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Table 4 Population coverage (%) for specific epitopes containing HLA-binding alleles of MHC class I, class II, as well as combined class I and class II

From: A computational approach to design a multiepitope vaccine against H5N1 virus

population/area

Class I

Class II

Class combined

Coveragea

Average_hitb

pc90c

Coveragea

Average_hitb

pc90c

Coveragea

Average_hitb

pc90c

Algeria

0.0%

0.0

0.0

83.55%

1.42

0.61

83.55%

1.42

0.61

Argentina

83.23%

1.73

0.6

92.37%

1.78

1.07

98.72%

3.51

2.03

Australia

85.67%

1.71

0.7

84.53%

1.31

0.65

97.78%

3.02

1.63

Austria

92.54%

2.28

1.09

76.61%

1.24

0.43

98.26%

3.52

1.85

Belgium

85.65%

2.06

0.7

77.25%

1.25

0.44

96.74%

3.3

1.52

Brazil

84.17%

1.74

0.63

85.76%

1.43

0.7

97.75%

3.18

1.69

Canada

0.0%

0.0

0.0

93.63%

1.66

1.11

93.63%

1.66

1.11

Central Africa

84.85%

1.6

0.66

90.38%

1.65

1.01

98.54%

3.24

1.96

Central America

6.44%

0.07

0.11

88.25%

1.39

0.85

89.0%

1.46

0.91

Chile

82.4%

1.64

0.57

82.25%

1.45

0.56

96.88%

3.09

1.52

China

78.98%

1.39

0.48

86.03%

1.5

0.72

97.06%

2.88

1.52

Colombia

2.84%

0.03

0.1

84.34%

1.45

0.64

84.79%

1.48

0.66

Croatia

94.5%

2.33

1.19

96.26%

2.13

1.27

99.79%

4.46

2.86

Czech Republic

87.79%

2.07

0.82

94.04%

2.05

1.15

99.27%

4.12

2.29

Denmark

0.0%

0.0

0.0

93.03%

2.29

1.13

93.03%

2.29

1.13

East Africa

87.8%

1.9

0.82

95.27%

1.96

1.2

99.42%

3.86

2.31

East Asia

96.97%

2.36

1.37

80.31%

1.37

0.51

99.4%

3.73

2.29

England

95.12%

2.74

1.24

91.7%

2.12

1.07

99.59%

4.86

2.74

Europe

92.13%

2.33

1.08

89.14%

1.82

0.92

99.15%

4.15

2.28

France

95.51%

2.63

1.28

95.14%

2.32

1.24

99.78%

4.94

3.04

Germany

94.18%

2.5

1.18

95.55%

2.27

1.25

99.74%

4.77

2.87

Greece

0.0%

0.0

0.0

92.99%

1.88

1.1

92.99%

1.88

1.1

Hong Kong

86.36%

1.59

0.73

0.0%

0.0

0.0

86.36%

1.59

0.73

India

80.13%

1.61

0.5

86.55%

1.58

0.74

97.33%

3.19

1.61

Indonesia

65.87%

1.02

0.29

84.82%

1.31

0.66

94.82%

2.33

1.22

Iran

83.59%

1.46

0.61

88.19%

1.62

0.85

98.06%

3.08

1.77

Ireland Northern

95.02%

2.69

1.23

81.01%

1.46

0.53

99.05%

4.15

2.21

Israel

81.19%

1.75

0.53

93.51%

1.94

1.13

98.78%

3.69

2.08

Italy

94.7%

2.53

1.2

93.46%

1.84

1.11

99.65%

4.37

2.58

Japan

97.56%

2.39

1.44

82.55%

1.4

0.57

99.57%

3.79

2.4

Korea; South

95.86%

2.26

1.27

74.06%

1.16

0.39

98.93%

3.42

2.08

Lebanon

0.0%

0.0

0.0

84.42%

1.38

0.64

84.42%

1.38

0.64

Malaysia

55.3%

0.78

0.22

65.45%

0.85

0.29

84.56%

1.63

0.65

Mexico

88.79%

1.78

0.89

84.16%

1.41

0.63

98.22%

3.19

1.83

Morocco

91.75%

2.32

1.07

87.3%

1.61

0.79

98.95%

3.93

2.19

Netherlands

0.0%

0.0

0.0

91.94%

2.0

1.07

91.94%

2.0

1.07

New Zealand

0.0%

0.0

0.0

73.31%

1.09

0.37

73.31%

1.09

0.37

North Africa

87.26%

1.9

0.78

87.97%

1.67

0.83

98.47%

3.56

2.02

North America

91.84%

2.14

1.07

92.53%

2.0

1.09

99.39%

4.13

2.39

Northeast Asia

80.08%

1.41

0.5

86.03%

1.5

0.72

97.22%

2.91

1.55

Norway

0.0%

0.0

0.0

94.51%

2.34

1.2

94.51%

2.34

1.2

Oceania

86.77%

1.74

0.76

91.99%

1.77

1.06

98.94%

3.5

2.09

Oman

93.04%

2.14

1.11

0.0%

0.0

0.0

93.04%

2.14

1.11

Paraguay

0.0%

0.0

0.0

45.49%

0.53

0.18

45.49%

0.53

0.18

Peru

80.75%

1.72

0.52

81.81%

1.31

0.55

96.5%

3.03

1.44

Philippines

86.69%

1.73

0.75

19.14%

0.2

0.12

89.24%

1.92

0.93

Portugal

92.4%

2.16

1.09

88.6%

1.73

0.88

99.13%

3.89

2.24

Russia

94.7%

2.45

1.21

92.16%

1.99

1.08

99.58%

4.44

2.6

Saudi Arabia

86.23%

1.96

0.73

58.23%

0.8

0.24

94.25%

2.76

1.23

Serbia

85.71%

1.2

0.7

0.0%

0.0

0.0

85.71%

1.2

0.7

Singapore

79.61%

1.4

0.49

74.83%

0.92

0.4

94.87%

2.31

1.22

South Africa

92.34%

2.14

1.09

25.52%

0.26

0.13

94.3%

2.4

1.2

South America

86.48%

1.71

0.74

84.11%

1.42

0.63

97.85%

3.13

1.7

South Asia

81.86%

1.66

0.55

86.6%

1.59

0.75

97.57%

3.24

1.67

Southeast Asia

87.1%

1.66

0.77

84.03%

1.43

0.63

97.94%

3.1

1.74

Southwest Asia

78.69%

1.58

0.47

85.65%

1.53

0.7

96.94%

3.1

1.53

Spain

80.9%

1.37

0.52

89.68%

1.78

0.97

98.03%

3.15

1.77

Sweden

96.98%

2.44

1.33

89.41%

1.85

0.94

99.68%

4.3

2.57

Thailand

78.36%

1.36

0.46

83.55%

1.42

0.61

96.44%

2.78

1.43

Tunisia

85.74%

1.91

0.7

86.64%

1.66

0.75

98.09%

3.57

1.9

Turkey

1.99%

0.02

0.1

95.32%

2.07

1.21

95.41%

2.09

1.22

Ukraine

0.0%

0.0

0.0

21.22%

0.42

0.25

21.22%

0.42

0.25

United Arab Emirates

13.32%

0.14

0.12

32.92%

0.33

0.15

41.86%

0.47

0.17

United Kingdom

0.0%

0.0

0.0

38.38%

0.38

0.16

38.38%

0.38

0.16

United States

92.06%

2.15

1.07

94.95%

2.13

1.19

99.6%

4.29

2.54

Vietnam

79.28%

1.42

0.48

73.86%

0.97

0.38

94.58%

2.39

1.21

West Africa

90.38%

1.88

1.01

98.42%

2.36

1.55

99.85%

4.24

2.85

West Indies

94.69%

2.35

1.21

93.76%

1.93

1.13

99.67%

4.28

2.65

Average

68.12

1.49

0.66

77.89

1.45

0.73

92.24

2.94

1.63

Standard deviation

36.06

0.87

0.43

24.34

0.6

0.37

14.94

1.15

0.74

  1. aProjected population coverage
  2. bAverage number of epitope hits / HLA combinations recognized by the population
  3. cMinimum number of epitope hits / HLA combinations recognized by 90% of the population
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