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Table 1 Compounds that reduce rotavirus infectivity without cytotoxicity

From: Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay

Manufacturer's ID Number Chemical Name FW Chemical Family Known Functions (Select references)
Group A     
TNP00130 18-β-Glycyrrhetinic Acid 470.68 Triterpene -Antiviral activity against a number of DNA and RNA viruses [25]
-Inhibits gap junction communication
TNP00088 Abietic Acid 302.45 Diterpene -Inhibits acute inflammation after topical or oral administration [26]
-Reduces neutrophil infiltration [26]
-Reduces COX-2 and TNF-α expression [16]
-Activates PPAR-γ in macrophages [16]
TNP00194 All-trans-Retinoic Acid 300.44 Retinoid -Increases expression of type I interferon receptors [27]
TNP00140 α-Mangostin 410.46 Xanthone -Used in treatment of skin infections, wounds and diarrhea in Southeast Asia [15]
-γ-Mangostin inhibits NF-κB activation and COX-2 expression [15]
-α-Mangostin preferentially inhibits growth of HL60 cells [28]
-Induces caspase-9 and -3 activation in HL60 cells [28]
Group B     
TNP00307 Kinetin-9-Riboside 347.33 Phytohormone -Cytokinin
-Antiviral activity against Tobacco Mosaic Virus [29]
-Causes a decrease in (poly rI) (poly rC) stimulated interferon response in VSV challenged mice [30]
-Reverses the effect of endotoxin-enhanced host resistance [31]
TNP00064 7,3'-Dihydroxyflavone 254.24 Flavone  
TNP00050 6,7-Dimethoxyflavone 282.29 Flavone  
TNP00044 8-Hydroxy-7-Methoxyflavone 268.27 Flavone  
TNP00151 Genistein 270.24 Isoflavone -Tyrosine kinase inhibitor [32]
-Down-regulates iNOS [33]
-Inhibits NF-κB activation [33]
-Inhibits COX-2 induction [33]
-Inhibits LPS induced IL-1β, IL-6, and TNF-α production in monocytes
TNP00227 Capsaicin 305.42 Phenylalkyl-Amine Alkaloid -Inhibits NF-κB activation [34]
-Activates transient receptor potential vanilloid-1 (TRPV-1) [35]
TNP00256 Securinine 217.26 Pseudoalkaloid -GABA receptor antagonist
-Antibacterial activity against E. coli, Staph. aureus and Myc. smegmatis [36]
-Antimalarial activity [37]
TNP00231 Isopimaric Acid 302.46 Diterpene -Inhibitory activity against multidrug-resistant strains of Staphylococcus aureus [38]
-activates large-conductance Ca2+-activated K+ channel α-subunit [39]
TNP00292 Parthenolide 248.32 Sesquiterpene Lactone -inhibits NFκB activation by preventing induction of IκB kinase [40]
TNP00006 Unknown 358.48   
TNP00014 Unknown 388.50