Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma

Table 3 eBL association with unique recombination events

Event	CDS cut by start breakpoint	CDS cut by end breakpoint	Frequency in eBLs (%)	Frequency in healthy (%)	Without controlling for viral type		Controlling for viral type
Event	CDS cut by start breakpoint	CDS cut by end breakpoint	Frequency in eBLs (%)	Frequency in healthy (%)	OR^a (95% CI)	p value	OR^b (95% CI)	p value
47	BRLF1, BZLF1	BDLF3.5, BDLF4	16/54 (29.6)	3/32 (9.4)	4.07 (1.21–1.87)	0.038^a	3.31 (0.99–1.58)	0.089^b
50	LMP2A, LMP2B	EBNA2	17/54 (31.5)	1/32 (3.1)	14.24 (2.69–2.84)	0.012^a	12.36 (2.18–2.34)	0.020^b

CDS coding sequence, eBL endemic Burkitt lymphoma, OR odds ratio, Ref reference
Bold text indicates a statistical significance with a p value < 0.05. ^aUnivariate and ^bMultivariate logistic regression was used to compute the Odds Ratios and p values non-significant p value by univariate analysis

ISSN: 1743-422X