Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, Wang H, Crameri G, Hu Z, Zhang H, et al.: Bats are natural reservoirs of SARS-like coronaviruses. Science 2005, 310: 676-679. 10.1126/science.1118391
Article
PubMed
CAS
Google Scholar
Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, et al.: Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003, 300: 1394-1399. 10.1126/science.1085952
Article
PubMed
CAS
Google Scholar
Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, et al.: The Genome sequence of the SARS-associated coronavirus. Science 2003, 300: 1399-1404. 10.1126/science.1085953
Article
PubMed
CAS
Google Scholar
Liu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Xiong H, Farmar J, Debnath AK, Tien P, Jiang S: Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 2004, 363: 938-947. 10.1016/S0140-6736(04)15788-7
Article
PubMed
CAS
Google Scholar
Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ: Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. Proc Natl Acad Sci USA 2004, 101: 8455-8460. 10.1073/pnas.0400576101
Article
PubMed
CAS
PubMed Central
Google Scholar
Simmons G, Reeves JD, Rennekamp AJ, Amberg SM, Piefer AJ, Bates P: Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc Natl Acad Sci USA 2004, 101: 4240-4245. 10.1073/pnas.0306446101
Article
PubMed
CAS
PubMed Central
Google Scholar
Buchholz UJ, Bukreyev A, Yang L, Lamirande EW, Murphy BR, Subbarao K, Collins PL: Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. Proc Natl Acad Sci USA 2004, 101: 9804-9809. 10.1073/pnas.0403492101
Article
PubMed
CAS
PubMed Central
Google Scholar
Yang ZY, Kong WP, Huang Y, Roberts A, Murphy BR, Subbarao K, Nabel GJ: A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 2004, 428: 561-564. 10.1038/nature02463
Article
PubMed
CAS
Google Scholar
Bisht H, Roberts A, Vogel L, Bukreyev A, Collins PL, Murphy BR, Subbarao K, Moss B: Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice. Proc Natl Acad Sci USA 2004, 101: 6641-6646. 10.1073/pnas.0401939101
Article
PubMed
CAS
PubMed Central
Google Scholar
Bukreyev A, Lamirande EW, Buchholz UJ, Vogel LN, Elkins WR, St Claire M, Murphy BR, Subbarao K, Collins PL: Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS. Lancet 2004, 363: 2122-2127. 10.1016/S0140-6736(04)16501-X
Article
PubMed
CAS
Google Scholar
ter Meulen J, Bakker AB, van den Brink EN, Weverling GJ, Martina BE, Haagmans BL, Kuiken T, de Kruif J, Preiser W, Spaan W, et al.: Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Lancet 2004, 363: 2139-2141. 10.1016/S0140-6736(04)16506-9
Article
PubMed
CAS
Google Scholar
He Y, Zhou Y, Wu H, Luo B, Chen J, Li W, Jiang S: Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines. J Immunol 2004, 173: 4050-4057.
Article
PubMed
CAS
Google Scholar
Wong SK, Li W, Moore MJ, Choe H, Farzan M: A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem 2004, 279: 3197-3201. 10.1074/jbc.C300520200
Article
PubMed
CAS
Google Scholar
Babcock GJ, Esshaki DJ, Thomas WD Jr, Ambrosino DM: Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J Virol 2004, 78: 4552-4560. 10.1128/JVI.78.9.4552-4560.2004
Article
PubMed
CAS
PubMed Central
Google Scholar
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, et al.: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003, 426: 450-454. 10.1038/nature02145
Article
PubMed
CAS
Google Scholar
He Y, Lu H, Siddiqui P, Zhou Y, Jiang S: Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies. J Immunol 2005, 174: 4908-4915.
Article
PubMed
CAS
Google Scholar
He Y, Li J, Li W, Lustigman S, Farzan M, Jiang S: Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. J Immunol 2006, 176: 6085-6092.
Article
PubMed
CAS
Google Scholar
He Y, Li J, Heck S, Lustigman S, Jiang S: Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine design. J Virol 2006, 80: 5757-5767. 10.1128/JVI.00083-06
Article
PubMed
CAS
PubMed Central
Google Scholar
He Y, Zhu Q, Liu S, Zhou Y, Yang B, Li J, Jiang S: Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines. Virology 2005, 334: 74-82. 10.1016/j.virol.2005.01.034
Article
PubMed
CAS
Google Scholar
Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S: The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol 2009, 7: 226-236. 10.1038/nrmicro2090
Article
PubMed
CAS
PubMed Central
Google Scholar
He Y, Jiang S: Vaccine design for severe acute respiratory syndrome coronavirus. Viral Immunol 2005, 18: 327-332. 10.1089/vim.2005.18.327
Article
PubMed
CAS
Google Scholar
Jiang S, He Y, Liu S: SARS vaccine development. Emerg Infect Dis 2005, 11: 1016-1020.
Article
PubMed
CAS
PubMed Central
Google Scholar
Du L, Zhao G, Chan CC, Sun S, Chen M, Liu Z, Guo H, He Y, Zhou Y, Zheng BJ, Jiang S: Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity. Virology 2009, 393: 144-150. 10.1016/j.virol.2009.07.018
Article
PubMed
CAS
PubMed Central
Google Scholar
Du L, Zhao G, He Y, Guo Y, Zheng BJ, Jiang S, Zhou Y: Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model. Vaccine 2007, 25: 2832-2838. 10.1016/j.vaccine.2006.10.031
Article
PubMed
CAS
Google Scholar
Du L, Zhao G, Lin Y, Sui H, Chan C, Ma S, He Y, Jiang S, Wu C, Yuen KY, et al.: Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. J Immunol 2008, 180: 948-956.
Article
PubMed
CAS
PubMed Central
Google Scholar
Zhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X, Hensley LE, Prabakaran P, Rockx B, Sidorov IA, et al.: Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc Natl Acad Sci USA 2007, 104: 12123-12128. 10.1073/pnas.0701000104
Article
PubMed
CAS
PubMed Central
Google Scholar
Sui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, Tallarico AS, Olurinde M, Choe H, et al.: Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc Natl Acad Sci USA 2004, 101: 2536-2541. 10.1073/pnas.0307140101
Article
PubMed
CAS
PubMed Central
Google Scholar
He Y, Li J, Du L, Yan X, Hu G, Zhou Y, Jiang S: Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV vaccine. Vaccine 2006, 24: 5498-5508. 10.1016/j.vaccine.2006.04.054
Article
PubMed
CAS
Google Scholar
He Y, Li J, Jiang S: A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity. Biochem Biophys Res Commun 2006, 344: 106-113. 10.1016/j.bbrc.2006.03.139
Article
PubMed
CAS
Google Scholar
He Y, Zhou Y, Liu S, Kou Z, Li W, Farzan M, Jiang S: Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine. Biochem Biophys Res Commun 2004, 324: 773-781. 10.1016/j.bbrc.2004.09.106
Article
PubMed
CAS
Google Scholar
He Y, Zhou Y, Siddiqui P, Jiang S: Inactivated SARS-CoV vaccine elicits high titers of spike protein-specific antibodies that block receptor binding and virus entry. Biochem Biophys Res Commun 2004, 325: 445-452. 10.1016/j.bbrc.2004.10.052
Article
PubMed
CAS
Google Scholar
He Y, Zhou Y, Siddiqui P, Niu J, Jiang S: Identification of immunodominant epitopes on the membrane protein of the severe acute respiratory syndrome-associated coronavirus. J Clin Microbiol 2005, 43: 3718-3726. 10.1128/JCM.43.8.3718-3726.2005
Article
PubMed
CAS
PubMed Central
Google Scholar
He Y, Zhou Y, Wu H, Kou Z, Liu S, Jiang S: Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus. J Clin Microbiol 2004, 42: 5309-5314. 10.1128/JCM.42.11.5309-5314.2004
Article
PubMed
CAS
PubMed Central
Google Scholar
Du L, Zhao G, Lin Y, Chan C, He Y, Jiang S, Wu C, Jin DY, Yuen KY, Zhou Y, Zheng BJ: Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection. Vaccine 2008, 26: 1644-1651. 10.1016/j.vaccine.2008.01.025
Article
PubMed
CAS
PubMed Central
Google Scholar
Wu LP, Wang NC, Chang YH, Tian XY, Na DY, Zhang LY, Zheng L, Lan T, Wang LF, Liang GD: Duration of antibody responses after severe acute respiratory syndrome. Emerg Infect Dis 2007, 13: 1562-1564.
Article
PubMed
PubMed Central
Google Scholar
Cao WC, Liu W, Zhang PH, Zhang F, Richardus JH: Disappearance of antibodies to SARS-associated coronavirus after recovery. N Engl J Med 2007, 357: 1162-1163. 10.1056/NEJMc070348
Article
PubMed
CAS
Google Scholar