Table 1 PRNT50 geometric mean tires to SARS-CoV-2 subvariants in those receiving four doses of BNT162b2 (BBBB)(n = 18) and three doses of BNT162b2 followed by BNT162b2 (WT + BA.4/5) bivalent vaccine (BBB + BIV) (n = 8)

BBBB

201.6

(122.1-332.9)

9.259

(6.949–12.34)

5.4

(4.831–6.037)

5.4

(4.831–6.037)

5.196

(4.791–5.636)

5

(5–5)

5

(5–5)

6.3

(5.33–7.446)

6.547

(5.507–7.783)

5

(5–5)

BBB + BIV

174.5

(64.14–474.6)

7.711

(4.17–14.26)

5.453

(4.442–6.692)

5

(5–5)

5

(5–5)

5

(5–5)

5

(5–5)

5.946

(4.547–7.775)

10.91

(5.296–22.45)

5

(5–5)

P value*

0.6754

0.3717

> 0.9999

0.5569

> 0.9999

> 0.9999

> 0.9999

> 0.9999

0.0697

> 0.9999

After 4th dose

GMT (95% CI) after booster

BBBB

1140

(848.5–1533)

35.64

(23.17–54.8)

8.249

(6.204–10.97)

7.349

(5.609–9.628)

7.937

(6.266–10.05)

8.249

(6.204–10.97)

6.062

(4.973–7.389)

7.937

(6.467–9.741)

9.622

(7.297–12.69)

6.547

(5.31–8.072)

BBB + BIV

1280

(748.5–2189)

246.8

(84.62–719.5)

28.28

(11.17–71.63)

25.94

(9.312–72.24)

23.78

(8.226–68.77)

25.94

(9.312–72.24)

18.34

(8.358–40.25)

16.82

(8.562–33.03)

43.62

(16.84–113)

11.89

(6.528–21.66)

P value*

0.609

0.0008

0.005

0.0058

0.0249

0.0145

0.0006

0.0245

0.0007

0.0375

Number (%) with PRNT₅₀titre ≥ 1:10

BBBB

18(100%)

18(100%)

10(56%)

7(39%)

10(56%)

9(50%)

4(22%)

11(61%)

13(72%)

6(33%)

BBB + BIV

8(100%)

8(100%)

7(88%)

6(75%)

6(75%)

6(75%)

7(88%)

7(88%)

8(100%)

6(75%)

Number (%) with PRNT₅₀titre ≥ 1:25.6#

BBBB

18(100%)

11(61%)

1(6%)

0(0%)

0(0%)

0(0%)

0(0%)

0(0%)

1(6%)

0(0%)

BBB + BIV

8(100%)

8(100%)

4(50%)

4(50%)

4(50%)

4(50%)

3(38%)

3(38%)

5(63%)

1(13%)