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Table 1 Comparison of pathogenicity of HK483 and MON3 in 1-day-, 2-week-, and 4-week-old ducks

From: The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks

Virus Age of ducks Mortalitya MDDb(range) Virus titersc
Brain Lung
HK483 1 day 0/3 ≥ 14 5.4, 2.5, 2.5 5.5, 4.5, 2.5
  2 weeks 0/6 ≥ 14 -, -, -d 4.3, 3.5, 2.5
  4 weeks 0/3 ≥ 14 -, -, - 2.5, -, -
MON3 1 day 9/9 2.2 (2–3) 8.0, 7.5 5.7, 5.5
  2 weeks 10/10 4.9 (4–7) 8.8, 7.3, 7.3 8.5, 5.5, 5.3
  4 weeks 1/3 7.0 5.5, 4.5, - 4.5, 2.5, 3.7
  1. a Number of dead ducks/number of examined ducks.
  2. b Mean death days post-inoculation.
  3. c At 3 days post-inoculation, the brains and lungs were collected. Suspension of each tissue sample was inoculated into 10-day-old embryonated eggs for titration. Virus titers in tissues were expressed as log 50% egg infectious dose (EID50)/g. The lower limit of detection was 101.5 EID50/g.
  4. d -: < 1.5 log EID50/g.