Table 3 Validity of serum ALT, AST and HBV DNA levels for the differentiation of patients with HBeAg (-) inactive chronic hepatitisB from active chronic HBeAg (-) carriers
Lab tests | Spe% | Sen% | PPV% | NPV% | Inactive carriers (n = 228) | Chronic carriers (n = 339) |
|---|---|---|---|---|---|---|
ALT (IU/L) | ||||||
≤ 20 | 99.1 | 87.7 | 99 | 92 | 200/28 | 2/337 |
≤ 30 | 97.4 | 99.1 | 96 | 99.3 | 226/2 | 8/331 |
≤ 35 | 96.6 | 99.6 | 96 | 99.6 | 227/1 | 9/330 |
≤ 40 | 93.4 | 100 | 93 | 100 | 228/0 | 16/323 |
AST (IU/L) | ||||||
≤ 20 | 93.5 | 83.7 | 82 | 89.5 | 191/37 | 40/317 |
≤ 30 | 79.1 | 95.6 | 75.4 | 96.4 | 218/10 | 71/268 |
≤ 35 | 77.8 | 98.6 | 75.2 | 98.8 | 225/3 | 74/264 |
≤ 40 | 63.1 | 99.1 | 64.4 | 99.5 | 227/1 | 124/214 |
HBV DNA (Copies/mL) | ||||||
≤ 2000 | 100 | 48.2 | 100 | 75 | 110/118 | 0/339 |
≤ 5000 | 100 | 75.4 | 100 | 84 | 172/56 | 0/339 |
≤ 20,000 | 100 | 95.1 | 100 | 95 | 217/21 | 0/339 |
≤ 50,000 | 100 | 99.1 | 100 | 99 | 227/1 | 0/339 |
≤ 100,000 | 100 | 100 | 100 | 100 | 228/0 | 0/339 |
ALT + HBV DNA (Our findings) | ||||||
ALT (30 M/19F) HBV DNA (≤ 100,000 copies/mL) | 92 | 98 | 97 | 94 | 210/18 | 5/334 |
ALT + HBV DNA (Assy et al.[22]) | ||||||
ALT (30 M/19F) HBV DNA (≤ 100,000 copies/mL) | 100 | 92 | 100 | 86 | - | - |