Skip to main content
Figure 6 | Virology Journal

Figure 6

From: Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter

Figure 6

COX-2 expression induced by demethylation-linked recruitment of multiple transcription factors during HBV infection. (A) In normal cells, the promoter region of COX-2 is hypermethylated, and transcription repressors such as DNMT3B bind to the methylated CpG sites and repress activity of the COX-2 promoter. (B) After HBV infection, the expression of viral proteins triggers demethylation of the COX-2 promoter by down-regulating DNMT3B. Transcriptional repression is relieved and interactions between HBx and C/EBPβ, NF-AT, and CBP/p300 enhance the recruitment of the complex to the promoter, resulting in expression of the COX-2 gene.

Back to article page

Virology Journal

ISSN: 1743-422X