XDL contributed to the overall design of the study. YLL and YLP executed the data analysis, interpreted the results. YLL wrote the initial draft. YYY and WHC helped the data analysis. All authors read and approved the final version of the manuscript.

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Correspondence to Xiaodong Li.

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Supplementary Information

Additional file 1: Table SI

: Quality assessment of included studies (cohort studies)

Additional file 2: Table SII

: Quality assessment of included studies (case–control studies)

Additional file 3: Figure S1

: Sensitivity analysis demonstrating the association of dyslipidemia with COVID-19 mortality.

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Liu, Y., Pan, Y., Yin, Y. et al. Association of dyslipidemia with the severity and mortality of coronavirus disease 2019 (COVID-19): a meta-analysis. Virol J 18, 157 (2021). https://doi.org/10.1186/s12985-021-01604-1

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  • DOI: https://doi.org/10.1186/s12985-021-01604-1

Keywords

  • Dyslipidemia
  • COVID-19
  • SARS-CoV-2
  • Severity
  • Mortality

Virology Journal

ISSN: 1743-422X