Skip to main content

Correction: Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice

The Original Article was published on 24 April 2023

Correction: Virology Journal (2023) 20:78

https://doi.org/10.1186/s12985-023-02027-w

Following publication of the original article [1], the authors would like to update the Fig. 4D.

The updated Fig. 4 is given below.

Fig. 4
figure 1

Pan-caspase inhibitor reduced lung inflammation and IAV-induced mortality. (A) Six to eight weeks old mice were treated with vehicle control or 20 mg/kg body weight Q-VD-Oph intraperitoneally on day − 1 and day 1 of intranasal infection with 100 pfu IAV (H1N1) PR/8/34 strain in 50 µl PBS and were monitored for (B) the percent change in body weight and (C) survival over a period of 14 days post-infection. n = 10/group; N = 2. (D) Lung viral load was analyzed using the median tissue culture infectious dose (TCID50) 5 days post-infection. The lowest detection limit of the TCID50 assay was approximately 10^2 and this has been shown as a dotted line. n = 6–8/group. (E) Microscopic evaluation of vehicle control or Q-VD-Oph-treated lung sections stained with hematoxylin and eosin for histopathological analysis at 5 days post-infection and quantification of inflammation score. The open arrows indicate inflammatory cell infiltration in the alveoli and septa. n = 6/group, Scale bar = 50 μm, error bars indicate mean ± SEM; p < 0.05 was considered significant

The original article has been corrected

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yohannes A. Mebratu.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The online version of the original article can be found at https://doi.org/10.1186/s12985-023-02027-w.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Soni, S., Walton-Filipczak, S., Nho, R.S. et al. Correction: Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice. Virol J 20, 95 (2023). https://doi.org/10.1186/s12985-023-02060-9

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/s12985-023-02060-9