Figure 3
Loss of Stat 1 alleviates innate host repression of ICP0- viruses in vivo. A. Strain 129 mice, rag2-/- mice, PML-/- mice, or stat1-/- mice were inoculated with 2 × 105 pfu per eye of the ICP0- virus n212 (n = 4 mice per group). The mean ± sem of the logarithm of viral titers recovered from mouse eyes is plotted over time. B. Strain 129 mice, rag2-/- mice, stat1-/- mice, or rag2-/- stat1-/- mice were inoculated with 2 × 105 pfu per eye of the ICP0- virus, 0--GFP (n = 4 mice per group). Dashed lines indicate the lower limit of detection of the plaque assay. C. Survival of strain 129 mice, rag2-/- mice, PML-/- mice, stat1-/- mice, or rag2-/- stat1-/- mice infected with the ICP0- viruses, n212 or 0--GFP. Bars represent the mean ± sem of survival frequency of ICP0- virus-infected mice at day 60 p.i. (n = 3 experiments; Σn = 14 mice per group).