Table 4 Analysis of amino acid mutations in epitopes domains of field strains and the CV777 attenuated vaccine strain (aa 498–637, aa 747–754 and aa 763–770 located in CV777 attenuated)

CV777 attenuated

T

L

S

A

H

G

I

T

R

T

S

K

K

S

L

G

E

S

G

F

Q

V

D

G

P

L

D

G

V

CV777

L

S

V

A

L

E

I

S

Y

CH/ZMDZY/11

S

R

T

S

N

S

E

S

S

CH/HNHB-1

D

S

S

S

E

S

S

CH/HNHB-2, CH/HNHB-5

A

S

S

S

D

S

E

S

S

CH/HNHB-3

P

S

S

S

E

S

S

D

CH/HNHB-4

A

S

S

N

S

E

S

S

CH/HNHB-6, CH/HNHB-7

A

S

S

S

D

E

S

S

CH/HNKF-1, CH/HNLY

S

S

S

E

S

S

CH/HNKF-2

S

S

Y

S

E

S

S

CH/HNKF-3

S

S

Y

P

S

E

S

S

CH/HNSMX

S

T

S

E

G

S

S

CH/SXYC

S

A

S

S

E

S

S

CH/HNXC

S

S

S

V

S

S

CH/HNXX

S

S

S

V

E

S

S

CH/HNAY

A

S

Y

S

S

E

L

S

S

CH/HNNY-1, CH/HNNY-2, CH/HNNY-3,

S

Y

S

S

E

S

S

CH/HNZMD

S

S

H

S

V

E

S

S

A

CH/HNPY

A

S

Y

S

S

E

L

S

S