Figure 1

Inhibition of HCV replication and multiplication by different IFN-α subtypes. A: Total RNA from Huh7-infected cells cultured with 260 pg/mL of different IFN α subtypes was used to quantify HCV intracellular RNA, as described in the Materials and methods. The inhibition was calculated by comparing the results to infected Huh7 cells in the absence of interferon. An asterisk indicates represents the IFN subtypes that were significantly more potent against HCV than IFN-α2a. B: Quantification of HCV multiplication by measuring the viral yield in the supernatant. The results were expressed in FFU/mL on a semi-logarithmic scale. An asterisk indicates the IFN subtypes that were significantly more potent against HCV than IFN-α2a. The results correspond to the mean of four independent experiments.