Fig. 5
Changes of cytokines and immunoglobulins in serum, correlation between anti-HBs and proportion of cell subsets. Changes of IL-2, IL-5, IL-6 and total IgG in serum of Vaccine group at different time points (A). Correlations between anti-HBs and the proportion of plasma B cells, CD24+CD38high Breg, Th1 cells Th2 cells and Tfh cells at week 24 (B). The statistical analysis of changes in cytokines and immunoglobulins was determined by Wilcoxon matched-pairs signed-rank test. The level of anti-HBs and the proportion of cell subsets were evaluated by spearman correlation. *p < 0.05; **p < 0.005; ***p < 0.001