Figure 3
From: Oncolytic parvoviruses: from basic virology to clinical applications
Towards individualized parvovirus-based treatments. A better understanding of PV-host interaction with identification of key cellular factors playing a role in the PV-life cycle and in virus-mediated cytotoxicity may provide valuable hints for a more rational and efficient use of PV-based therapies in clinical settings. Predictive tests may identify patients with a molecular portrait that makes them more likely to benefit from virus treatment or targeted combination therapies.