Figure 3
From: Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution
The putative mechanism for different transduction efficiencies of adeno-associated virus (AAV) types AAV6 and AAVM41 vectors in mouse heart. These two vectors entered the cardiac tissues with the similar efficiency as a whole. However, AAVM41 might preferentially transduce the cardiomyocytes whereas AAV6 tended to infect endothelial cells with the higher ratio. This discrepancy in tissue distribution enabled AAVM41 to exhibit higher transduction efficiency of myocardium compared with AAV6 after systemic administration. Note that the virus particles in the interior of the cells indicated only that these cells were positively transduced. The real intracellular localization and viral structure of AAV are not reflected in this chart for simplicity.