Table 2 Clinical implications of SARS-CoV-2 variants and mutations
Variant/Mutation | Clinical implications |
|---|---|
The Spike protein D614G mutation | Increase the infectivity of SARS-CoV-2 by reducing viral neutralization by adaptive immune response [115, 116, 179]. |
20I/501Y.V1/VOC 202,012/01 variant | Higher transmissibility rate and increased risk of death [180]. |
20 H/501Y.V2 variant | Higher transmissibility rate and more severe disease [127, 128] |
20 J/501Y.V3/ P.1 variant | Potential higher transmissibility and re-infection rates [127, 136, 181] |