Fig. 5

Histopathological evaluation of tissues from AYA2012004_L treated mice confirmed no toxicity to vital organs. Photomicrograph of lung, brain, kidney, heart, lymph node, spleen and liver from C57BL/6J mice administered with 200 ul of DPBS in the absence or presence of AYA2012004_L or ODN 1826 via bronchoalveolar lavage. Mice were euthanized at day 45 and tissues were harvested and processed for Hematoxylin and Eosin (H &E) staining. Histopathological evaluation of tissues were described in Table 1. Data are representative over three independent experiments