Presepsin as a prognostic biomarker in COVID-19 patients: combining clinical scoring systems and laboratory inflammatory markers for outcome prediction

Table 5 AUC for predicting COVID-19 mortality using various parameters and models

Variables	AUC	Standard error	P value	95% confidence interval
Variables	AUC	Standard error	P value	Lower limit	Upper limit
Presepsin	0.829	0.046	p < 0.001*	0.737	0.920
qSOFA	0.889	0.036	p < 0.001*	0.823	0.955
NEWS2	0.871	0.033	p < 0.001*	0.808	0.934
PSI	0.878	0.054	p < 0.001*	0.773	0.984
COVID-GRAM	0.841	0.056	p < 0.001*	0.730	0.953
CURB-65	0.897	0.042	p < 0.001*	0.817	0.978
PCT	0.768	0.049	p < 0.001*	0.670	0.866
CRP	0.781	0.048	p < 0.001*	0.686	0.876
NLR	0.677	0.066	p < 0.001*	0.546	0.808
CAR	0.798	0.046	p < 0.001*	0.706	0.890
LCR	0.812	0.048	p < 0.001*	0.716	0.907
Presepsin + qSOFA	0.933	0.020	p < 0.001*	0.893	0.972
Presepsin + NEWS2	0.906	0.025	p < 0.001*	0.856	0.955
Presepsin + PSI	0.888	0.051	p < 0.001*	0.789	0.987
Presepsin + COVID-GRAM	0.866	0.050	p < 0.001*	0.767	0.966
Presepsin + CURB-65	0.914	0.037	p < 0.001*	0.840	0.988
Presepsin + PCT	0.847	0.039	p < 0.001*	0.770	0.925
Presepsin + CRP	0.887	0.028	p < 0.001*	0.831	0.942
Presepsin + NLR	0.847	0.042	p < 0.001*	0.765	0.929
Presepsin + CAR	0.888	0.029	p < 0.001*	0.833	0.944
Presepsin + LCR	0.885	0.030	p < 0.001*	0.825	0.945

Abbreviations AUC, area under the receiver operating characteristic curve; qSOFA, quick sequential organ failure assessment; NEWS2, National Early Warning Score 2; PSI, Pneumonia Severity Index; PCT, Procalcitonin; CRP, C-reactive protein; NLR, Neutrophil-to-lymphocyte ratio; CAR, C-reactive protein-to-albumin ratio; LCR, Lymphocyte-to-C-reactive protein ratio

ISSN: 1743-422X