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Fig. 6 | Virology Journal

Fig. 6

From: Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B

Fig. 6

The associations between GPX4 promoter methylation level and related cytokines serum expression levels, and hepatitis B virus load. Significant correlation was observed between the PMR value of the GPX4 promoter and ROS serum expression level (a Spearman’s r = 0.3933, P<0.0001), and SOD serum expression level (b Spearman’s r = -0.3593, P<0.0001), and MDA serum expression level (c Spearman’s r = 0.3830, P<0.0001), and TNF-α serum expression level (d Spearman’s r = 0.2651, P = 0.0121), and IL-1β serum expression level (e Spearman’s r = 0.4748, P<0.0001), and IL-6 serum expression level (f Spearman’s r = 0.1974, P = 0.0388), and HBsAg level (g Spearman’s r = 0.2332, P = 0.0061), and HBeAg level (h Spearman’s r = 0.2615, P = 0.0144), and HBV DNA load (i Spearman’s r = 0.2279, P = 0.0074), ns, P>0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001

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Virology Journal

ISSN: 1743-422X