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Fig. 3 | Virology Journal

Fig. 3

From: Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B

Fig. 3

The expression levels of cGAS-STING pathway-related molecules in different groups. (a) Relative mRNA level of STING in PBMCs from IT, IA, LR, RA and HCs. Relative mRNA level of STING was significantly lower in IT(P = 0.0010), LR(P = 0.0078) and HC(P < 0.0001) than in IA and lower in IT(P = 0.0022), LR(P = 0.0057) and HC(P < 0.0001) than in RA, respectively, by using the Kruskal-Wallis Test and Dunn’s test. (b) Serum IFN-β level from IT, IA, LR, RA and HCs. Serum IFN-β level was significantly lower in IT(P < 0.0001), LR(P < 0.0001) and HC(P < 0.0001) than in IA and lower in IT(P = 0.0127), LR(P = 0.0013) and HC(P < 0.0001) than in RA, respectively, by using the Kruskal-Wallis Test and Dunn’s test. ns, P>0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001

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Virology Journal

ISSN: 1743-422X