Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cells

Table 1 Furin and A. fumigatus alkaline protease 1 and their proposed function in the context of COVID-19 development

Protease	Type of protease	Source	Function(s) in source organism	Function in the context of SARS-CoV-2 infection
Furin protease (PDB ID: 5JXH)	Serine-based	Homo sapiens	Activates proprotein substrates [36].	Proteolytic cleavage of the viral S1/S2 site [25, 26, 35].
A. fumigatus alkaline protease 1 (PDB ID: AFUA_4G11800)	Serine-based	Aspergillus fumigatus	Help to disrupt the host structural barriers [14].	Suggested to act on the furin cleavage site within the S1/S2 site [35].

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