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Table 3 Amino acid mutations in the HCV NS5A protein in DAA-naïve patients infected with HCV genotypes 1a (n = 32) or 1b (n = 30)

From: Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients

DAAs NS5A mutations in DAA-naïve patients
Genotype 1a Fold change in EC50 Genotype 1b Fold change in EC50 References
Daclatasvir M28V (1/32, 3.1%) α 1.3 L28M/V (1/30,3.3%) 2.0 [15, 17, 19]
  Q30E/H/R/K   R30H   
Daclatasvir L31M/(1/32, 3.1%) 341 L31M (2/30, 6.6%) 3 [15, 17, 19]
Ledipasvir L31M/(1/32, 3.1%) 140 L31M   [29]
GSK805 L31M/(1/32, 3.1%) >150 L31M   [30]
Samatasvir L31M   L31M (2/30, 6.6%) 3.6 [31]
  P32L   P32L   
Daclatasvir Q54H/L/N   Q54H (8/30, 26.6%) 1.0 [19]
Daclatasvir H58P (2/32, 6.2%) 1.2 P58S/T/L   [19]
  N69T   N69T   
  A92V   A92V   
Daclatasvir Y93C/H/N   Y93H (3/30, 10%) 24 [15, 17, 19]
Ledipasvir Y93C/H/N   Y93H (3/30, 10%) 1319 [29]
Samatasvir Y93C/H/N   Y93H (3/30, 10%) 93 [31]
  V153M   V153M   
  R157W   R157W   
  V198A   V198A   
  M202L   M202L   
  P223S   P223S   
  M265V   M265V   
GSK805 I280V   I280V (2/30, 6.6%) <2.0 [30]
  V298A   V298A   
  V362A   V362A   
  S364P   S364P   
  S368P   S368P   
  1. αAmino acid changes conferring resistance to NS5A inhibitors are reported in italics. The number and % of patients with mutated strains is reported in brackets.
  2. GeneBank accession number of NS5A reference sequence for HCV genotype 1a is AF009606, and for genotype 1b, AY045702.