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Fig. 3 | Virology Journal

Fig. 3

From: Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence

Fig. 3

Peripheral pathogenicity of ACVr HSV-1 clones and the parent HSV-1 TAS in mice. Mice were infected with each ACVr HSV-1 clone at the dose of 1.0 × 106 PFU / mouse through corneal route (one eye). This study was conducted twice independently [Experiment 1 (a) and Experiment 2 (b)]. Severity levels of dermatitis (upper panels) and keratitis (lower panels) were measured by using the scoring system introduced. All the mice inoculated with TAS or CL19 died within 7 days post infection

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