Fig. 1

A General workflow of the study. Poorly mapped and unmapped reads were extracted from the iHART dataset, reclassified to a database of bacteria, archaea, and GRCh38, and aggregated over species. Reads that were classified as human herpesvirus 6A, 6B, or 7 were mapped to the HHV genomes and analyzed in conjunction with their mates. B Number of total and poorly mapped or unmapped reads per sample, and the distributions of their reclassification phyla. C Phyla of Kraken reclassifications. Because Kraken classified the majority of reads down to the species level, we aggregated read counts by species/strain