Holly MK, Diaz K, Smith JG. Defensins in viral infection and pathogenesis. Annu Rev Virol. 2017;4:369–91.
Article
CAS
PubMed
Google Scholar
Lehrer RI. Primate defensins. Nat Rev Microbiol. 2004;2:727–38.
Article
CAS
PubMed
Google Scholar
Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005;6:551–7.
Article
CAS
PubMed
Google Scholar
Choi MK, Le MT, Nguyen DT, Choi H, Kim W, Kim JH, Chun J, Hyeon J, Seo K, Park C. Genome-level identification, gene expression, and comparative analysis of porcine ss-defensin genes. BMC Genet. 2012;13:98.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sang Y, Blecha F. Porcine host defense peptides: expanding repertoire and functions. Dev Comp Immunol. 2009;33:334–43.
Article
CAS
PubMed
Google Scholar
Sang Y, Patil AA, Zhang G, Ross CR, Blecha F. Bioinformatic and expression analysis of novel porcine beta-defensins. Mamm Genome. 2006;17:332–9.
Article
CAS
PubMed
Google Scholar
Bao YY, Li L, Zhang H, Gao CY, Xiao CB, Li CL. Preparation of polyclonal antibody against porcine beta defensin 2 and identification of its distribution in tissues of pig. Genet Mol Res. 2015;14:18863–71.
Article
CAS
PubMed
Google Scholar
Veldhuizen EJ, Rijnders M, Claassen EA, van Dijk A, Haagsman HP. Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Mol Immunol. 2008;45:386–94.
Article
CAS
PubMed
Google Scholar
Xu J, Zhong F, Zhang Y, Zhang J, Huo S, Lin H, Wang L, Cui D, Li X. Construction of Bacillus subtilis strain engineered for expression of porcine beta-defensin-2/cecropin P1 fusion antimicrobial peptides and its growth-promoting effect and antimicrobial activity. Asian-Australas J Anim Sci. 2017;30:576–84.
Article
CAS
PubMed
Google Scholar
Yang X, Cheng YT, Tan MF, Zhang HW, Liu WQ, Zou G, Zhang LS, Zhang CY, Deng SM, Yu L, et al. Overexpression of porcine Beta-Defensin 2 enhances resistance to Actinobacillus pleuropneumoniae infection in pigs. Infect Immun. 2015;83:2836–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Han F, Zhang H, Xia X, Xiong H, Song D, Zong X, Wang Y. Porcine beta-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol. 2015;194:1882–93.
Article
CAS
PubMed
Google Scholar
Tang Z, Xu L, Shi B, Deng H, Lai X, Liu J, Sun Z. Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intestinal toll-like receptor-4 and inflammatory cytokines in weaned piglets challenged with enterotoxigenic Escherichia coli. Anim Sci J. 2016;87:1258–66.
Article
CAS
PubMed
Google Scholar
Huang C, Yang X, Huang J, Liu X, Yang X, Jin H, Huang Q, Li L, Zhou R. Porcine Beta-Defensin 2 provides protection against bacterial infection by a direct bactericidal activity and alleviates inflammation via interference with the TLR4/NF-kappaB pathway. Front Immunol. 2019;10:1673.
Article
CAS
PubMed
PubMed Central
Google Scholar
Quintero-Gil C, Parra-Suescun J, Lopez-Herrera A, Orduz S. In-silico design and molecular docking evaluation of peptides derivatives from bacteriocins and porcine beta defensin-2 as inhibitors of hepatitis E virus capsid protein. Virusdisease. 2017;28:281–8.
Article
PubMed
PubMed Central
Google Scholar
Mettenleiter TC. In: BWJ M, MHV VR, editors. Pseudorabies Virus. In Encyclopedia of Virology (Third Edition). Oxford: Academic Press; 2008. p. 341–51.
Google Scholar
Sun Y, Luo Y, Wang CH, Yuan J, Li N, Song K, Qiu HJ. Control of swine pseudorabies in China: opportunities and limitations. Vet Microbiol. 2016;183:119–24.
Article
PubMed
Google Scholar
Tong-Qing A, Jin-Mei P, Zhi-Jun T, Hong-Yuan Z, Na L, Yi-Min L, Jia-Zeng C, Chao-Liang L, Yan S, Dan C, Guang-Zhi T. Pseudorabies virus variant in Bartha-K61–vaccinated pigs, China, 2012. Emerg Infect Dis J. 2013;19:1749.
Article
Google Scholar
Liu Y, Zhang S, Xu Q, Wu J, Zhai X, Li S, Wang J, Ni J, Yuan L, Song X, et al. Investigation on pseudorabies prevalence in Chinese swine breeding farms in 2013-2016. Trop Anim Health Prod. 2018;50:1279–85.
Article
PubMed
Google Scholar
Daher KA, Selsted ME, Lehrer RI. Direct inactivation of viruses by human granulocyte defensins. J Virol. 1986;60:1068–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, Keller MJ, Lehrer RI, Herold BC. Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol. 2006;177:8658–66.
Article
CAS
PubMed
Google Scholar
Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W. Multivalent binding of carbohydrates by the human alpha-defensin, HD5. J Immunol. 2009;183:480–90.
Article
CAS
PubMed
Google Scholar
Sinha S, Cheshenko N, Lehrer RI, Herold BC. NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2. Antimicrob Agents Chemother. 2003;47:494–500.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, et al. Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. J Virol. 2013;87:2835–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yasin B, Pang M, Turner JS, Cho Y, Dinh NN, Waring AJ, Lehrer RI, Wagar EA. Evaluation of the inactivation of infectious herpes simplex virus by host-defense peptides. Eur J Clin Microbiol Infect Dis. 2000;19:187–94.
Article
CAS
PubMed
Google Scholar
Nigro E, Colavita I, Sarnataro D, Scudiero O, Zambrano G, Granata V, Daniele A, Carotenuto A, Galdiero S, Folliero V, et al. An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule. Sci Rep. 2015;5:18450.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S. Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool. Int J Nanomedicine. 2015;10:6523–39.
CAS
PubMed
PubMed Central
Google Scholar
Mackenzie-Dyck S, Kovacs-Nolan J, Snider M. Babiuk LA, van Drunen Littel-van den Hurk S: inclusion of the bovine neutrophil beta-defensin 3 with glycoprotein D of bovine herpesvirus 1 in a DNA vaccine modulates immune responses of mice and cattle. Clin Vaccine Immunol. 2014;21:463–77.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mackenzie-Dyck S, Latimer L, Atanley E, Kovacs-Nolan J, Attah-Poku S, Babiuk LA, van Drunen Littel-van den Hurk S. Immunogenicity of a bovine herpesvirus 1 glycoprotein D DNA vaccine complexed with bovine neutrophil beta-defensin 3. Clin Vaccine Immunol. 2015;22:79–90.
Article
PubMed
CAS
Google Scholar
Crack LR, Jones L, Malavige GN, Patel V, Ogg GS. Human antimicrobial peptides LL-37 and human beta-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virus. Clin Exp Dermatol. 2012;37:534–43.
Article
CAS
PubMed
Google Scholar
Brandt CR, Akkarawongsa R, Altmann S, Jose G, Kolb AW, Waring AJ, Lehrer RI. Evaluation of a theta-defensin in a murine model of herpes simplex virus type 1 keratitis. Invest Ophthalmol Vis Sci. 2007;48:5118–24.
Article
PubMed
Google Scholar
Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI. Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol. 2004;78:5147–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen H, Fang L, He Q, Jin M, Suo X, Wu M. Study on the isolation and identification of the Ea strain of pseudorabies virus. Acta Veterinaria et Zootechnica Sinica. 1998;29:156–61.
Google Scholar
Reed LJ, Muench H. A simple method of estimating fifty per cent endpoints12. Am J Epidemiol. 1938;27:493–7.
Article
Google Scholar
Wilson SS, Wiens ME, Smith JG. Antiviral mechanisms of human defensins. J Mol Biol. 2013;425:4965–80.
Article
CAS
PubMed
Google Scholar
John M, Keller MJ, Fam EH, Cheshenko N, Hogarty K, Kasowitz A, Wallenstein S, Carlucci MJ, Tuyama AC, Lu W, et al. Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. J Infect Dis. 2005;192:1731–40.
Article
CAS
PubMed
Google Scholar
Chen J, Qi S, Guo R, Yu B, Chen D. Different messenger RNA expression for the antimicrobial peptides beta-defensins between Meishan and crossbred pigs. Mol Biol Rep. 2010;37:1633–9.
Article
CAS
PubMed
Google Scholar
Caruso C, Vitale N, Prato R, Radaelli MC, Zoppi S, Possidente R, Dondo A, Chiavacci L, Moreno Martin AM, Masoero L. Pseudorabies virus in north-west Italian wild boar (Sus scrofa) populations: prevalence and risk factors to support a territorial risk-based surveillance. Vet Ital. 2018;54:337–41.
PubMed
Google Scholar
Minamiguchi K, Kojima S, Sakumoto K, Kirisawa R. Isolation and molecular characterization of a variant of Chinese gC-genotype II pseudorabies virus from a hunting dog infected by biting a wild boar in Japan and its pathogenicity in a mouse model. Virus Genes. 2019;55:322–31.
Article
CAS
PubMed
Google Scholar
Yang X, Zhou T, Yu L, Tan W, Zhou R, Hu Y. A competitive chemiluminescence enzyme immunoassay method for beta-defensin-2 detection in transgenic mice. Luminescence. 2015;30:228–34.
Article
CAS
PubMed
Google Scholar
García-Valtanen P, Martinez-Lopez A, Ortega-Villaizan M, Perez L, Coll JM, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish β-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antivir Res. 2014;101:136–47.
Article
PubMed
CAS
Google Scholar
Vemula SV, Amen O, Katz JM, Donis R, Sambhara S, Mittal SK. Beta-defensin 2 enhances immunogenicity and protection of an adenovirus-based H5N1 influenza vaccine at an early time. Virus Res. 2013;178:398–403.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao H, Zhou J, Zhang K, Chu H, Liu D, Poon VK, Chan CC, Leung HC, Fai N, Lin YP, et al. A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016;6:22008.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jiang Y, Zhu R, Luo L, Mu Q, Zhu Y, Luo H, Zou X, Shen X. Recombinant mouse β-Defensin 3 protects against Coxsackievirus B3-induced myocarditis in mice. Intervirology. 2015;58:343–9.
Article
CAS
PubMed
Google Scholar
Jiang Y, Yang D, Li W, Wang B, Jiang Z, Li M. Antiviral activity of recombinant mouse β-defensin 3 against influenza a virus in vitro and in vivo. Antivir Chem Chemother. 2012;22:255–62.
Article
CAS
PubMed
Google Scholar
Peng Z, Wang A, Feng Q, Wang Z, Ivanova IV, He X, Zhang B, Song W. High-level expression, purification and characterisation of porcine beta-defensin 2 in Pichia pastoris and its potential as a cost-efficient growth promoter in porcine feed. Appl Microbiol Biotechnol. 2014;98:5487–97.
Article
CAS
PubMed
Google Scholar