Table 2 MHC-I epitopes prediction. HA and NA epitopes have been chosen according to MHC-I HLAs binding affinity (nM), %rank and antigenicity rate
From: A computational approach to design a multiepitope vaccine against H5N1 virus
pos | HLA | Peptide | Affinity(nM) | Allergenicity | Toxicity | Solubility | Antigenicity |
|---|---|---|---|---|---|---|---|
HA protein | |||||||
14 | HLA-A0101 | KSDQICIGY | 38.08 | No | Non-Toxin | Good | 2.07 |
223 | HLA-A3101 | RLVPKIATR | 9.27 | No | Non-Toxin | Good | 1.009 |
240 | HLA-A3201 | RMEFFWTIL | 7.29 | No | Non-Toxin | Good | 1.195 |
304 | HLA-A3207 | MPFHNIHPL | 17.58 | No | Non-Toxin | Good | 1.263 |
304 | HLA-A3215 | MPFHNIHPL | 26.87 | No | Non-Toxin | Good | 1.263 |
304 | HLA-A6601 | MPFHNIHPL | 986.12 | No | Non-Toxin | Good | 1.2633 |
304 | HLA-A6823 | MPFHNIHPL | 9.68 | No | Non-Toxin | Good | 1.2633 |
304 | HLA-B0801 | MPFHNIHPL | 40.2 | No | Non-Toxin | Good | 1.2633 |
304 | HLA-B1402 | MPFHNIHPL | 980.92 | No | Non-Toxin | Good | 1.2633 |
239 | HLA-B2705 | GRMEFFWTI | 16.64 | No | Non-Toxin | Good | 1.2086 |
239 | HLA-B2720 | GRMEFFWTI | 8.67 | No | Non-Toxin | Good | 1.2086 |
304 | HLA-B3501 | MPFHNIHPL | 6.01 | No | Non-Toxin | Good | 1.2633 |
150 | HLA-B3503 | CPYLGSPSF | 1547.44 | No | Non-Toxin | Good | 1.1181 |
306 | HLA-B3801 | FHNIHPLTI | 370.07 | No | Non-Toxin | Good | 1.3066 |
304 | HLA-B3901 | MPFHNIHPL | 6.61 | No | Non-Toxin | Good | 1.2633 |
240 | HLA-B4013 | RMEFFWTIL | 140.81 | No | Non-Toxin | Good | 1.1954 |
304 | HLA-B4201 | MPFHNIHPL | 16.2 | No | Non-Toxin | Good | 1.2633 |
447 | HLA-B4402 | MENERTLDF | 12.92 | No | Non-Toxin | Good | 1.5311 |
447 | HLA-B4403 | MENERTLDF | 32.05 | No | Non-Toxin | Good | 1.5311 |
240 | HLA-B4801 | RMEFFWTIL | 244.69 | No | Non-Toxin | Good | 1.1954 |
150 | HLA-B5101 | CPYLGSPSF | 429.32 | No | Non-Toxin | Good | 1.1181 |
150 | HLA-B5301 | CPYLGSPSF | 22.92 | No | Non-Toxin | Good | 1.1181 |
304 | HLA-B5401 | MPFHNIHPL | 16.45 | No | Non-Toxin | Good | 1.2633 |
237 | HLA-B5801 | QSGRMEFFW | 3.97 | No | Non-Toxin | Good | 1.0528 |
237 | HLA-B5802 | QSGRMEFFW | 9413.88 | No | Non-Toxin | Good | 1.0528 |
304 | HLA-B8301 | MPFHNIHPL | 97.78 | No | Non-Toxin | Good | 1.2633 |
NA protein | |||||||
105 | HLA-A0202 | HLECRIFFL | 25.01 | No | Non-Toxin | Good | 1.1819 |
23 | HLA-A0206 | LQIGNIISI | 7.02 | No | Non-Toxin | Good | 1.2621 |
393 | HLA-A0207 | GLDCIRPCF | 13,931.8 | No | Non-Toxin | Good | 1.4833 |
7 | HLA-A0211 | ITIGSICMV | 3.12 | No | Non-Toxin | Good | 2.0061 |
23 | HLA-A0212 | LQIGNIISI | 10.88 | No | Non-Toxin | Good | 1.2621 |
105 | HLA-A0217 | HLECRIFFL | 71.01 | No | Non-Toxin | Good | 1.1819 |
322 | HLA-A2301 | AYGVKGFSF | 99.25 | No | Non-Toxin | Good | 1.2975 |
322 | HLA-A2402 | AYGVKGFSF | 60.32 | No | Non-Toxin | Good | 1.2975 |
14 | HLA-A2601 | MVIGMVSLM | 5.23 | No | Non-Toxin | Good | 1.0720 |
14 | HLA-A2602 | MVIGMVSLM | 6.85 | No | Non-Toxin | Good | 1.0720 |
324 | HLA-A2902 | GVKGFSFKY | 22.73 | No | Non-Toxin | Good | 1.1111 |
324 | HLA-A3002 | GVKGFSFKY | 67.34 | No | Non-Toxin | Good | 1.1111 |
14 | HLA-A6601 | MVIGMVSLM | 2301.39 | No | Non-Toxin | Good | 1.0720 |
105 | HLA-B0802 | HLECRIFFL | 1975.27 | No | Non-Toxin | Good | 1.1819 |
105 | HLA-B0803 | HLECRIFFL | 5079.26 | No | Non-Toxin | Good | 1.1819 |
291 | HLA-B1501 | YQIGYICSG | 66.4 | No | Non-Toxin | Good | 1.3358 |
289 | HLA-B4001 | LEYQIGYIC | 158.53 | No | Non-Toxin | Good | 1.9916 |
289 | HLA-B4002 | LEYQIGYIC | 41.21 | No | Non-Toxin | Good | 1.9916 |
13 | HLA-B4801 | CMVIGMVSL | 1001.31 | No | Non-Toxin | Good | 1.9406 |
397 | HLA-C0702 | IRPCFWVEL | 644.03 | No | Non-Toxin | Good | 1.1888 |
328 | HLA-C0802 | FSFKYGNGV | 891.48 | No | Non-Toxin | Good | 1.3196 |
328 | HLA-C1203 | FSFKYGNGV | 12.1 | No | Non-Toxin | Good | 1.3196 |